Review
Biochemistry & Molecular Biology
Tadej Petreski, Nejc Piko, Robert Ekart, Radovan Hojs, Sebastjan Bevc
Summary: Chronic kidney disease is a major health problem in modern society, with a continuously rising prevalence. Recent studies have identified novel markers and gained new insights into the pathogenesis of CKD. Further large-scale studies are needed to establish the role of these markers in clinical practice.
Article
Multidisciplinary Sciences
Margherita De Marzio, Ayse Kilic, Enrico Maiorino, Jennifer Mitchel, Chimwemwe Mwase, Michael J. O'Sullivan, Maureen McGill, Robert Chase, Jeffrey J. Fredberg, Jin-Ah Park, Kimberly Glass, Scott T. Weiss
Summary: By conducting compression experiments on bronchial epithelial cells, the genome-wide analysis of UJT revealed different activation stages of intracellular and extracellular molecular networks induced by compression. Furthermore, the study found common genomic patterns associated with ECM remodeling in nonasthmatic and asthmatic bronchial epithelial cells.
Article
Biochemistry & Molecular Biology
Nilofer Qureshi, Julia Desousa, Adeela Z. Siddiqui, David C. Morrison, Asaf A. Qureshi
Summary: Inflammation is associated with several diseases and can be influenced by proteasome modulators such as resveratrol and lectins. These modulators have the ability to alter gene expression involved in inflammation-induced signaling pathways in human peripheral blood mononuclear cells. The findings suggest that inflammation-based diseases may be prevented or reversed through dietary interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Pavel Rossner, Tereza Cervena, Michal Vojtisek-Lom, Jiri Neca, Miroslav Ciganek, Kristyna Vrbova, Antonin Ambroz, Zuzana Novakova, Fatima Elzeinova, Michal Sima, Zuzana Simova, Vladimir Holan, Vit Beranek, Martin Pechout, David Macoun, Andrea Rossnerova, Jan Topinka
Summary: Exposure to emissions from ordinary gasoline may lead to inflammatory respiratory disorders, while the effects of alternative fuel are relatively weak. In experiments, MucilAir(TM) cells exposed to E5 gasoline emissions exhibited a pronounced pro-inflammatory response, whereas cells exposed to E20 ethanol blend showed anti-inflammatory effects.
Article
Multidisciplinary Sciences
Xian Jiang, Richard Sando, Thomas C. Sudhof
Summary: The study revealed that interference with microtubules or actin filaments, JNKs, PKA, or AKT signaling pathways can affect heterologous synapse formation, with JNK and PKA inhibitors suppressing both pre- and postsynaptic specialization formation, while AKT inhibitors only impairing postsynaptic specialization formation. By targeting PTEN, an enzyme regulating AKT activation, to postsynaptic sites, a decrease in excitatory synapse function was observed, indicating a multifaceted and multistage kinase network underlying heterologous synapse formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Patrizia Caprari, Elisabetta Profumo, Sara Massimi, Brigitta Buttari, Rachele Rigano, Vincenza Regine, Marco Gabbianelli, Stefania Rossi, Roberta Risoluti, Stefano Materazzi, Giuseppina Gullifa, Laura Maffei, Francesco Sorrentino
Summary: The rheological properties of blood, including increased aggregation and reduced deformability of red blood cells, as well as increased adherence to vascular endothelial cells, play a crucial role in the regulation of blood flow in microcirculation and macrocirculation. Thalassemia patients, both transfusion-dependent and non-transfusion-dependent, exhibit altered hemorheological profiles that may indicate vascular impairment and disease severity. Evaluation of hemorheological profiles, along with the levels of inflammation biomarkers, can provide new indicators for preventing thromboembolic events in thalassemia.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, Research & Experimental
