Article
Medicine, General & Internal
Armin Luik, Kerstin Schmidt, Annika Haas, Laura Unger, Panagiotis Tzamalis, Bernd Brueggenjuergen
Summary: The treatment of atrial tachycardia following catheter ablation of atrial fibrillation is often challenging, but new ablation approaches have shown promising results. However, long-term data on the freedom from any atrial tachycardia or any arrhythmia are still limited. This study presents 12-month success and mean 30 month follow-up data of catheter ablation of left atrial tachycardia, demonstrating high long-term clinical success rates with individual ablation strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Giichi Nitta, Osamu Inaba, Shunichi Kato, Toshikazu Kono, Takashi Ikenouchi, Kazuya Murata, Yasuaki Hada, Miki Kanoh, Tomomasa Takamiya, Yukihiro Inamura, Ken Negi, Akira Sato, Tsunehiro Yamato, Yutaka Matsumura, Kazuo Eguchi, Junichi Nitta, Yoshihide Takahashi, Masahiko Goya, Tetsuo Sasano
Summary: The study evaluated the 1-year success rate of maintaining sinus rhythm after catheter ablation for atrial fibrillation in patients with or without congestive heart failure. The arrhythmia-induced cardiomyopathy patients had significantly better survival than non-AIC patients. Both groups showed significant improvement in left atrial dilation, brain natriuretic peptide level, and left ventricular ejection function before and after CA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Biology
Shahana Hussain, Catrin Sohrabi, Rui Providencia, Syed Ahsan, Nikolaos Papageorgiou
Summary: Catheter ablation is more effective than antiarrhythmic drugs in maintaining sinus rhythm and improving quality of life. Radiofrequency and cryoablation are two effective methods. However, catheter-only ablation strategies have not been consistently successful in treating longstanding and persistent AF patients. Hybrid ablation, which combines surgical ablation with endocardial catheter ablation, is emerging as the preferred treatment for such cases. Promising results have been shown, but further large-scale randomized studies are needed to evaluate these strategies for managing AF.
Review
Health Care Sciences & Services
Sho Suzuki, Takeshi Kitai, John Skoularigis, Kyriakos Spiliopoulos, Andrew Xanthopoulos
Summary: Atrial fibrillation (AF) and heart failure (HF) are common cardiac disorders that often coexist and may have a causal relationship. AF is a significant risk factor for adverse outcomes in HF patients. Catheter ablation (CA) has emerged as a promising treatment option, but there are still some unknowns.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jien-Jiun Chen, Fu-Chun Chiu, Sheng-Nan Chang, Hsiao-Liang Cheng, Pang-shuo Huang, Cho-Kai Wu, Yi-Chih Wang, Juey-Jen Hwang, Chia-Ti Tsai
Summary: This pioneer study investigated the impact of pre-existing left atrial appendage occluder (LAAO) on atrial fibrillation (AF) substrates and outcomes of pulmonary vein isolation (PVI). Results showed that LAAO may modulate left atrial substrate and induce peridevice fibrosis, peridevice left atrial flutter, and complex fractionate atrial electrogram.
Article
Cardiac & Cardiovascular Systems
Lucas Malta Westergaard, Amna Alhakak, Rasmus Rorth, Emil L. Fosbol, Soren L. Kristensen, Jesper H. Svendsen, Claus Graff, Jonas B. Nielsen, Gunnar H. Gislason, Lars Kober, Christian Torp-Pedersen, Christina J. Y. Lee, Peter E. Weeke
Summary: This study aimed to evaluate the risk of new-onset heart failure and all-cause mortality in patients with atrial fibrillation (AF) according to ventricular rate. The results showed that patients with ventricular rates ≥100 bpm had a higher risk of new-onset heart failure and all-cause mortality compared to those with rates of 60-79 bpm. This suggests that ventricular rates ≥100 bpm may be associated with increased risk in AF patients receiving rate control drug treatment.
Article
Cardiac & Cardiovascular Systems
Maura M. Zylla, Johannes Leiner, Ann-Kathrin Rahm, Tobias Hoffmann, Patrick Lugenbiel, Patrick Schweizer, Eberhard Scholz, Derliz Mereles, Dorothea Kronsteiner, Meinhard Kieser, Hugo A. Katus, Norbert Frey, Dierk Thomas
Summary: This study evaluates the outcome of cryoballoon ablation for atrial fibrillation in patients with heart failure with preserved ejection fraction (HFpEF). The results show that patients with HFpEF have a higher risk of atrial fibrillation recurrence and heart failure-related hospitalization after ablation. There is limited improvement in cardiac function and quality of life in these patients.
