Article
Hematology
Stephanie Taylor, Joel David, Karen Partington, Sam Pemberton, Sarah Mangles, Anna Wells, Nicola Curry
Summary: This study evaluated the efficacy of intra-articular Ostenil Plus (TM) (HA) for ankle arthropathy in persons with haemophilia. The results showed that this treatment can significantly reduce pain, improve joint function, and increase patients' confidence in daily activities.
Article
Biotechnology & Applied Microbiology
Devon E. Anderson, Katherine G. Broun, Paromita Kundu, Xingyu Jing, Xiang Tang, Christopher Lu, Alexander Kotelsky, Sandeep Mannava, Whasil Lee
Summary: The aim of this study was to investigate the mechanotransduction of glenohumeral articular chondrocytes mediated by PIEZO1 in the altered biomechanical environment following a massive rotator cuff tear (RCT), and to identify potential therapeutic targets to attenuate cartilage degeneration after rotator cuff repair. The results showed that in the early stage of cuff tear arthropathy (CTA), the expression and activity of PIEZO1 were not increased but rather downregulated. This may be due to the decreased axial loading after glenohumeral joint decoupling in RCT limbs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Alexandre Porcello, Paula Gonzalez-Fernandez, Olivier Jordan, Eric Allemann
Summary: This study proposes the use of thermoresponsive nanoforming hyaluronic acid derivatives for the treatment of osteoarthritis pain through injection in the joints. By adding specific chemicals, the residence time of the hydrogel in the body can be prolonged and it exhibits improved resistance to degradation and optimal viscoelastic properties. The results demonstrate the significant potential of these engineered hyaluronic acid derivatives as next-generation long-acting viscosupplementation products for osteoarthritic patients.
Article
Orthopedics
Kyoung Ho Yoon, Woo Seung Wan, Yoon-Seok Kim, Jae-Young Park
Summary: This study aimed to evaluate the efficacy of viscosupplementation after arthroscopic partial meniscectomy. The results showed that viscosupplementation significantly reduced pain and improved range of motion (ROM) of the knee at 2 weeks post-surgery. However, no significant differences were observed in other scores between the viscosupplementation group and the control group. These findings suggest that viscosupplementation may have benefits in terms of pain relief and functional recovery.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Christoph Bauer, Lukas B. Moser, Vivek Jeyakumar, Eugenia Niculescu-Morzsa, Daniela Kern, Stefan Nehrer
Summary: This study investigated the effect of GC, HA, and a mixture of both on cytokine-treated chondrocytes in vitro. Results showed that adding HA or GC/HA increased metabolic activity of chondrocytes, reduced the side effects of GC supplementation, and decreased the release of pro-inflammatory cytokines.
Article
Rheumatology
Mihaela C. Micu, Alexandru Micu, Sorana D. Bolboaca
Summary: The study suggests that HA-USGIAI may be an effective and safe treatment for moderate hip OA with short- and medium-term benefits.
CLINICAL RHEUMATOLOGY
(2022)
Article
Thermodynamics
Laszlo G. Not, Andras Bata, Hajnalka Szabo, Janos Cifra, Denes Lorinczy
Summary: The assessment of rotator cuff tear prior to shoulder replacement is crucial, and the use of novel methods such as differential scanning calorimetry (DSC) shows promise in determining the grade of rotator cuff damage. DSC curves demonstrated clear differences in thermal parameters between healthy and pathological samples, indicating its potential as an additional method for evaluating rotator cuff tear arthropathies in future studies.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Chemistry, Applied
Gemma Leone, Simone Pepi, Marco Consumi, Stefania Lamponi, Marco Fragai, Marco Martinucci, Veronica Baldoneschi, Oscar Francesconi, Cristina Nativi, Agnese Magnani
Summary: The functionalization of sodium hyaluronate with a small molecule MMPI resulted in the derivative HA-MMPI, which showed increased resistance to degradation, viscoelastic properties similar to healthy human synovial fluid, compatibility with chondrocytes, and affinity towards MMP12. Therefore, HA-MMPI can be considered a promising viscosupplement for the treatment of knee osteoarticular disease.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, General & Internal
Tomasz Blicharski, Piotr Lukasik, Rafal Plebanski, Zbigniew Zegota, Marek Szuscik, Erik Moster, Karel Pavelka, Seonhui Jeon, So La Park
Summary: This study compares the safety and efficacy of Hyruan ONE and Durolane in treating mild-to-moderate knee osteoarthritis. The results show that there is no significant difference between the two products in terms of treatment effectiveness and adverse events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Teng-Le Huang, Chun-Hao Tsai
