期刊
EUROPEAN RESPIRATORY JOURNAL
卷 34, 期 3, 页码 655-661出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00178508
关键词
CC chemokines; children; cystic fibrosis; macrophages
资金
- Australian Cystic Fibrosis Research Trust (North Rycle, NSW, Australia)
- Australian National Health and Medical Research Council (Canberra, ACT)
- Cystic Fibrosis Foundation (Bethesda, MD, USA)
Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF lung disease. Children with CF (median age 3.1 yrs) participated in a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples were obtained from non-CF children (median age 3.1 yrs; n=24) investigated for persistent respiratory symptoms. Pulmonary infection was detected in 31% (16 out of 51) and 38% (nine out of 24) of children from the CF and non-CF groups, respectively. Alveolar macrophages in BAL were increased in CF compared with non-CF in the absence of infection (223 x 10(3) versus 85 x 10(3) cells.mL(-1); p=0.001) and were associated with elevations in the CC chemokines (macrophage inflammatory protein (MIP)-3 alpha (chemokine (C-C motif) ligand (CCL)20; 355.8 versus 46.0 pg.mL(-1); p<0.001), monocyte chemotactic protein-1 (CCL2; 263.5 versus 25.3 pg.mL(-1); p<0.001), MIP-1 alpha (CCL3; 38.2 versus 4.9 pg.mL(-1); p<0.001) and MIP-1 beta (CCL4; 326.6 versus 27.5 pg.mL(-1); p<0.001)). Total cell counts and neutrophil numbers increased in the presence of infection; however, there was no additional effect of CF. Alveolar macrophages and CC chemokines are elevated in the lungs in young children with CF even in the absence of pulmonary infection. Longitudinal studies are required to determine the clinical relevance of these findings.
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