Article
Biotechnology & Applied Microbiology
Yulu Qiu, Chang Liu, Yumeng Shi, Nannan Hao, Wenfeng Tan, Fang Wang
Summary: Based on high-throughput sequencing of the Gene Expression Omnibus database, the study identified the association between rheumatoid arthritis-related usual interstitial pneumonia (RA-UIP) and biological processes such as oxidative phosphorylation. The analysis also revealed differential gene expression and immune regulation characteristics in the lung tissues of RA-UIP compared to idiopathic pulmonary fibrosis-associated UIP.
Review
Medicine, General & Internal
Hui Huang, Ruxuan Chen, Chi Shao, Zuojun Xu, Paul J. Wolters
Summary: Respiratory complications are common in rheumatoid arthritis (RA), with interstitial lung disease being the most common manifestation. Recent progress has been made in understanding the management and progression of RA-associated interstitial lung disease (RA-ILD) and other respiratory diseases in RA. In this review, we will update the diagnosis and treatment of RA-associated ILD, methotrexate-associated lung disease, and the complication of Pneumocystis jiroveci pneumonia in RA from a chest physicians' perspective.
CHINESE MEDICAL JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinhui Chen, Ge Cheng, Xinguan Yang, Yuting Liao, Zhipeng Zhou
Summary: This article explores the potential use of lung texture in CT images to distinguish between usual interstitial pneumonia and nonspecific interstitial pneumonia. Through a retrospective analysis, it was found that lung texture features can effectively differentiate between these two types of pneumonia.
ACADEMIC RADIOLOGY
(2023)
Review
Respiratory System
Scott M. Matson, M. Kristen Demoruelle, Mario Castro
Summary: This article discusses the involvement of airway disease in patients with rheumatoid arthritis, highlights clinical research issues, and discusses future research directions and a screening algorithm for patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Rheumatology
Kyoko Honne, Masashi Bando, Makiko Naka Mieno, Masahiro Iwamoto, Seiji Minota
Summary: This study found that bronchiectasis and interstitial lung disease in patients with rheumatoid arthritis increase the risk of severe pneumonia, and this risk is more pronounced during treatment with biologic DMARDs as compared to normal conditions.
RHEUMATOLOGY INTERNATIONAL
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Takuya Hino, Kyung Soo Lee, Joungho Han, Akinori Hata, Kousei Ishigami, Hiroto Hatabu
Summary: The evolution of various interstitial lung diseases, including UIP, NSIP, and ILA, has highlighted the importance of a multidisciplinary team approach for diagnosis and management. Traction bronchiectasis and bronchiolectasis are recognized as crucial indices for assessing the severity and prognosis of fibrotic lung diseases, with the TBI being able to stratify patient prognoses. The correlation between CT findings and pathologic evaluation plays a key role in understanding the spectrum of pulmonary fibrosis and proposing the CT-based UIP score.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Physiology
Jiwoong Choi, Kum Ju Chae, Gong Yong Jin, Ching-Long Lin, Archana T. Laroia, Eric A. Hoffman, Chang Hyun Lee
Summary: This study used quantitative CT image matching to assess lung motion in idiopathic interstitial lung diseases (UIP and NSIP) and found different characteristics between UIP and NSIP.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Joyce S. Lee, Janet La, Sara Aziz, Evgenia Dobrinskikh, Robert Brownell, Kirk D. Jones, Natalia Achtar-Zadeh, Gary Green, Brett M. Elicker, Jeffrey A. Golden, Michael A. Matthay, Jasleen Kukreja, David A. Schwartz, Paul J. Wolters
Summary: The study found that molecular markers of telomere dysfunction and senescence are pathologically expressed in both IPF and non-IPF UIP lungs, suggesting that common molecular drivers may contribute to the pathogenesis of UIP-associated pulmonary fibrosis, regardless of the clinical diagnosis.
