Review
Agriculture, Dairy & Animal Science
Lina Hamabe, Ahmed S. Mandour, Kazumi Shimada, Akiko Uemura, Zeki Yilmaz, Kentaro Nagaoka, Ryou Tanaka
Summary: Two-dimensional speckle-tracking echocardiography is an advanced imaging technique that allows comprehensive evaluation of myocardial function through deformation imaging. It has gained importance in human medicine over the past decade, with applications for assessing myocardial function, detecting subclinical dysfunction, and as a prognostic indicator. In veterinary medicine, it is particularly useful for early detection of left ventricular dysfunction in dogs.
Article
Veterinary Sciences
Takahiro Saito, Ryohei Suzuki, Yunosuke Yuchi, Haru Fukuoka, Shuji Satomi, Takahiro Teshima, Hirotaka Matsumoto
Summary: In recent years, hypertrophic cardiomyopathy (HCM) in cats has become more common due to improvements in diagnostic techniques. This study compared myocardial function in HCM-affected cats with and without left ventricular outflow tract obstruction (DLVOTO) using speckle-tracking echocardiography. The results showed that LV myocardial function was more compromised in HCM-affected cats with DLVOTO, indicating the importance of DLVOTO in affecting LV function in HCM-affected cats.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Lina Hamabe, Kazumi Shimada, Ahmed S. Mandour, Tomohiko Yoshida, Miki Hirose, Hanan Hendawy, Hussein M. El-Husseiny, Ryou Tanaka
Summary: Standard and advanced echocardiographic techniques are important tools for assessing cardiac performance in animals. Factors such as breed, age, and body weight can affect echocardiographic parameters, but breed does not have a significant association with these parameters. However, left ventricular dimensions increase with body weight, and certain parameters are influenced by age.
VETERINARY SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Manouk J. W. van Mourik, Dominik Linz, Harm J. A. Verwijs, Sebastiaan C. A. M. Bekkers, Jerremy Weerts, Ulrich Schotten, Hanspeter Brunner-La Rocca, Joost Lumens, Harry J. G. M. Crijns, Bob Weijs, Christian Knackstedt
Summary: The objective of this study was to evaluate subtle alterations in left ventricular (LV) function in patients with idiopathic atrial fibrillation (IAF) using speckle-tracking echocardiography (STE) based global longitudinal strain (GLS). The results showed that patients with IAF had more negative GLS compared to healthy controls, but the difference was not significant when indexed for ventricular cycle length. Patients with IAF did not show any overt LV or left atrial (LA) dysfunction compared to healthy controls.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aurore Lyon, Manouk van Mourik, Laura Cruts, Jordi Heijman, Sebastiaan C. A. M. Bekkers, Ulrich Schotten, Harry J. G. M. Crijns, Dominik Linz, Joost Lumens
Summary: This study aimed to elucidate the impact of RR-interval and heart rate on left ventricular function during atrial fibrillation (AF). The research found that changes in preload and heart rate can significantly affect LV peak strain, with faster heart rates showing greater sensitivity to RR-interval changes. The simulations suggest that longer LV activation relative to the preceding RR-interval plays a key role in determining LV systolic function during AF.
Article
Health Care Sciences & Services
Massimiliano Cantinotti, Pietro Marchese, Marco Scalese, Paola Medino, Vivek Jani, Eliana Franchi, Pak Vitali, Giuseppe Santoro, Cecilia Viacava, Nadia Assanta, Shelby Kutty, Martin Koestenberger, Raffaele Giordano
Summary: STE epsilon analysis revealed significant LV systolic impairment after surgery, with improvement thereafter but incomplete normalization at discharge. Differences between base and apex emerged, with apical segments showing relative hypercontractility after surgery. Slower recovery of LV epsilon values compared to LVEF suggests that STE epsilon analysis may be more accurate for follow-up of mild LV post-surgical impairment.