Joanna Bronikowska, Malgorzata Klosek, Tomasz Janeczko, Edyta Kostrzewa-Suslow, Zenon P. Czuba
Summary: The study evaluated the effects of methoxy-derivatives of 2'-hydroxychalcones on the release of various factors by colon cancer cells. The compounds showed significant modulation on certain factors released by the cancer cells, indicating a potential therapeutic effect on colon cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Jia Hao, Hao Zhou, Kristen Nemes, Daniel Yen, Winfield Zhao, Charles Bramlett, Bowen Wang, Rong Lu, Keyue Shen
Summary: This research demonstrates that membrane-bound factors play a unique role in regulating stem cell morphology and function, uncovering the signaling mechanism involved in the interaction between hematopoietic stem cells and niche stromal cells.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuan Liu, Yinbiao Wang, Rui Zhang, Shaolan Wang, Juan Li, Zhen An, Jie Song, Weidong Wu
Summary: Fine particulate matter (PM2.5) pollution and influenza viruses may interact to aggravate airway inflammation. This study used the transcriptome sequencing approach to identify responsive genes in airway epithelial cells following exposure to PM2.5 and influenza A (H3N2) viruses. The results provide insights into the potential mechanisms of PM2.5- and influenza virus-induced airway inflammation.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y. Li, J. Zhang, W. Cai, C. Wang, Z. Yu, Z. Jiang, K. Lai, Y. Wang, G. Yang
Summary: The long-term success rate of dental implants can be improved by establishing a favorable biological sealing with a high-quality epithelial attachment. The application of mesenchymal stem cells (MSCs) holds promise for facilitating the soft tissue integration around implants, but the molecular mechanism is still unclear and the general application of MSC sheet for soft tissue integration is also relatively unexplored.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Massimiliano G. Bianchi, Valeria Dall'Asta, Bianca Maria Rotoli
Summary: This study found that exposure to supernatants from S1-activated macrophages caused A549 cells to release inflammatory mediators, with massive concentrations of IL-8. Molecular pathway analyses revealed the involvement of NF-kB in the transcription of IP-10 and RANTES, and that STATs drive the expression of various cytokines/chemokines, except for IL-8 which is regulated by AP-1. The cytokines/chemokines produced by spike-activated macrophages may contribute to dysfunction in barrier integrity of alveolar epithelial cells.
Article
Biochemistry & Molecular Biology
Dan Mao, Hiroshi Inoue, Takuya Notomi, Seiji Goda
Summary: The p38a isoform is crucial for TNF-a-induced IL-8 production in Ca9-22 cells, and its activation is associated with the phosphorylation of threonine 180 and tyrosine 182. This study highlights p38a as a potential therapeutic target for preventing and treating periodontal disease.
Article
Toxicology
Magne Refsnes, Tonje Skuland, Johan Ovrevik, Marit Lag
Summary: The study found that silica nanoparticles can induce inflammatory responses in bronchial epithelial cells through different mechanisms, with scavenger receptors (SRs) playing important roles in mediating cytokine responses and TGF-α release. Specifically, SR-B1 seems to be crucial in mediating these responses, while MAP-kinases and NF-KB do not appear to have downstream effects in this process.
