Article
Clinical Neurology
Timothy P. Howarth, Natalie Gentin, Nayellin Reyes-Chicuellar, Catherine Jonas, Bruce Williamson, Greg Blecher, John Widger, Subash S. Heraganahally
Summary: This study found that Indigenous Australian children have issues with sleep quality, including a higher prevalence and severity of obstructive sleep apnoea, higher daytime sleepiness scores, later bedtimes, and reduced total sleep time compared to their non-Indigenous peers.
Article
Multidisciplinary Sciences
Adam Domonkos Tarnoki, David Laszlo Tarnoki, Csaba Olah, Marcell Szily, Daniel T. Kovacs, Andras Dienes, Marton Piroska, Bianka Forgo, Marina Pinheiro, Paulo Ferreira, Laszlo Kostyal, Martina Meszaros, Judit Pako, Laszlo Kunos, Andras Bikov
Summary: This study found that patients with OSA had more lumbar abnormalities compared to non-OSA controls, and markers of OSA severity were correlated with the development of lumbar spondylosis in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Gregoire Justeau, Sebastien Bailly, Chloe Gerves-Pinquie, Wojciech Trzepizur, Nicole Meslier, Francois Goupil, Thierry Pigeanne, Sandrine Launois, Laurene Leclair-Visonneau, Philippe Masson, Acya Bizieux-Thaminy, Jean-Louis Racineux, David Gozal, Frederic Gagnadoux
Summary: This study aimed to investigate the association between adherence to continuous positive airway pressure (CPAP) therapy and the incidence of cancer in patients with obstructive sleep apnoea (OSA). The results showed that adherence to CPAP therapy did not significantly reduce the risk of all-cancer incidence. Further evaluation is needed to determine if adherent CPAP therapy for OSA can reduce the risk of specific cancer sites.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Susan Redline, Ali Azarbarzin, Yuksel Peker
Summary: In this Review, the authors summarize the shared risk factors and causal links between obstructive sleep apnoea (OSA) and cardiovascular disease (CVD), as well as the emerging knowledge on the heterogeneity of OSA. They also explore the potential role of new biomarkers for cardiovascular risk stratification in patients with OSA.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Nissim Arish, Gabriel Izbicki, Ariel Rokach, Amir Jarjou'i, George Kalak, Shmuel Goldberg
Summary: Patients with both COVID-19 and obstructive sleep apnoea (OSA) have worse outcomes. This study found that high OSA risk was associated with severe COVID-19 and longer hospitalization. The Berlin and ESS questionnaires should be completed for every COVID-19-infected patient, especially those with comorbidities.
Review
Medicine, General & Internal
Aline Rocha, Ana Carolina Pereira Nunes Pinto, Daniela Pachito, Luciano F. Drager, Geraldo Lorenzi-Filho, Alvaro N. Atallah
Summary: Central sleep apnoea (CSA) is a condition characterized by impaired breathing during sleep, and pharmacological treatment has shown some benefit in improving the symptoms and quality of life in patients with CSA. However, the available evidence is uncertain and further research is needed to establish the effectiveness and safety of pharmacological agents for CSA.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Medicine, General & Internal
Andras Bikov, Stefan M. Frent, Martina Meszaros, Laszlo Kunos, Alexander G. Mathioudakis, Alina Gabriela Negru, Laura Gaita, Stefan Mihaicuta
Summary: OSA is associated with increased insulin resistance, and the triglyceride-glucose index (TyG) has been found to be significantly higher in OSA patients, related to disease severity. However, further evaluation in non-obese, non-diabetic subjects is needed to determine the clinical significance of TyG in OSA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Domenico Scrutinio, Pietro Guida, Maria Aliani, Giorgio Castellana, Patrizia Guido, Mauro Carone
Summary: This study found that comorbidities in patients with severe OSAS are closely related to all-cause mortality, with age and comorbidities being key predictors of death. Recursive-partitioning analysis showed that patients with a combination of CKD and CVD or COPD have the highest mortality risk.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Respiratory System
Patrick Levy, Matthew T. Naughton, Renaud Tamisier, Martin R. Cowie, T. Douglas Bradley
Summary: Heart failure and sleep disordered breathing often coexist and can lead to myocardial damage and worse prognosis in patients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Satu Strausz, Sanni Ruotsalainen, Hanna M. Ollila, Juha Karjalainen, Tuomo Kiiskinen, Mary Reeve, Mitja Kurki, Nina Mars, Aki S. Havulinna, Elina Luonsi, Dina Mansour Aly, Emma Ahlqvist, Maris Teder-Laving, Priit Palta, Leif Groop, Reedik Magi, Antti Makitie, Veikko Salomaa, Adel Bachour, Tiinamaija Tuomi, Aarno Palotie, Tuula Palotie, Samuli Ripatti
Summary: This study identified five genetic loci associated with OSA risk and found high genetic correlations between OSA and comorbidities such as obesity. The findings support a causal link between obesity and OSA, indicating a joint genetic basis between OSA and related health conditions.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Nutrition & Dietetics
Kaitlin Day, Kay Nguo, Bradley A. Edwards, Denise M. O'Driscoll, Terry P. Haines, Garun S. Hamilton, Ladan Ghazi, Claire Bristow, Helen Truby
Summary: This study aimed to evaluate the impact of a 6-month weight loss intervention on regional body composition in patients diagnosed with moderate-severe OSA and obesity. The results showed that the intervention led to significant reductions in fat mass and visceral adipose tissue in males, while females mainly experienced a decrease in waist circumference. Additionally, improvements in OSA severity were associated with changes in regional body composition in males. Females and males may require different treatment approaches.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Ziyad Alshehri, Anuradhaa Subramanian, Nicola J. Adderley, Krishna M. Gokhale, Muhammad Ali Karamat, Clare J. Ray, Prem Kumar, Krishnarajah Nirantharakumar, Abd A. Tahrani
Summary: Individuals with type 1 diabetes are at an increased risk of obstructive sleep apnoea compared with people without diabetes. Clinicians should suspect obstructive sleep apnoea in patients with type 1 diabetes if they are old, have obesity, are male, have atrial fibrillation or depression, or if they are taking lipid-lowering or antihypertensive drugs.
