Review
Oncology
Yongshu Li, Winnie Wailing Tam, Yuanyuan Yu, Zhenjian Zhuo, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Xiaokang Wang, Weijing Wang, Yongyi Li, Yanyang Tu, Yunhua Gao
Summary: Biomarkers are detectable molecules that can indicate specific diseases, and nucleic acid aptamers have emerged as a powerful tool in biomarker discovery. SELEX-based methods have been developed to construct aptamers for discovering new biomarkers in different cell locations, and SOMAScan is a multiplexed protein biomarker detection technology. These methods have greatly accelerated biomarker discovery in various diseases.
BIOMARKER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Charles Gwellem Anchang, Cong Xu, Maria Gabriella Raimondo, Raja Atreya, Andreas Maier, Georg Schett, Vasily Zaburdaev, Simon Rauber, Andreas Ramming
Summary: The increasing incidence rates of immune-mediated inflammatory diseases (IMIDs) are concerning, as current standard immunotherapies only have a 40-60% response rate. Moreover, these therapies require lifelong usage and cannot achieve true disease cure. The development of various OMICs technologies offers hope for improving IMIDs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Yinan Xiao, Meiyu Bi, Hongyan Guo, Mo Li
Summary: This review summarizes the recent advances and perspectives in the use of multi-omics technologies in ovarian cancer research, highlighting their potential applications in identifying novel biomarkers and improving clinical assessments.
Article
Allergy
Urszula Radzikowska, Katja Baerenfaller, Jose Antonio Cornejo-Garcia, Cagatay Karaaslan, Elena Barletta, Basak Ezgi Sarac, Damir Zhakparov, Alma Villasenor, Ibon Eguiluz-Gracia, Cristobalina Mayorga, Milena Sokolowska, Coral Barbas, Domingo Barber, Markus Ollert, Tomas Chivato, Ioana Agache, Maria M. Escribese
Summary: Allergic diseases and asthma are complex chronic inflammatory conditions that are influenced by environmental and genetic factors. Omics technologies provide a way to study the underlying biochemical systems and processes related to allergies. Systems biology approaches can help us understand these complex diseases and support precision medicine.
Article
Agronomy
Keith D. Wing
Summary: New neuroactive insecticides are discovered/registered differently, with lower value in use compared to neuroactive pharmaceuticals, but show clear similarities in their biochemical modes of action. This paper examines recent trends in pharmaceutical science and identifies technologies that may represent complementary approaches to insecticide discovery and mode of action determination.
PEST MANAGEMENT SCIENCE
(2021)
Review
Peripheral Vascular Disease
Pedrum Mohammadi-Shemirani, Tushar Sood, Guillaume Pare
Summary: This review discusses the purpose, characteristics, and applications of 'omics studies, as well as the challenges and advantages of integrating multiple types of 'omics data. By integrating multiple types of 'omics data, disease diagnosis and prediction can be improved, and the underlying mechanisms of diseases can be better understood.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Medicine, Research & Experimental
Hong-Wei Zhang, Chao Lv, Li-Jun Zhang, Xin Guo, Yi-Wen Shen, Dale G. Nagle, Yu-Dong Zhou, San-Hong Liu, Wei-Dong Zhang, Xin Luan
Summary: This review summarizes successful studies regarding the application of integrative omics-based methods in natural product target discovery, discussing the advantages and disadvantages of each technique while introducing emerging micro-scale single-cell-based techniques.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Jie Huang, Xinxin Chen, Xuekun Fu, Zheng Li, Yuhong Huang, Chao Liang
Summary: The discovery and identification of biomarkers are crucial for the advancement of medical diagnosis and therapeutics. Aptamers, as a potential technology for biomarker discovery, offer many advantages such as flexible design and easy synthesis, and have been successfully applied in CELL-SELEX and SOMAScan technologies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pathology
Jing Yang, Jun Wu
Summary: Global aging has led to an increasing prevalence of osteoporosis, with osteoporotic fractures significantly impacting patients' quality of life and mortality rates. Early diagnosis is crucial for timely intervention. This review discusses the epidemiological status and pathogenesis of osteoporosis, as well as the latest advancements in individual- and multi-omics technologies for identifying diagnostic biomarkers.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Immunology
Qiongrong Huang, Xiuli Zhang, Zhiyuan Hu
Summary: This study established an artificial intelligence model based on fecal multi-omics data for multi-classification diagnosis of IBD and its subtypes. Three individualized diagnosis models with less features and high accuracy were obtained, providing a valuable method for high accuracy, noninvasive diagnosis and subtype identification of IBD patients. Simple noninvasive fecal sampling can be used to detect metabolomics and metatranscriptomics data, thus replacing the tedious and painful clinical colonoscopy and biopsy procedures.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Immunology
Jessica M. Zielinski, Jason J. Luke, Silvia Guglietta, Carsten Krieg
Summary: High throughput single cell multi-omics platforms have enabled unprecedented insights into biological and clinical questions, creating whole atlases of cell types and interaction networks. Combining different -omic workflows on a single cell level can help examine cellular phenotypes and immune effector functions, as well as accelerate cellular biomarker discovery and definition of druggable target pathways. Challenges in the field include sharing disruptive technologies to scientific communities while incorporating new approaches like genomic cytometry and single cell metabolomics.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Nhan Nguyen, Danyel Jennen, Jos Kleinjans
Summary: This paper provides an overview of using omics applications to understand drug side effects at the molecular level. It discusses available omics technologies, their possible uses, as well as their advantages and limitations.
