Article
Pharmacology & Pharmacy
Yuanyuan Han, Mao Jiang, Rongling He, Xin Lv, Xiaohua Liao, Yijun He, Fan Zhang, Lingzhi Long, Guoliang Jiang, Zhangzhe Peng, Lijian Tao, Gaoyun Hu, Jie Meng
Summary: The study found that the newly synthesized drug MFD can alleviate lung fibrosis by suppressing TGF-beta/Smad2 and MAPK pathways, reducing cell apoptosis and EMT in the fibrotic process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Yuan, Yali Li, Guoqiang Qiao, Yilu Zhou, Zijian Xu, Charlotte Hill, Zhenglin Jiang, Yihua Wang
Summary: The prevalence of pulmonary fibrosis is increasing, and the burden is expected to rise due to COVID-19. Approved therapies only slow disease progression, highlighting the need for innovative treatments. Recent studies suggest that HBO may have a positive impact on pulmonary fibrosis, attenuating the severity in mouse models.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aurelien Justet, Mada Ghanem, Tiara Boghanim, Mouna Hachem, Eirini Vasarmidi, Madeleine Jaillet, Aurelie Vadel, Audrey Joannes, Pierre Mordant, Philippe Bonniaud, Martin Kolb, Lei Ling, Aurelie Cazes, Herve Mal, Arnaud Mailleux, Bruno Crestani
Summary: This study identifies FGF19 as an antifibrotic molecule with potential therapeutic interest in fibrotic lung disorders. In vivo and in vitro experiments demonstrate that FGF19 can decrease lung fibrosis and fibrotic markers, modulate apoptosis of lung epithelial cells, and prevent myofibroblast differentiation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nuechel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Gyoerfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Joerg H. W. Distler
Summary: This study demonstrates that TGF beta activates autophagy through an epigenetic mechanism, promoting fibrotic diseases. Inhibition of aberrant autophagy activation can suppress TGF beta-induced fibroblast activation and ameliorate experimental dermal and pulmonary fibrosis.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Tinghui Shao, Yujia Xue, Mingming Fang
Summary: The study investigated the transcriptional regulation mechanism of Clca2 in cardiac fibrosis, revealing that the Twist1-HDAC1 complex can suppress the expression of Clca2 in cardiac fibroblasts, potentially leading to FMyT and cardiac fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Peijun Ju, Jianhua Chen, Le Ma, Ying Cheng, Jiwei Liu, Ying Sun, Cuizhen Zhu, Zhe Shen, Wei Wang, Yanmin Peng, Usman Ali, Nanjie Xu, Jinghong Chen
Summary: The deterioration of inhibitory synapses may be a neurological basis for abnormal social behaviors. Manipulating GABAergic transmission has been linked to improved sociability. Ephrin-B2 (EB2), a synaptic protein, plays a key role in the maintenance and rearrangement of inhibitory synapses in the medial prefrontal cortex (mPFC). However, the specific role of EB2 in inhibitory cell types in the pathophysiology and treatment of social deficits is still unknown. This study found that depletion of EB2 specifically occurred in GABAergic neurons, leading to social deficits. Overexpression of mPFC EB2 restored the defective social behavior. The findings suggest that the effect of EB2 on social deficits is specific to certain anatomical and cell types. Furthermore, an upregulation of HDAC4 expression was observed in EB2-deficient mice, with nuclear HDAC4 playing a role in mediating the mechanism underlying the impairment. Treatment with LMK235 significantly rescued social deficits, indicating a potential use for HDAC targeting agents in treating social deficits.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Review
Medicine, Research & Experimental
Shigeki Saito, Brian Deskin, Mohammad Rehan, Santosh Yadav, Yasuka Matsunaga, Joseph A. Lasky, Victor J. Thannickal
Summary: Lung fibrosis can occur in various settings, and the most common form is idiopathic pulmonary fibrosis, which is strongly associated with aging. Recent studies suggest that targeting certain components of aging biology may be effective in mitigating age-related fibrosis. This review explores molecular targets that may be relatively more selective in mediating tissue fibrosis, as well as epigenetic mechanisms and metabolic pathways that regulate aging and fibrosis.
