Article
Multidisciplinary Sciences
Arnoult Morrone, Imad Bentellis, Jean-Christophe Bernhard, Karim Bensalah, Cecile Champy, Franck Bruyere, Nicolas Doumerc, Jonathan Olivier, Francois Audenet, Bastien Parier, Martin Brenier, Jean-Alexandre Long, Francois-Xavier Nouhaud, Nicolas Branger, Herve Lang, Thomas Charles, Evanguelos Xylinas, Thibaut Waeckel, Florie Gomez, Romain Boissier, Benjamin Rouget, Aysha Shaikh, Daniel Chevallier, Damien Ambrosetti, Matthieu Durand
Summary: The oncological impact of positive surgical margins (PSM) after robot-assisted partial nephrectomy (RAPN) is still under debate. This study compared PSM and Negative Surgical Margins (NSM) in terms of recurrence-free survival (RFS), metastasis-free survival (MFS), and overall survival (OS) after RAPN. The results showed that PSM did not have any significant impact on RFS, MFS, or OS. The predictors of PSM were a lower RENAL score, longer warm ischemia time (WIT), and Chromophobe Renal Cell Carcinoma (chrRCC).
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Jihion Yu, Jun-Young Park, Jai-Hyun Hwang, Cheryn Song, Young-Kug Kim
Summary: The periarterial administration of papaverine after renal artery clamping improved intraoperative renal artery blood flow and early postoperative glomerular filtration rate in robot-assisted partial nephrectomy, suggesting it as a valuable option for improving renal function.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Victor Audige, Adnan Baghli, Jacques Hubert, Charles Mazeaud, Stephane Larre, Benjamin Branchu
Summary: This study compared the clinical and perioperative outcomes of open partial nephrectomy and robotic-assisted partial nephrectomy. It found that robotic-assisted partial nephrectomy had better perioperative outcomes with shorter hospital stay and less blood loss, as well as fewer complications.
JOURNAL OF ROBOTIC SURGERY
(2023)
Article
Urology & Nephrology
Yudai Ishiyama, Tsunenori Kondo, Hidekazu Tachibana, Kazuhiko Yoshida, Junpei Iizuka, Kazunari Tanabe, Toshio Takagi
Summary: This study found that there is a correlation between warm ischemic time (WIT) and the occurrence of acute kidney injury (AKI) in patients undergoing robot-assisted partial nephrectomy (RAPN), with the strength of this correlation increasing in patients with more severe baseline chronic kidney disease (CKD). Additionally, there is a significant but clinically modest correlation between WIT and renal function.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Urology & Nephrology
Tuna Till Mut, Omer Acar, Ayse Armutlu, Said Incir, Annemarie Uhlig, Lale A. Ertuglu, Melis Ozel, Ali Cihan Taskin, Dilek Ertoy Baydar, Mehmet Kanbay, Tarik Esen
Summary: The study found that while RIPC failed to mitigate the detrimental effects of PN under warm ischemia on renal function in a solitary kidney animal model, there were marginal histological findings supportive of RIPC's renoprotective potential.
