Article
Medicine, General & Internal
Chia -Yen Lin, Chun -Li Wang, Shian-Shiang Wang, Cheng-Kuang Yang, Jian-Ri Li, Chuan-Shu Chen, Sheng-Chun Hung, Kun-Yuan Chiu, Chen-Li Cheng, Yen-Chuan Ou, Shun-Fa Yang
Summary: The study investigated the associations between WWOX polymorphisms, clinicopathologic features of prostate cancer, and risk of postoperative biochemical recurrence. The findings suggest that WWOX SNPs are significantly associated with aggressive pathologic features of PCa and an elevated risk of post-RP biochemical recurrence.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Editorial Material
Oncology
Robert J. Hamilton
Summary: Vaselkiv and colleagues provide strong evidence for the long-term safety of 5-alpha reductase inhibitor (5-ARI) use, showing no association with advanced prostate cancer development or mortality. However, with increasing use of active surveillance for low-grade prostate cancer and advancements in technologies focusing on detecting clinically significant cancers, the role of 5-ARIs in chemoprevention may have become less important.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Urology & Nephrology
Ugo G. Falagario, Anna Lantz, Ivan Jambor, Gian Maria Busetto, Carlo Bettocchi, Marco Finati, Anna Ricapito, Stefano Luzzago, Matteo Ferro, Gennaro Musi, Angelo Totaro, Marco Racioppi, Umberto Carbonara, Enrico Checcucci, Matteo Manfredi, Damiano D'Aietti, Antonio Benito Porcaro, Tobias Nordstrom, Lars Bjornebo, Marco Oderda, Francesco Soria, Pekka Taimen, Hannu J. Aronen, Ileana Montoya Perez, Otto Ettala, Michele Marchioni, Giuseppe Simone, Mariaconsiglia Ferriero, Aldo Brassetti, Luigi Napolitano, Luca Carmignani, Claudia Signorini, Andrea Conti, Giuseppe Ludovico, Marcello Scarcia, Carlo Trombetta, Francesco Claps, Fabio Traunero, Emanuele Montanari, Luca Boeri, Martina Maggi, Francesco Del Giudice, Pierluigi Bove, Valerio Forte, Vincenzo Ficarra, Marta Rossanese, Giuseppe Mucciardi, Vincenzo Pagliarulo, Alessandro Tafuri, Vincenzo Mirone, Luigi Schips, Alessandro Antonelli, Paolo Gontero, Luigi Cormio, Alessandro Sciarra, Francesco Porpiglia, Pierfrancesco Bassi, Pasquale Ditonno, Peter J. Bostrom, Emanuele Messina, Valeria Panebianco, Ottavio De Cobelli, Giuseppe Carrieri, PROMOD Study Grp
Summary: The purpose of this study was to evaluate the impact of 5-alpha-reductase inhibitors (5-ARIs) on the performance of MRI in diagnosing clinically significant Prostate Cancer (csPCa). The study found that 5-ARIs did not affect the association between PIRADS score and csPCa, but treated patients had a higher detection rate of high-grade prostate cancer.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Lin Wang, Guoping Ren, Biaoyang Lin
Summary: This study identified global coexpression and comethylation modules in PCa, revealing the important roles of DNA methyltransferases in pathologic phenotypes and immune infiltration patterns. A two-factor predictive model using DNMT3B and DNMT1 expression features successfully predicted the biochemical recurrence status of patients with PCa.
Article
Biochemistry & Molecular Biology
Ke Wang, Weibo Zhong, Zining Long, Yufei Guo, Chuanfan Zhong, Taowei Yang, Shuo Wang, Houhua Lai, Jianming Lu, Pengxiang Zheng, Xiangming Mao
Summary: This study identified and characterized a series of m5C-related long non-coding RNAs in prostate cancer, establishing a prognostic model consisting of 17 lncRNAs that significantly predict biochemical recurrence-free survival. The model's accuracy was further validated using ROC curves and a decision curve analysis. Functional enrichment analysis revealed the involvement of these lncRNAs in numerous cellular metabolic pathways, with experimental validation suggesting that MAFG-AS1 may promote prostate cancer progression. This predictive model offers potential clinical value for improving patient prognosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Zhengtong Lv, Jianlong Wang, Xuan Wang, Miao Mo, Guyu Tang, Haozhe Xu, Jianye Wang, Yuan Li, Ming Liu
Summary: A risk model containing nine ferroptosis-related genes was constructed in this study, demonstrating strong prognostic and therapeutic predictive power in prostate cancer. The higher risk score calculated by the model was significantly associated with adverse clinicopathological characteristics, immune infiltration, probability of biochemical recurrence, and treatment response in PCa. The findings provide new insights and potential clinical applications of ferroptosis in PCa.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Urology & Nephrology
Ziting Wang, Kaiying Wang, Han Yang Ong, Woon Chau Tsang, Qing Hui Wu, Edmund Chiong
Summary: This study investigates the impact of 5-alpha reductase inhibitor (5-ARI) therapy on the MRI findings and biopsy yield in patients with suspected prostate cancer. The results show significant differences in imaging and biopsy characteristics between patients receiving and not receiving 5-ARI therapy, suggesting that 5-ARI use may confound MRI findings.
