Article
Respiratory System
Catia Cilloniz, Miquel Ferrer, Juan M. Pericas, Leyre Serrano, Raul Mendez, Albert Gabarrus, Hector Jose Peroni, Luis Alberto Ruiz, Rosario Menendez, Rafael Zalacain, Antoni Torres
Summary: This study aimed to validate the accuracy of the 2007 IDSA/ATS guidelines for community-acquired pneumonia (CAP) in very elderly patients (VEP) aged 80 years and above. The results showed that the severe CAP criteria had a moderate predictive ability for ICU admission in VEP, and VEP with only minor criteria can be adequately managed in general wards.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Infectious Diseases
Ignacio Martin-Loeches, Adrian Ceccato, Marco Carbonara, Gianluigi li Bassi, Pierluigi di Natale, Stefano Nogas, Otavio Ranzani, Carla Speziale, Tarek Senussi, Francesco Idone, Anna Motos, Miquel Ferrer, Antoni Torres
Summary: This study revealed that persistent cardiovascular failure significantly impacts the outcomes of patients with ICU-acquired pneumonia (ICUAP), resulting in higher mortality rates. Persistent CVF may lead to treatment failures and bacterial superinfections, highlighting the importance of timely recognition to optimize patient management.
Article
Multidisciplinary Sciences
Ines Lakbar, Sophie Medam, Romain Ronfle, Nadim Cassir, Louis Delamarre, Emmanuelle Hammad, Alexandre Lopez, Alain Lepape, Anais Machut, Mohamed Boucekine, Laurent Zieleskiewicz, Karine Baumstarck, Anne Savey, Marc Leone
Summary: This study found that ICU-acquired pneumonia caused by highly antimicrobial-resistant (HAMR) bacteria is associated with a significantly increased ICU mortality rate. The research also showed that patients with pneumonia caused by HAMR bacteria had longer ICU length of stay and mechanical ventilation duration.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew F. Shorr, James Simmons, Nicolas Hampton, Scott T. Micek, Marin H. Kollef
Summary: Although macrolide resistance is common in Streptococcus pneumoniae ICU CAP, the addition of azithromycin to the antibiotic regimen is significantly associated with reduced in-hospital mortality, independent of multiple factors.
RESPIRATORY MEDICINE
(2021)
Review
Medicine, General & Internal
Neng Wang, Congchen Tang, Lichun Wang
Summary: This study systematically evaluated risk factors for S. maltophilia pneumonia in ICU patients and found that APACHE-II score > 20, COPD, malignant tumor, mechanical ventilation, tracheotomy, endotracheal intubation, beta-Lactamase inhibitors, aminoglycosides, carbapenems, and quinolones were risk factors for ICU-acquired S. maltophilia pneumonia.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Alex R. Schuurman, Robert F. J. Kullberg, Willem Joost Wiersinga
Summary: There has been significant progress in understanding the gut microbiome in health and disease over the past decade. The gut microbiome interacts with the immune system and plays a crucial role in defending the host against pathogens. However, disturbances in the gut microbiome due to disease or interventions like antibiotic treatment can have negative consequences. This review focuses on the potential role of probiotics in the ICU, summarizes evidence from randomized clinical trials, and discusses challenges and future prospects.
Review
Biochemistry & Molecular Biology
Marcela Kanova, Pavel Kohout
Summary: Skeletal muscle declines under catabolic conditions such as critical illness. Aging leads to gradual muscle loss, especially with decreased physical activity. Intensive care unit-acquired weakness is a serious neuromuscular complication characterized by systemic inflammatory response, metabolic stress, and muscle dysfunction. Mitochondrial dysfunction is a common mechanism in both aging-related decline of muscle mass and function, and in critical illness-induced muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Jean-Francois Llitjos, Swann Bredin, Jean-Baptiste Lascarrou, Thibaud Soumagne, Mariana Cojocaru, Maxime Leclerc, Arnaud Lepetit, Albin Gouhier, Julien Charpentier, Gael Piton, Matthieu Faron, Annabelle Stoclin, Frederic Pene
Summary: The study showed that COVID-19 patients have a higher risk of developing ICU-acquired pneumonia compared to patients with bacterial or non-SARS-CoV-2 viral pneumonia. The risk of ICU-acquired pneumonia remained independently associated with COVID-19 in mechanically ventilated patients, suggesting a potential unique pathogenesis of pneumonia in COVID-19 patients. Additional research is needed to investigate the underlying mechanisms leading to this increased risk.
