Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Eun Lee, Kum Ju Chae, Young Ju Suh, Won Gi Jeong, Taebum Lee, Yun-Hyeon Kim, Gong Yong Jin, Yeon Joo Jeong
Summary: This study investigated the prevalence of interstitial lung abnormalities (ILAs) in an Asian health screening cohort and found that fibrotic ILA was associated with increased risks of ILA progression, lung cancer development, and mortality over a 10-year follow-up period.
Article
Oncology
Fanny Pinot, David Bourhis, Vincent Bourbonne, Romain Floch, Maelle Mauguen, Frederique Blanc-Beguin, Ulrike Schick, Mohamed Hamya, Ronan Abgral, Gregoire Le Gal, Pierre-Yves Salaun, Francois Lucia, Pierre-Yves Le Roux
Summary: This study aimed to develop and evaluate an automated threshold method based on total lung function for the delineation of lung functional volumes using Gallium-68 MAA lung PET/CT imaging. The results showed that the WLF threshold method provided more reliable and consistent functional volumes, especially in patients with normal PFTs, as compared to the pmax method. This new approach, relatively unaffected by the presence of hot spots, is clinically meaningful for clinicians.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Cai, Natthaya Triphuridet, Yeqing Zhu, Nan You, Rowena Yip, David F. Yankelevitz, Claudia Henschke
Summary: Bronchiectasis is prevalent in smokers undergoing low-dose CT screening, and the occurrence of respiratory symptoms and acute events increases with the severity of the Early Lung and Cardiac Action Program Bronchiectasis score.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofei Yang, Monique D. Dorrius, Wenzhen Jiang, Zhenhui Nie, Rozemarijn Vliegenthart, Harry J. M. Groen, Marjolein A. Heuvelmans, Grigory Sidorenkov, Marleen Vonder, Zhaoxiang Ye, Geertruida H. de Bock
Summary: This study aimed to evaluate the association between visual emphysema and the presence of lung nodules, and Lung-RADS category with low-dose CT (LDCT). The results showed that emphysema is independently related to the presence of lung nodules and specifically centrilobular emphysema (CLE) is related to positive CT classification. The risk of lung nodules increases with the severity of CLE.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Cristian Crisosto, Andreas Voskrebenzev, Marcel Gutberlet, Filip Klimes, Till F. Kaireit, Gesa Poehler, Tawfik Moher, Lea Behrendt, Robin Mueller, Maximilian Zubke, Frank Wacker, Jens Vogel-Claussen
Summary: This study aimed to improve automated lung segmentation on 2D lung MR images using balanced augmentation and artificially-generated consolidations for training of a convolutional neural network (CNN). The results showed that by increasing balanced augmentation and artificially-generated consolidations, the CNN performance was improved, especially in datasets with parenchymal consolidations. This is an important step towards a robust automated postprocessing of lung MRI datasets in clinical routine.
Article
Radiology, Nuclear Medicine & Medical Imaging
Verena Gross, Katrin Zahn, Kristina Maurer, Lucas Wessel, Thomas Schaible, Stefan O. Schoenberg, Christel Weiss, Frank G. Zoellner, Meike Weis
Summary: In 10-year-old children after CDH repair, lung perfusion remains reduced on the ipsilateral side and is correlated with spirometric measurements. MRI measurements without ionizing radiation may be a promising follow-up parameter after CDH.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alan A. Peters, Oliver Weinheimer, Oyunbileg von Stackelberg, Jonas Kroschke, Lars Piskorski, Manuel Debic, Kai Schlamp, Linn Welzel, Moritz Pohl, Andreas Christe, Lukas Ebner, Hans-Ulrich Kauczor, Claus Peter Heussel, Mark O. Wielpuetz
Summary: Quantitative computed tomography (QCT) of the whole lung and nodule-bearing lobe can be valuable in assessing the malignancy risk of pulmonary nodules. The study shows that nodules in subjects with higher emphysema levels and less fibrosis in the lungs are more likely to be malignant.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Thuy D. Do, Stephan Skornitzke, Uta Merle, Maximilian Kittel, Stefan Hofbaur, Claudius Melzig, Hans-Ulrich Kauczor, Mark O. Wielpuetz, Oliver Weinheimer
Summary: Fully automatic lung quantification based on spectral CT and laboratory parameters can be used for prognostic prediction in COVID-19 pneumonia, and it can predict the need for invasive ventilation in patients.