Summary: The study showed that a single injection of CHAP-HA is more effective and safe in knee osteoarthritis patients compared to three injections of linear HA, with pain relief effects lasting up to 52 weeks. CHAP-HA was found to be more preferable for patients with more severe OA, and repeat treatment or use of CHAP-HA after a three-injection HA was proven to be safe.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Andrea Bernetti, Francesco Agostini, Federica Alviti, Nicola Giordan, Federica Martella, Valter Santilli, Marco Paoloni, Massimiliano Mangone
Summary: The study demonstrates that a single intra-articular injection of the new HA derivative hydrogel, Hymovis MO.RE., provides significant efficacy and safety in improving knee function, pain, and quality of life for adult regular sports players with osteoarthritis. No severe adverse events were detected, indicating it may be a viable therapeutic option for this patient subgroup. Further investigations are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fabio Ramos Costa, Mariana Ramos Costa Marques, Vinicius Calumby Costa, Gabriel Silva Santos, Rubens Andrade Martins, Marcia da Silva Santos, Maria Helena Andrade Santana, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Joao Vitor Bizinotto Lana, Jose Fabio Santos Duarte Lana
Summary: Musculoskeletal diseases, such as osteoarthritis and tendinopathies, have a significant impact on society and individuals' quality of life. Intra-articular hyaluronic acid (HA) has emerged as a safe and effective treatment option for these conditions, providing multiple benefits such as lubrication, anti-inflammation, and stimulation of cellular activity. This review addresses the scientific, commercial, and clinical aspects of HA, providing physicians with a deeper understanding of disease processes, tissue repair mechanisms, and the advantages of different HA types.
Article
Clinical Neurology
Carlos Gavin, Francisco J. Blanco, Jose L. Pablos, Miguel A. Caracuel, Jose Rosas, Enrique Gomez-Barrena, Francisco Navarro, Maria Pilar Coronel, Mercedes Gimeno
Summary: The study demonstrates that a new formulation of hyaluronic acid with a single injection is effective in treating patients with knee osteoarthritis, significantly improving pain, stiffness, and physical function. Patient tolerability and safety were also optimal.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Orthopedics
Sascha Colen, Alexander Hoorntje, Liselore Maeckelbergh, Marcus van Diemen, Alain Dalemans, Michel P. J. van den Bekerom, Michiel Mulier
Summary: This study found that injecting IAHA within 6 months prior to THA in patients with hip osteoarthritis may increase the risk of periprosthetic joint infection. While there were no significant differences in clinical outcomes and other complications, the rates of PJI and postoperative wound infections were higher in the injection group.
JOURNAL OF ARTHROPLASTY
(2021)
Review
Orthopedics
Xinzhao Jiang, Hong Zhang, Qing Wu, Yun Chen, Tian Jiang
Summary: This study compared the clinical effectiveness of three common shoulder injections (corticosteroid, sodium hyaluronate, and platelet-rich plasma) for rotator cuff tears. The results showed that sodium hyaluronate injection provided short-term pain relief and functional improvement, while platelet-rich plasma injection showed better long-term results in both pain relief and functional improvement. The study suggests that platelet-rich plasma injection may be an alternative to corticosteroids, but more research is needed to provide high-quality recommendations for injection treatments of rotator cuff tears.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alberto Stefano Tagliafico, Federica Rossi, Bianca Bignotti, Lorenzo Torri, Alessandro Bonsignore, Liliana Belgioia, Alida Domineitto
Summary: This study investigated the relationship between muscle mass and bone damage on CT scans in patients with multiple myeloma (MM). It found that patients with low muscle mass had higher levels of bone damage, while patients with normal muscle mass had lower levels of bone damage. Multiple logistic regression analysis did not show any significant relationship with factors such as sex, cytogenetic status, staging, and relapse. However, neither muscle mass nor bone damage significantly correlated with overall survival.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luca Maria Sconfienza, Miraude Adriaensen, Domenico Albano, Andrea Alcala-Galiano, Georgina Allen, Maria Pilar Aparisi Gomez, Giacomo Aringhieri, Alberto Bazzocchi, Ian Beggs, Vito Chianca, Angelo Corazza, Danoob Dalili, Miriam De Dea, Jose Luis del Cura, Francesco Di Pietto, Elena Drakonaki, Fernando Facal de Castro, Dimitrios Filippiadis, Salvatore Gitto, Andrew J. Grainger, Simon Greenwood, Harun Gupta, Slavcho Ivanoski, Monica Khanna, Andrea Klauser, Ramy Mansour, Silvia Martin, Vasco Mascarenhas, Giovanni Mauri, Catherine McCarthy, David McKean, Eugene McNally, Kalliopi Melaki, Carmelo Messina, Rebeca Miron Mombiela, Ricardo Moutinho, Cyprian Olchowy, Davide Orlandi, Raquel Prada Gonzalez, Mahesh Prakash, Magdalena Posadzy, Saulius Rutkauskas, Ziga Snoj, Alberto Stefano Tagliafico, Alexander Talaska, Xavier Tomas, Violeta Vasilevska Nikodinovska, Jelena Vucetic, David Wilson, Federico Zaottini, Marcello Zappia, Amanda Isaac