Review
Biochemistry & Molecular Biology
Andras Bikov, Martina Meszaros, Esther Irene Schwarz
Summary: Obstructive sleep apnoea (OSA) is a common disease characterized by upper airway collapse during sleep, leading to chronic intermittent hypoxaemia and systemic inflammation. OSA is associated with increased risk for cardiovascular morbidity and mortality, affecting coagulation and fibrinolysis processes. Further research is needed to understand the mechanisms and clinical implications of OSA-related changes in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Emma C. Johns, Daniel L. Halligan, Triin Tammsalu, Elizabeth A. Hill, Renata L. Riha, Fiona C. Denison, Rebecca M. Reynolds
Summary: This study compared the gene expression differences in placenta between obese women with and without OSA. The study found downregulation of genes involved in O-linked glycosylation and Wnt signaling pathways in OSA placentae. Additionally, gene set enrichment analysis revealed an increase in genes related to the reversible hydration of carbon dioxide in OSA placentae, which may contribute to adverse pregnancy outcomes in women with OSA.
Article
Cardiac & Cardiovascular Systems
Shashwati Dutta, Desmond Li, Andy Wang, Mark Ishak, Kristina Cook, Melissa Farnham, Hasthi Dissanayake, Peter Cistulli, Imre Hunyor, Renping Liu, Ian Wilcox, Yen Chin Koay, Jean Yang, Sean Lal, John F. O'Sullivan
Summary: The study found that metabolites were associated with cardiac function, energy- and lipid-storage metabolites were related to left ventricular wall thickness and mass, and plasma levels of nicotine metabolite cotinine were linked to increased time spent with a sleep oxygen saturation less than 90%. Smokers with sleep apnoea had a significantly higher risk for adverse outcomes. Central sleep apnoea was significantly associated with heart failure with preserved ejection fraction (HFpEF) but not heart failure with reduced ejection fraction.
Article
Transplantation
Phil McEwan, Rebecca Boyce, Juan Jose Garcia Sanchez, C. David Sjostrom, Bergur Stefansson, Stephen Nolan, Ricardo Correa-Rotter, Peter Rossing, Glenn M. Chertow, John J. McMurray, David C. Wheeler, Hiddo J. L. Heerspink
Summary: The DAPA-CKD trial demonstrated that dapagliflozin has significant benefits in patients with chronic kidney disease and albuminuria. Using a Markov model, it was predicted that dapagliflozin treatment would lead to longer time in lower CKD stages, reduced mortality, and fewer complications such as heart failure and kidney function decline.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Meir Schechter, Niels Jongs, Glenn M. Chertow, Ofri Mosenzon, John J. McMurray, Ricardo Correa-Rotter, Peter Rossing, Anna Maria Langkilde, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: This study aimed to determine the effects of dapagliflozin on hospitalizations in patients with chronic kidney disease (CKD). The results showed that dapagliflozin reduced the risk of hospitalization for any cause in patients with CKD, regardless of whether they had type 2 diabetes or not.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jelle M. Beernink, Frederik Persson, Niels Jongs, Gozewijn D. Laverman, Glenn M. Chertow, John J. V. McMurray, Anna Maria Langkilde, Ricardo Correa-Rotter, Peter Rossing, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: This study aimed to determine whether the benefits of dapagliflozin varied by background glucose-lowering therapy (GLT) in patients with type 2 diabetes and chronic kidney disease (CKD). The results demonstrated consistent effects of dapagliflozin on both primary and secondary endpoints across different baseline GLT classes or combinations. Therefore, dapagliflozin has significant clinical implications in reducing kidney and cardiovascular events.
