Article
Multidisciplinary Sciences
Nathalie Mathern, Ehsan Yousefian, Hani Ridwan, Omid Nikoubashman, Martin Wiesmann
Summary: By comparing the arterial diameters of swine with those of human cerebral arteries, it was found that swine weighing between 55-74 kg have the closest match, making them optimal for neuroendovascular research and training.
Article
Biochemistry & Molecular Biology
Milan Krticka, Ladislav Planka, Lucy Vojtova, Vladimir Nekuda, Premysl Stastny, Radek Sedlacek, Adam Brinek, Michaela Kavkova, Eduard Gopfert, Vera Hedvicakova, Michala Rampichova, Leos Kren, Kvetoslava Liskova, Daniel Ira, Jana Dorazilova, Tomas Suchy, Tomas Zikmund, Jozef Kaiser, David Stary, Martin Faldyna, Martin Trunec
Summary: This study applied FGF2-STAB(R) in combination with a bioresorbable scaffold to improve lumbar fusion efficiency and safety in a porcine model. The bioresorbable hybrid implant showed significant advantages in fusion quality and biomechanical properties compared to the autograft group.
Article
Multidisciplinary Sciences
Xiang Wu, Shen Yu, Shuang Shen, Wenlong Liu
Summary: The study investigated the response characteristics of human cupula to temperature changes, and found that the decrease of cupula deformation when SCCs' temperature reduced by 1 degree C may be due to the increase in elastic modulus.
SCIENTIFIC REPORTS
(2021)
Review
Anatomy & Morphology
Hans-Joachim Wilke, Volker Michael Betz, Annette Kienle
Summary: Based on the kangaroo's bipedal locomotion and upright position, it is suggested that the kangaroo could be an interesting model for spine research and a reasonable surrogate for biomechanical in vitro tests. This in vitro study aimed to provide biomechanical properties of the kangaroo spine and compare them with human spinal data. The flexibility of the kangaroo spine was found to be greater overall, with similarities only found in the cervical, lower thoracic, and lumbar regions.
JOURNAL OF ANATOMY
(2023)
Article
Medicine, Research & Experimental
Rene Rissel, Louisa Kirchner, Miriam Renz, Katja Mohnke, Julian Riedel, Robert Ruemmler, Erik K. Hartmann, Jens Kamuf, Alexander Ziebart
Summary: This study investigated the anti-inflammatory effects of intravenous resveratrol in a porcine ARDS model. The results demonstrated that high-dose resveratrol significantly reduced TNF-alpha expression in lung tissue, increased functional residual capacity (FRC), and decreased pulmonary edema. These findings suggest the potential therapeutic use of resveratrol in ARDS.
Article
Surgery
Adeline Schwein, Louis Magnus, Judit Markovits, Ponraj Chinnadurai, Kyle Autry, Leslie Jenkins, Rebecca Barnes, Dragoslava P. Vekilov, Dipan Shah, Nabil Chakfe, Jean Bismuth
Summary: This study developed a large animal model of iliocaval deep venous thrombosis (DVT) for the development and evaluation of interventional management and existing imaging modalities. The researchers used an endovascular approach combined with thrombin infusion to successfully induce acute and subacute DVT.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Health Care Sciences & Services
Hai-Bin Yu, Wei-Hsun Tai, Jing Li, Rui Zhang, Wei-Ya Hao, Jian-Zhi Lin
Summary: This study found that different midsole hardnesses affect lower extremity muscle activation during jump rope exercise, resulting in changes in muscle activity during jumping.
Article
Clinical Neurology
Shun Yamamoto, Masoud Malakoutian, Marine Theret, John Street, Fabio Rossi, Stephen H. M. Brown, Mitsuru Saito, Thomas R. Oxland
Summary: The study found that surgical injury increased the passive stiffness of the multifidus fiber bundles, likely due to increased collagen content in the extracellular matrix. These changes may play an important role in postoperative compensation of the spine.