Article
Surgery
Daojun Lv, Zanfeng Cao, Wenjie Li, Haige Zheng, Xiangkun Wu, Yongda Liu, Di Gu, Guohua Zeng
Summary: This study developed a 5-protein-based prognostic prediction signature using protein expression and clinical data, which effectively predicted the survival outcomes of PCa patients with BCR. The signature was validated as an independent prognostic marker, providing valuable guidance for medical decision-making and prognosis prediction in PCa patients.
FRONTIERS IN SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Leo Blondel, Savandara Besse, Emily L. Rivard, Guillem Ylla, Cassandra G. Extavour
Summary: The gene oskar plays a crucial role in specifying germ cells in many insects. However, its germ line function is believed to have originated from a previous somatic role.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Anesthesiology
Felipe P. Rangel, Jose O. C. Auler Jr, Maria J. C. Carmona, Mauricio D. Cordeiro, William C. Nahas, Rafael F. Coelho, Claudia M. Simoes
Summary: Intraoperative opioid use does not affect biochemical recurrence rates and biochemical recurrence-free survival in patients with intermediate and high D'Amico risk prostate cancer undergoing radical prostatectomy. Factors such as obesity, high D'Amico risk, laparoscopic surgery, stage 3 tumor pathology, N1 status, and positive surgical margins are associated with shorter biochemical recurrence-free survival.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Biology
Jialin Meng, Yu Guan, Bijun Wang, Lei Chen, Junyi Chen, Meng Zhang, Chaozhao Liang
Summary: In this study, we established and validated an eleven-consensus-gene classifier for prostate cancer patients, which provides valuable information for prognosis assessment and may improve the current staging system. SRD5A2 inhibits cell proliferation, while ITGA11 promotes cell migration and invasion, possibly through the PI3K/AKT signaling pathway.
COMMUNICATIONS BIOLOGY
(2022)
Review
Urology & Nephrology
Pedro Glusman Knijnik, Pietro Waltrick Brum, Eduardo Tosetto Cachoeira, Artur de Oliveira Paludo, Antonio Rebello Horta Gorgen, Lucas Medeiros Burttet, Jeruza Lavanholi Neyeloff, Brasil Silva Neto
Summary: The study showed that 5-alpha-reductase inhibitors significantly reduce the risk of being diagnosed with PCa without increasing high-grade disease or overall/cancer-specific mortality. However, due to the relatively short mean follow-up of most studies, the mortality analysis is limited.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Gaohaer Kadeerhan, Bo Xue, Xiaolin Wu, Xiaofeng Hu, Jun Tian, Dongwen Wang
Summary: In this study, a robust 8-gene signature was established based on transcriptome profiles of prostate cancer for accurately predicting the risk of biochemical recurrence. PRAME, a risk-related gene, was found to be upregulated in high-risk prostate cancer samples and correlated with chemotherapeutic drug response. Knocking down PRAME reduced the proliferation, migration, and invasion of prostate cancer cells. This study provides a novel tool for stratifying high-risk prostate cancer patients and sheds light on the mechanism of prostate cancer progression.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Jane B. Vaselkiv, Carl Ceraolo, Kathryn M. Wilson, Claire H. Pernar, Emily M. Rencsok, Konrad H. Stopsack, Sydney T. Grob, Anna Plym, Edward L. Giovannucci, Aria F. Olumi, Adam S. Kibel, Mark A. Preston, Lorelei A. Mucci
Summary: The use of 5-alpha reductase inhibitor (5-ARI) is not associated with an increased risk of lethal prostate cancer or cancer-specific death, but is instead linked to a reduced risk of overall and localized disease. These findings suggest that 5-ARI use is safe in terms of prostate cancer mortality.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Medicine, General & Internal
Hua Huang, Jiangyan He, Dongyang Deng, Rong Chen, Yiyuan Zhou
Summary: This retrospective study aims to identify the single nucleotide polymorphisms (SNPs) of 5,10-methylenetetrahydrofolate reductase (MTHFR) (C677T, A1298C), methionine synthase reductase (MTRR) (A66G) and explore their correlation with folate metabolism risk in pregnant women. The study analyzed the demographic data of 8735 pregnant women and tested their blood samples. The results showed that certain genotypes of MTHFR C677T and MTRR A66G were significantly related to the risk levels of folate metabolism.