CIRCULATION-HEART FAILURE
(2022)
Review
Medicine, General & Internal
Leonard Bergau, Philipp Bengel, Vanessa Sciacca, Thomas Fink, Christian Sohns, Philipp Sommer
Summary: Atrial fibrillation is the most common sustained arrhythmia worldwide and is strongly associated with heart failure. Two therapeutic strategies, rhythm control and rate control, are accepted as the standard of care in AF patients with heart failure. Recent important studies have investigated the optimal therapeutic strategy in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Michael Derndorfer, Shaojie Chen, Helmut Puererfellner
Summary: Atrial fibrillation (AF) and heart failure (HF) are closely linked, with successful treatment of one potentially benefiting the other; adherence to guidelines is crucial, with AF patients potentially benefiting from ablation and HF patients having alternative treatment options depending on their LVEF levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Christian Sohns, Nassir F. Marrouche, Angelika Costard-Jackle, Samuel Sossalla, Leonard Bergau, Rene Schramm, Uwe Fuchs, Hazem Omran, Kerstin Rubarth, Daniel Dumitrescu, Frank Konietschke, Volker Rudolph, Jan Gummert, Philipp Sommer, Henrik Fox
Summary: The CASTLE-HTx trial aims to test the hypothesis that atrial fibrillation (AF) ablation has beneficial effects on mortality in patients with end-stage heart failure (HF) eligible for heart transplantation (HTx). The trial will randomize 194 patients to assess the impact of AF ablation on mortality in HF patients.
Article
Medicine, General & Internal
Shingo Maeda, Masahiko Goya, Yasuhiro Shirai, Atsuhiko Yagishita, Susumu Tao, Jackson Jeikai Liang, Ruben Casado Arroyo, Yoshihide Takahashi, Mihoko Kawabata, Tetsuo Sasano, Kenzo Hirao
Summary: This study aimed to identify novel predictors of effective atrial anti-tachycardia pacing (A-ATP) for terminating atrial fibrillation (AF) in patients undergoing catheter ablation. The results showed that simultaneous biatrial A-ATP from the right atrium (RA) and coronary sinus (CS) could terminate AF in patients with paroxysmal AF. The predictors for successful termination included longer AF cycle length and higher AF stability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Ramanathan Parameswaran, Ahmed M. Al-Kaisey, Jonathan M. Kalman
Summary: Catheter ablation is a key strategy for managing atrial fibrillation, with technological advancements focusing on improving safety and effectiveness. Guidelines recommend the procedure for symptomatic patients with paroxysmal or persistent AF, but evidence from trials is mixed. Pulmonary vein isolation remains a cornerstone technique in AF ablation, with ongoing developments in technology aimed at enhancing patient outcomes.
NATURE REVIEWS CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Stepan Havranek, Zdenka Fingrova, Tomas Skala, Adrian Reichenbach, Milan Dusik, Pavel Jansa, David Ambroz, Vladimir Dytrych, Dalibor Klimes, Martin Hutyra, Josef Kautzner, Ales Linhart, Dan Wichterle
Summary: This study aimed to investigate whether more extensive radiofrequency catheter ablation of the bi-atrial arrhythmogenic substrate instead of clinical arrhythmia ablation alone results in superior clinical outcomes in patients with pulmonary arterial hypertension (PH) and supraventricular arrhythmias. The results showed similar arrhythmia recurrence rates between the two treatment groups, and no excess of procedural complications or clinical events in the extensive ablation group.
Article
Cardiac & Cardiovascular Systems
Darren Lau, Roopinder K. Sandhu, Jason G. Andrade, Justin Ezekowitz, Helen So, Scott Klarenbach
Summary: Catheter ablation as a second line intervention for HF patients with symptomatic atrial fibrillation is likely to be cost-effective, with an incremental cost-effectiveness ratio of $35,360/QALY, as long as over half of the relative mortality benefit observed in extant trials is borne out in future studies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Michael L. Bernard, Francis Benn, Cody M. Williams, A. Elise Hiltbold, Paul A. Rogers, Glenn M. Polin, Sammy Khatib, Sana M. Al-Khatib, Daniel P. Morin
Summary: Atrial fibrillation and heart failure with reduced ejection fraction often coexist, presenting limited therapeutic options. Recent studies have shown that catheter ablation in atrial fibrillation patients with reduced ejection fraction can improve outcomes.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Rakesh Gopinathannair, Arjun Sharma, Paul Jones, Connor English, Stephen Furmanek, Brian Olshansky
Summary: The study evaluated whether heart rate score (HRSc) and mean intrinsic heart rate (MIHR) independently predicted mortality and heart failure hospitalization in cardiac patients. The results showed that HRSc was a robust and independent predictor of death and heart failure hospitalization, and high MIHR and HRSc, although correlated, each independently predicted outcomes.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Artur Fedorowski, Fabrizio Ricci, Viktor Hamrefors, Kristin E. Sandau, Tae Hwan Chung, James A. S. Muldowney, Rakesh Gopinathannair, Brian Olshansky
Summary: Orthostatic hypotension (OH) is a common disorder associated with various diseases, with debilitating symptoms and risks. It requires a multidisciplinary approach to identify the underlying cause, treat accompanying conditions, and provide individualized treatment.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Brian Olshansky, Fabrizio Ricci, Artur Fedorowski
Summary: Resting heart rate is a critical parameter that predicts adverse outcomes and disease development. It can reflect disease severity and has predictive capabilities. However, its impact on outcomes in healthy individuals remains uncertain.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Valentina Bayer, Agnieszka Kotalczyk, Bory Kea, Christine Teutsch, Peter Larsen, Dana Button, Menno Huisman, Gregory Y. H. Lip, Brian Olshansky
Summary: This study investigated the use of oral anticoagulants (OACs) in patients with atrial fibrillation (AF) in different regions and types of healthcare sites. The findings showed significant geographic variability and suboptimal implementation of guideline recommendations in the initiation of OAC treatment. Optimizing OAC use in AF patients could lead to better outcomes and cost reduction in healthcare.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Catherine Vanchiere, Rithika Thirumal, Aditya Hendrani, Parinita Dherange, Angela Bennett, Runhua Shi, Rakesh Gopinathannair, Brian Olshansky, Denise L. Smith, Paari Dominic
Summary: This study explored the association between occupational exposure and atrial fibrillation in firefighters. The results showed that firefighters who fought a higher number of fires per year had a higher prevalence of atrial fibrillation. Multivariable logistic regression analysis indicated that a higher number of fires fought per year was associated with an increased risk of atrial fibrillation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Cardiac & Cardiovascular Systems
Cody R. Hou, Brian Olshansky, Daniel Cortez, Sue Duval, David G. Benditt
Summary: There is inconsistency in the definitions of inappropriate sinus tachycardia in current literature, and professional society consensus definitions have limited impact.
