Review
Medicine, General & Internal
Hussein Assallum, Tian Yue Song, Wilbert S. Aronow, Dipak Chandy
Summary: With the increasing prevalence of obesity globally, obstructive sleep apnoea (OSA) is on the rise, leading to chronic intermittent hypoxia (CIH) which is considered a risk factor for atherosclerosis. While most risk factors for atherosclerosis are well understood, factors like CIH are less explored in their association with the disease.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Respiratory System
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Atul Malhotra, Jean-Louis Pepin
Summary: Respiratory effort is a main feature of obstructive sleep apnoea (OSA), and is associated with sympathetic overactivity. This study found that the percentage of total sleep time spent with increased respiratory effort (REMOV,%TST), measured by mandibular jaw movements, can predict the prevalence of hypertension in adults with OSA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Medicine, General & Internal
Aline Rocha, Ana Carolina Pereira Nunes Pinto, Daniela Pachito, Luciano F. Drager, Geraldo Lorenzi-Filho, Alvaro N. Atallah
Summary: Central sleep apnoea (CSA) is a condition characterized by impaired breathing during sleep, and pharmacological treatment has shown some benefit in improving the symptoms and quality of life in patients with CSA. However, the available evidence is uncertain and further research is needed to establish the effectiveness and safety of pharmacological agents for CSA.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Review
Neurosciences
Nanduri R. Prabhakar, Ying-Jie Peng, Jayasri Nanduri
Summary: Carotid bodies are important sensory organs that detect changes in arterial blood oxygen concentration, and they play a key role in regulating the sympathetic tone, blood pressure, and breathing. This review discusses the effects of intermittent hypoxia on the carotid bodies, including its role in increased sympathetic tone and hypertension, as well as the underlying cellular, molecular, and epigenetic mechanisms. The review also presents evidence for the contribution of a hypersensitive carotid body to obstructive sleep apnoea (OSA) and potential therapeutic interventions for OSA in a murine model.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Respiratory System
Nicola Andrea Marchi, Geoffroy Solelhac, Mathieu Berger, Jose Haba-Rubio, Nadia Gosselin, Peter Vollenweider, Pedro Marques-Vidal, Julius Popp, Armin von Gunten, Martin Preisig, Bogdan Draganski, Raphael Heinzer
Summary: Using data from the HypnoLaus study, we found that the relationship between obstructive sleep apnoea (OSA) and cognitive decline in the elderly population is controversial. Our results showed that lower mean peripheral oxygen saturation during sleep and longer time spent asleep with SpO2 <90% were associated with steeper declines in cognitive scores. This study provides evidence of the contribution of OSA and nocturnal hypoxaemia to cognitive decline in the elderly population.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Bastien Lechat, Sarah Appleton, Yohannes Adama Melaku, Kristy Hansen, R. Doug McEvoy, Robert Adams, Peter Catcheside, Leon Lack, Danny J. Eckert, Alexander Sweetman
Summary: The combined effect of coexisting insomnia and obstructive sleep apnoea on mortality risk is unclear. This study found that comorbid insomnia and sleep apnoea were associated with an increased risk of all-cause mortality.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Patrick Levy, Matthew T. Naughton, Renaud Tamisier, Martin R. Cowie, T. Douglas Bradley
Summary: Heart failure and sleep disordered breathing often coexist and can lead to myocardial damage and worse prognosis in patients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Ricardo S. Osorio, Miguel Angel Martinez-Garcia, David M. Rapoport
Summary: With the aging population and global obesity epidemic, obstructive sleep apnoea (OSA) is becoming more prevalent in the elderly. There is a bidirectional causation between OSA and aging, with potential acceleration of pathological processes. The importance of studying the complex relationship between OSA and aging is increasingly recognized.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Helga Szabo, Marton Piroska, Anita Hernyes, Luca Zoldi, Janos Juhasz, Balazs Ligeti, Nora Makra, Dora Szabo, Andras Bikov, Laszlo Kunos, Adam Domonkos Tarnoki, David Laszlo Tarnoki
Summary: This study aimed to analyze the relationship between the gut microbiome and atherosclerosis in adult patients with OSA. The results showed that dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in OSA patients. Further research is needed to reveal a more precise background.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Martina Meszaros, Andras Bikov
Summary: Obstructive sleep apnoea (OSA) is associated with cardiovascular and metabolic comorbidities. There are multiple mechanisms that may contribute to dyslipidaemia in OSA, including elevated levels of triglyceride-rich lipoproteins and decreased levels of high-density lipoprotein (HDL).