DRUG DISCOVERY TODAY
(2022)
Editorial Material
Immunology
Qinglong Wu, Kang Ning, Xiaoxiao Zhao, Feng Liao, Min Wang, Longgang Chang, Yanmin Liu, Jinmiao Chen, Ming Zhao, Zhangran Chen
Summary: Autoimmune diseases affect 5% to 8% of the global population and their pathogenesis remains unclear, posing a significant challenge to healthcare systems.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dimitra Kerdidani, Nikos E. Papaioannou, Evangelia Nakou, Themis Alissafi
Summary: Immune-mediated inflammatory diseases (IMIDs) are a group of autoimmune and chronic inflammatory disorders. This review discusses the use of multi-omics approaches to study the mechanisms of these diseases and discover effective therapeutic interventions.
Review
Cell Biology
Yi Lei, Ju Guo, Shikun He, Hua Yan
Summary: This review summarizes the applications of multi-omics technology in investigating retinal vascular diseases to further understand their pathogenesis and complex molecular mechanisms. It also proposes multi-omics-based methodologies for biomarker and therapeutic strategy discovery, optimizing the approaches to clinical and basic medicinal research on retinal vascular diseases. Lastly, the opportunities, challenges, and future prospects of multi-omics analyses in retinal vascular disease studies are discussed in detail.
Review
Respiratory System
Ekaterina Khaleva, Anna Rattu, Chris Brightling, Andrew Bush, Apostolos Bossios, Arnaud Bourdin, Kian Fan Chung, Rekha Chaudhuri, Courtney Coleman, Sven-Erik Dahlen, Ratko Djukanovic, Antoine Deschildre, Louise Fleming, Stephen J. Fowler, Atul Gupta, Eckard Hamelmann, Simone Hashimoto, Gunilla Hedlin, Gerard H. Koppelman, Erik Melen, Clare S. Murray, Charles Pilette, Celeste Porsbjerg, Katharine C. Pike, Franca Rusconi, Clare Williams, Birgit Ahrens, Peter Alter, Freja Anckers, Maarten van den Berge, Katharina Blumchen, Guy Brusselle, Graham W. Clarke, Danen Cunoosamy, Barbro Dahlen, Piers Dixey, Andrew Exley, Urs Frey, Erol A. Gaillard, Lisa Giovannini-Chami, Jonathan Grigg, Diana Hartenstein, Liam G. Heaney, Bulent Karadag, Susanne Kaul, Inger Kull, Amelia Licari, Anke H. Maitland-van der Zee, Vera Mahler, Ann-Marie M. Schoos, Prasad Nagakumar, Jenny Negus, Hanna Nielsen, James Paton, Marielle Pijnenburg, Valeria Ramiconi, Sofia Romagosa Vilarnau, Stefania Principe, Niels Rutjes, Sejal Saglani, Paul Seddon, Florian Singer, Heribert Staudinger, Steve Turner, Susanne Vijverberg, Tonya Winders, Valentyna Yasinska, Graham Roberts
Summary: The COMSA Working Group developed two Core Outcome Measures (COM) sets for paediatric and adult severe asthma, including FEV1 as z-scores, frequency of severe exacerbations and oral corticosteroid use. These COM sets will inform future clinical trials, enhance comparability of biological therapies' efficacy and effectiveness, and assess their socioeconomic value.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Critical Care Medicine
Santiago Ponce Aix, Tudor Eliade Ciuleanu, Alejandro Navarro, Sophie Cousin, Laura Bonanno, Egbert F. Smit, Alberto Chiappori, Maria Eugenia Olmedo, Ildiko Horvath, Christian Grohe, Anna F. Farago, Jose Antonio Lopez-Vilarino, Martin Cullell-Young, Antonio Nieto, Noelia Vasco, Javier Gomez, Carmen Kahatt, Ali Zeaiter, Enric Carcereny, Jaromir Roubec, Konstantinos Syrigos, Gregory Lo, Isidoro Barneto, Anthony Pope, Amparo Sanchez, Joseph Kattan, Konstantinos Zarogoulidis, Cornelius F. Waller, Helge Bischoff, Oscar Juan-Vidal, Niels Reinmuth, Manuel Domine, Luis Paz-Ares
Summary: The study aimed to evaluate the efficacy and safety of combined lurbinectedin and doxorubicin treatment for relapsed small-cell lung cancer. The results showed that the combination therapy did not improve overall survival compared to the control group, but had fewer hematological adverse events.
