Review
Immunology
Hualin Chen, Wenjie Yang, Xiaoqiang Xue, Yingjie Li, Zhaoheng Jin, Zhigang Ji
Summary: Neoadjuvant immunotherapy and chemoimmunotherapy have been found to be effective and safe in the treatment of muscle-invasive bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuhan Yang, Xiuhe Zou, Yixi Wang, Xuelei Ma
Summary: A deep-learning convolution neural network (DL-CNN) system was developed to differentiate muscle-invasive bladder cancer (MIBC) and non-muscle-invasive bladder cancer (NMIBC) on contrast-enhanced CT images, achieving favorable AUROCs. The VGG16 model showed the highest AUROC among the eight deep learning algorithms tested, with promising sensitivity and specificity. The DL-CNN system has the potential to assist in improving diagnostic accuracy in patients with bladder cancer by classifying NMIBC and MIBC based on contrast-enhanced CT images.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jiexin Pan, Guibin Hong, Hong Zeng, Chengxiao Liao, Huarun Li, Yuhui Yao, Qinghua Gan, Yun Wang, Shaoxu Wu, Tianxin Lin
Summary: This study aimed to develop a pathological artificial intelligence diagnostic model for bladder cancer. The model was developed using deep learning algorithm and achieved good performance in identifying invasion depth and histologic grade. The model also showed great potential in patch-level recognition.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Urology & Nephrology
Christine G. J. I. van Straten, Max H. Bruins, Siebren Dijkstra, Erik B. Cornel, Michael D. H. Kortleve, Thijn F. de Vocht, Lambertus A. L. M. Kiemeney, Antoine G. van der Heijden
Summary: The prognosis of muscle-invasive bladder cancer (MIBC) has not improved for three decades. The standard procedure, transurethral resection of the bladder tumor (TURBT), has limitations in tumor staging. Recent studies have shown that mpMRI is accurate in staging bladder tumors. This study compares the diagnostic efficacy of urethrocystoscopy (UCS) with pathology.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Zhang, Xiaoyang Li, Li Yang, Ying Tang, Junting Guo, Ding Li, Shuo Li, Yan Li, Le Wang, Ying Lei, Hong Qiao, Guoqiang Yang, Xiaochun Wang
Summary: The study aimed to explore the use of multi-sequence and multi-regional MRI-based radiomics models for assessing muscle invasion in bladder cancer (BCa). The results showed that the radiomics-clinical nomogram was superior to the clinical model in assessing BCa muscle invasion.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Lifeng Zhang, Shenglin Gao, Xiaokai Shi, Yin Chen, Shuzhang Wei, Yuanyuan Mi, Li Zuo, Chunjian Qi
Summary: This study reveals that NUPR1 plays a carcinogenic role in bladder cancer (BLCA) and its expression is significantly higher in BLCA tissues compared to controls. Lentivirus-mediated interference of NUPR1 can delay tumor growth in BLCA by interfering with cell cycle progression and through epithelial-mesenchymal transition (EMT). Macrophages are the most related immune cells associated with the expression of NUPR1 in BLCA.
