Review
Nanoscience & Nanotechnology
Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Siavash Iravani, Rajender S. Varma
Summary: Magnetic resonance imaging (MRI) is a widely used noninvasive clinical imaging modality in bio- and nanomedicine, especially for tumor detection and high-quality three-dimensional imaging. The design of efficient nanoscale contrast agents (NCAs) is crucial for specific detection and imaging of tumors. However, there are still challenges to be addressed in the clinical applications of these agents, including nanotoxicology and biosafety issues.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Reza Malekzadeh, Behnaz Babaye Abdollahi, Marjan Ghorbani, Jalil Pirayesh Islamian, Tohid Mortezazadeh
Summary: A novel targeted tumor contrast agent for magnetic resonance imaging was synthesized and evaluated. The system exhibited excellent stability, blood compatibility, and contrast enhancement, making it a promising candidate for accurate cancer diagnosis.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Kun Liu, Zhongyuan Cai, Xiaoqin Chi, Bilun Kang, Shengxiang Fu, Xiangjie Luo, Zhi-Wei Lin, Hua Ai, Jinhao Gao, Hongyu Lin
Summary: This study reports a new strategy to improve the performance of nanoparticle-based T1 contrast agents by utilizing the photoinduced super-hydrophilic assistance (PISA) effect. By doping gadolinium into citrate-coated titanium dioxide ellipsoidal nanoparticles (GdTi-SC NPs), the r1 value of the nanoparticles significantly increases upon UV irradiation. The existence of the PISA effect is confirmed by the reduced water contact angle and increased surface hydroxyl groups, leading to enhanced paramagnetic relaxation enhancement (PRE) efficiency and improved imaging performance. In vivo MRI experiments on rats demonstrate that GdTi-SC NPs can serve as a high-performance contrast agent for sensitive imaging of blood vessels and accurate diagnosis of vascular lesions, indicating the success of the proposed strategy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerome Hodel, Meike W. Vernooij, Mona K. Beyer, Mariasavina Severino, Xavier Leclerc, Alain Creange, Abir Wahab, Neesmah Badat, Sarah Toledano, Luc van den Hauwe, Ana Ramos, Antonella Castellano, Alexandre Krainik, Tarek Yousry, Alex Rovira
Summary: This study evaluated compliance with recommendations in imaging for multiple sclerosis (MS). The results showed that while MS imaging practices are relatively consistent across Europe, there is still partial adherence to recommendations.
EUROPEAN RADIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Shiwei Guo, Xiaoming Wang, Zhiqian Li, Dayi Pan, Yan Dai, Yun Ye, Xiaohe Tian, Zhongwei Gu, Qiyong Gong, Hu Zhang, Kui Luo
Summary: A water-soluble biodegradable nitroxides-based mCA with high relaxivity and stability was successfully prepared, showing long blood retention time, passive tumor targeting ability, and clear MRI enhancement at the tumor site in mice. It demonstrated great biosafety, hemocompatibility, and biocompatibility, making it a potential candidate as a substitute for metal-based MRI CAs in clinical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isabelle Riederer, Mark Muehlau, Claus Zimmer, Magaly Gutbrod-Fernandez, Nico Sollmann, Jan S. Kirschke
Summary: The study found that pre-contrast T1-w imaging does not significantly increase diagnostic confidence or detection rate of contrast-enhancing lesions in spinal cord MRI follow-up exams for patients with multiple sclerosis (MS).
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yongyin Geng, Tianze Wu, Qiuyue Han, Yongtai Yang, Zhenxia Chen, Xuanxuan Li, Bo Yin, Yaming Zhou, Yun Ling
Summary: In this study, nonionic cyclen-based GBCAs with carboxylate groups on the DO3A-pyridine scaffold were synthesized. [Gd-DO3A-4cp] with a free carboxylate group at the 4-position of pyridine was isolated and showed a higher r1 relaxivity compared to [Gd-DOTA] used in clinics. The possible mechanisms behind the enhanced relaxivity were explored through structure-property relationship studies. In vivo studies demonstrated the good MRI performance, biodistribution, and excretion pathway of [Gd-DO3A-4cp].
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Shifaa M. Siribbal, Shaista Ilyas, Alexander M. Renner, Sumiya Iqbal, Sergio Munoz Vazquez, Abubakar Moawia, Martin Valldor, Muhammad S. Hussain, Klaus Schomaecker, Sanjay Mathur
Summary: This study developed functionalized nanocarriers for site-specific delivery in imaging applications. The nanocarriers improved the imaging capabilities of conventional contrast agents and increased targeting accuracy. Through a multi-layer formation approach and covalent binding, the nanocarriers showed excellent biocompatibility and the ability to serve as target-specific imaging probes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michal Rivlin, Debbie Anaby, Noam Nissan, Moritz Zaiss, Anagha Deshmane, Gil Navon, Miri Sklair-Levy
Summary: The feasibility of using GlcN CEST MRI technique to distinguish between tumor and surrounding tissue in diagnosing breast cancer in a clinical setting is indicated by the results of this initial study.