TOXICOLOGY LETTERS
(2021)
Review
Immunology
Qian Zou, Xue Lei, Aijing Xu, Ziqi Li, Qinglian He, Xiujuan Huang, Guangxian Xu, Faqing Tian, Yuanlin Ding, Wei Zhu
Summary: Chemokines, as a crucial component in the tumor microenvironment, play a significant role in the oncogenesis and progression of colorectal cancer. They recruit or polarize immune cells, participate in the cross talk among signaling pathways and non-coding RNAs, and are associated with immune escape and drug resistance of tumor cells. Therefore, chemokines are of great importance for the diagnosis, therapy, and prognosis of patients with colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
An-nan Zhang, Nan Li, Zhuo-chang Chen, Ya-li Guo, Cui-jie Tian, Dong-jun Cheng, Xue-yi Tang, Xiao-yu Zhang
Summary: Objective of this study was to investigate the effect of amygdalin, an active ingredient in bitter almonds, on TGF-beta-induced EMT in bronchial epithelial cells and elucidate the underlying mechanisms. The results showed that amygdalin treatment relieved airway wall remodeling and decreased the expressions of EMT markers. Furthermore, amygdalin inhibited TGF-beta-induced EMT through regulating the expression of HPSE.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Dermatology
Kam Lun Hon, Margaret Ip, Chun Kwok Wong, Ben Chung Lap Chan, Ping Chung Leung, Ting Fan Leung
JOURNAL OF DERMATOLOGICAL TREATMENT
(2018)
Article
Rheumatology
Jiayun Shen, Steven H. Lam, Qing Shang, Chun-Kwok Wong, Edmund K. Li, Priscilla Wong, Emily W. Kun, Isaac T. Cheng, Martin Li, Tena K. Li, Tracy Y. Zhu, Jack Jock-Wai Lee, Mimi Chang, Alex Pui-Wai Lee, Lai-Shan Tam
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Rheumatology
Ngar-Woon Kam, Dehua Liu, Zhe Cai, Wah-Yan Mak, Chun-Kwok Wong, Kwok-Hing Chiu, Kam-Yiu Wong, Wai-Leuk Tsang, Lai-Shan Tam
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Integrative & Complementary Medicine
Tianbo Zhang, Mengjie Xiao, Chun-Kwok Wong, Ka-Pun Chris Mok, Xin Zhao, Huihui Ti, Pang-Chui Shaw
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Multidisciplinary Sciences
Dehua Liu, Ben Chung-Lap Chan, Ling Cheng, Miranda Sin-Man Tsang, Jing Zhu, Chun-Wai Wong, Delong Jiao, Helen Yau-Tsz Chan, Ping Chung Leung, Christopher Wai-Kei Lam, Chun Kwok Wong
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Jing Zhu, Jie Dong, Lu Ji, Peiyong Jiang, Ting Fan Leung, Dehua Liu, Lai Guan Ng, Miranda Sin-Man Tsang, Delong Jiao, Christopher Wai-Kei Lam, Chun-Kwok Wong
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Miranda Sin-Man Tsang, Sau-Wan Cheng, Jing Zhu, Karam Atli, Ben Chung-Lap Chan, Dehua Liu, Helen Yau-Tsz Chan, Xiaoyu Sun, Ida Miu-Ting Chu, Kam-Lun Hon, Christopher Wai-Kei Lam, Pang-Chui Shaw, Ping-Chung Leung, Chun-Kwok Wong
Article
Pharmacology & Pharmacy
Xiao-Xiao Wu, Grace Gar-Lee Yue, Jin-Run Dong, Christopher Wai-Kei Lam, Chun-Kwok Wong, Ming-Hua Qiu, Clara Bik-San Lau
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Miranda Sin-Man Tsang, Pang-Chui Shaw, Ida Miu-Ting Chu, Ling Cheng, Eric Chun-Wai Wong, David Tai-Wai Lau, Christopher Wai-Kei Lam, Chun-Kwok Wong
Meeting Abstract
Immunology
C. -K. Wong, T. -H. Hou, K. -L. Hon, J. Zhu, C. W. -K. Lam
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
M. S. M. Tsang, C. K. Wong
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Review
Immunology
Ben C. L. Chan, Christopher W. K. Lam, Lai-Shan Tam, Chun K. Wong
FRONTIERS IN IMMUNOLOGY
(2019)
Meeting Abstract
Rheumatology
T. H. Cheng, Q. Shang, E. K. M. Li, P. C. H. Wong, L. H. P. Tam, T. Y. Zhu, M. M. Chang, J. J. W. Lee, C. K. Wong, A. P. W. Lee, L. S. Tam
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Meeting Abstract
Pediatrics
Y. H. Xing, C. K. Wong, S. M. Tsang, J. Li, W. K. Wong
PEDIATRIC PULMONOLOGY
(2018)
Meeting Abstract
Rheumatology
S. L. Yu, Y. B. Huo, C. H. Huang, Y. Tao, W. H. Huang, C. K. Wong, L. S. Tam, H. N. Qiu, R. L. Chen, C. H. Huang, L. Zhong
ANNALS OF THE RHEUMATIC DISEASES
(2018)