Article
Biochemistry & Molecular Biology
Agnes S. Meidert, Alexander Chouker, Siegfried Praun, Gustav Schelling, Michael E. Dolch
Summary: Markers of oxidative stress, including acetone, isoprene, and propionaldehyde, can be detected in the oxygenator outflow gas of severe ARDS patients treated with veno-venous extracorporeal membrane oxygenation (ECMO). The concentrations of these volatile organic compounds (VOCs) in breath and oxygenator outflow gas are comparable, showing a parallel course with time.
Article
Biochemical Research Methods
Fen Xiong, Kaiyuan Jiang, Jianuo Chen, Yongqin Yan, Yiyang Zhou, Zihao Chen, Hong Zheng, Yuping Li, Hongchang Gao
Summary: Metabolic profiling can be used to assess CAP patients with or without ARDS and evaluate therapeutic effects. Significant differences in metabolites were found between ARDS and non-ARDS patients, mainly involving purines and fatty acids. The biomarker panel showed better accuracy in distinguishing between ARDS and non-ARDS patients than traditional severity indexes. Defined biomarkers can be used to predict the development of ARDS and assess therapeutic effects.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Oncology
Laura A. Hagens, Nanon F. L. Heijnen, Marry R. Smit, Alwin R. M. Verschueren, Tamara M. E. Nijsen, Inge Geven, Marcus J. Schultz, Dennis C. J. J. Bergmans, Ronny M. Schnabel, Lieuwe D. J. Bos
Summary: This study aims to validate the diagnostic accuracy of a metabolic biomarker for ARDS by measuring octane in the exhaled breath of ICU patients and comparing it with non-ARDS patients. The study strengths include early phase assessment, longitudinal sampling, and reliable ARDS diagnosis by an expert panel.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Respiratory System
Laura A. Hagens, Nanon F. L. Heijnen, Marry R. Smit, Alwin R. M. Verschueren, Tamara M. E. Nijsen, Inge Geven, Cristian N. Presura, Ronald Rietman, Dominic W. Fenn, Paul Brinkman, Marcus J. Schultz, Dennis C. J. J. Bergmans, Ronny M. Schnabel, Lieuwe D. J. Bos
Summary: The use of exhaled octane concentration as a biomarker for ARDS in invasively ventilated ICU patients was not accurate, as demonstrated by both POC breath test and GC-MS analysis.
Article
Cell Biology
Wadah Ibrahim, Michael J. Wilde, Rebecca L. Cordell, Matthew Richardson, Dahlia Salman, Robert C. Free, Bo Zhao, Amisha Singapuri, Beverley Hargadon, Erol A. Gaillard, Toru Suzuki, Leong L. Ng, Tim Coats, Paul Thomas, Paul S. Monks, Christopher E. Brightling, Neil J. Greening, Salman Siddiqui, EMBER Consortium
Summary: Acute cardiorespiratory breathlessness is a significant cause of emergency hospitalizations. This study identified breath volatile organic compound biomarkers that can diagnose acute cardiorespiratory disease and investigated the metabolic enrichment patterns in acute disease. The findings demonstrate that the multibiomarker score can effectively differentiate acute disease from health and different subtypes of acute cardiorespiratory exacerbation. Furthermore, the study revealed specific enrichment patterns in different subgroups of acute disease.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Francois Arrive, Remi Coudroy, Arnaud W. Thille
Summary: ARDS is a life-threatening condition characterized by severe hypoxemia and bilateral pulmonary infiltrates. The need for a more comprehensive definition has been highlighted, particularly in light of the COVID-19 pandemic, to include patients treated with noninvasive oxygenation strategies. Early identification and accurate etiological diagnosis are crucial for initiating appropriate treatment in ARDS patients.