Article
Biochemistry & Molecular Biology
Matteo Berni, Francesca Veronesi, Milena Fini, Gianluca Giavaresi, Gregorio Marchiori, Francesca Oliviero
Summary: This study aimed to investigate the relationship between articular tissue structure/composition and cartilage viscoelasticity in a large animal model of early osteoarthritis (OA) treated with orthobiologics. The results showed a potential correlation between cartilage elastic modulus and cartilage thickness (CT), synovial fluid interleukin 6 (IL6), and prostaglandin E2 (PGE2), as well as between cartilage relaxation time and CT and PGE2. This work provides important indications for future studies focusing on these relationships and advanced regeneration targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
David W. Sutherland, Aisling McEleney, Matheus de Almeida, Masaki Kajimoto, Giselle Ventura, Brett C. Isenberg, Michael A. Portman, Scott E. Stapleton, Corin Williams
Summary: This study provides anatomical measurements and mechanical properties of porcine cardiovascular tissues, which are crucial for the development of pediatric heart valve replacements. The researchers also developed a novel method to measure tissue stiffness and validated it against a traditional testing method.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Robbert N. van Amstel, Richard T. Jaspers, Annelies L. Pool-Goudzwaard
Summary: Low back pain is associated with mobility impairments in the spine, pelvis, and hip. This study aimed to assess the effects of fascia tissue manipulation through lumbodorsal skin displacement (SKD) on the range of motion (ROM) in healthy subjects. The results showed that SKD had a significant effect on flexion and extension ROM, with the effect depending on the location and displacement direction. The intertester and intratester reliability of SKD were also found to be good.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Jianni Huang, George Bayliss, Shougang Zhuang
Summary: This article discusses the advantages of using pigs as a model for medical research, including their similar physiological patterns to humans and their role in narrowing the gap between clinical and preclinical studies of acute kidney injury (AKI). It compares the pros and cons of large versus small animal models and provides an overview of the development and application of porcine AKI models induced by clinically relevant insults.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jun Liu, Zhikang Liao, Jingkun Wang, Hongyi Xiang, Xiyan Zhu, Xingping Che, Yuqian Tang, Jingru Xie, Chengyi Mao, Hui Zhao, Yan Xiong
Summary: This study developed a new experimental animal model to investigate the impact injury of the gastrocnemius muscle. The results showed that the gastrocnemius was injured at an impact speed of 6.63 m/s +/- 0.25 m/s and a peak force of 1,556.80 N +/- 110.79 N. After the impact injury, changes such as edema, mitochondrial vacuolation, and infiltration of inflammatory cells were observed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Francesca Veronesi, Matteo Berni, Gregorio Marchiori, Giorgio Cassiolas, Aurelio Muttini, Barbara Barboni, Lucia Martini, Milena Fini, Nicola Francesco Lopomo, Maurilio Marcacci, Elizaveta Kon
Summary: This study aimed to treat early osteoarthritis in sheep using three different cell therapies and evaluate their effectiveness through mechanical testing, gross evaluation, and biochemical analysis. The results showed improvements in cartilage surface pathology and reduction in pro-inflammatory cytokines in the synovial fluid for all treatments.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Engineering, Biomedical
Ankush Aggarwal, Luke T. Hudson, Devin W. Laurence, Chung-Hao Lee, Sanjay Pant
Summary: A Bayesian approach was used to calculate the relative probabilities of different constitutive models for porcine aortic valve tissue based on experimental data. The May-Newman model was found to be the most probable model for the overall data, while the Lee-Sacks model and May-Newman model were equally probable for non-coronary cusps. The results demonstrate the ability of a PCA-based statistical model to capture significant variations in the mechanical properties of soft tissues.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Marco Palanca, Christian Liebsch, Shamila Hubner, Daniele Marras, Maria Luisa Ruspi, Francesco Marconi, Luca Cristofolini, Hans-Joachim Wilke