Article
Cardiac & Cardiovascular Systems
Serkan Unlu, Stephanie Bezy, Marta Cvijic, Jurgen Duchenne, Marion Delcroix, Jens Uwe Voigt
Summary: RVFW LS/sPAP ratio as a new prognostic echocardiographic marker significantly predicts all-cause mortality and heart-lung transplantation in patients with pre-capillary PAH, and is superior to other well-established parameters, providing important value in understanding the relationship between RV function and afterload.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Hyue Mee Kim, In-Chang Hwang, Yeonyee Elizabeth Yoon, Jun-Bean Park, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Yaeji Lim, Goo-Yeong Cho
Summary: This study found that 2D global longitudinal strain (GLS) is associated with cardiovascular outcomes in patients with left bundle-branch block, but the predictive value of 3D speckle-tracking echocardiography has not been investigated in these patients. The study retrospectively analyzed the association between 2D and 3D strains and left ventricular ejection fraction (LVEF) in patients with preserved or reduced LVEF. The results showed that 2D-GLS is predictive of maintaining LVEF in patients with preserved LVEF, while a lower 3D-global circumferential strain is associated with persistently reduced LVEF in patients with reduced LVEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaojun Yan, Yuman Li, Juanjuan Liu, Ting Zhou, Yi Zhou, Wei Sun, Chenchen Sun, Jing Ma, Li Zhang, You Shang, Mingxing Xie
Summary: This study aimed to investigate the serial changes in left ventricular (LV) myocardial deformation in patients with sepsis. The results showed that LV myocardial strain gradually improved during the ten-day period, but was not fully recovered to normality by the seventh to the tenth days.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jinling Hu, Qiaojin Zheng, Weidong Ren
Summary: This study aimed to evaluate the myocardial stratified strains in children with KD in different stages and identify the index that can predict myocardial function injury. The results showed that the systolic function of the whole myocardium decreased in children with KD, but gradually recovered with the extension of the disease course. LVGLS could identify the abnormal left ventricular contractility in patients with KD at the acute stage.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Franziska Sciuk, Theresa Vilsmaier, Marie Kramer, Magdalena Langer, Brenda Kolbinger, Pengzhu Li, Andre Jakob, Nina Rogenhofer, Robert Dalla-Pozza, Christian Thaler, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer
Summary: This study aimed to compare the left ventricular (LV) systolic function between subjects conceived through assisted reproductive technologies (ART) and spontaneously conceived peers. Results showed that the ART group had significantly lower M-Mode assessed EF and FS values, but after adjustment, there were no significant differences between the two groups. Other LV morphology and systolic function parameters were comparable between the groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Christian Schach, Thomas Koertl, Rolf Wachter, Lars S. Maier, Samuel Sossalla
Summary: This study demonstrated that in patients with tachyarrhythmia and reduced ejection fraction, electrical cardioversion leads to immediate improvement in ejection fraction and global longitudinal strain, while heart rate-corrected left ventricular contractility remains unchanged. This suggests that the immediate effects of rhythm restoration are mostly related to changes in left ventricular volume, rather than an acute improvement in heart-rate independent contractility.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Mengmeng Ji, Wenqian Wu, Lin He, Lang Gao, Yanting Zhang, Yixia Lin, Mingzhu Qian, Jing Wang, Li Zhang, Mingxing Xie, Yuman Li
Summary: This review summarizes the utility of RV longitudinal strain (RVLS) in evaluating RV function in patients with heart failure (HF), highlighting its important prognostic value.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zimian Chen, Suming Zhang, Aijuan Fang, Jun Shao, Hong Shen, Bugao Sun, Guanjun Guo, Lei Liu
Summary: Hyperbilirubinemia can cause myocardial injury in neonates. 2D speckle tracking imaging is effective in evaluating changes in left ventricular contractility. The study found that stratified strain parameters in the myocardium were significantly lower in the HBN group compared to the control group.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Obstetrics & Gynecology
Xiaolu Sun, Bowen Zhao, Yan Chen, Mei Pan, Bei Wang, Xiaohui Peng
Summary: The study introduced a novel method, aCMQ, to measure the global and regional longitudinal strain of the fetal left ventricle, showing high success rate and comprehensive data for evaluating fetal cardiac function.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Eui-Young Choi, Jin-Sun Park, Deulle Min, Soohyun Ahn, Jeong-Ah Ahn
Summary: A mobile self-management app program called Heart Failure-Smart Life was developed to support heart failure patients. The experimental study showed significant improvements in symptom and cardiac diastolic function in the experimental group after 3 months of using the app. This study provides evidence that smartphone apps can effectively guide and support heart failure patients in self-management.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Olli Raitakari, Noora Kartiosuo, Katja Pahkala, Nina Hutri-Kahonen, Lydia A. Bazzano, Wei Chen, Elaine M. Urbina, David R. Jacobs Jr, Alan Sinaiko, Julia Steinberger, Trudy Burns, Stephen R. Daniels, Alison Venn, Jessica G. Woo, Terry Dwyer, Markus Juonala, Jorma Viikari
Summary: Elevated Lp(a) level in youth is associated with increased risk of adult atherosclerotic cardiovascular disease outcomes, but not with increased carotid intima-media thickness. This conclusion was derived from two similar studies.