Article
Pharmacology & Pharmacy
Fengchen Shen, Xiying Hou, Tingting Li, Jianjun Yu, Huizhen Chen, Na Liu, Andong Qiu, Shougang Zhuang
Summary: HDAC4 plays a critical role in renal fibrosis and tubular injury, and could be a potential therapeutic target for chronic fibrotic kidney disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Chen, Azeem Alam, Aurelie Pac-Soo, Qian Chen, You Shang, Hailin Zhao, Shanglong Yao, Daqing Ma
Summary: The study found that VPA prevented EMT in a time- and concentration-dependent manner both in vitro and in vivo, leading to improvement in lung structure. Pretreatment with VPA increased the survival rate and prevented weight loss in mice, associated with Smad2/3 deactivation.
LABORATORY INVESTIGATION
(2021)
Article
Chemistry, Medicinal
Dimitrios Triantafyllos Gerokonstantis, Christiana Mantzourani, Dimitrios Gkikas, Kai-Chen Wu, Huy N. Hoang, Ierasia Triandafillidi, Ilianna Barbayianni, Paraskevi Kanellopoulou, Alexandros C. Kokotos, Panagiota Moutevelis-Minakakis, Vassilis Aidinis, Panagiotis K. Politis, David P. Fairlie, George Kokotos
Summary: Benzamides, as HDAC inhibitors, have shown promising anticancer activity and potential for treating fibrotic disorders.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Giulio Bontempi, Michela Terri, Sabrina Garbo, Claudia Montaldo, Davide Mariotti, Veronica Bordoni, Sergio Valente, Clemens Zwergel, Antonello Mai, Alessandra Marchetti, Alessandro Domenici, Paolo Mene, Cecilia Battistelli, Marco Tripodi, Raffaele Strippoli
Summary: Histone deacetylase 1 (HDAC1) inhibition plays an important role in reversing fibrosis. The study found that HDAC1 inhibition can reverse cell-to-cell transformation and limit cell migration and invasion by promoting the expression of miR-769-5p. Additionally, miR-769-5p targets and regulates the expression of several crucial genes.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Fuyang Jiang, Qiyue Jiang, Jing Zhao, Zhonghui Zhu, Qiyue Jia, Wenming Xue, Hongwei Wang, Yan Wang, Lin Tian
Summary: Silica can induce macrophage pyroptosis, which plays an important role in activating myofibroblasts during the progression of silicosis. Inhibiting macrophage pyroptosis could be a feasible clinical strategy to alleviate silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Zhonghai Shen, Kang Ji, Zhenhai Cai, Chenglong Huang, Xiaojun He, Hongwei Xu, Gang Chen
Summary: The study showed that using the selective inhibitor Tubastatin A to inhibit HDAC6 has a significant effect on TBHP-treated chondrocytes and a mouse OA model, reducing oxidative stress and ECM degradation, maintaining chondrocyte survival, and activating autophagy. The results suggest that HDAC6 inhibition may prevent OA development and serve as a potential therapeutic target for OA management.
Article
Biochemistry & Molecular Biology
Juan Yin, Jing Wang, Xinxin Zhang, Yan Liao, Wei Luo, Sha Wang, Jiawei Ding, Jie Huang, Mengling Chen, Wei Wang, Shencun Fang, Jie Chao
Summary: This study revealed a specific pattern of fibroblast proliferation and found that targeting anoikis resistance may inhibit the pathological process of pulmonary fibrosis. This provides a new approach for treating pulmonary fibrosis and offers new insights into the potential application of ZC3H4 in the development of novel therapeutic strategies for mitigating pulmonary fibrosis.
