Review
Medicine, General & Internal
Tomonori Yano, Tatsunori Minamide, Kenji Takashima, Keiichiro Nakajo, Tomohiro Kadota, Yusuke Yoda
Summary: Photodynamic therapy using a conventional photosensitizer was replaced by second-generation photosensitizer talaporfin sodium to reduce adverse reactions in treating esophageal cancer. Endoscopic PDT using talaporfin sodium was approved as a salvage treatment for patients with local failure after chemoradiotherapy for esophageal cancer, based on favorable clinical trial results. Further evaluation is needed to determine the importance of PDT in the treatment of esophageal cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Tatsuya Kobayashi, Masayuki Nitta, Kazuhide Shimizu, Taiichi Saito, Shunsuke Tsuzuki, Atsushi Fukui, Shunichi Koriyama, Atsushi Kuwano, Takashi Komori, Kenta Masui, Taketoshi Maehara, Takakazu Kawamata, Yoshihiro Muragaki
Summary: Retrospective analysis showed that talaporfin sodium mediated photodynamic therapy (PDT) could potentially provide survival benefits for recurrent glioblastoma (GBM) patients, and its efficacy is independent of the pre-recurrence pathology.
Article
Medicine, General & Internal
Jiro Akimoto, Shinjiro Fukami, Kenta Nagai, Michihiro Kohno
Summary: PD and PDT using talaporfin sodium have been widely used in Japan for intracranial malignant tumors. However, there is a lack of research on malignant spinal cord tumors, which have poorer clinical outcomes compared to brain tumors. This report presents the first case of using PD and PDT for a malignant spinal cord tumor, showing promising efficacy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Takaaki Tsuchida, Yuji Matsumoto, Tatsuya Imabayashi, Keigo Uchimura
Summary: Photodynamic therapy (PDT) has been proven effective and safe in treating malignant central airway stenosis. However, the appropriate laser dose for talaporfin PDT remains unclear. This review of cases treated with talaporfin PDT suggests that a laser dose of 100 J/cm2 is feasible for improving airway stenosis in malignant central airway stenosis.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Engineering, Biomedical
Sharmin Akter, Sachiko Saito, Mizuho Inai, Norihiro Honda, Hisanao Hazama, Tomoyuki Nishikawa, Yasufumi Kaneda, Kunio Awazu
Summary: The study found that Laserphyrin (R)-HVJ-E prepared with 15 mM of Laserphyrin (R) had high photocytotoxicity and maintained the ability of HVJ-E to induce direct cytotoxicity. The therapeutic effect of Laserphyrin (R)-HVJ-E was substantially equivalent to that of Laserphyrin (R) alone, even at half the concentration. By combining the cytotoxicities of HVJ-E and PDT, Laserphyrin (R)-HVJ-E showed higher potency than Laserphyrin (R).
LASERS IN MEDICAL SCIENCE
(2021)
Article
Oncology
Makiko Sasaki, Mamoru Tanaka, Yuki Kojima, Hirotada Nishie, Takaya Shimura, Eiji Kubota, Hiromi Kataoka
Summary: Photodynamic therapy (PDT) is an anti-cancer therapy that uses a photosensitizer and specific light irradiation. The combination of TS-PDT and anti-PD-1 antibody shows potential in enhancing anti-tumor immunity. TS-PDT induces cell death and the release/expression of damage-associated molecular patterns (DAMPs) in vitro. In mouse models, the combination treatment inhibits tumor growth compared to single treatments or non-treatment groups.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Dermatology
Mariachiara Arisi, Benedetta Galli, Edoardo Guasco Pisani, Giuseppe La Rosa, Gaetano Licata, Sara Rovaris, Cesare Tomasi, Mariateresa Rossi, Marina Venturini, Luigi Spiazzi, Piergiacomo Calzavara-Pinton
Summary: The study compares the efficacy and tolerability of conventional photodynamic therapy (c-PDT) and indoor daylight photodynamic therapy (idl-PDT) for the treatment of actinic cheilitis (AC). Both treatment options were found to be highly effective, with idl-PDT showing milder inflammatory reaction and pain scores.