Article
Critical Care Medicine
Wassim W. Labaki, Meng Xia, Susan Murray, Charles R. Hatt, Abdullah Al-Abcha, Michael C. Ferrera, Catherine A. Meldrum, Lauren A. Keith, Craig J. Galban, Douglas A. Arenberg, Jeffrey L. Curtis, Fernando J. Martinez, Ella A. Kazerooni, MeiLan K. Han
Summary: The study demonstrated an association between quantitative emphysema measured on LDCT imaging and lung cancer incidence, mortality, and airflow obstruction. An increase of 1% in emphysema was independently associated with higher risks of lung cancer incidence, mortality, and all-cause mortality, as well as increased likelihood of airflow obstruction.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marilisa Schiwek, Simon M. F. Triphan, Juergen Biederer, Oliver Weinheimer, Monika Eichinger, Claus F. Vogelmeier, Rudolf A. Joerres, Hans-Ulrich Kauczor, Claus P. Heussel, Philip Konietzke, Oyunbileg von Stackelberg, Frank Risse, Bertram J. Jobst, Mark O. Wielpuetz
Summary: QDP computed using DCE-MRI showed strong correlations with MRI perfusion score and CT PRM indices, particularly with Otsu's method. It is associated with established markers of disease severity and may be a useful tool for future clinical studies in COPD.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samia Boussouar, Amira Benattia, Jean. -Baptiste Escudie, Laure Gibault, Frederique Capron, Anne Legrand, Pierre-Yves Brillet, Xavier Jeunemaitre, Philippe A. Grenier, Elie Mousseaux, Michael Frank, Olivier Sanchez
Summary: This study describes the CT features of lung involvement in patients with vEDS, with around 57.3% of patients showing abnormalities in lung parenchyma, most commonly emphysema. Surgical samples histologically revealed lung issues often correlated with arterial abnormalities.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hendrik Wisselink, Danielle J. D. A. Steerenberg, Mieneke Rook, Gert-Jan H. Pelgrim, Marjolein Heuvelmans, Maarten van den Berge, Geertruida de Bock, Rozemarijn Vliegenthart
Summary: Predicted lung volumes based on the GLI model are used in pulmonary disease detection and monitoring. This study aimed to compare the GLI-2021 model predictions of TLC with CT-derived TLV.
Article
Critical Care Medicine
Paul F. Pinsky, David A. Lynch, David S. Gierada
Summary: This study analyzed the relationship between incidental respiratory findings on low dose CT lung cancer screenings and respiratory disease mortality. The results showed that emphysema on LDCT imaging was associated with significantly increased risk of respiratory disease mortality.
Review
Respiratory System
Moises Selman, Annie Pardo
Summary: Interstitial lung diseases (ILDs) encompass a diverse group of disorders characterized by diffuse lung damage, with different types of ILD posing a risk for developing progressive pulmonary fibrosis referred to as PF-ILD. PF-ILD, similar to idiopathic pulmonary fibrosis, describes a group of ILDs with similar clinical behavior that may progress to irreversible fibrosis. Understanding the cellular and molecular mechanisms underlying PF-ILD is crucial for identifying risk factors and developing effective therapeutic strategies.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alejandro A. Diaz, Pietro Nardelli, Wei Wang, Ruben San Jose Estepar, Andrew Yen, Seth Kligerman, Diego J. Maselli, Wojciech R. Dolliver, Andrew Tsao, Jose L. Orejas, Stefano Aliberti, Timothy R. Aksamit, Kendra A. Young, Gregory L. Kinney, George R. Washko, Edwin K. Silverman, Raul San Jose Estepar
Summary: An artificial intelligence-based CT method was used to assess bronchiectasis, and it was found that the airway-to-artery diameter ratio (AAR) was associated with exacerbations over time.
