Article
Medicine, General & Internal
Naofumi Sato, Ryoji Ogura, Yuji Iwanami, Ikuko Okuni, Satoru Ebihara
Summary: This study examined the effects of L-menthol olfactory stimulation on exertional dyspnea in patients with chronic breathlessness syndrome. The results showed that L-menthol olfactory stimulation can reduce dyspnea in these patients. Evaluation: 8/10.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Yuki Nakashima, Daisuke Iwaki, Toshihiro Kawae, Kenichi Fudeyasu, Kenichiro Uemura, Hiroaki Kimura
Summary: This study aimed to determine the decline in 6 MWD in preoperative pancreatic cancer patients by performing FTSTS and identify the cutoff value for diagnosing the decline. The results showed that FTSTS was a significant assessment scale with high sensitivity and specificity.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Medicine, General & Internal
Unnati Kumbhare, Pallavi Yelne, Sanket Tekale
Summary: New insights into the treatment options and drugs for pulmonary arterial hypertension (PAH) have been discovered, but the prognosis for the disease remains mediocre. Recent research has identified several new targeted therapies, primarily focused on administering drugs through the inhalation route. Although these drugs have received clinical approval, extensive clinical trials are still needed to confirm their therapeutic efficacy and safety.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Hilary M. M. DuBrock, Kimberly Forde, Karen Krok, Mamta Patel, Nadine Al-Naamani, Grace Lin, Jae K. K. Oh, Michael B. B. Fallon, Steven M. M. Kawut, Michael J. J. Krowka
Summary: This study compared cardiac index (CI) in patients with and without hepatopulmonary syndrome (HPS) and assessed the relationship between CI and symptoms, quality of life, gas exchange, and exercise capacity. The results showed that patients with HPS had a higher CI, which was associated with decreased oxygenation, increased intrapulmonary vasodilatation severity, and biomarkers of angiogenesis. Higher CI was also independently associated with dyspnea, worse functional class, quality of life, and arterial oxygenation.
LIVER TRANSPLANTATION
(2023)
Article
Health Care Sciences & Services
Barbara Stollfuss, Manuel Richter, Daniel Droemann, Hans Klose, Martin Schwaiblmair, Ekkehard Gruenig, Ralf Ewert, Martin C. Kirchner, Frank Kleinjung, Valeska Irrgang, Christian Mueller
Summary: By digitally tracking physical parameters of patients with pulmonary arterial hypertension starting treatment with iloprost, this study aimed to investigate correlations between changes in digital physical activity measures and changes in traditional clinical measures and health-related quality of life. Results suggest that parallel monitoring of physical activity, heart rate, and iloprost inhalation is feasible in patients with pulmonary arterial hypertension and may complement traditional measures in guiding treatment, despite the limitations of the study's sample size.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Primary Health Care
Ankit Kumar, Naveen Hegde, J. Kumaravel, Ritin Mohindra, Roop Kishor Soni, Ramya Rathod, Mohan Kumar, Valliappan Muthu, Nanda Gamad, Amol N. Patil, P. L. Sharma
Summary: This study compared two exercise tests in COVID-19 positive patients and found that M2ST is a reliable alternative for 6MWT, offering time and cost savings, as well as ease of execution.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2022)
Article
Cardiac & Cardiovascular Systems
H. Olschewski, M. Canepa, G. Kovacs
Article
Oncology
Carina Seidl, Katrin Panzitt, Alexandra Bertsch, Luka Brcic, Sandra Schein, Maximilian Mack, Katharina Leithner, Felix Prinz, Horst Olschewski, Karin Kornmueller, Andelko Hrzenjak
Review
Oncology
Elisabeth Smolle, Katharina Leithner, Horst Olschewski
Letter
Critical Care Medicine
Andrea Olschewski, Chandran Nagaraj, Diana Zabini, Bence M. Nagy, Grazyna Kwapiszewska, Horst Olschewski
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Medicine, General & Internal
Horst Olschewski
Summary: Chronic lung diseases are strongly linked with pulmonary hypertension, with severe PH possibly originating from COPD as the largest subgroup within COPD and severe PH patients. It is crucial to complete diagnostic procedures and identify the main cause of PH before deciding on PAH drugs.
Article
Allergy
Mathias Hochgerner, Eva M. Sturm, Diana Schnoegl, Grazyna Kwapiszewska, Horst Olschewski, Leigh M. Marsh
Summary: High-altitude therapy may have therapeutic effects on allergic asthma by reducing mucosal hypersecretion and airway hyper-responsiveness. This therapy suppresses the adaptive immune response to allergens in both mouse and human immune cells. Hypoxia interferes with antigen-presenting cell/T-cell crosstalk, leading to an unresponsive phenotype in antigen-presenting cells.