Article
Biochemistry & Molecular Biology
Eun Hye Lee, Jae-Wook Chung, Eunji Sung, Bo Hyun Yoon, Minji Jeon, Song Park, So Young Chun, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Tae Hwan Kim, Seock Hwan Choi, Eun Sang Yoo, Tae Gyun Kwon, Ho Won Kang, Wun-Jae Kim, Seok Joong Yun, Sangkyu Lee, Yun-Sok Ha
Summary: This study evaluated the role of PDK4 in bladder cancer and its related protein changes. It was found that elevated expression of PDK4 was observed in high-grade bladder cancers. Knockdown of PDK4 in bladder cancer cells resulted in reduced cell migration and invasion. Additionally, a PDK4 knockdown xenograft model showed reduced bladder cancer growth. These findings suggest that PDK4 plays a critical role in the metastasis and growth of bladder cancer cells through changes in ERK, SRC, and JNK.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gabriela Vanessa Flores Monar, Thomas Reynolds, Maxie Gordon, David Moon, Chulso Moon
Summary: Bladder cancer is a financially burdensome cancer with significant impact on patients and the medical community. Current detection methods have limitations and there is a need to explore new screening assays. This article provides a comprehensive overview of bladder cancer and analyzes FDA-approved assays for diagnosis and monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Interdisciplinary Applications
Jianpeng Li, Zhengxuan Qiu, Kangyang Cao, Lei Deng, Weijing Zhang, Chuanmiao Xie, Shuiqing Yang, Peiyan Yue, Jian Zhong, Jiegeng Lyu, Xiang Huang, Kunlin Zhang, Yujian Zou, Bingsheng Huang
Summary: This study compared the effectiveness of radiomics, single-task deep learning (DL), and multi-task DL methods in predicting muscle-invasive bladder cancer (MIBC) status based on T2-weighted imaging (T2WI). The multi-task model performed better in the test cohort compared to other models. The multi-task DL method had the advantage of saving time and effort compared to radiomics, and it was more lesion-focused and reliable for clinical reference compared to the single-task DL method.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yumiko Okuno, Mami Hattori-Kato, Hiroki Tanaka, Akiko Tonooka, Takumi Takeuchi
Summary: The ZNF668 gene encodes a zinc-finger protein with 16 C2H2-type zinc fingers and acts as a tumor suppressor in breast cancer. The expression of ZNF668 protein was analyzed in bladder cancer and mutations of the ZNF668 gene were examined in 68 bladder cancer cases. The protein was expressed in the nuclei of bladder cancer cells, with significantly lower expression in cases with submucosal and muscular infiltration. Somatic mutations in the gene were found in 7.3% of the cases, resulting in amino acid sequence alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yang Dong, Wei-ming Ma, Zhen-duo Shi, Zhi-guo Zhang, Jia-he Zhou, Yang Li, Shao-qi Zhang, Kun Pang, Bi-bo Li, Wen-da Zhang, Tao Fan, Guang-yuan Zhu, Liang Xue, Rui Li, Ying Liu, Lin Hao, Cong-hui Han
Summary: Bladder urothelial carcinoma (BC) is a deadly malignancy, and Neuropilin-1 (NRP1) has been found to be highly expressed in BC tissues and cells. Knockdown of NRP1 promotes apoptosis and inhibits proliferation, angiogenesis, migration, and invasion of BC cells, potentially serving as a new therapeutic target for BC treatment. Additionally, NRP1 affects various biological functions through MAPK signaling and cancer pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Acoustics
Xing Hu, Chuanyu Sun, Xinping Ren, Shengyang Ge, Chunmei Xie, Xiangyu Li, Yingfeng Zhu, Hong Ding
Summary: By comparing the experimental group and the control group, the usefulness of contrast-enhanced ultrasound (CEUS) combined with elastography in assessing muscle invasion by bladder cancer (MIBC) was evaluated. The results showed that PI, E-mean, MVD, and CFC were significantly higher in the experimental group than in the control group. There were significant correlations between PI and MVD, and between E-mean and CFC. The comprehensive utilization of PI and E-mean improved diagnostic accuracy and have clinical application.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Oncology
Ryohei Kufukihara, Eiji Kikuchi, Keisuke Shigeta, Koichiro Ogihara, Yuki Arita, Hirotaka Akita, Tatsuya Suzuki, Takayuki Abe, Ryuichi Mizuno, Masahiro Jinzaki, Mototsugu Oya
Summary: This study compared the diagnostic performance of VI-RADS scoring with diagnostic cystoscopy in bladder cancer diagnosis and evaluated the diagnostic accuracies based on tumor locations. The results showed that VI-RADS had significantly higher diagnostic accuracy for detecting muscle-invasive bladder cancer (MIBC) compared to cystoscopy, especially for tumors located at the bladder neck, trigone, dome, and posterior and anterior walls. However, VI-RADS was inferior to cystoscopy in terms of MIBC detection for tumors located on the lateral wall or ureteral orifice. Therefore, a combination of diagnostic tools is recommended for accurate staging of these tumors.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Cell Biology
Han-Jie Yang, Tian Liu, Yang Xiong
Summary: The study investigates the function of LINC00478 in bladder cancer and uncovers its inhibitory mechanism through the recruitment of histone demethylation transferase KDM1A to the MMP9 promoter region. The findings provide potential implications for novel therapeutic targets against bladder cancer.
