Article
Radiology, Nuclear Medicine & Medical Imaging
Hsien-Jen Chiang, Ming-Chung Chou, Yi-Hsuan Chuang, Chun-Wei Li, Chih-Che Lin, Hock-Liew Eng, Chao-Long Chen, Yu-Fan Cheng
Summary: The objective of this study is to evaluate the diagnostic performance of BOLD MRI in patients with ACR post-liver transplant and to monitor treatment response.
EUROPEAN RADIOLOGY
(2022)
Review
Immunology
Tuula Penate Medina, Jan Philip Kolb, Gereon Huttmann, Robert Huber, Oula Penate Medina, Linh Ha, Patricia Ulloa, Naomi Larsen, Arianna Ferrari, Magdalena Rafecas, Mark Ellrichmann, Mariya S. Pravdivtseva, Mariia Anikeeva, Jana Humbert, Marcus Both, Jennifer E. Hundt, Jan-Bernd Hovener
Summary: This article reviews the recent advances in imaging technologies and their potential applications in the medical field, focusing on the development of imaging in precision medicine for inflammation. It also analyzes the challenges and opportunities faced by imaging technologies, showcasing some current or near-clinical applications as examples.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Xiaoxia Yang, De-Cai Tian, Wenyan He, Wei Lv, Junwan Fan, Haowen Li, Wei-Na Jin, Xia Meng
Summary: Stem cells have strong proliferation and differentiation abilities, transplantation of which is important for treating neurological diseases, and tracking technologies help monitor the survival and distribution of transplanted cells.
STROKE AND VASCULAR NEUROLOGY
(2021)
Review
Oncology
Wencheng Zhang, Yangyang Cui, Yuan Du, Yong Yang, Ting Fang, Fengfeng Lu, Weixia Kong, Canjun Xiao, Jun Shi, Lola M. Reid, Zhiying He
Summary: The liver is composed of various types of cells and has a high regenerative capacity. The main cell types, hepatocytes and cholangiocytes, work together with non-parenchymal cells to perform liver functions. The regulation of liver cells involves complex interactions between the extracellular matrix and soluble signals. Recent advancements in genetic sequencing have allowed for a better understanding of liver cell composition and regulation. Furthermore, breakthroughs in cell transplantation strategies offer potential solutions for treating end-stage liver diseases.
FRONTIERS OF MEDICINE
(2023)
Review
Cell Biology
Sunitha Vimalesvaran, Jessica Nulty, Anil Dhawan
Summary: Liver transplantation is the most effective treatment for pediatric end-stage liver disease, but its wider application is hindered by various limitations. Cellular therapies, such as hepatocytes and mesenchymal stromal cells (MSCs), are emerging as attractive alternatives. This review presents the world experience in hepatocyte and MSC transplantation and explores their potential for future effective applications.
Article
Cell Biology
Amani Remmo, Norbert Lowa, Olaf Kosch, Dietmar Eberbeck, Antje Ludwig, Lena Kampen, Cordula Gruettner, Frank Wiekhorst
Summary: Magnetic particle imaging (MPI) is a noninvasive imaging technique that allows for the visualization of magnetic nanoparticles (MNPs) with high accuracy. In this study, a method for preparing magnetically labeled THP-1 monocytes for MPI cell tracking was developed. The factors influencing the loading of MNPs onto cells were systematically investigated, providing a foundation for the development of a reliable MPI monocyte tracking method in the future.
Article
Chemistry, Multidisciplinary
Younggeun Park, Hyeun Joong Yoon, Somin Eunice Lee, Luke P. Lee
Summary: This study presents an integrated nanostructure of mesoporous-silica nanospheres and optical nanocrescent antennas for multifunctional cellular targeting, drug delivery, and molecular imaging with high spatial and temporal resolution.
Review
Biotechnology & Applied Microbiology
Li Wu, Chunting Wang, Yu Li
Summary: This review discusses the targeting mechanisms, toxicity issues, and applications of iron oxide nanoparticles (IONPs) in tumor MRI and therapy. The authors highlight the advantages of targeting IONPs and aim to increase the possibility of converting them from biomedical applications to clinical applications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jae Seok Bae, Dong Ho Lee, Kyung-Suk Suh, Kwang-Woong Lee, Nam-Joon Yi, Suk Kyun Hong
Summary: The study investigated the role of attenuation imaging (ATI) in screening potential liver donors for fatty liver detection. The results showed that ATI had good diagnostic performance and a high negative predictive value for significant fatty liver detection among potential liver donors.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Engineering, Biomedical
Hongping Deng, Jingxuan Ju, Xuan Mo, Guangbo Ge, Xinyuan Zhu
Summary: In vivo imaging and tracking of macrophage behaviors are crucial for understanding their biological functions and fate in various diseases. To overcome the limitations of small molecular probes, researchers have developed functional nanoprobes for targeted imaging of macrophages in different diseases such as cancer, atherosclerosis, and obesity. This review systematically summarizes the recent advances in nanoprobes for in vivo and ex vivo imaging of macrophages, as well as discusses the challenges and prospects of achieving precise imaging of macrophages with improved signal-to-background ratios.
