Article
Orthopedics
Qing-Yi Zhang, Jie Tan, Kai Huang, Hui-Qi Xie
Summary: This study compared the clinical and radiographic efficacy of Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF) and Oblique lateral Interbody Fusion (OLIF). The results showed that OLIF had shorter operation time, less intraoperative blood loss, better leg pain alleviation, disc height restoration, and subsidence resistance compared to MIS-TLIF. However, there were no significant differences in back pain relief, functional recovery, complications, disc angle restoration, lumbar lordosis restoration, and fusion rate between the two procedures. Further high-level studies are needed to confirm these findings.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Clinical Neurology
Ruud Droeghaag, Sem M. M. Hermans, Inge J. M. H. Caelers, Silvia M. A. A. Evers, Wouter L. W. van Hemert, Henk van Santbrink
Summary: This study conducted a systematic literature review and meta-analysis to evaluate the cost-effectiveness of OTLIF compared to MITLIF in patients with lumbar spondylolisthesis or degenerative disease. The results indicated that MITLIF is more cost-effective than OTLIF. Considering the rising costs of instrumented spine surgery, cost-effectiveness could play a crucial role in surgical decision-making.
Review
Clinical Neurology
Johan L. Heemskerk, Oluwaseun Oluwadara Akinduro, William Clifton, Alfredo Quinones-Hinojosa, Kingsley O. Abode-Iyamah
Summary: After analyzing 16 studies, it was found that MIS-TLIF and open-TLIF have comparable long-term clinical outcomes. Both surgeries significantly reduce pain and improve PROMs, with no significant differences between the two treatments at a minimum follow-up of 2 years.
Review
Clinical Neurology
Xijian Hu, Lei Yan, Xinjie Jin, Haifeng Liu, Jing Chai, Bin Zhao
Summary: A network meta-analysis compared the clinical efficacy and safety of endoscopic lumbar interbody fusion (Endo-LIF), minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF), and open transforaminal lumbar interbody fusion (OTLIF) in the treatment of lumbar degenerative diseases (LDDs). The results showed that Endo-LIF was superior to MIS-TLIF and OTLIF in reducing blood loss, hospital stay, time to ambulation, and back pain visual analog scale (VAS) score. MIS-TLIF was superior to Endo-LIF in terms of improving Oswestry disability index (ODI), and OTLIF required the shortest intraoperative fluoroscopy time. There were no significant differences in operative time, complication rate, fusion rate, leg pain VAS score, or Japanese Orthopaedic Association (JOA) score among the three procedures.
GLOBAL SPINE JOURNAL
(2023)
Review
Clinical Neurology
Michael C. Prabhu, Kevin C. Jacob, Madhav R. Patel, Hanna Pawlowski, Nisheka N. Vanjani, Kern Singh
Summary: The minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a widely used surgical technique for lumbar arthrodesis, offering improved efficacy and safety through minimizing soft tissue damage. This article provides an overview of the historical development of posterior-approach treatment for discogenic radiculopathy, culminating in the introduction of MIS-TLIF. The characteristics, technical variability, and reported outcomes of modern MIS-TLIF are evaluated, along with a glimpse into potential future technologies.
Article
Medicine, General & Internal
Quan-You Gao, Fei-Long Wei, Tian Li, Kai-Long Zhu, Ming-Rui Du, Wei Heng, Fan Yang, Hao-Ran Gao, Ji-Xian Qian, Cheng-Pei Zhou
Summary: This study compared the outcomes and complications of patients with lumbar spinal stenosis (LSS) undergoing oblique lateral interbody fusion (OLIF) or minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). The results showed that OLIF and MIS-TLIF had similar postoperative improvements, but OLIF was more successful at restoring disc height, foraminal height, and lumbar lordotic angle. The complication rates were comparable between the two procedures.