Article
Oncology
Michele Rouleau, Flora Nguyen Van Long, Veronique Turcotte, Patrick Caron, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Levesque, Chantal Guillemette
Summary: Naturally occurring germline gene deletions (KO) of UGT2B17 and UGT2B28 genes lead to metabolic rewiring, promoting prostate cancer growth and metastasis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Louis Lacombe, Helene Hovington, Herve Brisson, Sadia Mehdi, Deborah Beilevaire, Jean-Philippe Emond, Antoine Wagner, Lyne Villeneuve, David Simonyan, Veronique Ouellet, Veronique Barres, Mathieu Latour, Armen Aprikian, Alain Bergeron, Vincent Castonguay, Felix Couture, Simone Chevalier, Fadi Brimo, Ladan Fazli, Neil Fleshner, Martin Gleave, Pierre I. Karakiewicz, Jean-Baptiste Lattouf, Dominique Trudel, Theodorus Van der Kwast, Anne-Marie Mes-Masson, Frederic Pouliot, Yves Fradet, Etienne Audet-Walsh, Fred Saad, Chantal Guillemette, Eric Levesque
Summary: UGT2B28, a pathway involved in androgen inactivation, has been identified as a predictor of progression in localized prostate cancer. This study demonstrated that UGT2B28 is overexpressed in tumors and associated with inferior clinical outcomes. Functional analysis revealed that UGT2B28 promotes cell proliferation and its expression is regulated by the androgen receptor (AR)/ARv7. Furthermore, UGT2B28 interacts with huntingtin-interacting protein 1 (HIP1) to activate AR/epidermal growth factor receptor (EGFR) pathways, leading to cell proliferation and epithelial-to-mesenchymal transition (EMT).
Article
Urology & Nephrology
Cylia Dahmani, Patrick Caron, David Simonyan, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Levesque, Chantal Guillemette
Summary: Preoperative circulating levels of 11-oxygenated androgens are associated with metastasis-free survival in men with localized prostate cancer undergoing radical prostatectomy and are influenced by 5α-reductase inhibitor treatment.
JOURNAL OF UROLOGY
(2023)
Review
Urology & Nephrology
Lucas Germain, Camille Lafront, Virginie Paquette, Bertrand Neveu, Jean-Sebastien Paquette, Frederic Pouliot, Etienne Audet-Walsh
Summary: Prostate cancer depends on androgen receptor (AR) for growth and survival, making it the main target for pharmacological treatment. However, prostate cancer eventually becomes castration-resistant, with most resistance mechanisms involving reactivation of AR. The definition of preclinical models and cell lines for studying prostate cancer and castration resistance is still unclear. Understanding the limitations and advantages of these models is crucial for effective translation of scientific knowledge to clinical applications. Evaluation: x/10
NATURE REVIEWS UROLOGY
(2023)
Article
Multidisciplinary Sciences
Chee-Hong Chan, Pei Lin, Tse-Yen Yang, Bo-Ying Bao, Jhen-Yang Jhong, Yui-Ping Weng, Te-Hsiu Lee, Hui-Fen Cheng, Te-Ling Lu
Summary: Apical-basal cell polarity is crucial for the formation of epithelial cysts and tubules in various epithelial organs. MST3 plays a role in the establishment of cell polarity through the regulation of Cdc42.
Article
Endocrinology & Metabolism
Lih-Chyang Chen, Shu-Pin Huang, Chieh-Tien Shih, Chia-Yang Li, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Cheng-Hsueh Lee, Jiun-Hung Geng, Bo-Ying Bao
Summary: This study investigated the association between 222 single-nucleotide polymorphisms (SNPs) in eight phospholipid-transporting ATPase genes and cancer-specific survival (CSS) and overall survival (OS) of prostate cancer patients treated with androgen-deprivation therapy (ADT). After multivariate Cox regression analysis and multiple testing correction, it was found that ATP8B1 rs7239484 was significantly associated with CSS and OS after ADT. The study also found that ATP8B1 expression was downregulated in tumor tissues and higher expression was associated with a better patient prognosis.
Article
Nutrition & Dietetics
Hanane Moussa, Karine Robitaille, Jean-Francois Pelletier, Roxane Tourigny, Yves Fradet, Louis Lacombe, Paul Toren, Michele Lodde, Rabi Tiguert, Thierry Dujardin, Yves Caumartin, Thierry Duchesne, Pierre Julien, Josee Savard, Caroline Diorio, Vincent Fradet
Summary: This study aimed to evaluate the effects of long-chain omega-3 fatty acid supplementation on prostate cancer-specific quality of life in men treated by radical prostatectomy. The results showed that LCn3 supplementation may improve urinary irritation function in men undergoing radical prostatectomy. Larger-scale studies are needed to further investigate this relationship.
