期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 66, 期 12, 页码 1378-1391出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2015.07.037
关键词
atherogenesis; genetic and epigenetic effects; smoke-free legislation; thrombosis; tobacco cessation
资金
- Eli Lilly and Company
- Daiichi-Sankyo
- Bristol-Myers Squibb
- Pfizer
- Abbott Vascular
- Medtronic
Cardiovascular morbidity and mortality as a result of inhaled tobacco products continues to be a global healthcare crisis, particularly in low- and middle-income nations lacking the infrastructure to develop and implement effective public health policies limiting tobacco use. Following initiation of public awareness campaigns 50 years ago in the United States, considerable success has been achieved in reducing the prevalence of cigarette smoking and exposure to secondhand smoke. However, there has been a slowing of cessation rates in the United States during recent years, possibly caused by high residual addiction or fatigue from cessation messaging. Furthermore, tobacco products have continued to evolve faster than the scientific understanding of their biological effects. This review considers selected updates on the genetics and epigenetics of smoking behavior and associated cardiovascular risk, mechanisms of atherogenesis and thrombosis, clinical effects of smoking and benefits of cessation, and potential impact of electronic cigarettes on cardiovascular health. (C) 2015 by the American College of Cardiology Foundation.
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