Article
Respiratory System
Lu Yan, Zhihui Zhao, Qing Zhao, Qi Jin, Yi Zhang, Xin Li, Anqi Duan, Qin Luo, Zhihong Liu
Summary: OSA is relatively common in patients with PH, especially in those with chronic thromboembolic pulmonary hypertension and lung disease- or hypoxia-associated PH. Older age, male sex, and lower daytime arterial oxygen pressure are risk factors for OSA in PH patients.
BMC PULMONARY MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Andras Bikov, Martina Meszaros, Esther Irene Schwarz
Summary: Obstructive sleep apnoea (OSA) is a common disease characterized by upper airway collapse during sleep, leading to chronic intermittent hypoxaemia and systemic inflammation. OSA is associated with increased risk for cardiovascular morbidity and mortality, affecting coagulation and fibrinolysis processes. Further research is needed to understand the mechanisms and clinical implications of OSA-related changes in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Lu Tan, Michael Furian, Taomei Li, Xiangdong Tang
Summary: This study aims to investigate the effects of acetazolamide on 24-hour blood pressure, sleep-disordered disturbance, and daytime cognitive performance in patients with OSA living at high altitude.
Article
Respiratory System
Mohammad Badran, Abdelnaby Khalyfa, Aaron C. Ericsson, Clementine Puech, Zachary McAdams, Shawn B. Bender, David Gozal
Summary: This study used a novel approach, fecal microbiota transplantation (FMT), to investigate the effects of obstructive sleep apnoea (OSA) on vascular function by altering the gut microbiome. The research found that mice with OSA exhibited changes in their gut microbiome, as well as abnormalities in vascular function and blood pressure. Additionally, administration of probiotics to mice with OSA alleviated these abnormalities.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Sebastien Bailly, Ludger Grote, Jan Hedner, Sofia Schiza, Walter T. McNicholas, Ozen K. Basoglu, Carolina Lombardi, Zoran Dogas, Gabriel Roisman, Athanasia Pataka, Maria R. Bonsignore, Jean-Louis Pepin
Summary: Eight distinct clinical OSA phenotypes were identified in a large pan-European database. Four clusters were gender-based, while the remaining four clusters mainly consisted of men with various combinations of age range, BMI, AHI, and comorbidities.
Article
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Holger Woehrle, Muriel Salvat, Gilles Barone-Rochette, Cecile Rocca, Eik Vettorazzi, Helmut Teschler, Martin Cowie, Patrick Levy
Summary: This study investigated the effect of ASV on sympathetic tone in patients with HFrEF and CSA. The results showed that ASV did not effectively suppress sympathetic activation in heart failure patients and was associated with increased cardiovascular mortality.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Patrick Levy, Sophia Schiza
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Endocrinology & Metabolism
Jean-Louis Pepin, Sebastien Bailly, Joelle B. B. Texereau, Emmanuel Sonnet, Sylvie Picard, Bruno Verges, Christine Coffin Boutreux, Gwenaelle Arnault Ouary, Laurence Kessler, Bruno Guerci, Brigitte Anton Kuchly, Salha Fendri Gaied, Alain Cuperlier, Christel Voinot, Christele Derrien, Severine Dubois, Florent Lavergne, Anne Laure Borel, Renaud Tamisier, Pierre-Yves Benhamou
Summary: This study investigated sleep apnoea prevalence, factors influencing severity, and associations between sleep apnoea severity and micro-/macrovascular complications in patients with type 1 diabetes. The findings highlight the significance of sleep apnoea as a comorbidity in these patients and emphasize the importance of screening and management.