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Review
Critical Care Medicine
Kevin G. Buell, Bhakti K. Patel
Summary: This review examines the evidence for the use of helmet noninvasive ventilation (NIV) in patients with severe acute hypoxic respiratory failure (AHRF). The findings suggest that helmet NIV may reduce the need for endotracheal intubation and days of mechanical ventilation compared to standard nasal cannula, facemask NIV, or high-flow nasal oxygen. However, there is inconsistent evidence on patient survival. Facemask NIV may worsen lung injury and be inferior to mechanical ventilation in delivering lung protective strategies. Further studies are needed to investigate the use of helmet NIV as a separate clinical entity.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Christopher L. Carroll, Natalie Napolitano, Marti Pons-Odena, Narayan Prabhu Iyer, Steven Kwasi Korang, Sandrine Essouri
Summary: This study developed evidence-based recommendations for the effectiveness of noninvasive respiratory support for pediatric acute respiratory distress syndrome (PARDS), including considerations of timing, duration, disease severity, and treatment delivery. The study found that noninvasive ventilation (NIV) is widely used for respiratory failure in children and may be beneficial for some patients with PARDS, but close monitoring is required for worsening disease and NIV failure.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Chemistry, Analytical
Laura A. Hagens, Alwin R. M. Verschueren, Ariana Lammers, Nanon F. L. Heijnen, Marry R. Smit, Tamara M. E. Nijsen, Inge Geven, Marcus J. Schultz, Dennis C. J. J. Bergmans, Ronny M. Schnabel, Lieuwe D. J. Bos
Summary: This study demonstrates that a newly developed POC breath test can reliably detect octane in the exhaled breath of invasively ventilated ICU patients. The method shows excellent repeatability and is able to detect clinically relevant levels of octane in low ppb range.
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pathology
Chaorui Duan, Luke Buerer, Jing Wang, Samuel Kaplan, Gavin Sabalewski, Gregory D. Jay, Sean F. Monaghan, Andrea E. Arena, William G. Fairbrother
Summary: The Bubbler breathalyzer is more predictive of lower respiratory tract involvement and less invasive than alternatives when testing for SARS-CoV-2; samples tested using the Bubbler are threefold more enriched for SARS-CoV-2 RNA than tongue swabs, indicating direct sampling of virus particles; the Bubbler has been shown to have the potential for rapid diagnosis in large batches of mixed samples in the medical field.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Article
Respiratory System
Catharina C. Moor, Judith C. Oppenheimer, Gizal Nakshbandi, Joachim G. J. V. Aerts, Paul Brinkman, Anke-Hilse Maitland-van der Zee, Marlies S. Wijsenbeek
Summary: Exhaled breath analysis using eNose technology shows promising results in accurately distinguishing between ILD patients and healthy controls, as well as different ILD subgroups. This noninvasive diagnostic tool could potentially be a novel biomarker for timely diagnosis in the future.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Critical Care Medicine
Youjin Chang, Hyun Ju Yoo, Su Jung Kim, Kwangha Lee, Chae-Man Lim, Sang-Bum Hong, Younsuck Koh, Jin Won Huh
Summary: This study used targeted metabolomics to identify metabolites that could distinguish sepsis-induced ARDS patients from non-ARDS controls. It also confirmed that sepsis-induced direct and indirect ARDS are metabolically distinct subgroups. Glycerophospholipid and sphingolipid metabolism were found to be the most significant metabolic pathways involved in sepsis-induced ARDS.
Article
Biochemistry & Molecular Biology
Martin Osswald, Dario Kohlbrenner, Nora Nowak, Jorg Sporri, Pablo Sinues, David Nieman, Noriane Andrina Sievi, Johannes Scherr, Malcolm Kohler
Summary: This study utilized SESI-HRMS to continuously monitor metabolites in exhaled breath during a graded cycle ergometry cardiopulmonary exercise test, revealing significant changes in various metabolic pathways. Real-time monitoring enabled high-resolution data collection on metabolite shifts from rest to voluntary exhaustion, providing insights into metabolite changes during exercise.