LANCET RESPIRATORY MEDICINE
(2023)
Review
Respiratory System
Anna Rattu, Ekaterina Khaleva, Chris Brightling, Sven-Erik Dahlen, Apostolos Bossios, Louise Fleming, Kian Fan Chung, Erik Melen, Ratko Djukanovic, Rekha Chaudhuri, Andrew Exley, Gerard H. Koppelman, Arnaud Bourdin, Franca Rusconi, Celeste Porsbjerg, Courtney Coleman, Clare Williams, Hanna Nielsen, Elizabeth Davin, Phil Taverner, Sofia Romagosa Vilarnau, Graham Roberts
Summary: The recommendations of the National Institutes of Health (NIH) on outcome measurement instruments for asthma are widely used in clinical practice and research. However, there is no consensus on which outcome measures are important to patients with severe asthma and are valid for this population. Guidelines recommend the use of patient-reported outcome measures (PROMs) to evaluate treatment response, but do not provide specific instruments. Additionally, the outcomes that patients consider important, such as quality of life, are not consistently considered by physicians when evaluating treatment response.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Environmental Sciences
Prashant Kumar, Juan C. Zavala-Reyes, Gopinath Kalaiarasan, Hisham Abubakar-Waziri, Gloria Young, Ian Mudway, Claire Dilliway, Ramzi Lakhdar, Sharon Mumby, Michal M. Klosowski, Christopher C. Pain, Ian M. Adcock, Jonathan S. Watson, Mark A. Sephton, Kian Fan Chung, Alexandra E. Porter
Summary: The study examined the distribution characteristics of ultrafine particles in a London underground platform, finding that particle number concentrations gradually increased and reached a peak between 18:00 and 21:00. Harmful organic compounds and metal mixtures were also identified, highlighting the need for improved ventilation conditions in underground railway systems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Allergy
Isabella Annesi-Maesano, Lorenzo Cecchi, Benedetta Biagioni, Kian Fan Chung, Bernard Clot, Martine Collaud Coen, Gennaro D. Amato, Athanasios Damialis, Javier Dominguez-Ortega, Carmen Galan, Stefanie Gilles, Stephen Holgate, Mohamed Jeebhay, Stelios Kazadzis, Nikolaos G. Papadopoulos, Santiago Quirce, Joaquin Sastre, Fiona Tummon, Claudia Traidl-Hoffmann, Jolanta Walusiak-Skorupa, Pablo Alonso-Coello, Carlos Canelo-Aybar, Yahveth Cantero-Fortiz, David Rigau, Josefina Salazar, Francisca Verdugo-Paiva, Marek Jutel, Cezmi A. Akdis, Ioana Agache
Summary: This study aimed to investigate the impact of pollen exposure on asthma exacerbations and found that outdoor pollen exposure may have an effect on asthma exacerbation, particularly in children under 18 years of age. Further research is needed to evaluate the effects of pollen on asthma exacerbation, considering factors such as pollen sensitization, hay fever, air pollution, green spaces, and pre-existing medications, in order to improve preventive measures.
Article
Virology
Hung-Yu Huang, Chun-Yu Lo, Fu-Tsai Chung, Yu-Tung Huang, Po-Chuan Ko, Chang-Wei Lin, Yu-Chen Huang, Kian Fan Chung, Chun-Hua Wang
Summary: This study aimed to investigate the clinical outcomes and identify risk factors associated with hospitalization and mortality following influenza infection in adult patients with bronchiectasis. The results showed that patients with bronchiectasis had higher hospitalization rates and mortality rates in influenza-related infection. Influenza infection exacerbated the severity of bronchiectasis, and older patients, those with high bronchiectasis aetiology comorbidity index (BACI), and previous exacerbations were more likely to be hospitalized and have higher mortality rates.
Review
Biochemistry & Molecular Biology
Zsuzsanna Miklos, Ildiko Horvath
Summary: Oxidative stress driven by environmental and local airway factors is a significant contributor to chronic obstructive bronchiolitis, a key feature of COPD. The imbalance between oxidants and antioxidants amplifies local inflammation, worsens cardiovascular health, and contributes to COPD-related cardiovascular dysfunctions and mortality. This review provides an overview of recent advances in understanding the mechanisms and countermeasures of oxidative stress, with a focus on the interplay between local and systemic processes. It also introduces major regulatory mechanisms and suggests areas for further research in this field.
