期刊
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
卷 41, 期 5, 页码 221-227出版社
SPRINGER WIEN
DOI: 10.1007/s10353-009-0487-4
关键词
Gene expression profiling; breast cancer; prognostic marker; database; tumor size; triple-negative
类别
资金
- Austrian Society of Surgery
- Agendia BV
BACKGROUND: The Netherlands Cancer Institute used DNA microarray analyses to identify a 70-gene expression profile strongly predictive of a short interval to distant metastases in breast cancer. For patients with small tumors, the signature is not yet adequately validated. Furthermore, 95% of estrogen-receptor or triple-negative tumors are assigned to poor prognosis by the profile. METHODS: A pooled database was constructed containing clinical, pathological and microarray data of 1696 patients. The database will be used to study the performance of the 70-gene profile in patients with small-sized T1 tumors. In addition, patients with triple-negative tumors will be identified and whole genome microarray analysis will be performed of these tumors to develop a new prognostic gene expression profile for this subgroup. RESULTS AND CONCLUSIONS: If the 70-gene profile is accurate for small tumors, patients at risk may be assigned to adjuvant treatment. A new prognostic classifier for triple-negative tumors may help to identify women, in whom adjuvant treatment may safely be omitted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据