Article
Biochemistry & Molecular Biology
Neha Sharma, Chandran Nagaraj, Bence M. Nagy, Leigh M. Marsh, Natalie Bordag, Diana Zabini, Malgorzata Wygrecka, Walter Klepetko, Elisabeth Gschwandtner, Guillem Genove, Akos Heinemann, E. Kenneth Weir, Grazyna Kwapiszewska, Horst Olschewski, Andrea Olschewski
Summary: RGS5 plays a role in allergic pulmonary diseases, and its loss can preserve lung function and attenuate hyperinflammation in the short term, particularly in bleomycin-induced pulmonary fibrosis and LPS-induced lung injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Divya Guntur, Horst Olschewski, Peter Enyedi, Reka Csaki, Andrea Olschewski, Chandran Nagaraj
Summary: Potassium ion concentrations play a significant role in regulating membrane potential and vessel tone, with BKCa channels responding rapidly to voltage changes and affecting pulmonary arterial vascular cells. The complexity and high conductance of BKCa channels make them a potential therapeutic target for vasodilation.
Article
Biochemistry & Molecular Biology
Chandran Nagaraj, Yingji Li, Bi Tang, Natalie Bordag, Divya Guntur, Peter Enyedi, Horst Olschewski, Andrea Olschewski
Summary: This paper investigates the changes in resting membrane potential and potassium channel activities in smooth muscle cells during the transition from fetal to neonatal circulation in the pulmonary arteries and the Ductus Arteriosus Botalli. The study reveals that these cells utilize a similar set of potassium channels, but their activity level is dependent on the cell type and oxygen level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Horst Olschewski, Ernst Eber, Brigitte Bucher, Klaus Hackner, Sabin Handzhiev, Konrad Hoetzenecker, Marco Idzko, Walter Klepetko, Gabor Kovacs, Bernd Lamprecht, Judith Loeffler-Ragg, Michael Meilinger, Alexander Mueller, Christian Prior, Otmar Schindler, Helmut Taeubl, Angela Zacharasiewicz, Ralf Harun Zwick, Britt-Madelaine Arns, Josef Bolitschek, Katharina Cima, Elisabeth Gingrich, Maximilian Hochmair, Fritz Horak, Peter Jaksch, Roland Kropfmueller, Andreas Pfleger, Bernhard Puchner, Christoph Puelacher, Patricia Rodriguez, Helmut J. F. Salzer, Peter Schenk, Ingrid Stelzmueller, Volker Strenger, Matthias Urban, Marlies Wagner, Franz Wimberger, Holger Flick
Summary: The Austrian Society of Pneumology (ASP) released a statement on SARS-CoV-2 infection, highlighting the impact of the virus variants, particularly the delta and omicron variants. The statement also addresses the risks and precautions for patients with chronic lung diseases and healthcare professionals who provide care to these patients.
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Letter
Critical Care Medicine
Philipp Douschan, Alexander Avian, Vasile Foris, Teresa Sassmann, Gerhard Bachmaier, Piet Rosenstock, Katarina Zeder, Horst Olschewski, Gabor Kovacs
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Andreas Horner, Horst Olschewski, Sylvia Hartl, Arschang Valipour, Georg-Christian Funk, Michael Studnicka, Monika Merkle, Bernhard Kaiser, Eva Maria Wallner, Stephan Brecht, Bernd Lamprecht
Summary: In stable COPD outpatients in Austria, nearly half of the patients reported symptoms of depression. These symptoms were associated with lower levels of self-reported physical activity, more pain, and respiratory symptoms, with particularly strong associations in SGRQ-C.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Substance Abuse
Stefan Scheidl, Alexander Avian, Holger Flick, Sonja Gaal, Hildegard Greinix, Horst Olschewski
Summary: This study shows that smoking history, lifetime cigarette dose, and continued smoking are significantly associated with increased all-cause mortality and reduced event-free survival in patients undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancies. Different smoking statuses and doses have a significant impact on patient outcomes.
NICOTINE & TOBACCO RESEARCH
(2021)
Meeting Abstract
Respiratory System
Juergen Behr, Martin Kolb, Horst Olschewski, Jin Woo Song, Fabrizio Luppi, Birgit Schinzel, Susanne Stowasser, Manuel Quaresma, Fernando J. Martinez
EUROPEAN RESPIRATORY JOURNAL
(2019)
Meeting Abstract
Medicine, General & Internal
Piet Rosenstock, Alexander Avian, Philip Douschan, Vasile Foris, Michael Pienn, Teresa Sassmann, Horst Olschewski, Gabor Kovacs
WIENER KLINISCHE WOCHENSCHRIFT
(2019)