ANNALS OF INTENSIVE CARE
(2021)
Review
Multidisciplinary Sciences
Wei Zhang, Yun Tang, Huan Liu, Li ping Yuan, Chu chu Wang, Shu fan Chen, Jin Huang, Xin yuan Xiao
Summary: Most ICU-AW risk prediction models show good efficacy for high-risk groups, but there is bias in their development and verification processes. Large-sample, multi-center studies are needed in the future to provide a reliable basis for ICU-AW risk prediction models.
Article
Cell Biology
Hina N. Khan, Aldo Jongejan, Lonneke A. van Vught, Janneke Horn, Marcus J. Schultz, Aeilko H. Zwinderman, Olaf L. Cremer, Marc J. Bonten, Tom van der Poll, Brendon P. Scicluna
Summary: This study investigated the shifts in circulatory small RNA levels in critically ill patients with CAP-associated sepsis, and found significantly altered levels of mature miRNAs in CAP patients, as well as specific alterations in small nuclear RNA levels depending on the causal pathogen. Pathway analysis revealed enrichment for specific biological pathways unique to different infections.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Critical Care Medicine
Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna, Tom van der Poll
Summary: The study found that CAP patients with delayed ICU admission exhibited a more immune suppressive phenotype upon ICU admission compared to patients directly transferred to the ICU.
ANNALS OF INTENSIVE CARE
(2021)
Article
Respiratory System
Morgane Heitz, Albrice Levrat, Vladimir Lazarevic, Olivier Barraud, Stephane Bland, Emmanuelle Santiago-Allexant, Karen Louis, Jacques Schrenzel, Sebastien Hauser
Summary: This study demonstrates the technical feasibility and clinical validity of metagenomic next-generation sequencing (mNGS) for detecting and characterizing etiologic agents causing hospital-acquired and ventilator-associated pneumonia. mNGS can accurately detect pathogens and identify additional potential pathogens associated with pneumonia that cannot be diagnosed by culture.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, General & Internal
Semih Aydemir, Derya Hosgun
Summary: This study aimed to investigate the role of acute-phase reactants and inflammation-based biomarkers in predicting 90-day mortality in patients aged over 65 years who were hospitalized in intensive care unit (ICU) due to hospital-acquired pneumonia (HAP). The results showed that serum white blood cell count (WBC) level can be used to predict long-term mortality and prognosis, with a high WBC value being significant in predicting 90-day independent mortality.
Article
Microbiology
Mohammad H. Alshaer, Nicole Maranchick, Chen Bai, Kelly L. Maguigan, Bethany Shoulders, Timothy W. Felton, Sumith K. Mathew, Mamoun T. Mardini, Charles A. Peloquin
Summary: This study aimed to evaluate the association of early and cumulative beta-lactam pharmacokinetic/pharmacodynamic (PK/PD) parameters with therapy outcomes in pneumonia. The study found that beta-lactam exposure had a significant impact on pneumonia outcomes, and therefore should be optimized early and maintained throughout therapy.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Yong Du, Zhanjun Lu, Jing Jin, Tianyun Shi, Yi Ding, Ling Qian, Wei He, Qihui Huang, Jingjing Feng, Rong Jiang, Xuru Chen, Handong Jiang, Zhijun Jie
Summary: The study revealed that 2019-nCoV pneumonia should be considered a systemic disease. Lymphocyte percentage, blood urea nitrogen, calcium, myohemoglobin, and IL-6 levels are closely associated with patient prognosis. The survival rate of patients in the severe group was higher than that of patients in the critical group.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Critical Care Medicine
Ser Hon Puah, Andrew Li, Matthew Edward Cove, Jason Phua, Vicky Ng, Amit Kansal, Qiao Li Tan, Juliet Tolentino Sahagun, Juvel Taculod, Addy Yong-Hu Tan, Kollengode Ramanathan, Amartya Mukhopadhyay, Chee Kiang Tay, Yew Woon Chia, Duu Wen Sewa, Meiying Chew, Sennen J. W. Lew, Shirley Goh, Shekhar Dhanvijay, Jonathan Jit-Ern Tan, Kay Choong See
Summary: This study examined the clinical practices of physicians and respiratory therapists in the use of high-flow nasal cannula (HFNC). The results of the survey showed variations in the indications and thresholds for HFNC initiation among different intensive care units.
