期刊
EUROPEAN RESPIRATORY JOURNAL
卷 52, 期 3, 页码 -出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/13993003.00504-2018
关键词
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资金
- Southern California Environmental Health Sciences Center - National Institute of Environmental Health Sciences [P30ES007048]
- NIH [T32 ES013678]
- European Community [261357, 241604]
- Netherlands Organisation for Health Research and Development [ZonMw 40-00812-98-11010]
- Swedish Research Council
- Swedish Heart and Lung Foundation
- Swedish Research Council for Working Life and Social Welfare
- Swedish Asthma and Allergy Association Research Foundation
- Swedish Research Council Formas
- European Commission's Seventh Framework 29 Programme MeDALL [261357]
- Foundation for Medical Research (FRM)
- National Agency for Research (ANR)
- National Institute for Research in Public health
- French Ministry of Health (DGS)
- French Ministry of Research
- INSERM Bone and Joint Diseases National Research (PRO-A)
- Human Nutrition National Research Programmes
- French National Institute for Population Health Surveillance (InVS)
- French National Institute for Health Education (INPES)
- European Union
- Diabetes National Research Program
- Mutuelle Generale de l'Education Nationale a complementary health insurance (MGEN)
- French national agency for food security
- Erasmus Medical Center, Rotterdam
- Erasmus University Rotterdam
- Netherlands Organization for Health Research and Development (ZonMw)
- Netherlands Organisation for Scientific Research (NWO)
- Ministry of Health, Welfare and Sport
- Ministry of Youth and Families
- European Union's Horizon 2020 research and innovation programme (the LIFECYCLE project) [733206]
- European Research Council [ERC-2014-CoG-648916]
- ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL) [696295]
- ZonMW The Netherlands [529051014]
- Science Foundation Ireland [SFI/16/ERA-HDHL/3360]
- Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041]
- Spanish Ministry of Health [FIS-PIO41436, PI06/0867, PI081151, FIS-FEDER 03/1615, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647]
- Generalitat de Catalunya-CIRIT [1999SGR00241]
- Conselleria de Sanitat Generalitat Valenciana
- Department of Health of the Basque Government [2005111093, 2009111069]
- Provincial Government of Gipuzkoa [DFG06/004, DFG08/001]
- FrieslandCampina
- Netherlands Asthma Foundation [3.2.07.022, 3.2.03.48]
- Netherlands Heart Foundation [2014 T037]
- Netherlands Organization for Health Research and Development (ZonMw Prevention Program) [1.210-00-090]
- Triodos Foundation
- Phoenix Foundation
- Raphael Foundation
- Iona Foundation
- Foundation for the Advancement of Heilpedagogie, all in the Netherlands - German Federal Ministry of Education and Research (BMBF) [07015633, 07 ALE 27, 01EE9406]
- German Research Foundation (DFG) [KE 1462/2-1]
- Netherlands Organisation for Scientific Research, the Netherlands Asthma fund
- Netherlands Ministry of Spatial Planning, Housing and the Environment and the Netherlands Ministry of Health, Welfare and Sport
- RHEA: the Rhea
- European projects (EU) [16320]
- EU FP6 STREP Hiwate [36224]
- EU FP7 ENV [226285]
- EU [241604]
- EU-FP7 [EU-FP7-HEALTH-2012]
- Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children)
- Italian Ministry of Health [502/92]
- Medical Research Council
- British Heart Foundation
- Food Standards Agency
- British Lung Foundation
- Arthritis Research UK
- NIHR Southampton Biomedical Research Centre
- University Hospital Southampton NHS Foundation Trust
- Stockholm County Council
- Paris-Sud University
- Nestle
- ANSES
- French Association of Diabetic Patients (AFD)
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES007048, T32ES013678] Funding Source: NIH RePORTER
- MRC [MC_UP_A620_1017, MC_UU_12011/4] Funding Source: UKRI
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood. This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age. Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09). Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.
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