Editorial Material
Critical Care Medicine
Chloe I. Bloom, Ian M. Adcock
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Alen Faiz, Rashad M. Mahbub, Fia Sabrina Boedijono, Milan I. Tomassen, Wierd Kooistra, Wim Timens, Martijn Nawijn, Philip M. Hansbro, Matt D. Johansen, Simon D. Pouwels, Irene H. Heijink, Florian Massip, Maria Stella de Biase, Roland F. Schwarz, Ian M. Adcock, Kian F. Chung, Anne van der Does, Pieter S. Hiemstra, Helene Goulaouic, Heming Xing, Raolat Abdulai, Emanuele de Rinaldis, Danen Cunoosamy, Sivan Harel, David Lederer, Michael C. Nivens, Peter A. Wark, Huib A. M. Kerstjens, Machteld N. Hylkema, Corry-Anke Brandsma, Maarten van den Berge
Summary: Smoking leads to a decrease in IL-33 expression at the gene and protein level, possibly due to a reduction in resting basal cells. These findings may explain why anti-IL-33 treatment is more effective in former smokers with COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yohannes Tesfaigzi, Jeffrey L. Curtis, Irina Petrache, Francesca Polverino, Farrah Kheradmand, Ian M. Adcock, Stephen I. Rennard
Summary: The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current approaches to define distinct disease phenotypes are lacking. This perspective discusses the role of different cell types in COPD pathogenesis and the application of new technologies in understanding the pathophysiology and clinical heterogeneity of COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Christos Rossios, Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M. Band, Louise A. Burton, Vera Cvoro, Peter T. Donnan, Gordon W. Duncan, Jacob George, Adam L. Gordon, Celia L. Gregson, Adrian Hapca, Cheryl Hume, Thomas A. Jackson, Simon Kerr, Alixe Kilgour, Tahir Masud, Andrew Mckenzie, Emma Mckenzie, Harnish Patel, Kristina Pilvinyte, Helen C. Roberts, Avan A. Sayer, Karen T. Smith, Roy L. Soiza, Claire J. Steves, Allan D. Struthers, Divya Tiwari, Julie Whitney, Miles D. Witham, Paul R. Kemp
Summary: This study aimed to investigate the association between ACE gene polymorphisms and muscle mass, strength, in individuals with sarcopenia. The results indicated an over-representation of the D allele in the study cohort, particularly in men. Men with the I allele had greater leg strength, and individuals with the DD genotype showed an increase in quadriceps strength over 12 months.
Article
Immunology
Ilaria Salvato, Luca Ricciardi, Jessica Dal Col, Annunziata Nigro, Giorgio Giurato, Domenico Memoli, Assunta Sellitto, Erwin Pavel Lamparelli, Maria Assunta Crescenzi, Monica Vitale, Alessandro Vatrella, Francesco Nucera, Paola Brun, Federico Caicci, Paola Dama, Thomas Stiff, Leandro Castellano, Sobia Idrees, Matt D. Johansen, Alen Faiz, Peter A. Wark, Philip M. Hansbro, Ian M. Adcock, Gaetano Caramori, Cristiana Stellato
Summary: AU-rich-element factor-1 (AUF-1), an RNA-binding protein, is involved in posttranscriptional regulation of genes related to inflammation and cellular senescence, both of which are pathogenic mechanisms in chronic obstructive pulmonary disease (COPD). Decreased expression of AUF-1 is observed in bronchiolar epithelium of COPD patients and in human airway epithelial cells exposed to cytokines and cigarette smoke. This study identifies AUF-1-targeted transcripts and demonstrates its association with inflammation and senescence-related pathways in COPD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Han-Kyul Kim, Ji-One Kang, Ji Eun Lim, Tae-Woong Ha, Hae Un Jung, Won Jun Lee, Dong Jun Kim, Eun Ju Baek, Ian M. M. Adcock, Kian Fan Chung, Tae-Bum Kim, Bermseok Oh
Summary: Using the UK Biobank dataset, we identified four distinct asthma subtypes based on onset age and lung function. Our study revealed that early onset asthma with reduced lung function had the highest genetic predisposition. Furthermore, clusters with reduced lung function were genetically distinct from clusters with normal lung function.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Materials Science, Multidisciplinary
Carlos Palo-Nieto, Anna Blasi-Romero, Corine Sandstrom, David Balgoma, Mikael Hedeland, Maria Stromme, Natalia Ferraz
Summary: Wood derived cellulose nanofibrils (CNFs) have been explored as interesting materials for biomedicine. This study proposed the functionalization of CNFs with a ROS-sensitive oligopeptide to develop a novel CNF-based material for medical conditions associated with high levels of ROS. Various approaches were used to optimize the reaction conditions and characterize the properties of the CNF materials. The results showed that the functionalized CNF hydrogels promoted cell survival in an oxidative environment, indicating their potential for use in chronic wound therapies.
MATERIALS ADVANCES
(2023)