期刊
EUROPEAN RADIOLOGY
卷 24, 期 9, 页码 2326-2333出版社
SPRINGER
DOI: 10.1007/s00330-014-3172-3
关键词
Arterial spin-labelling; Magnetic resonance imaging; Brain perfusion; Dementia; Alzheimer disease
资金
- Alzheimer Center of the VU University Medical Center Amsterdam, the Netherlands
- Alzheimer Center VUmc
- Vereniging AEGON
- Brain Foundation of the Netherlands
- Alzheimer Nederland
- Biogen Idec
- Bayer Healthcare
- Roche
- Janssen Cilag
- Alzheimer Assistance Foundation
- Center for Translational Molecular Imaging
- Alzheimer Association
- De Hersenstichting Nederland
- Internationale Stichting Alzheimer Onderzoek
- Lilly
- GE Healthcare
- Lundbeck
- Danone
- Jansen AI-Pfizer
- Stichting Dioraphte
- Stichting VUmc fonds
- Dutch MS Society (EU-FP7)
- Serono Symposia Foundation
- Danone Researcrh
- MERCK
To compare pseudo-continuous arterial spin-labelled (PCASL) magnetic resonance imaging (MRI) measured quantitative cerebral blood flow (CBF) of patients with frontotemporal dementia (FTD), dementia with Lewy Bodies (DLB), Alzheimer's disease (AD) and controls, in a region of interest (ROI) and voxel-wise fashion. We analysed whole-brain 3D fast-spin-echo PCASL images of 20 FTD patients, 14 DLB patients, 48 AD patients and 50 controls from the Amsterdam Dementia Cohort. Regional CBF patterns were compared using analyses of variance for repeated measures. Permutation tests were used for voxel-wise comparisons. Analyses were performed using uncorrected and partial volume corrected (PVC) maps. All analyses were corrected for age and sex. There was an interaction between diagnosis and region (p < 0.001), implying differences in regional CBF changes between diagnostic groups. In AD patients, CBF was decreased in all supratentorial regions, most prominently so in the posterior regions. DLB patients showed lowest CBF values throughout the brain, but temporal CBF was preserved. Supratentorial PVC cortical CBF values were lowest in the frontal lobes in FTD patients, and in the temporal lobes in AD patients. Patients with AD, FTD and DLB display distinct patterns of quantitative regional CBF changes. 3D-PCASL may provide additional value in the workup of dementia patients. aEuro cent Patterns of regional CBF changes differ between AD, FTD and DLB patients aEuro cent CBF is lower throughout the brain in DLB than AD and FTD aEuro cent 3D-PCASL MRI is a potential non-invasive and easily accessible alternative to FDG-PET aEuro cent 3D-PCASL MRI may be of additional value in the workup of dementia.
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