Article
Cardiac & Cardiovascular Systems
Luke Chong, Rakesh Gopinathannair, Ali Ahmad, Philip Mar, Brian Olshansky
Summary: Arrhythmia-induced cardiomyopathy (AIC) is a condition where left ventricular (LV) systolic dysfunction is caused by or worsened by atrial or ventricular arrhythmias. The identification of patients at risk for AIC remains an ongoing challenge.
CURRENT CARDIOVASCULAR RISK REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Deepak Kumar Pasupula, Sudeep K. Siddappa Malleshappa, Muhammad B. Munir, Anusha Ganapati Bhat, Antony Anandaraj, Avaneesh Jakkoju, Michael Spooner, Ketan Koranne, Jonathan C. Hsu, Brian Olshansky, A. John Camm
Summary: This study investigated the safety and feasibility of combining percutaneous catheter ablation (CA) for atrial fibrillation with left atrial appendage occlusion (LAAO) as a single procedure. The analysis of the US National Readmission Database showed an increasing rate of combined LAAO + CA procedures in the USA. The study found no significant difference in major adverse cardiovascular events and 30-day readmission rates between combined LAAO + CA patients and matched LAAO-only or CA-only patients.
Letter
Cardiac & Cardiovascular Systems
Christian Anderson, Brian Olshansky
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Christian Anderson, Brian Olshansky
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Letter
Medicine, General & Internal
Christian E. Anderson, Randy A. Lieberman, Brian Olshansky
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Brian Olshansky, Deepak L. L. Bhatt, Michael Miller, Ph. Gabriel Steg, Eliot A. A. Brinton, Terry A. A. Jacobson, Steven B. B. Ketchum, Ralph T. T. Doyle Jr, Rebecca A. A. Juliano, Lixia Jiao, Peter R. R. Kowey, James A. A. Reiffel, Jean-Claude Tardif, Christie M. M. Ballantyne, Mina K. K. Chung
Summary: In the REDUCE-IT study, icosapent ethyl (IPE) reduced cardiovascular events but was associated with increased atrial fibrillation/atrial flutter (AF) hospitalization. The study analyzed the relationships between IPE and outcomes in patients with or without prior AF and with or without in-study AF hospitalization. Overall, in-study AF hospitalization rates were higher in patients with prior AF, especially in those randomized to IPE. Serious bleeding rates also trended higher in these patients. However, patients with prior AF or in-study AF hospitalization showed consistent risk reductions in cardiovascular events with IPE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Katsuhide Hayashi, Haruhiko Abe, Brian Olshansky, Arjun D. Sharma, Paul W. Jones, Nicholas Wold, David Perschbacher, Ritsuko Kohno, Mark Richards, Bruce L. Wilkoff
Summary: Heart rate score (HRSc), a measure of atrial pacing and sensing events in the largest bin of a pacemaker's rate histogram, predicts survival in cardiac device patients, but not the development of atrial fibrillation (AF). This study examines the relationship between HRSc and the incidence of newly developed atrial tachyarrhythmias (ATAs) in patients with pacemakers.
Review
Cardiac & Cardiovascular Systems
Marcus Stahlberg, Ali Mahdi, Madeleine Johansson, Artur Fedorowski, Brian Olshansky
Summary: This article explores the cardiovascular dysautonomia in postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection caused by COVID-19. It defines the condition, discusses its associated symptoms and potential mechanisms, and provides a comprehensive overview of management approaches. The article also highlights future research directions and knowledge gaps that need to be addressed.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
William H. Parker, Brian Olshansky