Article
Oncology
Kazuyuki Numakura, Mizuki Kobayashi, Atsushi Koizumi, Soki Kashima, Ryohei Yamamoto, Taketoshi Nara, Mitsuru Saito, Shintaro Narita, Takamitsu Inoue, Tomonori Habuchi
Summary: This study investigated the impact of RENAL nephrometry score and clinical factors on warm ischemia time in robot-assisted laparoscopic partial nephrectomy (RALPN). The study found that a large tumor in the central lesion indicated by the RENAL L-component score was associated with increased warm ischemia time.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Qinyu Li, Yucong Zhang, Man Liu, Heng Li, Wei Guan, Xiaoyan Meng, Zhiquan Hu, Zhihua Wang, Shaogang Wang, Zhen Li, Jihong Liu, Zheng Liu
Summary: This study aims to identify new parameters for predicting outcomes after robot-assisted partial nephrectomy (RPN) by using three-dimensional reconstruction of preoperative enhanced computerized tomography (CT). The study found that a larger tumor bed area (TBA) was associated with longer warm ischemia time (WIT) and tumor resection time as well as elevated postoperative creatinine. TBA and distance from the tumor to the first bifurcation of the renal artery (DTA) were independent risk factors for prolonged WIT, and the combination of TBA, DTA, and RENAL score had a higher predictive effect for WIT compared to the RENAL score alone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Masashi Kubota, Toshinari Yamasaki, Shiori Murata, Yohei Abe, Yoichiro Tohi, Yuta Mine, Hiroki Hagimoto, Hidetoshi Kokubun, Issei Suzuki, Naofumi Tsutsumi, Koji Inoue, Mutsushi Kawakita
Summary: This study compared the surgical and functional outcomes between robot-assisted and laparoscopic methods of cortical-renorrhaphy-omitting partial nephrectomy. The study found that the robot-assisted group had better outcomes in terms of shorter operation time, warm ischemic time, less blood loss, lower incidence of complications, higher preservation rate of renal function, and higher achievement rate of trifecta compared to the laparoscopic group.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Longbin Xiong, Jane K. Nguyen, Yulu Peng, Zhaohui Zhou, Kang Ning, Nan Jia, Jing Nie, Dongxiang Wen, Zeshen Wu, Gustavo Roversi, Diego Aguilar Palacios, Emily Abramczyk, Carlos Munoz-Lopez, Jack A. Campbell, Yun Cao, Wencai Li, Xuepei Zhang, Zhisong He, Xiang Li, Jiwei Huang, Jianzhong Shou, Jitao Wu, Minfeng Chen, Xiaofeng Chen, Jiaxuan Zheng, Congjie Xu, Wen Zhong, Zaishang Li, Wen Dong, Juping Zhao, Hailang Zhang, Junhang Luo, Jianye Liu, Fanghu Sun, Hui Han, Shengjie Guo, Pei Dong, Fangjian Zhou, Chunping Yu, Steven C. Campbell, Zhiling Zhang
Summary: After partial nephrectomy, histologic deterioration of the preserved renal parenchyma may occur, primarily correlated with comorbidities such as hypertension, diabetes mellitus, or chronic kidney disease, rather than ischemia insult. The subsequent decline in renal function is mild and independent of histologic changes. This suggests that conventional, limited durations of ischemia have only limited impact on parenchyma deterioration after partial nephrectomy.
Article
Urology & Nephrology
B. Malik Wahba, Alexander K. Chow, Kefu Du, Kenneth G. Sands, Alethea G. Paradis, Joel M. Vetter, Ramakrishna Venkatesh, Eric H. Kim, Sam B. Bhayani, R. Sherburne Figenshau
Summary: This study retrospectively reviewed data of patients with clinically localized renal masses who underwent RPN from June 2007 to December 2012 at Washington University School of Medicine. It was found that patients with PSM had a 14-fold increased risk for disease recurrence, with higher incidence of chronic obstructive pulmonary disease and greater blood loss.
JOURNAL OF ENDOUROLOGY
(2021)
Article
Urology & Nephrology
Stephen T. Ryan, Devin N. Patel, Fady Ghali, Sunil H. Patel, Reith Sarkar, Kendrick Yim, Ahmed Eldefrawy, Brittney H. Cotta, Aaron W. Bradshaw, Margaret F. Meagher, Zachary A. Hamilton, James D. Murphy, Ithaar H. Derweesh
Summary: The study found that positive surgical margins (PSM) were associated with decreased overall survival (OS) in patients undergoing partial nephrectomy, especially in pT3a disease.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Oncology
Fabian Obrecht, Christian Padevit, Gabriel Froelicher, Simon Rauch, Marco Randazzo, Shahrokh F. Shariat, Hubert John, Beat Foerster
Summary: The study evaluated the association between ischemia type and duration during robot-assisted partial nephrectomy (RAPN) and postoperative acute kidney injury (AKI). The results showed that ischemia time thresholds of less than 17 minutes for warm ischemia (WI), less than 30 minutes for selective artery clamping (SAC), or zero ischemia (ZI) significantly reduced the risk of postoperative AKI.
Article
Oncology
Kiyoshi Takahara, Yoshiharu Ohno, Kosuke Fukaya, Ryo Matsukiyo, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Naohiko Fukami, Hitomi Sasaki, Mamoru Kusaka, Hiroshi Toyama, Makoto Sumitomo, Ryoichi Shiroki
Summary: This study evaluated the use of UHR-CT for intraoperative navigation during RAPN and compared its outcomes to those of ADCT. The results showed that UHR-CT provided shorter warm ischemia time and lower estimated blood loss than ADCT. However, there were no significant differences in short-term renal function between the two groups.