Article
Medicine, General & Internal
Daan F. L. Filippini, Laura A. Hagens, Nanon F. L. Heijnen, Claudio Zimatore, Leila N. Atmowihardjo, Ronny M. Schnabel, Marcus J. Schultz, Dennis C. J. J. Bergmans, Lieuwe D. J. Bos, Marry R. Smit
Summary: The RALE score is not universally prognostic in mechanically ventilated ICU patients, but early changes in RALE score are associated with mortality in ARDS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Anesthesiology
Marcelo Gama de Abreu, Marcus J. Schultz, Ary Serpa Neto
Summary: Spin and fragility are common in randomised controlled trials published in anaesthesia journals. Staying with the facts and addressing only the primary endpoint in the conclusion of clinical research reports might help reduce spin. Routinely reporting the fragility index, in turn, could deliver information about robustness, enhancing the transparency of positive dichotomous results. It is in the best interest of clinical research that authors, reviewers, and journals come together to reduce spin and address the fragility of randomised controlled trials.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Critical Care Medicine
Aranka Akkermans, Sanne Prins, Amber S. Spijkers, Jean Wagemans, Nanon H. M. Labrie, Dick L. Willems, Marcus J. Schultz, Thomas G. V. Cherpanath, Job B. M. van Woensel, Marc van Heerde, Anton H. van Kaam, Moniek van de Loo, Anne Stiggelbout, Ellen M. A. Smets, Mirjam A. de Vos
Summary: This study examines the argumentative practices of doctors and families in making decisions about life-sustaining treatment in ICUs. The research identifies the arguments used by both parties and explores how they structure their arguments during conversations. The study reveals that there is limited and brief exchange of arguments, although the types of arguments presented by doctors and families largely overlap.
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Malou Janssen, Henrik Endeman, Lieuwe D. J. Bos
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Willemke Stilma, Thijs A. Lilien, Lieuwe D. J. Bos, Aryen Saatpoor, Omar Elsayed, Frederique Paulus, Marcus J. Schultz, Reinout A. Bem, Rosalie S. N. Linssen
Summary: Critically ill patients on invasive mechanical ventilation are at higher risk for airway mucus accumulation, leading to complications. However, the efficacy of interventions such as humidification, endotracheal suctioning, and pharmacologic interventions is poorly supported by evidence, and there is variability in the choice and timing of interventions based on mucus classification score.
Article
Medicine, General & Internal
L. Robin Goossen, Marielle Verboom, Marielle Blacha, Illaa Smesseim, Ludo F. M. Beenen, David M. P. van Meenen, Frederique Paulus, J. Marcus Schultz
Summary: In this single-center cohort study in the Netherlands, the incidence of air leaks, including subcutaneous emphysema, pneumothorax, and pneumomediastinum, was found to be 8.4% in patients with COVID-19, which was comparable to previous reports in patients with acute hypoxemic respiratory failure.
Editorial Material
Respiratory System
M. J. Schultza, P. J. van Oostena, L. Hol
Article
Biochemistry & Molecular Biology
Luis Enrique Olmedilla Arnal, Oscar Diaz Cambronero, Guido Mazzinari, Jose Maria Perez Pena, Jaime Zorrilla Ortuzar, Marcos Rodriguez Martin, Maria Vila J. Montanes, Marcus Schultz, Lucas Rovira, Maria Pilar Argente Navarro
Summary: High intra-abdominal pressure during laparoscopic surgery is associated with reduced splanchnic blood flow. This study found that an individualized low-pneumoperitoneum-pressure strategy may prevent a reduction in liver perfusion.