Article
Clinical Neurology
Fee Benz, Dieter Riemann, Katharina Domschke, Kai Spiegelhalder, Anna F. Johann, Nathaniel S. Marshall, Bernd Feige
Summary: The objective of this study was to assess the agreement and linear relationships amongst multiple measures of sleep duration in patients with insomnia disorder and good sleeper controls. The results suggest that subjective and objective measures capture different aspects of sleep, even when addressing the same value. It is important to consider the population being studied and the assessment method when interpreting results.
JOURNAL OF SLEEP RESEARCH
(2023)
Letter
Medicine, General & Internal
Amelia Lin, Keith Wong, Simone K. Visser, Helen Jo, Yasmeen Al-Hindawi, Katrin Kosbab-Jackson, Molly Cocks, Anastasia Volovets, Paul Haber, Kirsten Hammond, Nicole Taylor, Veronica Yozghatlian, Edmund M. T. Lau, Nathaniel S. Marshall, Tara Aquino-Salomon, Sheila Sivam
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Orthopedics
L. S. Lohmander, M. Peltonen, J. C. Andersson-Assarsson, C. Maglio, K. Sjoholm, M. Taube, P. Jacobson, P-A. Svensson, L. M. S. Carlsson, S. Ahlin
Summary: This study investigated the long-term effect of obesity and bariatric surgery on the incidences of osteoarthritis and arthroplasty of hip and knee. The results showed that the bariatric surgery group had a lower incidence of hip osteoarthritis but a higher incidence of knee arthroplasty compared to the control group.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Editorial Material
Critical Care Medicine
Craig L. Phillips, Nathaniel S. Marshall
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Annemarie B. van der Aart-van Der Beek, Ellen Apperloo, Niels Jongs, Dennis B. Rouw, C. David Sjostrom, Iris Friedli, Lars Johansson, Daniel H. van Raalte, Klaas Hoogenberg, Hiddo J. L. Heerspink
Summary: This study evaluated the effects of dapagliflozin, exenatide, and the combination of dapagliflozin and exenatide on reducing albuminuria in patients with type 2 diabetes and microalbuminuria or macroalbuminuria. The study found that all three treatments could reduce albuminuria, with the combination therapy showing the most significant reduction.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Nayyar Iqbal, Philip Ambery, Jennifer Logue, Ashwini Mallappa, C. David Sjostrom
Summary: Treatment of T2D and obesity should include glycemic control, sustained weight loss, and organ protection. SGLT2i and GLP-1-glucagon dual agonists are two classes of drugs that can facilitate this approach by addressing the underlying pathophysiology, increasing periods of catabolic energy consumption, and potentially providing long-term cardio-renal benefits.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Environmental Sciences
Nathaniel S. Marshall, Garry Cho, Brett G. Toelle, Renzo Tonin, Delwyn J. Bartlett, Angela L. D'Rozario, Carla A. Evans, Christine T. Cowie, Oliver Janev, Christopher R. Whitfeld, Nick Glozier, Bruce E. Walker, Roo Killick, Miriam S. Welgampola, Craig L. Phillips, Guy B. Marks, Ronald R. Grunstein
Summary: This study tested the effects of inaudible infrasound produced by large electricity-generating wind turbines on human physiology and psychology, and found that it did not have negative impacts.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Editorial Material
Clinical Neurology
Christopher J. Gordon, Nathaniel S. Marshall
Editorial Material
Medicine, General & Internal
Nathaniel S. Marshall, Ronald R. Grunstein
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
Filip Yang Fisker, Nichlas Udholm, Milos Fuglsang, Soren Lundbye-Christensen, Nathaniel S. Marshall, Jesper Bille, Camilla Nyboe, Sebastian Udholm
Summary: In this nationwide study, the researchers used Danish population registries to estimate the excess risk of receiving permanent social security benefits for patients with obstructive sleep apnea (OSA) and to track their labour force participation.
Article
Medicine, General & Internal
Isobel Lavender, Danielle McCartney, Nathaniel Marshall, Anastasia Suraev, Chris Irwin, Angela L. DRozario, Christopher J. Gordon, Bandana Saini, Ronald R. Grunstein, Brendon Yee, Iain McGregor, Camilla M. Hoyos
Summary: This article describes a study protocol for investigating the effects of cannabinol (CBN) on sleep and next-day function in individuals with insomnia disorder. The study aims to provide preliminary data on the efficacy and safety of CBN as a treatment for insomnia. The results will inform larger clinical trials in the future.
Article
Cardiac & Cardiovascular Systems
Emanuele Bobbio, Per Eldhagen, Christian L. Polte, Clara Hjalmarsson, Kristjan Karason, Araz Rawshani, Pernilla Darlington, Susanna Kullberg, Peder Sorensson, Niklas Bergh, Entela Bollano
Summary: This study analyzed the correlation between different clinical phenotypes of cardiac sarcoidosis (CS) and outcomes in 141 patients. The results showed that patients with de novo CS had more severe disease and worse outcomes. Machine learning identified right ventricular dysfunction and de novo CS as strong predictors of impaired survival.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)