Article
Oncology
Chengwu Xiao, Yang Wang, Meimian Hua, Wei Zhang, Guanyu Ren, Bin Yang, Qing Yang
Summary: This study retrospectively analyzed the techniques and outcomes of complete transperitoneal laparoscopic nephroureterectomy (CTLNU) and laparoscopic nephroureterectomy with open bladder cuff excision (LNOBE) for upper urinary tract urothelial carcinoma (UTUC). The results showed that CTLNU in a single position had advantages of shorter operation time, less blood loss, and shorter incision length.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zhenkai Luo, Binbin Jiao, Yangxuanyu Yan, Yuhao Liu, Haijie Chen, Yunfan Guan, Zhenshan Ding, Guan Zhang
Summary: This study aimed to establish and validate a nomogram for predicting extraurothelial recurrence (EUR) after radical nephroureterectomy (RNU) in patients with upper urinary tract urothelial carcinoma (UTUC). The study retrospectively analyzed data from 521 UTUC patients who underwent RNU and divided them into a training cohort (n=301) and an external validation cohort (n=220). The nomogram was developed using multivariable Cox regression and validated using various parameters such as the concordance index (C-index) and decision curve analysis (DCA). The nomogram showed good discrimination ability and clinical net benefit in predicting EUR in UTUC patients after RNU.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jian Wang, Xiepeng Zuo, Yu Zhang, Weiwei Wang, Diansheng Zhou, Wenbo Liu, Guoqiang Han, Changli Wu, Dawei Tian
Summary: This study investigated the impact of histological variants (HV) in patients with upper tract urothelial carcinoma (UTUC) and analyzed the potential association between HV and postoperative bladder recurrence. The results showed that UTUC patients with HV were associated with biologically aggressive disease and recurrent MIBC after surgery. Therefore, bladder recurrence following surgery needs to be given more attention in advanced UTUC patients with HV.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Aleksander Slusarczyk, Piotr Zapala, Tomasz Piecha, Lukasz Zapala, Tomasz Borkowski, Piotr Radziszewski
Summary: The study found that patients who underwent radical nephroureterectomy for upper urinary tract urothelial cancer after radical cystectomy experienced poor overall survival and cancer-specific survival, with most surgeries being performed for locally advanced tumors. Independent risk factors for worse survival included UTUC T stage, presence of metastasis, and male gender.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jun Zhu, Xiaoqing Zhang, Wei Yu, Xuesong Li, Zhisong He, Liqun Zhou, Zhongyuan Zhang, Gengyan Xiong
Summary: This study identified the predictors for unfavorable pathological types of intravesical recurrence (IVR) after radical nephroureterectomy (RNU) in patients with upper urinary tract urothelial carcinoma (UTUC). Nomograms were developed based on these predictors and showed good agreement between observation and prediction cases. Early detection of IVR through active follow-up may benefit high-risk patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Jie Wu, Pei-Hang Xu, Wen-Jie Luo, Bo Dai, Yi-Jun Shen, Ding-Wei Ye, Yu-Chen Wang, Yi-Ping Zhu
Summary: The study examined the impact of standard primary bladder cancer surgical strategy on the survival of patients diagnosed with upper urinary tract urothelial carcinoma-bladder cancer (UTUC-BC). Results showed that UTUC-BC patients had a worse prognosis after surgery compared to primary BC patients, indicating that current primary BC surgical guidelines may not be entirely appropriate for UTUC-BC patients. Independent risk factors for UTUC-BC patients included older age, advanced disease stage, and shorter interval between UTUC and BC diagnosis. Further studies are needed to improve prognosis and guidelines for managing UTUC-BC patients.