Article
Oncology
Alisson Clemenceau, Aurelie Lacouture, Juliette Bherer, Genevieve Ouellette, Annick Michaud, Etienne Audet-Walsh, Caroline Diorio, Francine Durocher
Summary: This study investigated the potential causal role of decreased SFRP1 expression in early breast carcinogenesis. The results support the hypothesis that a lack of SFRP1 could have a causal role in early breast carcinogenesis.
Article
Oncology
Donald Poirier, Jenny Roy, Rene Maltais, Cindy Weidmann, Etienne Audet-Walsh
Summary: Prostate cancer ranks fourth among all new cancer cases worldwide, and metastatic PC is the leading cause of death with limited treatment options. The development of new innovative drugs is urgently needed, and the aminosteroid derivative RM-581 has shown promising antiproliferative activity on various cancer cell types. It effectively blocked tumor growth in mice at a low dose and demonstrated non-toxicity, suggesting its potential as a safe and effective treatment for prostate cancer.
Article
Oncology
Mame-Kany Diop, Oscar Eduardo Molina, Mirela Birlea, Helene LaRue, Helene Hovington, Bernard Tetu, Louis Lacombe, Alain Bergeron, Yves Fradet, Dominique Trudel
Summary: The immune infiltrate of intraductal carcinoma of the prostate (IDC-P) is generally reduced compared to the surrounding tissues, especially regarding antigen-presenting cells. These findings could contribute to a better understanding of the immune response to lethal prostate cancer and the development of new therapies.
Article
Cell Biology
Antoine Wagner, Michele Rouleau, Lyne Villeneuve, Trang Le, Cheryl Peltier, Eric P. Allain, Caroline Beaudoin, Sophie Tremblay, Frederic Courtier, Flora Nguyen Van Long, Isabelle Laverdiere, Eric Levesque, Versha Banerji, Katrina Vanura, Chantal Guillemette
Summary: In chronic lymphocytic leukemia (CLL), elevated UGT2B17 expression is associated with poor survival and drug response. UGT2B17 interacts with kinases in the BCR pathway, including ZAP70, SYK, and BTK, potentially contributing to a pro-survival signaling cascade. UGT2B17 and ZAP70 exhibit a strong correlation and their combined high expression levels define a prognostic group with the highest risk of poor survival.
Article
Gastroenterology & Hepatology
Zeni Wu, Jessica L. Petrick, Andrea A. Florio, Chantal Guillemette, Laura E. Beane Freeman, Julie E. Buring, Gary Bradwin, Patrick Caron, Yu Chen, A. Heather Eliassen, Lawrence S. Engel, Neal D. Freedman, J. Michael Gaziano, Edward L. Giovannuci, Jonathan N. Hofmann, Wen-Yi Huang, Victoria A. Kirsh, Cari M. Kitahara, Jill Koshiol, I. -Min Lee, Linda M. Liao, Christina C. Newton, Julie R. Palmer, Mark P. Purdue, Thomas E. Rohan, Lynn Rosenberg, Howard D. Sesso, Rashmi Sinha, Meir J. Stampfer, Caroline Y. Um, Stephen K. Van Den Eeden, Kala Visvanathan, Jean Wactawski-Wende, Anne Zeleniuch-Jacquotte, Xuehong Zhang, Barry I. Graubard, Peter T. Campbell, Katherine A. Mcglynn
Summary: The incidence rates of liver cancer are higher among men than women, and this study investigated the association between sex hormone levels and liver cancer risk in men. The study found that higher concentrations of testosterone, dihydrotestosterone, estrone, estradiol, and sex hormone-binding globulin were associated with increased risk, while higher levels of dehydroepiandrosterone were associated with decreased risk.
Article
Integrative & Complementary Medicine
Hsin-En Wu, Chia-Cheng Su, Shu-Chi Wang, Po-Len Liu, Wei-Chung Cheng, Hsin-Chih Yeh, Chih-Pin Chuu, Jen-Kun Chen, Bo-Ying Bao, Cheng Hsueh Lee, Chien-Chih Ke, Yuan-Ru Chen, Yun-Hsin Yu, Shu-Pin Huang, Chia-Yang Li
Summary: This study demonstrated that morusin, a prenylated flavonoid isolated from Morus alba L., has significant inhibitory effects on the growth, migration, and invasion of prostate cancer cells. It achieves this by regulating the Akt/mTOR signaling pathway, inducing cell cycle arrest, and promoting apoptosis. These findings suggest that morusin could be a potential drug for the treatment of castration-resistant prostate cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