CELL DEATH DISCOVERY
(2022)
Article
Cardiac & Cardiovascular Systems
Atsushi Kagimoto, Yasuhiro Tsutani, Yoshihisa Shimada, Takahiro Mimae, Yoshihiro Miyata, Hiroyuki Ito, Haruhiko Nakayama, Norihiko Ikeda, Morihito Okada
Summary: Segmentectomy is feasible for clinically early-stage NSCLC, regardless of the presence of LY, V, PL, or lymph node metastasis.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Letter
Urology & Nephrology
Georges Mjaess, Eddy Lilly, Raymond Mansour, Simone Albisinni, Elie Nemr, Fouad Aoun, Thierry Roumeguere
WORLD JOURNAL OF UROLOGY
(2022)
Review
Urology & Nephrology
Theo van der Kwast, Fredrik Liedberg, Peter C. Black, Ashish Kamat, Bas W. G. van Rhijn, Ferran Algaba, David M. Berman, Arndt Hartmann, Antonio Lopez-Beltran, Hemamali Samaratunga, Murali Varma, Liang Cheng
Summary: This article explores the requirements for an optimal grading system for non-muscle-invasive bladder cancer through expert opinion. It suggests splitting the WHO 2004 high-grade category into WHO 1973 grade 2 and 3 subsets, providing more detailed histological criteria. These changes may lead to better treatment decisions for patients with bladder cancer.
EUROPEAN UROLOGY FOCUS
(2022)
Letter
Urology & Nephrology
Theo van der Kwast, Bas Van Rhijn, Ashish Kamat, Liang Cheng
EUROPEAN UROLOGY FOCUS
(2022)
Article
Oncology
Georges Mjaess, Aya Karam, Fouad Aoun, Simone Albisinni, Thierry Roumeguere
Article
Oncology
Nieves Martinez Chanza, Brandon Bernard, Philippe Barthelemy, Anna Accarain, Marianne Paesmans, Laurence Desmyter, Daphne T'Kint de Roodenbeke, Thierry Gil, Spyridon Sideris, Thierry Roumeguere, Anis A. Hamid, Christopher J. Sweeney
Summary: This study evaluated the prevalence and clinical outcomes of patients with localized or de novo metastatic hormone-sensitive prostate cancer harboring tumor BRCA mutations. While tBRCAm appears to be associated with greater relapse risk in localized disease, it does not influence the clinical outcomes of patients with de novo metastatic disease treated with conventional therapies.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Renu Jeyapala, Shivani Kamdar, Ekaterina Olkhov-Mitsel, Alexandre Zlotta, Neil Fleshner, Tapio Visakorpi, Theodorus van der Kwast, Bharati Bapat
Summary: This study validates the prognostic ability of IDC/C and CAPRA-S in predicting biochemical recurrence (BCR) in prostate cancer (PCa) patients. The combined assessment of IDC/C and CAPRA-S improves the predictive accuracy of BCR and helps identify patients at different risk levels.
CLINICAL GENITOURINARY CANCER
(2022)
Review
Oncology
Georges Mjaess, Aya Karam, Thierry Roumeguere, Romain Diamand, Fouad Aoun, Kevin McVary, Judd W. Moul, Cosimo De Nunzio, Simone Albisinni
Summary: This study systematically reviewed the role of urinary microbiota in prostatic diseases. The findings showed that patients with BPH had different urinary microbial composition, which was associated with greater severity of lower urinary tract symptoms. Certain bacterial phyla/genera/classes/species were found to be more abundant in PCa and predicted higher grade disease. In patients with CP, a different microbiota composition and higher diversity were observed.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Cell Biology
Thierry Roumeguere, Caroline Noyon, Pierre Van Antwerpen, Philippe Poelvoorde, Isabelle Bar, Fadi Abdulsater, Alexandre Rousseau, Cedric Delporte, Luc Vanhamme, Michel Vanhaeverbeek, Paul Delree, Karim Zouaoui Boudjeltia
Summary: This study aimed to test the production of MPO in prostate tissue and its potential inflammatory effects on prostate pathology. Immunohistochemistry and in situ hybridization experiments were performed on human prostate tissue, and the results indicated the presence of MPO in prostate epithelial cells with pro-oxidant properties. Although a direct role of MPO in prostate has not been demonstrated, further research is necessary to investigate the potential impact of MPO in the development of prostatic diseases.