EUROPEAN RADIOLOGY
(2022)
Article
Materials Science, Biomaterials
Shadab Dabagh, Somayeh Asadi Haris, Yavuz Nuri Ertas
Summary: Polyethylene glycol (PEG) was used to functionalize zinc ferrite nanoparticles (NPs) synthesized by the hydrothermal process in order to improve biocompatibility and prevent aggregation. Various spectroscopy techniques confirmed the structure, size, morphology, and magnetic properties of the NPs. PEG coating resulted in spherical shape, increased stability, and decreased zeta potential of the NPs. High saturation magnetization indicated their potential for biomedical applications. The PEG-coated NPs showed negligible cytotoxicity and were successfully used as a contrast agent in magnetic resonance imaging (MRI).
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Masoud Salehipour, Shahla Rezaei, Jafar Mosafer, Zahra Pakdin-Parizi, Ali Motaharian, Mehdi Mogharabi-Manzari
Summary: This review discusses the application of surface-chemically modified superparamagnetic iron oxide nanoparticles in magnetic resonance imaging, emphasizing the surface coating strategies to improve the stability of magnetic iron oxide contrast agents in physiological conditions, as well as the improved biocompatibility of polymer-coated agents. The review also compares the disadvantages of traditional contrast agents with the potential advantages of iron oxide alternatives and provides an outlook on the future developments and applications of magnetic nanoparticles.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Review
Oncology
Federico Bruno, Vincenza Granata, Flavia Cobianchi Bellisari, Ferruccio Sgalambro, Emanuele Tommasino, Pierpaolo Palumbo, Francesco Arrigoni, Diletta Cozzi, Francesca Grassi, Maria Chiara Brunese, Silvia Pradella, Maria Luisa Mangoni di S. Stefano, Carmen Cutolo, Ernesto Di Cesare, Alessandra Splendiani, Andrea Giovagnoni, Vittorio Miele, Roberto Grassi, Carlo Masciocchi, Antonio Barile
Summary: This article introduces the application of magnetic resonance imaging in the field of nanomedicine and the characteristics of nanoparticles as diagnostic and therapeutic tools. Imaging techniques play an important role in studying the properties of nanoconstructs and their interactions with the biological environment.
Article
Medicine, General & Internal
Ou Ou Yang, Tian Lan, Jun Ling He, Hai Bin Xu, Liang Hao, Chang Shu, Zu Jian Hu, Hua Luo
Summary: Primary breast angiosarcoma is a rare and aggressive entity that is difficult to diagnose, leading to recurrence and metastasis. Combining contrast-enhanced ultrasound and MRI can help in the diagnosis of breast angiosarcomas.
Article
Radiology, Nuclear Medicine & Medical Imaging
Augusto Lio M. Goncalves Filho, Komal Manzoor Awan, John Conklin, Chanon Ngamsombat, Stephen F. Cauley, Kawin Setsompop, Wei Liu, Daniel N. Splitthoff, Wei-Ching Lo, John E. Kirsch, Pamela W. Schaefer, Otto Rapalino, Susie Y. Huang
Summary: This study compared a highly accelerated Wave-T1-MPRAGE sequence with the standard T1-MPRAGE sequence for visualizing enhancing lesions in brain imaging. The results showed that Wave-T1-MPRAGE was comparable to the standard sequence in delineating enhancing lesions and had equivalent perception of noise, motion artifacts, and overall diagnostic quality.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Songbai Zhang, Vega Lloveras, Silvia Lope-Piedrafita, Pilar Calero-Perez, Shuang Wu, Silvia Lope-Piedrafita, Ana Paula Candiota, Jose Vidal-Gancedo
Summary: MRI is a highly required imaging approach for the early diagnosis and follow-up of tumors, especially brain cancer. Organic radicals anchored on a dendrimer macromolecule surface show promising potential as alternatives to traditional Gd-based contrast agents, with similar contrast enhancement effects, lower toxicity, and longer biological stability.