AUSTRALIAN CRITICAL CARE
(2022)
Article
Geriatrics & Gerontology
Sierra Beck, Frances B. Kinnear, Anne Maree Kelly, Kevin H. Chu, Win Sen Kuan, Gerben Keijzers, Richard Body, Mehmet A. Karamercan, Sharon Klim, Tissa Wijeratne, Sinan Kamona, Colin A. Graham, Tom Roberts, Daniel Horner, Said Laribi
Summary: The study found that older emergency department patients with non-traumatic headache exhibited different clinical features and were more likely to have a serious secondary cause of headache compared to younger adults. There should be a low threshold for investigation in older patients presenting to the emergency department with non-traumatic headache.
AUSTRALASIAN JOURNAL ON AGEING
(2022)
Article
Emergency Medicine
Tom Roberts, Daniel E. Horner, Kevin Chu, Martin Than, Anne-Maree Kelly, Sharon Klim, Frances Kinnear, Gerben Keijzers, Mehmet Akif Karamercan, Tissa Wijeratne, Sinan Kamona, Win Sen Kuan, Colin A. Graham, Richard Body, Said Laribi
Summary: This study found that patients presenting with thunderclap headache in the emergency department are at higher risk for serious intracranial pathology, especially subarachnoid hemorrhage. However, the majority of thunderclap headache cases had a benign cause.
EMERGENCY MEDICINE JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Tissa Wijeratne, Win Sen Kuan, Anne Maree Kelly, Kevin H. Chu, Frances B. Kinnear, Gerben Keijzers, Richard Body, Mehmet A. Karamercan, Sharon Klim, Sinan Kamona, Colin A. Graham, Tom Roberts, Daniel Horner, Said Laribi
Summary: This study investigated the assessment and management patterns of acute migraine presentations in emergency departments and found that therapeutic practices are not in line with current guidelines, especially for patients with severe symptoms.
Article
Multidisciplinary Sciences
Ljubomir Buturovic, Hong Zheng, Benjamin Tang, Kevin Lai, Win Sen Kuan, Mark Gillett, Rahul Santram, Maryam Shojaei, Raquel Almansa, Jose Angel Nieto, Sonsoles Munoz, Carmen Herrero, Nikolaos Antonakos, Panayiotis Koufargyris, Marina Kontogiorgi, Georgia Damoraki, Oliver Liesenfeld, James Wacker, Uros Midic, Roland Luethy, David Rawling, Melissa Remmel, Sabrina Coyle, Yiran E. Liu, Aditya M. Rao, Denis Dermadi, Jiaying Toh, Lara Murphy Jones, Michele Donato, Purvesh Khatri, Evangelos J. Giamarellos-Bourboulis, Timothy E. Sweeney
Summary: This study developed a blood-based host-gene-expression classifier for predicting the severity of viral infections and validated it in various viral infection settings, including COVID-19. The classifier showed good accuracy and predictive performance in identifying the severity of COVID-19 patients. It has the potential to assist in risk assessment and treatment decisions for COVID-19 and other acute viral infections.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Mui Teng Chua, Wei Ming Ng, Qingshu Lu, Matthew Jian Wen Low, Amila Punyadasa, Matthew Edward Cove, Ying Wei Yau, Faheem Ahmed Khan, Win Sen Kuan
Summary: This study evaluated the efficacy of HFNC oxygenation for maintaining higher SpO(2) during RSI in emergency department patients. The results showed that HFNC oxygenation did not improve the lowest SpO(2) during the first intubation attempt compared to usual care, but it may prolong safe apnoea time.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Article
Emergency Medicine
Anne-Maree Kelly, Kevin H. Chu, Win Sen Kuan, Gerben Keijzers, Frances B. Kinnear, Alejandro Cardozo-Ocampo
Summary: This study investigated the prevalence and causes of serious secondary headaches in pregnant emergency department patients. The study found that the proportion of patients with serious headache causes was not significantly different between pregnant female, non-pregnant female, and male patient subgroups. Therefore, the inclusion of pregnancy as a 'red flag' in emergency department headache assessment is not supported by these data.