DERMATOLOGY AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mamoru Tanaka, Makiko Sasaki, Taketo Suzuki, Hirotada Nishie, Hiromi Kataoka
Summary: The study investigated the efficacy of combining talaporfin PDT with olaparib for gastric cancer treatment, demonstrating excellent synergistic action and significant tumor growth suppression. This combination therapy has the potential to be an effective antitumor treatment for gastric cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Surgery
Guodong Li, Qiuping Pang, Hailan Zhai, Xiujuan Zhang, Yanchun Dong, Ji Li, Xinyong Jia
Summary: The clinical efficacy and safety of SpyGlass-guided laser lithotripsy LCBDE for large CBD stones are comparable to traditional LCBDE, but with less invasiveness. Patients in Group A had shorter hospital stays and enhanced recovery compared to Group B.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, Research & Experimental
Yuichiro Ikebuchi, Akira Yoshida, Hiroki Kurumi, Yu Kamitani, Sho Yasui, Yusuke Nakada, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto
Summary: Talaporfin sodium photodynamic therapy (TS-PDT) has been shown to be highly effective and less invasive for esophageal squamous cell carcinoma patients with local failure after chemoradiotherapy. This study aimed to evaluate the efficacy and safety of PST in Tottori University Hospital, Japan. Results showed that TS-PDT was safe and effective in the first eight cases, with a high L-CR rate of 87.5% and a 2-year OS rate of 87%.
YONAGO ACTA MEDICA
(2021)
Article
Oncology
Maximilien Vermandel, Clement Dupont, Fabienne Lecomte, Henri-Arthur Leroy, Constantin Tuleasca, Serge Mordon, Constantinos G. Hadjipanayis, Nicolas Reyns
Summary: The study confirmed the feasibility and safety of intraoperative 5-ALA photodynamic therapy for treating GBM after maximal tumor resection, while also improving patient survival rates and survival time.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Takashi Iizumi, Toshiyuki Okumura, Naoyuki Hasegawa, Kazunori Ishige, Kuniaki Fukuda, Emiko Seo, Hirokazu Makishima, Hikaru Niitsu, Mizuki Takahashi, Yuta Sekino, Hiroaki Takahashi, Daichi Takizawa, Yoshiko Oshiro, Keiichiro Baba, Motohiro Murakami, Takashi Saito, Haruko Numajiri, Masashi Mizumoto, Kei Nakai, Hideyuki Sakurai
Summary: The study aimed to clarify the efficacy and safety of proton beam therapy for hepatocellular carcinoma with bile duct invasion. The results showed that proton beam therapy is a feasible and tolerable treatment option for patients with bile duct invasion hepatocellular carcinoma.
BMC GASTROENTEROLOGY
(2023)
Article
Oncology
Claudio Teruo Kassa, Luciana Toledo Costa Salviatto, Ana Carolina A. C. Tortamano, Ketlyn Sthefany Rost-Lima, Carla Andreotti Damante, Christiane Pavani, Alessandro Deana, Ilka Tiemy Kato, Mark Wainwright, Renato Araujo Prates
Summary: The photodynamic effect of methylene blue in sodium dodecyl sulfate in periodontitis was evaluated in this study. The results showed no significant reduction in bacterial plaque or clinical parameters.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Hideya Yamazaki, Takuya Kimoto, Motohisa Suzuki, Masao Murakami, Osamu Suzuki, Masaru Takagi, Norio Katoh, Takeshi Arimura, Takashi Ogino, Hiroyuki Ogino
Summary: This study examined the outcomes of patients with biliary duct carcinoma treated with particle beam therapy. The results showed that particle beam therapy has good efficacy for biliary duct carcinoma, with higher radiation doses improving overall survival. In particular, higher radiation doses were associated with better outcomes for patients with extrahepatic biliary duct carcinoma.
Article
Oncology
Jun-Yi Wu, Li-Ming Huang, Yan-Nan Bai, Jia-Yi Wu, Yong-Gang Wei, Zhi-Bo Zhang, Mao-Lin Yan
Summary: HCC patients with B1-B3 BDTT have more advanced tumor stages and adverse clinicopathological features. The imaging features of HCC with BDTT on CT and MRI scans, including HCC lesions and intrahepatic bile duct dilation, might facilitate the early diagnosis of B1-B3 BDTT.
FRONTIERS IN ONCOLOGY
(2021)