Article
Genetics & Heredity
Maryanne Caruana, Marieke J. Baars, Evy Bashiardes, Kalman Benke, Erik Bjorck, Andrei Codreanu, Elena de Moya Rubio, Julia Dumfarth, Arturo Evangelista, Maarten Groenink, Klaus Kallenbach, Marlies Kempers, Anna Keravnou, Bart Loeys, Laura Muino-Mosquera, Edit Nagy, Olivier Milleron, Stefano Nistri, Guglielmina Pepe, Jolien Roos-Hesselink, Zoltan Szabolcs, Gisela Teixido-Tura, Janneke Timmermans, Ingrid Van de Laar, Roland van Kimmenade, Aline Verstraeten, Yskert Von Kodolitsch, Julie De Backer, Guillaume Jondeau
Summary: This document provides a patient pathway that improves care for patients with heritable thoracic aortic diseases (HTAD). It recommends referral to an expert center for evaluation based on specific criteria and suggests using transthoracic echocardiography for aortic imaging, with additional magnetic resonance imaging or computed tomography if necessary. Genetic testing should be considered for those with a high suspicion of underlying genetic aortopathy. The implementation of these strategies can standardize the diagnostic work-up and follow-up of patients with suspected HTAD and their relatives.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2023)
Article
Peripheral Vascular Disease
Kazuki Shiina, Hirofumi Tomiyama, Atsushi Tanaka, Takumi Imai, Itaru Hisauchi, Isao Taguchi, Akira Sezai, Shigeru Toyoda, Kaoru Dohi, Haruo Kamiya, Keisuke Kida, Toshihisa Anzai, Taishiro Chikamori, Koichi Node
Summary: SGLT2 inhibitors have been found to reduce the risk of heart failure progression and mortality rates. This study shows that SGLT2 inhibitors can chronically reduce estimated plasma volume and improve heart failure prognosis in patients with type 2 diabetes and chronic heart failure, especially in those with preserved ejection fraction. The subanalysis of the CANDLE trial indicates that canagliflozin significantly reduces estimated plasma volume without worsening renal function and lowers serum uric acid without causing major electrolyte abnormalities.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Anderson C. Armstrong, Rodrigo Cerci, Matthew B. Matheson, Tiago Magalhaes, Satoru Kishi, Jeff Brinker, Melvin E. Clouse, Carlos E. Rochitte, Christopher Cox, Joao A. C. Lima, Armin Arbab-Zadeh
Summary: Coronary artery calcium (CAC) scanning has limited value for risk stratification in symptomatic patients. This study aimed to identify and validate predictors of significant coronary obstruction (SCO) in symptomatic patients without CAC. Results showed that an algorithm to assess the risk of SCO in patients without CAC effectively predicted the risk of significant coronary obstruction.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Yumin Kim, Andrew D. Choi, Anha Telluri, Isabella Lipkin, Andrew J. Bradley, Alfateh Sidahmed, Rebecca Jonas, Daniele Andreini, Ravi Bathina, Andrea Baggiano, Rodrigo Cerci, Eui-Young Choi, Jung-Hyun Choi, So-Yeon Choi, Namsik Chung, Jason Cole, Joon-Hyung Doh, Sang-Jin Ha, Ae-Young Her, Cezary Kepka, Jang-Young Kim, Jin Won Kim, Sang-Wook Kim, Woong Kim, Gianluca Pontone, Todd C. Villines, Iksung Cho, Ibrahim Danad, Ran Heo, Sang-Eun Lee, Ji Hyun Lee, Hyung-Bok Park, Ji-min Sung, Tami Crabtree, James P. Earls, James K. Min, Hyuk-Jae Chang
Summary: We compared the diagnostic performance, costs, and association with major adverse cardiovascular events (MACE) of clinical coronary computed tomography angiography (CCTA) interpretation and a semiautomated artificial intelligence and machine learning approach (AI-QCT) for atherosclerosis imaging. The use of AI-QCT significantly reduced the rates and costs of invasive coronary angiography (ICA) in stable patients referred for nonemergent ICA, with no change in 1-year MACE.