Article
Oncology
Hugo Otaola-Arca, Alfred Krebs, Hugo Bermudez, Raul Lyng, Marcelo Orvieto, Alberto Bustamante, Conrado Stein, Andres Labra, Marcela Schultz, Mario Fernandez
Summary: Robot-assisted partial nephrectomy (RAPN) for renal cell carcinoma (RCC) has been shown to result in excellent long-term survival and preserved renal function in most patients. The incidence of local and distant relapse is low in this large cohort.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Yudai Ishiyama, Tsunenori Kondo, Hidekazu Tachibana, Kazuhiko Yoshida, Toshio Takagi, Junpei Iizuka, Kazunari Tanabe
Summary: The study found that extended warm ischemia during robot-assisted partial nephrectomy has limited impact on patients' renal function, especially for those with large and complex tumors.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Michael Baboudjian, Bastien Gondran-Tellier, Zineddine Khene, Pierre Bigot, Arnaud Mejean, Herve Lang, Cedric Lebacle, Nicolas Doumerc, Franck Bruyere, Francois-Xavier Nouhaud, Idir Ouzaid, Karim Bensalah, Jean Christophe Bernhard, Romain Boissier
Summary: This study assessed the oncological outcomes of renal cell carcinoma (RCC) with tumor thrombus and identified predictive factors of recurrence. The results showed that adjuvant therapy was effective in reducing cancer recurrence risk.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Clement Michiels, Zine-Eddine Khene, Thomas Prudhomme, Astrid Boulenger de Hauteclocque, Francois H. Cornelis, Melanie Percot, Helene Simeon, Laure Dupitout, Henri Bensadoun, Gregoire Capon, Eric Alezra, Vincent Estrade, Franck Bladou, Gregoire Robert, Jean-Marie Ferriere, Nicolas Grenier, Nicolas Doumerc, Karim Bensalah, Jean-Christophe Bernhard
Summary: In robot-assisted partial nephrectomy (RAPN), using three-dimensional model reconstructions for preoperative planning and intraoperative guidance can reduce complications and improve perioperative clinical outcomes.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Mechanics
George El Haber, Jonathan Viquerat, Aurelien Larcher, David Ryckelynck, Jose Alves, Aakash Patil, Elie Hachem
Summary: The availability of accurate and efficient numerical simulation tools is crucial for the design and optimization of industrial processes. Machine learning techniques integrated with numerical simulation tools can reduce computational burden and provide reliable deep learning-assisted numerical solvers.
Article
Urology & Nephrology
Gabriele Sorce, Benedikt Hoeh, Lukas Hohenhorst, Andrea Panunzio, Stefano Tappero, Zhe Tian, Andrea Kokorovic, Alessandro Larcher, Umberto Capitanio, Derya Tilki, Carlo Terrone, Felix K. H. Chun, Alessandro Antonelli, Fred Saad, Shahrokh F. Shariat, Francesco Montorsi, Alberto Briganti, Pierre I. Karakiewicz
Summary: This study found that local tumor destruction (LTD) treatment for T1a renal cell carcinoma (RCC) patients is associated with higher cancer-specific mortality (CSM) compared to partial nephrectomy (PN) treatment, especially for patients with tumor size between 3.1 and 4 cm.
EUROPEAN UROLOGY FOCUS
(2023)
Editorial Material
Urology & Nephrology
Alessandro Larcher, Federico Belladelli, Umberto Capitanio, Francesco Montorsi
Letter
Oncology
Umberto Capitanio, Giuseppe Rosiello, Andrea Necchi, Francesco Montorsi, Alessandro Larcher
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Urology & Nephrology
Umberto Capitanio, Massimo Freschi, Giuseppe Rosiello, Giuseppe Fallara, Giacomo Musso, Francesco Cei, Giuseppe Basile, Isaline Rowe, Daniela Canibus, Roberta Luciano, Claudio Doglioni, Chiara Re, Andrea Salonia, Alessandro Larcher, Francesco Montorsi
Article
Urology & Nephrology
Daniele Cignoli, Giuseppe Basile, Giuseppe Fallara, Giuseppe Rosiello, Federico Belladelli, Francesco Cei, Giacomo Musso, Chiara Re, Roberto Bertini, Pierre Karakiewicz, Alexandre Mottrie, Federico Deho, Andrea Gallina, Francesco Montorsi, Andrea Salonia, Umberto Capitanio, Alessandro Larcher
Summary: This study aimed to investigate the impact of longer warm ischemia time (WIT) on renal function and intraoperative hemorrhagic risk. The results showed that longer WIT was associated with decreased postoperative renal function and increased hemorrhagic risk. Therefore, it is important for patients and clinicians to avoid excessive WIT during partial nephrectomy.
