期刊
EUROPEAN SURGICAL RESEARCH
卷 48, 期 3, 页码 111-120出版社
KARGER
DOI: 10.1159/000336875
关键词
Apoptosis; Autophagy; Endoplasmic reticulum stress; Unfolded protein response; Necroptosis
类别
资金
- Schuchtermann-Stiftung, Germany
Resistance to cell death induction has been recognized as a hallmark of cancer. Increasing understanding of the underlying molecular events regulating different cell death mechanisms like apoptosis, endoplasmic reticulum stress, autophagy, necroptosis and others has opened new possibilities for targeted interference with these pathways. While conventional chemotherapeutic agents usually inhibit cell cycle progression, DNA replication or mitosis execution, novel agents like small molecule kinase inhibitors also target survival-related kinases and signaling pathways and contribute to overcome resistance to chemotherapy and apoptosis. Additionally, antibodies targeting cellular death receptors have been described to specifically target tumor cells only. This review briefly highlights the pathways involved in (apoptotic) cell death and summarizes the current state of development of specific modulators of cell death and how they can help to improve the tolerability of chemotherapy regimens and increase survival rates in patients with advanced cancer diseases. Copyright (C) 2012 S. Karger AG, Basel
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