CLINICAL CARDIOLOGY
(2023)
Letter
Respiratory System
Motahareh Vameghestahbanati, Coralynn Sack, Artur Wysoczanski, Eric A. Hoffman, Elsa Angelini, Norrina B. Allen, Alain G. Bertoni, Junfeng Guo, David R. Jacobs Jr, Joel D. Kaufman, Andrew Laine, Ching-Long Lin, Daniel Malinsky, Erin D. Michos, Elizabeth C. Oelsner, Steven J. Shea, Karol E. Watson, Andrea Benedetti, R. Graham Barr, Benjamin M. Smith
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Laura Galian-Gay, Antonia Pijuan-Domenech, Javier Cantalapiedra-Romero, Berta Serrano, Maria Goya, Nerea Maiz, Manel Casellas, Susana Manrique, Elena Suarez-Edo, Berta Miranda-Barrio, Blanca Gordon Ramirez, Gisela Teixido-Tura, Laura Gutierrez-Moreno, Victor Gonzalez-Fernandez, Lydia Dux-Santoy, Andrea Guala, Arturo Evangelista, Laura Dos-Subira, Jose F. Rodriguez-Palomares, Ignacio Ferreira-Gonzalez
Summary: This study investigates the aortic-related risks associated with pregnancy in women with bicuspid aortic valve (BAV) and evaluates changes in aortic diameter during pregnancy. The results show that pregnant women with BAV have a low rate of cardiac complications and aortic complications are rare. However, there is a small but significant increase in aortic diameter during pregnancy.
Article
Cardiac & Cardiovascular Systems
Daisaku Nakatani, Tomoharu Dohi, Shungo Hikoso, Atsushi Tanaka, Mamoru Nanasato, Wataru Shimizu, Koichi Node, Yasushi Sakata
Summary: There were limited clinical studies on the relationship between SGLT2 inhibitors and hematopoiesis in patients with diabetes and heart failure. In the CANDLE trial, 226 patients were studied, and it was found that canagliflozin was associated with increased hematocrit and hemoglobin levels compared to glimepiride. In conclusion, canagliflozin improved hematologic parameters in patients with diabetes and heart failure.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Sport Sciences
Tyler D. Quinn, Abbi Lane, Kelley Pettee Gabriel, Barbara Sternfeld, David R. Jacobs, Peter Smith, Bethany Barone Gibbs
Summary: This study examined the associations between fitness and leisure-time physical activity (LTPA) and occupational physical activity (OPA). The results showed a positive correlation between LTPA and fitness, while OPA was negatively correlated with fitness. These findings are important for physical activity research and public health promotion.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biochemistry & Molecular Biology
Drew R. R. Nannini, Yinan Zheng, Brian T. Joyce, Kyeezu Kim, Tao Gao, Jun Wang, David R. R. Jacobs, Pamela J. J. Schreiner, Kristine Yaffe, Philip Greenland, Donald M. M. Lloyd-Jones, Lifang Hou
Summary: The study reveals the association between marijuana use and DNA methylation levels, with a stronger correlation in recent and cumulative users. The research also identifies pathways and diseases related to cellular proliferation, hormone signaling, infections, schizophrenia, bipolar disorder, and substance-related disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Laura Galian-Gay, Gisela Teixido-Tura, Guillem Casas, Elena Ferrer-Sistach, Cristina Mitroi, Susana Mingo, Vanessa Monivas, Daniel Saura, Barbara Vidal, Sergio Moral, Francisco Calvo, Violeta Sanchez, Ariana Gonzalez, Gabriela Guzman-Martinez, Marta Noris Mora, Miguel Angel Arnau Vives, Jesus Peteiro, Alberto Bouzas, Teresa Gonzalez-Alujas, Laura Gutierrez, Ruben Fernandez-Galera, Filipa Valente, Andrea Guala, Aroa Ruiz-Munoz, Lydia Dux-Santoy, Ruper Olivero Soldevila, Augusto Sao Aviles, Jose F. Rodriguez Palomares, Ignacio Ferreira-Gonzalez, Artur Evangelista
Summary: This study aimed to assess the disease progression and evolution of echocardiographic variables in patients with severe low-flow low-gradient AS. The results showed that the progression of mean gradient in low-gradient groups (LFLG and NFLG) was greater compared to the high-gradient group (HG), while the reduction of AVA was slower in LFLG group compared to NFLG. Most patients initially classified as LFLG AS changed over time to other severe forms of AS and received aortic valve replacement with high-gradient AS.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniel A. Duprez, David R. Jacobs Jr
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.