CELL AND BIOSCIENCE
(2022)
Article
Environmental Sciences
Meng Yang, Dongming Wang, Shiming Gan, Bin Wang, Linling Yu, Yujia Xie, Lieyang Fan, Jixuan Ma, Weihong Chen
Summary: The administration of T3 can reduce lung damage, inflammation, and fibrosis caused by silica exposure. This protective effect may be partially mediated through thyroid hormone receptors and involve a reduction in glycolysis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Pediatrics
Lucinda J. Weaver, Colm P. Travers, Namasivayam Ambalavanan, David Askenazi
Summary: This article discusses the impact of excessive fluid accumulation on neonates and its related pathophysiology, and provides clinical recommendations for monitoring, prevention, and treatment of fluid overload.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Jeremy M. Loberger, Ryan M. Jones, Adeline S. Phillips, Jeremy A. Ruhlmann, A. K. M. Fazlur Rahman, Namasivayam Ambalavanan, Priya Prabhakaran
Summary: This study aimed to evaluate the relationship between endotracheal secretions and pediatric extubation failure, and found that the evaluation of secretion character by bedside nurses was independently associated with extubation failure. A model combining other key factors showed good discrimination for predicting extubation outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jean Lowe, Janell F. Fuller, Allison G. Dempsey, Barbara Do, Carla M. Bann, Abhik Das, Kathryn E. Gustafson, Betty R. Vohr, Susan R. Hintz, Kristi L. Watterberg
Summary: This study found that a blunted cortisol awakening response is associated with memory and attention problems in preterm children. This has implications for stress reactivity and learning problems in preterm children.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amelia E. Freeman, Kent A. Willis, Luhua Qiao, Ahmed S. Abdelgawad, Brian Halloran, Gabriel Rezonzew, Zoha Nizami, Nancy Wenger, Amit Gaggar, Namasivayam Ambalavanan, Trent E. Tipple, Charitharth Lal
Summary: Bronchopulmonary dysplasia (BPD) is a common lung disease in premature infants caused by hyperoxia exposure and microbial dysbiosis. This study reveals that airway dysbiosis impairs Nrf2-dependent antioxidant function, leading to a more severe phenotype of BPD. Furthermore, supporting colonization with Lactobacillus species to enhance Nrf2-mediated antioxidant activity can improve dysbiotic-augmented lung injury.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Matthew Clark, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: In extremely preterm infants on respiratory support on postnatal day 28, the presence and longer duration of patent ductus arteriosus (PDA) were associated with the development of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Arie Nakhmani, Premananda Indic, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: Early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is crucial due to the higher risk of death. We investigated the intermittent hypoxemia (IH) patterns in infants with BPD-PH and compared them with infants with BPD alone. Our findings showed that infants with BPD-PH had longer duration of hypoxemic events, which was associated with both the diagnosis of BPD-PH and death in these infants.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Engineering, Biomedical
Pravinkumar G. Kandhare, Namasivayam Ambalavanan, Colm P. Travers, Waldemar A. Carlo, Nikolay M. Sirakov, Arie Nakhmani
Summary: Prediction of biomedical signal changes is useful for clinical applications, but evaluation and applicability of prediction tools depend on specific clinical contexts. This study proposes a novel method to evaluate and compare vital sign predictors and validates it for rare events scenarios. Experimental results show that simple statistical predictors can outperform state-of-the-art deep learning architectures for low-dimensional signals.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Pediatrics
Jane E. Brumbaugh, Betty R. Vohr, Edward F. Bell, Carla M. Bann, Colm P. Travers, Elisabeth C. Mcgowan, Heidi M. Harmon, Waldemar A. Carlo, Andrea F. Duncan, Susan R. Hintz
Summary: This study aims to analyze the relationship between social determinants of health (SDOH) and outcomes for extremely preterm infants. The results showed that infants born to mothers with public/no insurance had older postmenstrual age (PMA) at discharge and were more likely to be readmitted. Children exposed to multiple risk-associated SDOH at birth had higher rates of neurodevelopmental impairment (NDI) and death postdischarge compared to those not exposed.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Vivek V. Shukla, A. K. M. Fazlur Rahman, Xuejun Shen, Allison Black, Nitin Arora, C. Vivek Lal, Edward F. Bell, Arie Nakhmani, Chengcui Zhang, Namasivayam Ambalavanan, Waldemar A. Carlo