Summary: Experimental characterization of human ribs revealed two main mechanisms of failure: brittle and buckling. Ribs undergoing brittle fracture had thicker cortical bone than those undergoing buckling, and larger tensile strains were observed in specimens with brittle fractures. This supports the focus on cortical thickness modeling to enhance computational models for forensic investigations and device design.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Raquel M. Goncalves, Taryn Saggese, Zhiyao Yong, Joana R. Ferreira, Anita Ignatius, Hans-Joachim Wilke, Cornelia Neidlinger-Wilke, Graciosa Q. Teixeira
Summary: This study investigated the impact of the MSC secretome on human annulus fibrosus cells exposed to mechanical loading and a pro-inflammatory environment. The results showed that the inflammatory milieu had a stronger impact on the cells than physiological mechanical stress. The MSC secretome decreased the production of certain proteases in the cells and increased the production of TIMP-1.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Clinical Neurology
Alexander L. Hornung, Christopher M. Hornung, G. Michael Mallow, J. Nicolas Barajas, Augustus Rush, Arash J. Sayari, Fabio Galbusera, Hans-Joachim Wilke, Matthew Colman, Frank M. Phillips, Howard S. An, Dino Samartzis
Summary: This article reviews the history, applications, and future developments of artificial intelligence and machine learning in spine research. Artificial intelligence and machine learning have been extensively used in various aspects of spine care, including imaging techniques, predictive modeling, and pathology algorithms. The article emphasizes the importance for spine specialists to understand and assess the utility of novel AI research.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Samuel S. Rudisill, Alexander L. Hornung, J. Nicolas Barajas, Jack J. Bridge, G. Michael Mallow, Wylie Lopez, Arash J. Sayari, Philip K. Louie, Garrett K. Harada, Youping Tao, Hans-Joachim Wilke, Matthew W. Colman, Frank M. Phillips, Howard S. An, Dino Samartzis
Summary: This study developed and validated a machine learning model to predict the risk of early-onset adjacent segment degeneration (EO-ASD) following anterior cervical discectomy and fusion (ACDF). The model demonstrated good performance in predicting EO-ASD based on preoperative demographic, clinical, and radiographic parameters. This ML approach addresses the limitations of traditional statistics and has the potential to support discovery and clinical decision-making in spine care.
EUROPEAN SPINE JOURNAL
(2022)
Article
Orthopedics
James D. Baker, Arash J. Sayari, Youping Tao, Philip K. Louie, Bryce A. Basques, Fabio Galbusera, Frank Niemeyer, Hans-Joachim Wilke, Howard S. An, Dino Samartzis
Summary: Modic changes (MC) and endplate abnormalities (EA) may have a negative impact on cervical alignment. This study found that patients with MC and endplate pathologies such as the Modic-Endplate-Complex (MEC) had worse cervical alignment compared to those without these phenotypes.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Daniel L. Belavy, Gabriele Armbrecht, Kirsten Albracht, Helena Brisby, Deborah Falla, Richard Scheuring, Roope Sovelius, Hans-Joachim Wilke, Kajsa Rennerfelt, Eduardo Martinez-Valdes, Michail Arvanitidis, Fabian Goell, Bjoern Braunstein, Svenja Kaczorowski, Vera Karner, Nitin Kumar Arora
Summary: This study aims to investigate the impact of spaceflight on the risk of cervical intervertebral disc herniation and explore the adaptations in astronauts' cervical spine. Data collection will involve MRI, cervical 3D kinematics, muscle testing, and questionnaires. The results will inform preventive measures for astronauts and contribute to the understanding of disc herniation risk in the cervical spine for people on Earth, as well as provide insights into the etiology of neck pain.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Frank Niemeyer, Annika Zanker, Rene Jonas, Youping Tao, Fabio Galbusera, Hans-Joachim Wilke
Summary: This study developed a deep learning-based tool that can automatically and accurately segment lumbar muscles and validated the tool on an external dataset. The tool can be used for large-scale studies on spinal disorders and sarcopenia, overcoming the limitations of manual segmentation.