EMERGENCY MEDICINE AUSTRALASIA
(2022)
Article
Multidisciplinary Sciences
Andrew Li, Matthew Edward Cove, Jason Phua, Ser Hon Puah, Vicky Ng, Amit Kansal, Qiao Li Tan, Juliet Tolentino Sahagun, Juvel Taculod, Addy Yong-Hui Tan, Amartya Mukhopadhyay, Chee Kiang Tay, Kollengode Ramanathan, Yew Woon Chia, Duu Wen Sewa, Meiying Chew, Sennen J. W. Lew, Shirley Goh, Shekhar Dhanvijay, Jonathan Jit-Ern Tan, Kay Choong See
Summary: Delaying intubation in patients who fail HFNC may lead to increased mortality. The ROX index demonstrates moderate discriminatory power among AHRF patients, both pneumonia and non-pneumonia related, at both HFNC initiation and one hour later.
Article
Medical Laboratory Technology
Hyun Suk Yang, Mina Hur, Kyeong Ryong Lee, Hanah Kim, Hahn Young Kim, Jong Won Kim, Mui Teng Chua, Win Sen Kuan, Horng Ruey Chua, Chagriya Kitiyakara, Phatthranit Phattharapornjaroen, Anchalee Chittamma, Thiyapha Werayachankul, Urmila Anandh, Sanjeeva Herath, Zoltan Endre, Andrea Rita Horvath, Paola Antonini, Salvatore Di Somma
Summary: NephroCheck can predict the development of AKI and short-term mortality in the emergency department. NephroCheck is a useful biomarker for early ruling out or ruling in the diagnosis of AKI in the emergency department.
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Medicine, General & Internal
Charles Chin Han Lew, Puay Shi Ng, Kok Wah Wong, Ser Hon Puah, Cassandra Duan Qi Lim, Geetha Kayambu, Andrew Yunkai Li, Chee Hong Toh, Jonathen Venkatachalam, Amartya Mukhopadhyay
Summary: This retrospective observational study in 5 tertiary hospitals in Singapore described the characteristics, treatment modalities, and clinical outcomes of 83 critically ill patients with SARS-CoV-2, comparing their nutrition interventions against ASPEN recommendations. Despite a high prevalence of obesity and comorbidities like hypertension and diabetes, patients did not receive adequate calories and protein, suggesting a need for further refinement of nutritional interventions for these patients.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Article
Medicine, General & Internal
Stephanie Q. Ko, Joel Goh, Yee Kian Tay, Norshima Nashi, Benjamin M. Y. Hooi, Nan Luo, Win Sen Kuan, John T. Y. Soong, Derek Chan, Yi Feng Lai, Yee Wei Lim
Summary: This study describes a home-based inpatient substitutive care programme in Singapore and demonstrates that hospital-at-home programmes appear to be safe and feasible alternatives to inpatient care in Singapore. Patient satisfaction rates were high, and further studies are warranted to compare clinical outcomes and cost to conventional inpatient care.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Article
Critical Care Medicine
Mui Teng Chua, Darius Shaw Teng Pan, Ming Zhou Lee, Mohammed Zuhary Thajudeen, Mohamed Madeena Faizur Rahman, Irfan Abdulrahman Sheth, Victor Yeok Kein Ong, Jonathan Zhe Ying Tang, Choon Peng Jeremy Wee, Win Sen Kuan
Summary: An ageing population has led to an increase in trauma cases among older patients, and it is important to investigate the impact of multiple co-morbidities and polypharmacy on clinical outcomes in this population.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Endocrinology & Metabolism
Jade Gek Sang Soh, Amartya Mukhopadhyay, Bhuvaneshwari Mohankumar, Swee Chye Quek, Bee Choo Tai
Summary: This study aimed to develop a prediction model for 30-day hospital readmission among adults with diabetes mellitus whose index admission was diabetes-related. The model performed well in both internal and external validation and included 4 predictors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Editorial Material
Medicine, General & Internal
Win Sen Kuan, Mui Teng Chua
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Article
Respiratory System
Jennifer Sumner, Anjali Bundele, Ravi Shankar, Lin Siew Chong, Yanika Kowitlawakul, Amartya Mukhopadhyay
Summary: Using the photovoice method, we gained an in-depth understanding of the lived experiences of COPD patients and found that COPD has a wide-ranging impact on their activities of daily living. This method offers a different way of communication for individuals who struggle to articulate their views through conventional interviews.
BMC PULMONARY MEDICINE
(2023)