Article
Immunology
Shuhua Wang, Yao Li, Yanchun Tang, Weilin Xie, Yue Zhang, Qingyan Liu
Summary: This study aims to evaluate the efficacy of tofacitinib (TOF) plus iguratimod (IGU) in the treatment of rheumatoid arthritis with usual interstitial pneumonia (RA-UIP). The results indicate that TOF plus IGU can simultaneously relieve rheumatoid arthritis and RA-UIP and has a higher response rate compared to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), making it a potential choice for dual treat-to-target.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Matteo Bonato, Piera Peditto, Nicholas Landini, Alessia Fraccaro, Cosimo Catino, Maria Cuzzola, Nicola Malacchini, Francesca Savoia, Nicola Roma, Mauro Salasnich, Martina Turrin, Francesca Zampieri, Giuseppe Zanardi, Fabiola Zeraj, Marcello Rattazzi, Mario Peta, Simonetta Baraldo, Marina Saetta, Michele Fusaro, Giovanni Morana, Micaela Romagnoli
Summary: SARS-CoV-2 may lead to pulmonary sequelae. A longitudinal study of severe COVID-19 survivors found that patients at three months from discharge showed functional impairment and radiological abnormalities, with respiratory symptoms related to airway sequelae.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Respiratory System
Fabrizio Luppi, Andreina Manfredi, Paola Faverio, Michael Brun Andersen, Francesca Bono, Fabio Pagni, Carlo Salvarani, Elisabeth Bendstrup, Marco Sebastiani
Summary: Usual Interstitial Pneumonia (UIP) can occur in various autoimmune rheumatic diseases (ARDs), such as rheumatoid arthritis. The imaging and pathological features can differentiate it from UIP related to IPF. A multidisciplinary approach is crucial in the differential diagnosis and evaluation of severity, progression, and treatment response. In ARD patients, functional evaluation and patient-reported outcomes may be influenced by systemic involvement and comorbidities. Immunosuppressants are considered the main therapy, although evidence is lacking in most cases; recently, antifibrotic drugs have also been proposed for progressive fibrosing ILDs other than IPF. This review summarizes the definition, features, risk factors, diagnostic criteria, prognostic evaluation, monitoring, and management approaches of UIP-ARDs.
BMC PULMONARY MEDICINE
(2023)
Article
Orthopedics
Shomi Oka, Takashi Higuchi, Hiroshi Furukawa, Kota Shimada, Akira Okamoto, Atsushi Hashimoto, Akiko Komiya, Koichiro Saisho, Norie Yoshikawa, Masao Katayama, Toshihiro Matsui, Naoshi Fukui, Kiyoshi Migita, Shigeto Tohma
Summary: This study investigated the association between rheumatoid arthritis (RA) and chronic lung diseases (CLD). The results showed that rheumatoid factor IgA was associated with interstitial lung disease, anti-citrullinated peptide antibody secretory component was associated with RA complicated with interstitial lung disease, and anti-carbamylated protein antibodies were associated with interstitial lung disease in RA.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Rheumatology
Ning Chen, Chao-Yue Diao, Jie Gao, Dong-Bao Zhao
Summary: This study aims to explore the impact of clinical characteristics, new biomarkers, and treatment options on the prognosis of RA-ILD patients. The results suggest that male, UIP pattern, and increased RF-IgA may be potential predicting factors for poor prognosis of RA-ILD patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Rheumatology
Owen Cronin, Olivia McKnight, Lindsay Keir, Stuart H. Ralston, Nikhil Hirani, Helen Harris
Summary: A retrospective study comparing the pulmonary safety of Janus kinase inhibitors (JAKi) and rituximab in patients with rheumatoid arthritis (RA) and existing interstitial lung disease (ILD) or bronchiectasis found that JAKi did not increase the rate of respiratory events compared to rituximab, indicating that JAK inhibition may be a relatively safe option for RA patients with such respiratory disorders.
RHEUMATOLOGY INTERNATIONAL
(2021)
Review
Rheumatology
Lily W. Martin, Lauren C. Prisco, Weixing Huang, Gregory McDermott, Nancy A. Shadick, Tracy J. Doyle, Jeffrey A. Sparks
Summary: The prevalence of bronchiectasis in patients with rheumatoid arthritis is approximately 20%, with risk factors including older age, longer disease duration, genetics, and undetectable circulating mannose binding lectin (MBL).
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)