FRONTIERS IN MEDICINE
(2022)
Article
Orthopedics
You-Di Xue, Wen-Bo Diao, Chao Ma, Jie Li
Summary: This study aimed to compare the clinical efficacy and imaging results of percutaneous endoscopic transforaminal lumbar interbody fusion (PETLIF) with minimally invasive surgery-transforaminal lumbar interbody fusion (MISTLIF). The results showed that PETLIF had less operative blood loss and shorter hospital stay compared to MISTLIF. Both procedures resulted in improved VAS scores postoperatively, with PETLIF showing a significantly lower VAS-B score than MISTLIF.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Orthopedics
Hao Chen, Goudi Zheng, Zhenyu Bian, Changju Hou, Maoqiang Li, Zhen Zhang, Liulong Zhu, Xuepeng Wang
Summary: This study compared the clinical efficacy and postoperative outcomes of MIS-TLIF and Endo-LIF in treating lumbar degenerative diseases. The results showed no significant differences in the clinical outcomes between the two groups at various timepoints. However, the Endo-LIF group had a longer operation time but less intraoperative blood loss, shorter hospital stay, and lower lower back pain scores.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Clinical Neurology
Yuanqiao Kou, Jianjun Chang, Xiaoming Guan, Qiang Chang, Haoyu Feng
Summary: A comparison between Endo-LIF and MIS-TLIF in treating lumbar degenerative diseases showed no significant differences in complication, reoperation, and fusion rates, as well as preoperative and postoperative pain scores and disability index. Endo-LIF had the advantage of less intraoperative blood loss, shorter hospital stay, and better long-term functional outcome compared to MIS-TLIF, despite a longer operative time.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Diogo Garcia, Oluwaseun O. Akinduro, Gaetano De Biase, Bernardo Sousa-Pinto, Daniel J. Jerreld, Ruchita Dholakia, Bijan Borah, Eric Nottmeier, H. Gordon Deen, W. Christopher Fox, Mohamad Bydon, Selby Chen, Alfredo Quinones-Hinojosa, Kingsley Abode-Iyamah
Summary: This study aimed to compare robotic-assisted and nonrobotic-assisted minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) through a cost-utility analysis. The results suggested that robotic-assisted MIS-TLIF was cost-effective in 63% of simulations at a willingness to pay of $50,000/quality-adjusted life year (QALY).
Article
Clinical Neurology
Yu-Cheng Yao, Po-Hsin Chou, Hsi-Hsien Lin, Shih-Tien Wang, Ming-Chau Chang
Summary: This study compared the clinical and radiographical outcomes of the titanium-polyetheretherketone (Ti/PEEK) composite cage with the standard PEEK cage in patients undergoing minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). The study found that the use of Ti/PEEK composite cage was as safe and effective as the use of PEEK cage, with comparable fusion rate, cage subsidence rate, and complication rate. The VAS and ODI scores also showed no difference between the two groups during the 2-year follow-up period.
GLOBAL SPINE JOURNAL
(2023)
Review
Clinical Neurology
Yong Ahn, Sol Lee, Woo-Kyung Kim, Sang-Gu Lee
Summary: Purpose: To discuss the cutoff point at which technical proficiency is achieved and ways to enhance the learning process for minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). Methods: A systematic review was conducted to identify learning curve studies on MI-TLIF. Results: Nine studies were included, representing 753 cases. The most commonly used outcome measure was the operative time, with a cutoff point of 31.33 +/- 11.98 cases. Conclusion: The learning curve for MI-TLIF may vary depending on the outcome measures used, and the learning rate may be influenced by patient and technical factors. Careful interpretation of the learning curve and proficiency cutoff point is necessary.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Patawut Bovonratwet, Andre M. Samuel, Jung Kee Mok, Avani S. Vaishnav, Kyle W. Morse, Junho Song, Michael E. Steinhaus, Yusef J. Jordan, Catherine H. Gang, Sheeraz A. Qureshi
Summary: This study compared the outcomes of minimally invasive unilateral laminotomy with bilateral decompression (MIS-ULBD) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for the treatment of low-grade lumbar degenerative spondylolisthesis. The results showed that both procedures resulted in significant improvements in pain and physical function for the patients.
Article
Orthopedics
Meng Ge, Yuan Zhang, Hang Ying, Chenchen Feng, Yanlei Li, Jinlong Tian, Tingxiao Zhao, Haiyu Shao, Yazeng Huang
Summary: This study compared hidden blood loss (HBL), visible blood loss (VBL), and total blood loss (TBL) following Endo-TLIF and Mis-TLIF and evaluated the clinical significance of these procedures. The results showed that Endo-TLIF significantly reduced HBL, VBL, and TBL compared to Mis-TLIF and had better short-term clinical outcomes. However, there were no significant differences in long-term clinical outcomes, fusion rates, and peri-operative complications between the two groups.