Summary: This study conducted a Delphi-based consensus on image-guided interventional procedures for peripheral nerves of the lower limb, concluding that while some treatments received strong consensus, there is still a lack of evidence on the efficacy of most procedures.
EUROPEAN RADIOLOGY
(2022)
Article
Orthopedics
Mattia Alessio-Mazzola, Chiara Stambazzi, Chiara Ursino, Alberto Tagliafico, Roberto Trentini, Matteo Formica
Summary: This study compared the clinical outcomes of chronic plantar fasciitis treated with ultrasound-guided platelet-rich plasma (PRP) and focal ultrasound-guided extracorporeal shockwave therapy (ESW). The results showed that both PRP and ESW were effective in treating plantar fasciitis, but PRP had lower recurrence rate and faster recovery time for athletes.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Medicine, General & Internal
Elisa Russo, Alberto Stefano Tagliafico, Lorenzo Derchi, Bianca Bignotti, Simona Tosto, Carlo Martinoli, Alessio Signori, Francesca Brigati, Francesca Viazzi
Summary: The study aimed to investigate the role of opportunistic kidney assessment on non-enhanced chest CT in COVID-19 patients. The results showed that low RPA values and the presence of PFS independently predicted the occurrence of AKI and increased risk for mortality, respectively.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Nicole Brunetti, Massimo Calabrese, Carlo Martinoli, Alberto Stefano Tagliafico
Summary: This study assessed the current development of ultrasound-based artificial intelligence in breast cancer. The results showed that AI has excellent performance in the diagnosis, prognosis, and treatment strategy of breast cancer. However, more prospective and multicenter studies are needed to evaluate the potential impact of AI in breast ultrasound.
Editorial Material
Oncology
Alberto Stefano Tagliafico, Nehmat Houssami
Review
Oncology
Martina Dameri, Gabriella Cirmena, Francesco Ravera, Lorenzo Ferrando, Paola Cuccarolo, Mario Stabile, Giuseppe Nicolo Fanelli, Pier Vitale Nuzzo, Massimo Calabrese, Alberto Tagliafico, Alberto Ballestrero, Gabriele Zoppoli
Summary: Liquid biopsy has the potential to revolutionize clinical practice by offering a non-invasive approach for cancer diagnosis and treatment. However, the lack of standardized protocols for sample handling has hindered its implementation in clinical settings. This study provides a critical review of available standard operating procedures (SOPs) for liquid biopsy management and presents SOPs developed and utilized in a clinical trial. The aim is to address common issues and promote the adoption of interlaboratory shared protocols for optimized preanalytical handling of blood and urine samples.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Sport Sciences
Alberto S. Tagliafico, Lorenzo Torri, Roberta Righetto
Summary: This study aimed to investigate the occurrence of padel tennis injuries in Liguria, Italy. A questionnaire was sent to members of the Italian Federation of Tennis who participated in official tournaments of padel tennis. The results showed that lower limb injuries were more common, with the knee being highly affected, and the elbow was the most affected area in the upper limb.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2023)
Article
Medicine, General & Internal
Daniel Alvarez Sanchez-Bayuela, Navid Ghavami, Cristina Romero Castellano, Alessandra Bigotti, Mario Badia, Lorenzo Papini, Giovanni Raspa, Gianmarco Palomba, Mohammad Ghavami, Riccardo Loretoni, Massimo Calabrese, Alberto Tagliafico, Gianluigi Tiberi
Summary: In this study, the effectiveness of the MammoWave microwave imaging device for breast cancer detection is investigated through a multicentric European clinical trial. The device uses a Huygens-principle-based radar algorithm for image reconstruction and dedicated image analysis software. Conductivity weighted microwave images are created for each breast, and various image parameters are used to quantify their non-homogenous behavior. Welch's t-test is used to verify the statistical significance between the selected image features and the gold standard radiological study review.