Letter
Urology & Nephrology
Zine-Eddine Khene, Alexander Kutikov, Riccardo Campi
Review
Urology & Nephrology
Giuseppe Fallara, Fabrizio DI Maida, Carlo A. Bravi, Ruben DE Groote, Federico Piramide, Filippo Turri, Iulia Andras, Marcio Moschovas, Alessandro Larcher, Alberto Breda, Paolo Dell'Oglio
Summary: Through a systematic review and meta-analysis, we found that robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC) are equally effective options for the surgical treatment of patients with localized muscle invasive or high-grade non-muscle invasive BCG unresponsive bladder cancer. Although ORC had a shorter operative time, RARC had a shorter length of hospital stay and lower estimated blood loss. However, there were no significant differences between the two approaches in terms of oncological and perioperative outcomes.
MINERVA UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Pierre Bigot, Jean-Christophe Bernhard, Zine-Eddine Khene, Charles Dariane, Souhil Lebdai, Nicolas Doumerc, Francois Xavier Nouhaud, Idir Ouzaid, Patrick Saulnier, Arnaud Mejean, Morgan Roupret, Karim Bensalah, French Comm Urologic Oncology
Summary: Surgical excision of renal tumours is associated with significant changes in blood pressure, with almost 20% of patients developing de novo hypertension. The type of surgery (partial nephrectomy vs radical nephrectomy) does not affect the risk of hypertension, and the predictors of de novo hypertension are age and body mass index.
Article
Urology & Nephrology
Alessio Pecoraro, Eduard Roussel, Daniele Amparore, Andrea Mari, Antonio Andrea Grosso, Enrico Checcucci, Francesco Montorsi, Alessandro Larcher, Hendrik Van Poppel, Francesco Porpiglia, Umberto Capitanio, Andrea Minervini, Maarten Albersen, Sergio Serni, Riccardo Campi
Summary: This study aims to evaluate the prevalence and risk of acute kidney injury (AKI) and new-onset clinically significant chronic kidney disease (csCKD) in patients with a single localized renal mass (LRM) who undergo partial nephrectomy (PN) or radical nephrectomy (RN) while preserving baseline renal function.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Article
Urology & Nephrology
Carlo Andrea Bravi, Giuseppe Rosiello, Elio Mazzone, Andrea Minervini, Andrea Mari, Fabrizio Di Maida, Karim Bensalah, Benoit Peyronnet, Zine-Eddine Khene, Riccardo Schiavina, Lorenzo Bianchi, Alexandre Mottrie, Geert De Naeyer, Alessandro Antonelli, Maria Furlan, Koon Ho Rha, Ahmad Almujalhem, Ithaar Derweesh, Aaronw Bradshaw, Jihak Kaouk, Guilherme Sawczynk, Riccardo Bertolo, Alberto Breda, Francesco Montorsi, Umberto Capitanio, Alessandro Larcher
Summary: This study compared the clinical outcomes of robot-assisted and open partial nephrectomy. The results showed that robot-assisted surgery had better outcomes in terms of postoperative complications. There were no significant differences between robot-assisted and open surgery in terms of renal function and cancer control.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Article
Urology & Nephrology
Alessandro Larcher, Francesco Cei, Federico Belladelli, Giuseppe Rosiello, Carlo Andrea Bravi, Giuseppe Fallara, Giuseppe Basile, Roberta Luciano, Pierre Karakiewicz, Alexandre Mottrie, Alberto Breda, Alberto Briganti, Andrea Salonia, Roberto Bertini, Francesco Montorsi, Umberto Capitanio
Summary: Although radical nephrectomy is the most common treatment for kidney cancer, the learning curve for this procedure is not known. This study investigated the impact of surgical experience on the outcomes of radical nephrectomy. The results showed that surgical experience did not significantly affect mortality, disease progression, complications, and renal function, but it was associated with shorter operative time.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)