Summary: The study evaluated the association between the COVID-19 pandemic and stillbirth and neonatal mortality rates. The findings showed that the neonatal mortality rate decreased during the pandemic periods compared to the baseline period, while the stillbirth rate did not significantly change.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Pravitha Ramanand, Premananda Indic, Colm P. Travers, Namasivayam Ambalavanan
Summary: This study aimed to investigate oxygenation patterns during two types of oxygen supplementation in preterm infants and assess their performance in hypoxemia risk screening during NICU monitoring. The findings showed that oxygen saturation had higher volatility and complexity during digitally-set servo-controlled oxygen environment supplementation. Additionally, variability measures of oxygen saturation exhibited early prognostic value in discriminating infants at higher risk of hypoxemic events. Multivariate models with two features showed good performance in risk stratification.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Bianca M. . Vamesu, Teodora Nicola, Rui Li, Snehashis Hazra, Sadis Matalon, Naftali Kaminski, Namasivayam Ambalavanan, Jegen Kandasamy
Summary: Mitochondrial dysfunction at birth is associated with the development of bronchopulmonary dysplasia (BPD) in extremely low-birth weight (ELBW) infants. Nebulized thyroid hormone (TH) has shown potential to improve mitochondrial function and reduce pulmonary fibrosis in adult animals. This study investigated the effects of intranasal T3 on neonatal lung injury and mitochondrial dysfunction in newborn mice, as well as its impact on lung fibroblasts and mesenchymal stem cells from ELBW infants. The results demonstrated that inhaled T3 attenuated hyperoxia-induced lung injury and improved mitochondrial function in mice, suggesting that TH supplementation might be a valuable therapeutic strategy for BPD.
Article
Medicine, General & Internal
Samuel J. Gentle, Matthew A. Rysavy, Lei Li, Matthew M. Laughon, Ravim. Patel, Erik A. Jensen, Susan Hintz, Namasivayam Ambalavanan, Waldemar A. Carlo, Kristi Watterberg
Summary: In extremely preterm infants, the use of hydrocortisone does not reduce the risk of bronchopulmonary dysplasia or death, nor does it increase the risk of neurodevelopmental impairment or death.
Article
Pediatrics
Debra E. Weese-Mayer, Juliann M. Di Fiore, Douglas E. Lake, Anna Maria Hibbs, Nelson Claure, Jiaxing Qiu, Namasivayam Ambalavanan, Eduardo Bancalari, James S. Kemp, Amanda M. Zimmet, John L. Carroll, Richard J. Martin, Katy N. Krahn, Aaron Hamvas, Sarah J. Ratcliffe, Narayanan Krishnamurthi, Premananda Indic, Alaleh Dormishian, Phyllis A. Dennery, J. Randall Moorman
Summary: The study found that cardioventilatory events peak during the first month of life in extremely preterm infants, but the trajectory afterwards depends on the type of event, race, sex, and use of mechanical ventilation. Apnea, periodic breathing, and intermittent hypoxemia events rose from day 3 of life then fell to near-resolution by 8-12 weeks of age. Apnea and intermittent hypoxemia were inversely correlated with gestational age, while periodic breathing was positively correlated with gestational age.
PEDIATRIC RESEARCH
(2023)
Article
Microbiology
Ahmed Abdelgawad, Teodora Nicola, Isaac Martin, Brian A. Halloran, Kosuke Tanaka, Comfort Y. Adegboye, Pankaj Jain, Changchun Ren, Charitharth V. Lal, Namasivayam Ambalavanan, Amy E. O'Connell, Tamas Jilling, Kent A. Willis
Summary: This study identifies a gut-lung axis driven by intestinal AMP expression and mediated by the intestinal microbiota that is linked to lung injury in newborns. These findings support that intestinal AMPs modulate lung injury and repair.
Article
Psychiatry
Carla M. Bann, Katherine C. Okoniewski, Leslie Clarke, Deanne Wilson-Costello, Stephanie Merhar, Sara DeMauro, Scott Lorch, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Catherine Limperopoulos, Brenda Poindexter, Jonathan M. Davis, Michele Walsh, Jamie Newman
Summary: This study found that perceived stigma in healthcare settings during pregnancy is associated with psychological distress in the postpartum period. Individuals who reported stigma had higher levels of depression, anxiety, and anger, and lower levels of well-being. They were also more likely to experience food insecurity, adverse childhood experiences, and abuse during pregnancy, and had less emotional support.
ARCHIVES OF WOMENS MENTAL HEALTH
(2023)