Article
Medicine, General & Internal
Alberto Stefano Tagliafico, Massimo Calabrese, Nicole Brunetti, Alessandro Garlaschi, Simona Tosto, Giuseppe Rescinito, Gabriele Zoppoli, Michele Piana, Cristina Campi
Summary: This study aimed to evaluate the advantages of using radiomics in the assessment of breast lesions amenable to MR-VABB. The results showed that a radiomics logistic regression model applied to DCE-MRI images increased the diagnostic accuracy compared to the standard radiological evaluation. This suggests that radiomics has the potential to reduce the number of biopsies required in suspicious breast lesions, benefiting both patients and healthcare resources.
Article
Multidisciplinary Sciences
Daniel alvarez Sanchez-Bayuela, Navid Ghavami, Gianluigi Tiberi, Lorenzo Sani, Alessandro Vispa, Alessandra Bigotti, Giovanni Raspa, Mario Badia, Lorenzo Papini, Mohammad Ghavami, Cristina Romero Castellano, Daniela Bernardi, Massimo Calabrese, Alberto Stefano Tagliafico
Summary: Microwave imaging is a safe and promising technology for breast radiology that avoids discomfort and radiation exposure. This study used a prospective clinical trial to investigate the effectiveness of a microwave imaging device in distinguishing between breasts with and without radiological findings. The results showed potential for identifying breast lesions in asymptomatic women.
Article
Radiology, Nuclear Medicine & Medical Imaging
Federico Zaottini, Riccardo Picasso, Federico Pistoia, Michelle Pansecchi, Luca Tovt, Marta Maccio, Sara Sanguinetti, Carlo Martinoli
Summary: Wrist and hand anatomy can have various clinically relevant variants affecting bones, muscles, tendons, and nerves. Understanding these abnormalities and their appearance in imaging studies is important for proper management. This review discusses the most common anatomical variants encountered in clinical practice, their embryogenesis, related syndromes, and the imaging techniques used to visualize them.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Federica Rossi, Matteo Lambertini, Nicole Brunetti, Sara De Giorgis, Maria Grazia Razeti, Massimo Calabrese, Alberto Stefano Tagliafico
Summary: The purpose of this study was to evaluate pectoralis muscle area (PMA) depletion in breast cancer patients aged 45 years or younger undergoing neoadjuvant chemotherapy (NAC) and its correlation with clinical and histopathological data. The results showed a decrease in PMA before and after NAC. However, there were no significant associations between PMA changes and other clinical and histopathological data. Therefore, assessing PMA variation on breast MRI during NAC could be a potential tool for monitoring body composition and improving outcomes in young breast cancer patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Simone Caprioli, Alberto Tagliafico, Martina Fiannacca, Fabio Borda, Riccardo Picasso, Cristina Conforti, Alessandro Casaleggio, Giuseppe Cittadini
Summary: Despite the use of antibiotics, deep neck infections remain a clinical problem with potential life-threatening complications. Imaging, particularly computed tomography, plays a crucial role in identifying the source, extent, and complications of these infections. Knowledge of neck anatomy allows radiologists to evaluate the spread of infections and communicate important information to surgeons. This review focuses on the imaging of deep neck infections, highlighting relevant anatomy and clinical scenarios to aid in prompt diagnosis and early recognition of complications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alberto Stefano Tagliafico, Cristina Campi, Bignotti Bianca, Chandra Bortolotto, Duccio Buccicardi, Coppola Francesca, Roberto Prost, Marco Rengo, Lorenzo Faggioni
Summary: The use of blockchain technology in healthcare, particularly in radiology, is still in its early stages. Despite limited experiences, radiologists should be aware of its potential and follow its future developments closely.