Article
Gastroenterology & Hepatology
C. A. Farzaneh, A. Pigazzi, W. Q. Duong, J. C. Carmichael, M. J. Stamos, F. Dekhordi-Vakil, F. Dayyani, J. A. Zell, M. D. Jafari
Summary: The timing of adjuvant chemotherapy (AC) for rectal cancer after neoadjuvant chemoradiation and surgical resection has a significant impact on patients' overall survival. Delayed AC initiation is associated with decreased 5-year survival, and patients in the delayed AC group have an increased risk of death compared to those receiving early or intermediate AC, despite having lower proportions of pathological lymph-node metastasis. Additionally, patients with higher socioeconomic and education status are more likely to receive early chemotherapy.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Oncology
Claudia M. Denkinger, Maike Janssen, Ulrike Schaekel, Julia Gall, Albrecht Leo, Patrick Stelmach, Stefan F. Weber, Johannes Krisam, Lukas Baumann, Jacek Stermann, Uta Merle, Markus A. Weigand, Christian Nusshag, Lars Bullinger, Jens-Florian Schrezenmeier, Martin Bornhaeuser, Nael Alakel, Oliver Witzke, Timo Wolf, Maria J. G. T. Vehreschild, Stefan Schmiedel, Marylyn M. Addo, Felix Herth, Michael Kreuter, Phil-Robin Tepasse, Bernd Hertenstein, Mathias Haenel, Anke Morgner, Michael Kiehl, Olaf Hopfer, Mohammad-Amen Wattad, Carl C. Schimanski, Cihan Celik, Thorsten Pohle, Matthias Ruhe, Winfried Kern, Anita Schmitt, Hanns-Martin Lorenz, Margarida Souto-Carneiro, Mary Gaeddert, Niels Halama, Stefan Meuer, Hans-Georg Kraeusslich, Barbara Mueller, Paul Schnitzler, Sylvia Parthe, Ralf Bartenschlager, Martina Gronkowski, Jennifer Klemmer, Michael Schmitt, Peter Dreger, Katharina Kriegsmann, Richard F. Schlenk, Carsten Muller-Tidow
Summary: Patients with cancer and compromised immune systems may benefit from convalescent/vaccinated plasma treatment to improve COVID-19 outcomes.
Article
Oncology
Maheswari Senthil, Farshid Dayyani
Summary: This study aims to assess the 1-year progression-free survival benefit of sequential systemic chemotherapy followed by paclitaxel intraperitoneal chemotherapy (NIPEC) in patients with gastric peritoneal carcinomatosis (PC). It is a single center, single arm, phase II trial. The primary endpoint is 1-year progression-free survival.
Article
Health Care Sciences & Services
Julia Michels, Jan Meis, Noemi Sturm, Florian Bornitz., Selina von Schumann., Aline. Weis, Benjamin. Neetz, Martina Bentner, Johanna Forstner, Nicola Litke, Michel Wensing, Stella Erdmann, Thomas Grobe, Timm Frerk, Axel Kempa, Claus Neurohr, Armin Schneider, Michael Mueller, Felix J. F. Herth, Joachim C. Szecsenyi, Franziska Trudzinski, Franziska Christina Trudzinski
Summary: This study aims to evaluate strategies for preventing long-term invasive mechanical ventilation (IMV) and improving weaning expertise and cooperation with adjacent intensive care units. Patient recruitment will be conducted in 40 intensive care units, and the primary outcome of successful weaning from IMV will be evaluated using mixed regression models.
BMC HEALTH SERVICES RESEARCH
(2023)
Review
Oncology
Jingjing Yu, Arsha Ostowari, Amber Gonda, Kiarash Mashayekhi, Farshid Dayyani, Christopher C. W. Hughes, Maheswari Senthil
Summary: Exosomes are small extracellular vesicles that carry important information for intercellular communication. They are produced abundantly by tumor cells and carry tumor-specific content, such as DNA, RNA, and proteins, which play significant roles in cancer development and progression. Due to their presence in various biofluids, exosomes can be developed as liquid biopsy tools for early diagnosis, molecular profiling, disease surveillance, and treatment response monitoring. This review focuses on the diagnostic, prognostic, and predictive potential of exosomal biomarkers in colorectal and gastric cancers, and discusses the challenges and limitations of their clinical application.