Editorial Material
Pathology
Murali Varma, Brett Delahunt, Liang Cheng, Runjan Chetty, Eva Comperat, Vikram Deshpande, Lars Egevad, Theodorus H. van der Kwast, Antonio Lopez-Beltran, W. Glenn McCluggage
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Neil E. Fleshner, Rashid K. Sayyid, Aaron R. Hansen, Joseph L. K. Chin, Ricardo Fernandes, Eric Winquist, Theodorus van der Kwast, Joan Sweet, Katherine Lajkosz, Miran Kenk, Karen Hersey, Rosette Veloso, Doron Berlin, Jaime O. Herrera-Caceres, Srikala Sridhar, Madeleine Moussa, Antonio Finelli, Robert J. Hamilton, Girish S. Kulkarni, Alexandre R. Zlotta, Anthony M. Joshua
Summary: The addition of neoadjuvant cabazitaxel to abiraterone acetate/leuprolide acetate prior to radical prostatectomy did not improve pathologic complete response or minimal residual disease in localized, high-risk prostate cancer.
CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Vincent Francis Castillo, Mehdi Masoomian, Kiril Trpkov, Michelle Downes, Fadi Brimo, Theodorus van Der Kwast, George M. Yousef, Abraam Zakhary, Fabio Rotondo, Gina Saad, Vy-nhan Nguyen, Wondwossen Kidanewold, Catherine Streutker, Corwyn Rowsell, Malek Hamdani, Rola M. Saleeb
Summary: This study evaluated the prognostic significance of ABCC2 expression in PRCC and found that ABCC2 IHC brush-border expression is associated with higher gene expression and predicts worse survival outcomes.
Article
Oncology
Etienne Courboin, Romain Mathieu, Valentina Panetta, Georges Mjaess, Romain Diamand, Gregory Verhoest, Mathieu Roumiguie, Anne Sophie Bajeot, Francesco Soria, Chiara Lonati, Claudio Simeone, Giuseppe Simone, Umberto Anceschi, Paolo Umari, Ashwin Sridhar, John Kelly, Laura S. Mertens, Rafael Sanchez-Salas, Anna Colomer, Maria Angela Cerruto, Alessandro Antonelli, Wojciech Krajewski, Thierry Quackels, Alexandre Peltier, Francesco Montorsi, Alberto Briganti, Jeremy Y. C. Teoh, Benjamin Pradere, Marco Moschini, Thierry Roumeguere, Simone Albisinni, Cosimo De Nunzio, Aldo Brassetti
Summary: This study compared the outcomes of robotic-assisted radical cystectomy with intracorporeal urinary diversion (iRARC) and open radical cystectomy (ORC) in the treatment of non-muscle-invasive bladder cancer (NMIBC). The results showed that iRARC was safer for patients, with lower blood loss, transfusion rate, and shorter hospital stay compared to ORC. The complication rates were similar between the two techniques. There were no significant differences in survival outcomes between iRARC and ORC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Maxime Verstraeten, George Bou Kheir, Louis Vande Perre, Romain Raffoul, Javier Chavez Cerda, Alain Delchambre, Thierry Roumeguere, Anne Vanhoestenberghe, Antoine Nonclercq
Summary: This study demonstrates the use of water-soluble 3D-printed moulds to fabricate accurate bladder phantoms with anatomical structures. The fabricated phantom accurately mimics the mechanical properties of the bladder during filling, and can be tuned to mimic various pathologies or human variability. The manufacturing method and mathematical model provide valuable tools for developing and validating medical devices for bladder and other soft and hollow organs.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2023)
Review
Pathology
Murali Varma, Laura C. Collins, Runjan Chetty, Dipti M. Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D. Guzman-Arocho, Adam Jones, Miranda Pring, W. Glenn Mccluggage
Summary: This paper highlights the importance of macroscopic examination and tissue sampling in histopathology reporting and discusses potential solutions and challenges. It emphasizes the need for adequate guidance and supervision in macroscopic examination and highlights the importance of clinical context, specimen fixation, macroscopic descriptions, and tissue sampling.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Cell Biology
Murali Varma, Eva Comperat, Theodorus van der Kwast
Summary: The grading of urothelial carcinoma varies globally, with different guidelines recommending different reporting methods. Some experts propose novel grading systems for urothelial carcinoma. This article discusses the arguments for and against splitting urothelial carcinomas into different grade categories.