INTERNATIONAL ORTHOPAEDICS
(2022)
Review
Orthopedics
Hao Han, Yifan Song, Yiming Li, Hengcai Zhou, Yufei Fu, Jie Li
Summary: This study compared the short-term clinical efficacy and safety of unilateral biportal endoscopic transforaminal lumbar interbody fusion (UBE-TLIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for the treatment of lumbar degenerative diseases through meta-analysis. The results showed that UBE-TLIF was superior to MIS-TLIF in terms of intraoperative blood flow, postoperative drainage flow, duration of hospital stay, VAS score for low back pain and ODI score, but had a longer operative time. There were no significant differences between the two groups in terms of total complication rate, modified Macnab grading criteria, fusion rate, VAS score of leg pain, lumbar lordosis, intervertebral disk height. Overall, both UBE-TLIF and MIS-TLIF are effective surgical modalities for the treatment of degenerative lumbar spine diseases, but UBE-TLIF has the advantages of less intraoperative blood loss, shorter postoperative hospital stay, and faster recovery.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell Biology
Libin Ni, Jian Xiao, Di Zhang, Zhenxuan Shao, Chongan Huang, Sheng Wang, Yaosen Wu, Naifeng Tian, Liaojun Sun, Aimin Wu, Yifei Zhou, Xiangyang Wang, Xiaolei Zhang
Summary: This study demonstrates the involvement of Irg-1 and itaconate in the recovery process of spinal cord injury (SCI). The overexpression of Irg-1 and treatment with itaconate show promising effects in suppressing inflammation and improving motor function recovery in SCI.
CELL DEATH & DISEASE
(2022)
Article
Orthopedics
Ben Wang, Jie Jin, Zhen-xuan Shao, Guang-yong Yang, Yan Lin, Hua-zi Xu, Cheng-long Xie, Jiao-xiang Chen, Xiao-lei Zhang, Zheng-hua Hong, Xiang-yang Wang
Summary: This study investigated a modified axial translaminar screw fixation for treating odontoid fractures, with accurate screw placement and simple operation being highlighted as key benefits. The surgical technique involved creating a small cortical window for visualized screw insertion, leading to successful outcomes and high patient satisfaction.
ORTHOPAEDIC SURGERY
(2022)
Article
Engineering, Environmental
Zengjie Zhang, Xiaolei Zhang, Chenggui Wang, Wangsiyuan Teng, Hongyuan Xing, Fangqian Wang, Eloy Yinwang, Hangxiang Sun, Yan Wu, Chengcheng Yu, Xupeng Chai, Zhiyong Qian, Xiaohua Yu, Zhaoming Ye, Xiangyang Wang
Summary: Persistent inflammation during the secondary injury of spinal cord injury is identified as the main cause of poor regenerative capability of spinal cord. Extracellular vesicles derived from M2 microglia have shown therapeutic potential for inflammation alleviation and neural regeneration. However, their applications in spinal cord injury treatment are limited due to issues such as poor accumulation, short retention, and lack of controlled release. Therefore, a novel thermosensitive hydrogel system was developed to deliver M2 derived extracellular vesicles for spinal cord injury treatment. The hydrogel enabled effective retention and controlled release of the vesicles, resulting in improved motor nerve functional recovery. Mechanistic study revealed that the sustained release of the vesicles attenuated local inflammation and inhibited neuron apoptosis, thus protecting the spinal cord. This approach provides a microenvironment-responsive and noninvasive method to improve spinal cord injury therapy through both anti-inflammatory and neural protective mechanisms.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Review
Biotechnology & Applied Microbiology
Yuhao Wu, Shiwei Shen, Yifeng Shi, Naifeng Tian, Yifei Zhou, Xiaolei Zhang
Summary: In this article, the involvement of senescence in intervertebral disc degeneration (IVDD) is reviewed, and the potential of senolytics in eliminating senescent disc cells and alleviating IVDD is discussed. A table listing potential drugs for IVDD therapy is also provided.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Chenghao Ren, Jie Jin, Chenchao Li, Jianwei Xiang, Yaosen Wu, Yifei Zhou, Liaojun Sun, Xiaolei Zhang, Naifeng Tian
Summary: This study found that metformin inhibits senescence in nucleus pulposus cells by inactivating the cGAS-STING pathway through autophagy. The research also revealed that metformin reduces DNA damage during oxidative stress. These findings suggest a new application for metformin in cGAS-STING pathway-related diseases.