Article
Biochemistry & Molecular Biology
C. Veith, M. A. Schneider, L. Maas, A. van der Vliet, F. J. van Schooten, M. Kreuter, M. Meister, A. W. Boots, N. Kahn
Summary: This study evaluated individual responses to pirfenidone, nintedanib, and SFK inhibitor saracatinib in IPF-derived human bronchial epithelial cells. The results showed that saracatinib was more effective in reducing redox imbalance and inflammation compared to standard antifibrotic drugs.
Article
Medicine, General & Internal
Philip Konietzke, Christian Brunner, Marilisa Konietzke, Willi Linus Wagner, Oliver Weinheimer, Claus Peter Heussel, Felix J. F. Herth, Franziska Trudzinski, Hans-Ulrich Kauczor, Mark Oliver Wielpuetz
Summary: This study used QCT parameters to phenotype emphysema and airway abnormalities in COPD patients and investigated their relative contribution to airflow limitation in each GOLD stage. The study found a significant increase in emphysema from GOLD 0-4 COPD and different spatial patterns of airway changes. Both emphysema index and relative wall thickness of airways were independently correlated with lung function decline.
FRONTIERS IN MEDICINE
(2023)
Article
Respiratory System
Judith Maria Brock, Sonja Zehetmayer, Daniela Gompelmann
Summary: Gender inequality is still an issue in the field of medicine, particularly in interventional pulmonology (IP). This study found that although there is an increasing proportion of female physicians, men still dominate leading positions and receive more academic awards in IP.
Correction
Respiratory System
A. Susanne Dittrich, Markus Dumke, Ferdinand Kapl, Philipp Schneider, Sabine Wege, Simon Graeber, Mirjam Stahl, Felix J. Herth, Lutz Naehrlich, Marcus A. Mall, Olaf Sommerburg, German CF Registry
Article
Respiratory System
Jing Zhang, Dong Zhou, Wan-Lei Fu, Jie-Ru Guo, Tian-Le Cheng, Yun-Qiu Jiang, Zan-Sheng Huang, Felix J. F. J. Herth, Ye Fan
Summary: Lung cancer is the leading cause of deaths from malignant neoplasms worldwide, and a satisfactory biopsy is critical for its diagnosis. The conventional needle aspiration technique used in EBUS-TBNA might have limited diagnostic capacity for uncommon thoracic tumors. A recently developed sampling strategy called transbronchial mediastinal cryobiopsy has shown added diagnostic value. Here, we present a case of thoracic SMARCA4-deficient undifferentiated tumor successfully diagnosed by mediastinal cryobiopsy additional to EBUS-TBNA.
Review
Respiratory System
Liangyuan Li, Xinyuan Zhang, Jingyu Shi, Yu Chen, Huajing Wan, Felix J. Herth, Fengming Luo
Summary: Airway stent insertion is crucial for patients with airway stenosis. Biodegradable airway stents, including polymers and alloys, offer the potential for avoiding the invasive removal procedures required with permanent stents. However, there are technical challenges and the efficacy and safety of these stents still need to be investigated and proven.
Meeting Abstract
Respiratory System
A. Unterschemmann, F. Trudzinski, J. Brock, D. Gompelmann, F. Herth, R. Eberhardt, K. Kontogianni
Meeting Abstract
Respiratory System
J. Zader, R. Joerres, I Mayer, P. Alter, R. Bals, H. Watz, P. Mertsch, K. Rabe, F. Herth, F. Trudzinski, T. Welte, H. Kauczor, J. Behr, J. Walter, C. Vogelmeier, K. Kahnert
Meeting Abstract
Respiratory System
J. Brock, P. Schuster, F. Boehmker, R. Eberhardt, D. Gompelmann, K. Kontogianni, F. Trudzinski, F. Herth
Meeting Abstract
Respiratory System
K. Buschulte, H. Kabitz, L. Hagmeyer, P. Hammerl, A. Esselmann, C. Wiederhold, D. Skowasch, C. Stolpe, M. Joest, S. Veitshans, M. Hoeffgen, P. Maqhuzu, L. Schwarzkopf, A. Hellmann, M. Pfeifer, J. Behr, R. Karpavicius, A. Guenther, F. Herth, P. Markart, M. Kreuter