Article
Clinical Neurology
Josep Puig, Gerard Blasco, Josep Daunis-i-Estadella, Angel Alberich-Bayarri, Marco Essig, Rajan Jain, Sebastian Remollo, David Hernandez, Montserrat Puigdemont, Javier Sanchez-Gonzalez, Gloria Mateu, Max Wintermark, Salvador Pedraza
Article
Clinical Neurology
Michael J. Ellis, Lesley J. Ritchie, Patrick J. McDonald, Dean Cordingley, Karen Reimer, Satnam Nijjar, Mark Koltek, Shahid Hosain, Janine Johnston, Behzad Mansouri, Scott Sawyer, Norm Silver, Richard Girardin, Shannon Larkins, Sara Vis, Erin Selci, Michael Davidson, Scott Gregoire, Angela Sam, Brian Black, Martin Bunge, Marco Essig, Peter MacDonald, Jeff Leiter, Kelly Russell
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2017)
Review
Oncology
M. N. Khan, A. M. Sharma, M. Pitz, S. K. Loewen, H. Quon, A. Poulin, M. Essig
Review
Sport Sciences
Michael J. Ellis, Lesley Ritchie, Dean Cordingley, Marco Essig, Behzad Mansouri
CURRENT SPORTS MEDICINE REPORTS
(2016)
Article
Clinical Neurology
Simon Nagel, Devesh Sinha, Diana Day, Wolfgang Reith, Rene Chapot, Panagiotis Papanagiotou, Elizabeth A. Warburton, Paul Guyler, Sharon Tysoe, Klaus Fassbender, Silke Walter, Marco Essig, Jens Heidenrich, Angelos A. Konstas, Michael Harrison, Michalis Papadakis, Eric Greveson, Olivier Joly, Stephen Gerry, Holly Maguire, Christine Roffe, James Hampton-Till, Alastair M. Buchan, Iris Q. Grunwald
INTERNATIONAL JOURNAL OF STROKE
(2017)
Article
Clinical Neurology
W. Alan C. Mutch, Michael J. Ellis, Lawrence N. Ryner, M. Ruth Graham, Brenden Dufault, Brian Gregson, Thomas Hall, Martin Bunge, Marco Essig, Joseph A. Fisher, James Duffin, David J. Mikulis
JOURNAL OF NEUROSURGERY
(2016)
Article
Orthopedics
Rainer Siebold, Ferzan Suezer, Benjamin Schmitt, Siegfried Trattnig, Marco Essig
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2018)
Article
Clinical Neurology
Philip Hoelter, Stefan Lang, Marina Weibart, Manuel Schmidt, Michael F. X. Knott, Tobias Engelhorn, Marco Essig, Stephan Kloska, Arnd Doerfler
Review
Sport Sciences
Michael J. Ellis, Lesley Ritchie, Marco Essig, Marcus Ng, Arturo Tamayo, Demitre Serletis
CURRENT SPORTS MEDICINE REPORTS
(2018)
Article
Clinical Neurology
Manmeet Ahluwalia, Gene H. Barnett, Di Deng, Stephen B. Tatter, Adrian W. Laxton, Alireza M. Mohammadi, Eric Leuthardt, Roukoz Chamoun, Kevin Judy, Anthony Asher, Marco Essig, Jorg Dietrich, Veronica L. Chiang
JOURNAL OF NEUROSURGERY
(2019)
Article
Clinical Neurology
W. Alan C. Mutch, Michael J. Ellis, Lawrence N. Ryner, Patrick J. McDonald, Marc P. Morissette, Philip Pries, Marco Essig, David J. Mikulis, James Duffin, Joseph A. Fisher
FRONTIERS IN NEUROLOGY
(2018)
Article
Clinical Neurology
Josep Puig, Gerard Blasco, Angel Alberich-Bayarri, Gottfried Schlaug, Gustavo Deco, Carles Biarnes, Marian Navas-Marti, Mireia Rivero, Jordi Gich, Jaume Figueras, Cristina Torres, Pepus Daunis-i-Estadella, Celia L. Oramas-Requejo, Joaquin Serena, Cathy M. Stinear, Amy Kuceyeski, Carles Soriano-Mas, Gotz Thomalla, Marco Essig, Chase R. Figley, Bijoy Menon, Andrew Demchuk, Kambiz Nael, Max Wintermark, David S. Liebeskind, Salvador Pedraza
Article
Oncology
Josep Puig, Carles Biarnes, Pepus Daunis-i-Estadella, Gerard Blasco, Alfredo Gimeno, Marco Essig, Carme Balana, Angel Alberich-Bayarri, Ana Jimenez-Pastor, Eduardo Camacho, Santiago Thio-Henestrosa, Jaume Capellades, Javier Sanchez-Gonzalez, Marian Navas-Marti, Blanca Domenech-Ximenos, Sonia Del Barco, Montserrat Puigdemont, Carlos Leiva-Salinas, Max Wintermark, Kambiz Nael, Rajan Jain, Salvador Pedraza
Article
Clinical Neurology
J. Puig, G. Blasco, M. Terceno, P. Daunis-i-Estadella, G. Schlaug, M. Hernandez-Perez, V Cuba, G. Carbo, J. Serena, M. Essig, C. R. Figley, K. Nael, C. Leiva-Salinas, S. Pedraza, Y. Silva
AMERICAN JOURNAL OF NEURORADIOLOGY
(2019)
Review
Clinical Neurology
Ankur M. Sharma, Michael Willcock, Oliver Bucher, Thelina Amaratunga, M. Nazir Khan, Shaun K. Loewen, Harvey Quon, Marco Essig, Marshall Pitz
NEURO-ONCOLOGY PRACTICE
(2019)