DIABETES OBESITY & METABOLISM
(2023)
Letter
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Patrick Levy
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Clinical Neurology
Claire Denis, Isabelle Jaussent, Lily Guiraud, Caroline Mestejanot, Caroline Arquizan, Isabelle Mourand, Sofiene Chenini, Beatriz Abril, Anne Wacongne, Renaud Tamisier, Sebastien Baillieul, Jean-Louis Pepin, Lucie Barateau, Yves Dauvilliers
Summary: Sleep disturbances after ischaemic stroke, including alterations of sleep architecture, obstructive sleep apnea (OSA), restless legs syndrome (RLS), daytime sleepiness and insomnia, were explored in this study. The impact of these disturbances on functional outcomes was assessed at 3 months after stroke, and the effectiveness of continuous positive airway pressure (CPAP) in patients with severe OSA was evaluated. The results showed no significant differences in functional independence, disability, and stroke severity between different OSA groups or between CPAP-treated and sham-treated groups. Poorer outcomes at 3 months were associated with insomnia, RLS, depressive symptoms, and decreased total sleep time and rapid eye movement sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Atul Malhotra, Kate V. V. Cole, Anita S. S. Malik, Jean-Louis Pepin, Fatima H. Sert H. Kuniyoshi, Peter A. A. Cistulli, Adam V. V. Benjafield, Virend K. K. Somers
Summary: This study assessed the impact of adherence to positive airway pressure (PAP) therapy on health care resource utilization in patients with obstructive sleep apnea (OSA) and heart failure with reduced ejection fraction. The results indicated that adherent patients had a reduction in emergency room visits and lower healthcare costs compared to nonadherent patients. These findings suggest that diagnosing and effectively treating OSA with PAP should be emphasized in patients with heart failure with reduced ejection fraction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Respiratory System
Monique Mendelson, Jeremy Duval, Francois Bettega, Renaud Tamisier, Sebastien Baillieul, Sebastien Bailly, Jean-Louis Pepin
Summary: CPAP is the first-line therapy for OSA, but adherence is a major issue, with up to 50% discontinuing CPAP within 3 years. This article discusses the individual and societal costs of non-adherence, factors associated with non-adherence, and strategies for improving adherence, including telehealth and behavioral interventions. Challenges in visualization and analysis of CPAP remote monitoring platforms are also addressed. Expert opinion highlights the need for tailored strategies to improve CPAP adherence, as well as the importance of refining visualization dashboards and utilizing telehealth and innovative analytics.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Clinical Neurology
Ami-Marie Bocoum, Sebastien Bailly, Marie Joyeux-Faure, Sebastien Baillieul, Francois Arbib, Clara-Lou Kang, Van Ngo, Pierre Boutouyrie, Renaud Tamisier, Jean Louis Pepin
Summary: This observational study aimed to analyze the association between long-term continuous positive airway pressure (CPAP) adherence and cardiovascular outcomes. The study found that long-term CPAP adherence was positively associated with a reduction in all-cause mortality, but it did not significantly affect the occurrence of cardiovascular events.
Editorial Material
Clinical Neurology
Sebastien Baillieul, Renaud Tamisier, Millene Rodrigues Camilo, Octavio Marques Pontes-Neto
Article
Cardiac & Cardiovascular Systems
Peter A. Cistulli, Atul Malhotra, Kate V. Cole, Anita S. Malik, Jean-Louis Pepin, Fatima Sert H. Kuniyoshi, Adam V. Benjafield, Virend K. Somers
Summary: This study examined the association between adherence to positive airway pressure (PAP) therapy and healthcare resource use in heart failure with preserved ejection fraction (HFpEF) patients with obstructive sleep apnea (OSA). The results showed that adherent patients had lower healthcare resource use, a decrease in hospitalizations by 57%, a decrease in emergency room visits by 36%, and lower total healthcare costs compared to nonadherent patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Jean-Louis Pepin, Pauline Lemeille, Helene Denis, Anne Josseran, Florent Lavergne, Arnaud Panes, Sebastien Bailly, Alain Palot, Arnaud Prigent
Summary: This study investigated the health trajectories of individuals with COPD before initiating at-home NIV and compared mortality outcomes between different pre-NIV health trajectory groups. The findings revealed significant heterogeneity in clinical initiation of NIV, indicating the lack of strong evidence and guideline recommendations. Knowledge about these different clusters should be used to promote more consistent and personalized use of domiciliary NIV in COPD.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Clinical Neurology
Jeremy Duval, Clementine Mouroux, Sophie Foury, Jean-Louis Pepin, Sebastien Bailly
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Kimberly L. Sterling, Naomi Alpert, Peter A. Cistulli, Jean-Louis Pepin, Suyog More, Kate V. Cole, Atul Malhotra
Summary: Obstructive sleep apnea (OSA) is a prevalent yet underdiagnosed disease that poses a significant economic burden on the US healthcare system. This retrospective study found that adherence to positive airway pressure (PAP) therapy is associated with reduced healthcare resource utilization and costs, providing additional evidence for the diagnosis and long-term treatment of OSA.
JOURNAL OF SLEEP RESEARCH
(2023)