Article
Health Care Sciences & Services
Katrijn Daenen, Jilske A. Huijben, Anders Boyd, Lieuwe D. J. Bos, Sara C. M. Stoof, Hugo van Willigen, Diederik A. M. P. J. Gommers, Hazra S. Moeniralam, Corstiaan A. den Uil, Nicole P. Juffermans, Merijn Kant, Abraham J. Valkenburg, Janesh Pillay, David M. P. van Meenen, Frederique Paulus, Marcus J. Schultz, Virgil A. S. H. Dalm, Eric C. M. van Gorp, Janke Schinkel, Henrik Endeman
Summary: This study aims to determine the optimal dosing and timing of corticosteroid therapy for hospitalized patients with COVID-19 and provide a personalized treatment approach to reduce morbidity and mortality. It will investigate the effect of high-dose corticosteroids throughout the entire clinical course and explore biomarker profiles for targeted therapy.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Physiology
Thijs A. Lilien, David M. P. Van Meenen, Marcus J. Schultz, Lieuwe D. J. Bos, Reinout A. Bem
Summary: The interest in oxygen toxicity has led to numerous studies, but there is still no consensus on the clinical impact of hyperoxia and hyperoxemia. This article explores the importance of hyperoxia-induced lung injury in current critical care practice, suggesting that it may be less important than other ventilator-related factors in patients with acute respiratory distress syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Editorial Material
Critical Care Medicine
Pedro D. Wendel-Garcia, Lieuwe D. J. Bos
Article
Critical Care Medicine
Ignacio Martin-Loeches, Luis Felipe Reyes, Saad Nseir, Otavio Ranzani, Pedro Povoa, Emili Diaz, Marcus J. Schultz, Alejandro H. Rodriguez, Cristian C. Serrano-Mayorga, Gennaro De Pascale, Paolo Navalesi, Mauro Panigada, Luis Miguel Coelho, Szymon Skoczynski, Mariano Esperatti, Andrea Cortegiani, Stefano Aliberti, Anselmo Caricato, Helmut J. F. Salzer, Adrian Ceccato, Rok Civljak, Paolo Maurizio Soave, Charles-Edouard Luyt, Pervin Korkmaz Ekren, Fernando Rios, Joan Ramon Masclans, Judith Marin, Silvia Iglesias-Moles, Stefano Nava, Davide Chiumello, Lieuwe D. Bos, Antoni Artigas, Filipe Froes, David Grimaldi, Fabio Silvio Taccone, Massimo Antonelli, Antoni Torres
Summary: This study aimed to report the clinical characteristics, microbiology, and clinical outcomes of ICU-admitted patients with nosocomial lower respiratory tract infections (LRTI). The study found that patients with ventilator-associated hospital-acquired pneumonia (VHAP) had the highest mortality rates, and multidrug-resistant pathogens were frequently the cause of the nosocomial LRTI in this multinational cohort study.
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Rombout B. E. van Amstel, Jason N. Kennedy, Brendon P. Scicluna, Lieuwe D. J. Bos, Hessel Peters-Sengers, Joe M. Butler, Eddie Cano-Gamez, Julian C. Knight, Alexander P. J. Vlaar, Olaf L. Cremer, Derek C. Angus, Tom van der Poll, Christopher W. Seymour, Lonneke A. van Vught
Summary: Among critically ill patients with sepsis, subtype strategies using clinical, biomarker, and transcriptomic data do not identify comparable patient populations and are likely to reflect disparate clinical characteristics and underlying biology.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Liselotte J. Hol, Marcus Schultz, Ignacio Martin-Loeches, David M. P. van Meenen, Ary Serpa Neto, Frederique Paulus
Summary: The aim of this analysis was to compare ventilation management and outcomes in invasively ventilated patients with acute hypoxemic respiratory failure due to COVID-19 between the first and second wave in the Netherlands. The study found that patients in the second wave were sicker, had more comorbidities, and had worse oxygenation parameters. Changes in ventilation management were observed, such as lower positive end-expiratory pressure and higher fraction inspired oxygen. Duration of ventilation was shorter, but mortality rates were similar.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Athiwat Tripipitsiriwat, Orawan Suppapueng, David M. P. van Meenen, Frederique Paulus, Markus W. Hollmann, Chaisith Sivakorn, Marcus J. Schultz, PRoVENT COVID Investigators
Summary: This study found that patients with chronic obstructive pulmonary disease (COPD) have a higher mortality rate in COVID-19 and higher 28-day mortality compared to non-COPD patients. The ventilation management and the use of prone positioning differed slightly between COPD and non-COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)