EUROPEAN SPINE JOURNAL
(2022)
Editorial Material
Clinical Neurology
Dino Samartzis, Fabio Galbusera, Hans-Joachim Wilke
EUROPEAN SPINE JOURNAL
(2022)
Review
Anatomy & Morphology
Hans-Joachim Wilke, Volker Michael Betz, Annette Kienle
Summary: Based on the kangaroo's bipedal locomotion and upright position, it is suggested that the kangaroo could be an interesting model for spine research and a reasonable surrogate for biomechanical in vitro tests. This in vitro study aimed to provide biomechanical properties of the kangaroo spine and compare them with human spinal data. The flexibility of the kangaroo spine was found to be greater overall, with similarities only found in the cervical, lower thoracic, and lumbar regions.
JOURNAL OF ANATOMY
(2023)
Article
Clinical Neurology
Hiroyuki Nakarai, Andrea Cina, Catherine Jutzeler, Alexandra Grob, Daniel Haschtmann, Markus Loibl, Tamas F. Fekete, Frank Kleinstuck, Hans-Joachim Wilke, Youping Tao, Fabio Galbusera
Summary: This study aims to develop a deep learning model for the automatic calculation of important spine parameters from lateral cervical radiographs. Two datasets were used for training and validation, and the results demonstrate the accuracy of the model in predicting cervical spine parameters.
GLOBAL SPINE JOURNAL
(2023)
Article
Cell & Tissue Engineering
E. Salzer, T. C. Schmitz, V. H. M. Mouser, A. Vernengo, B. Gantenbein, J. U. Jansen, C. Neidlinger-Wilke, H-j. Wilke, S. Grad, C. L. Le Maitre, M. A. Tryfonidou, K. Ito
Summary: Strategies to regenerate or repair intervertebral discs are being explored, and ex vivo disc cultures are frequently used for studying human intervertebral disc degeneration (IVDD). A systematic search of induction methods for degenerative changes revealed five categories and 129 studies. Currently, spontaneously degenerated disc cultures from large animals provide the closest resemblance to human IVDD. Future advancements in disc culture setups may better mimic human IVDD.
EUROPEAN CELLS & MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Guangsheng Song, Zhihui Qian, Kunyang Wang, Jing Liu, Yuyang Wei, Fabio Galbusera, Zhenmin Zou, Hans-Joachim Wilke, Luquan Ren, Lei Ren
Summary: The intervertebral disc is an important component of the human spine, and its degeneration can cause pain and disability. Total disc replacement is an effective treatment approach, but the complex environment and conditions present challenges in device design, materials, and processes. This review discusses the advantages and challenges of current total disc replacement devices and proposes a novel fabrication strategy to restore biofunction and improve performance.
PROGRESS IN MATERIALS SCIENCE
(2023)
Meeting Abstract
Cell & Tissue Engineering
Graciosa Q. Teixeira, Andreas Ekkerlein, Raquel M. Goncalves, Joana R. Ferreira, Yana Hoepfner, Julia Nothelfer, Anita Ignatius, Hans-Joachim Wilke, Cornelia Neidlinger-Wilke
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Andrea Vernengo, Nadine Kluser, Astrid Soubrier, Jan Gewiess, Jan Ulrich Jansen, Cornelia Neidlinger-Wilke, Hans-Joachim Wilke, Zhen Li, Mauro Alini, Sibylle Grad
TISSUE ENGINEERING PART A
(2022)
Article
Medicine, General & Internal
Markus Windolf, Maximilian Heumann, Viktor Varjas, Caroline Constant, Manuela Ernst, Robert Geoff Richards, Hans-Joachim Wilke, Lorin Michael Benneker
Summary: Spinal fusion is a widely used intervention with complications. Current diagnostic methods are limited, but a new implantable sensor system has the potential to overcome these limitations. However, its application in spinal fusion has not been demonstrated yet.
MEDICINA-LITHUANIA
(2022)