FRONTIERS IN SURGERY
(2021)
Article
Oncology
Guoyao Zhang, Wanping Shi, Enzhao Jia, Lei Zhang, Yongsheng Han, Ronald Rodriguez, Tianjiang Ma
Summary: The study validated a correlation between low FOXO3A expression and advanced stage, lymph node metastasis, lymphovascular invasion, and shorter survival time in UTUC patients. Multivariate analysis indicated that FOXO3A was a significant predictor for overall survival and recurrence-free survival in UTUC patients. The results suggest that FOXO3A may be involved in UTUC recurrence and have clinical value in therapeutic targeting and prognostic evaluation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Yu-Pin Huang, Eric Yi-Hsiu Huang, Hsiao-Jen Chung, Meng-Che Tai, Tzu-Hao Huang, Tzu-Chun Wei, Yu-Hua Fan, Chih-Chieh Lin, Tzu-Ping Lin, Junne-Yih Kuo, Shing-Hwa Lu, Yen-Hwa Chang, Alex Tong-Lung Lin, William Ji-Sien Huang
Summary: This study compared the outcomes of robot-assisted radical nephroureterectomy (RANU) and laparoscopic nephroureterectomy (LNU) for the treatment of upper urinary tract urothelial carcinoma (UTUC). The results showed that RANU and LNU had similar perioperative and oncologic outcomes, but RANU had lower intraoperative blood loss and shorter postoperative length of hospital stay.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Medicine, General & Internal
Tsu-Ming Chien, Ching-Chia Li, Yen-Man Lu, Yii-Her Chou, Hsueh-Wei Chang, Wen-Jeng Wu
Summary: The study found that high SII was associated with clinical and pathologic characteristics, high NLR was related to personal characteristics, and high PLR was associated with age and disease severity in UTUC patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Jianing Gao, Jingya Liu, Jianyu Liu, Shiyan Lin, Dexin Ding
Summary: Sex, presence of lymphovascular invasion (LVI), advanced pT stage, and lack of postoperative intravesical instillation were identified as independent prognostic factors for overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), and metastasis-free survival (MFS) in UTUC patients. Laparoscopic RNU was also associated with inferior OS, CSS, and MFS. High-risk patients may benefit from adjuvant or neoadjuvant chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tae Heon Kim, Hyun Hwan Sung, Jong Jin Oh, Seok Ho Kang, Ho Kyung Seo, Bumsik Hong, Ja Hyeon Ku, Byong Chang Jeong
Summary: This study evaluated the impact of preoperative renal function on oncological outcomes in patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy. The results showed that patients with chronic kidney disease had a higher risk of poor overall survival, cancer-specific survival, and progression-free survival.
Article
Oncology
Hsuan Alan Chen, Chao-Hsiang Chang, Chi-Ping Huang, Wen-Jeng Wu, Ching-Chia Li, Chung-Hsin Chen, Chao-Yuan Huang, Chi-Wen Lo, Chih-Chin Yu, Chung-You Tsai, Wei-Che Wu, Jen-Shu Tseng, Wun-Rong Lin, Yuan-Hong Jiang, Yu-Khun Lee, Yeong-Chin Jou, Ian-Seng Cheong, Thomas Y. Hsueh, Allen W. Chiu, Yung-Tai Chen, Jih-Sheng Chen, Bing-Juin Chiang, Yao-Chou Tsai, Wei Yu Lin, Chia-Chang Wu, Jen-Tai Lin, Chia-Cheng Yu
Summary: This study aimed to identify predicting factors of oncological outcomes following RNU for UTUC in Taiwan. The results showed that synchronous bladder UC and preoperative hydronephrosis were unfavorable prognostic factors, and laparoscopic RNU may provide better oncological control.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sandra Karanovic, Maude Ardin, Zuojian Tang, Karla Tomic, Stephanie Villar, Claire Renard, Elisa Venturini, Adam H. Lorch, Daniel S. Lee, Zelimir Stipancic, Neda Slade, Ivana Vukovic Brinar, Damir Dittrich, Kresimir Karlovic, Fran Borovecki, Kathleen G. Dickman, Magali Olivier, Arthur P. Grollman, Bojan Jelakovic, Jiri Zavadil
Summary: This study identified molecular programs underlying UTUC tumorigenesis in patients from regions with exposure to herbal carcinogen aristolochic acid nephropathy (AAN). They found UTUC-specific miRNA:mRNA networks involving cell cycle, DNA damage response, bladder cancer pathways, among others. Exome and transcriptome sequencing revealed AA-specific mutational signature SBS22 and identified UTUC-specific miRNAs as potential biomarkers for noninvasive urine-based screening of AAN patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Surgery
Danielle Whiting, Seshadri Sriprasad
Summary: The management of the distal ureter during laparoscopic nephroureterectomy for upper tract urothelial carcinoma is controversial, with different techniques showing variations in oncological outcomes. However, due to inadequate reporting of potential confounding factors, no definitive conclusion can be drawn on the superiority of any one technique, highlighting the need for further research.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2021)
Article
Oncology
Haidar Abdul-Muhsin, Noel De Lucia, Vijay Singh, Kassem Faraj, Kyle Rose, Stephen Cha, Nan Zhang, Nathanael Judge, Anojan Navaratnam, Mark Tyson, Thai Ho, Kenneth Jacobsohn, Erik Castle
Summary: This study aimed to predict survival outcomes for upper tract urothelial carcinoma patients following radical nephroureterectomy using simple patient data. The model showed high accuracy in predicting overall survival, cancer specific survival, and metastasis specific survival, with validation accuracy ranging from 71.4% to 78.4%.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)