JOURNAL OF CELL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Longfa Kou, Huirong Huang, Yingying Tang, Meng Sun, Yingtao Li, Jianing Wu, Shimin Zheng, Xinyu Zhao, Daosen Chen, Zucheng Luo, Xiaolei Zhang, Qing Yao, Ruijie Chen
Summary: This study proposes a novel strategy for drug delivery and treatment of osteoarthritis (OA) by using opsonized nanoparticles to attract and regulate macrophage polarization. The opsonized nanoparticles effectively promoted macrophage polarization toward the anti-inflammatory phenotype and protected nearby chondrocytes, resulting in enhanced therapeutic outcomes for OA.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Cell Biology
Sunlong Li, Yifeng Shi, Shuhao Zhang, Haobin Li, Ziyang Ye, Jiangqian Kong, Weijun Hong, Yiting Tu, Jiaping Ren, Zaher Meftah, Chenglong Xie, Xiangyang Wang, Xiaolei Zhang
Summary: The study found that corynoline (COR) can inhibit joint destruction and inflammation by modulating the NF-kappa B pathway and binding to Nrf2. Evaluation of the therapeutic effects of COR on osteoarthritis in the destabilization of medial meniscus (DMM) models showed improvement in the progression of osteoarthritis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Rheumatology
Shiyao Liao, Qiangqiang Zheng, Haotian Shen, Guang Yang, Yuzi Xu, Xiaolei Zhang, Hongwei Ouyang, Zongyou Pan
Summary: HECTD1 plays a crucial role in the pathogenesis of osteoarthritis by regulating chondrocyte autophagy through ubiquitinating and targeting Rubicon for proteasomal degradation. This finding reveals the importance of HECTD1 in the development of osteoarthritis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Orthopedics
S. Li, X. Pan, Y. Wu, Y. Tu, W. Hong, J. Ren, J. Miao, T. Wang, W. Xia, J. Lu, J. Chen, X. Hu, Y. Lin, X. Zhang, X. Wang
Summary: In this study, the protective effect of Interleukin-37 (IL-37) on intervertebral disc degeneration (IDD) was evaluated. IL-37 was found to decrease during the IDD process and the experimental results showed that IL-37 can suppress the SASP factors level and senescence phenotype in IL-1b treated cells. Animal experiments also demonstrated that IL-37 can alleviate IDD progression in a puncture-induced rat model. Mechanistic studies revealed that IL-37 inhibits IDD progression by downregulating the activation of the NF-kB pathway through the activation of IL-1R8.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Weiyi Xia, Jian Xiao, ChengLin Tong, Jiajie Lu, Yurong Tu, Sunlong Li, Libing Ni, Yifeng Shi, Peng Luo, Xiaolei Zhang, Xiangyang Wang
Summary: The effects of Orientin on murine chondrocytes treated with IL-1 beta were evaluated in vitro, and the healing effect of Orientin was assessed in a standard OA model in mice. Results showed that Orientin suppressed pro-inflammatory mediators and cartilage degradation, and downregulated activation of NF-kappa B by activating Nrf2/HO-1 axis and SIRT6 signaling pathway, suggesting its potential as a treatment for OA.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Chemistry, Medicinal
Cheng Teng, Jingtao Wu, Zhao Zhang, Jinquan Wang, Ye Yang, Chengji Dong, Long Wu, Zhen Lin, Yuezheng Hu, Jing Wang, Xiaolei Zhang, Zhongke Lin
Summary: This study investigated the effect of fucoxanthin (FX) on oxidative stress-induced nucleus pulposus (NP) cell apoptosis and its molecular mechanism. The results showed that FX could reduce apoptosis and extracellular matrix degradation by regulating the Sirt1 and PERK-eIF2 alpha-ATF4-CHOP signaling pathways. In vivo experiments demonstrated that FX improved intervertebral disc degeneration (IDD). These findings suggest that FX may be a potential drug for the treatment of IDD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yu Chen, Chenyu Wu, Xiaoying Zhao, Hongye Tan, Chenchao Li, Yuxin Deng, Ximiao Chen, Yaosen Wu, Naifeng Tian, Xiaolei Zhang, Yifei Zhou, Liaojun Sun
Summary: This study found that the drug 20-Deoxyingenol (20-DOI) can enhance the autophagy-lysosomal pathway in nucleus pulposus cells by activating transcription factor EB (TFEB), thereby suppressing cell senescence and impeding the progression of IVDD.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenxian Zhou, Yifeng Shi, Hui Wang, Linjie Chen, Caiyu Yu, Xufei Zhang, Lei Yang, Xiaolei Zhang, Aimin Wu
Summary: A study has found that physical exercise promotes the expression of a protein called irisin, which protects against intervertebral disc degeneration. This discovery suggests that increasing the activity of irisin through either exercise or drugs could help alleviate back pain and slow down the progression of the disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Sunlong Li, Chongan Huang, Jian Xiao, Yuhao Wu, Zengjie Zhang, Yifei Zhou, Naifeng Tian, Yaosen Wu, Xiangyang Wang, Xiaolei Zhang
Summary: This review summarizes the changes in plasma cytokine levels in diabetic patients and discusses the potential role of elevated cytokines in diabetes-induced IVDD.