Article
Chemistry, Multidisciplinary
Senol Mutlu, Oncay Yasa, Onder Erin, Metin Sitti
Summary: Minimally invasive medical procedures guided by magnetic resonance imaging (MRI) show significant clinical promise, and the use of Lorentz force-based electromagnetic actuators can overcome challenges related to MRI compatibility and miniaturization of precise positioning systems. A miniature, MRI-compatible, and optically powered wireless Lorentz force actuator module has been proposed for creating various wireless active structures for future interventional MRI applications. Proof-of-concept prototypes have already demonstrated the feasibility of using such actuator modules for positioning medical tools inside MRI scanners.
Article
Chemistry, Multidisciplinary
Homan Kang, Md Shamim, Xiaoran Yin, Eeswar Adluru, Takeshi Fukuda, Shinya Yokomizo, Hyejin Chang, Seung Hun Park, Yanan Cui, Austin J. Moy, Satoshi Kashiwagi, Maged Henary, Hak Soo Choi
Summary: The strategy of structure-inherent tumor targeting with cyanine-based fluorophores has gained attention due to its targetability of tumor microenvironments without the need for additional targeting ligands. This study demonstrates that heptamethine-cyanine-based fluorophores not only possess targetability but also provide second near-infrared spectral window imaging capabilities. The new mechanism of structure-inherent tumor targeting suggests that immune cells derived from bone marrow or residing in tissues/tumors can be principal targets for cancer detection.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yekkuni L. Balachandran, Wei Wang, Hongyi Yang, Haiyang Tong, Lulu Wang, Feng Liu, Hongsong Chen, Kai Zhong, Ye Liu, Xingyu Jiang
Summary: In this study, small heterogeneous iron oxide/dysprosium oxide nanoparticles were synthesized as a contrast agent for magnetic resonance imaging. These nanoparticles can target the liver and improve image resolution and signal-to-noise ratio at ultrahigh magnetic fields, allowing for precise diagnosis of liver fibrosis stages.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seo Yeon Youn, Bohyun Kim, Dong Hwan Kim, Ho Joong Choi, Pil Soo Sung, Joon-Il Choi
Summary: This study evaluated the factors predicting recurrence-free survival and overall survival after curative surgery in HCC patients treated with LRT. The study found that the LR-TR viable category at the time of surgery, preoperative AFP level, number of LRT sessions, and resection surgery independently predicted recurrence. A risk score categorized patients into different risk groups, predicting the 1-year recurrence rate. Postoperative recurrence and failure to meet the Milan criteria predicted death in patients.
EUROPEAN RADIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jeff W. M. Bulte, Chao Wang, Ali Shakeri-Zadeh
Summary: Superparamagnetic iron oxide (SPIO)-labeling of cells for magnetic resonance imaging (MRI) cell tracking has a long history, but studies have shown that the labeled cells may have different behaviors compared to unlabeled cells. With the emergence of magnetic particle imaging (MPI) cell tracking, there has been a renaissance in the formulation of SPIO nanoparticles optimized for MPI. Lessons learned from past experiences with SPIO-labeling for MRI could potentially facilitate the clinical translation of (combined) MRI/MPI cell tracking.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Enzo Bertuit, Emilia Benassai, Guillaume Meriguet, Jean-Marc Greneche, Benoit Baptiste, Sophie Neveu, Claire Wilhelm, Ali Abou-Hassan
Summary: Magnetite and maghemite multicore nanoflowers synthesized using modified polyol-mediated routes are highly effective nanoheaters in magnetic hyperthermia (MHT) and have also shown promising performances in photothermal therapy (PT) in the NIR-II biological window. The study investigates the influence of synthesis parameters on the size, shape, composition, cores, and crystallinity of the nanoflowers, establishing correlations between their structure, properties, and function in MHT and PT. Iron(III) and heating ramps are found to play a critical role in the formation of well-defined nanoflowers with multiple cores, with optical responses and photothermal properties depending on volume and structural disorder rather than stoichiometry. Defect concentration in the nanostructures affects optical behavior, with a transition in photothermal efficiency observed at a critical Urbach energy value.
Article
Orthopedics
Emeline Maurice, Thibault Godineau, Diane Pichard, Hanane El Hafci, Gwennhael Autret, Morad Bensidhoum, Veronique Migonney, Mathieu Manassero, Veronique Viateau
Summary: This study presents a cost-effective, new relevant and objective rat model associated with low morbidity for the preliminary study of bio-implantable materials designed for remnants-preserving ACL surgery after mid-substance ACL tear.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Oncology
Sophie Moog, Betty Salgues, Yasmine Braik-Djellas, Thomas Viel, Daniel Balvay, Gwennhael Autret, Estelle Robidel, Anne-Paule Gimenez-Roqueplo, Bertrand Tavitian, Charlotte Lussey-Lepoutre, Judith Favier
Summary: This study characterized an in vivo allograft model of SDHB-dependent PPGL and evaluated the response to various therapies. The results showed that sunitinib was the most effective treatment for SDHB-dependent PPGL, and H-1-MRS could potentially serve as an early biomarker of treatment response.
ENDOCRINE-RELATED CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriel Ifergan, Gwennhael Autret, Costantino Del Giudice, Augustin Lecler, Adrien Lalot, Camille Marijon, Amaury Casanova, Mailyn Perez-Liva, Valerie Bellamy, Patrick Bruneval, Olivier Clement, Marc Sapoval, Philippe Menasche, Daniel Balvay
Summary: Critical limb ischemia (CLI) is a severe disease that leads to muscle disorders in the limbs. Currently, there are no reliable tools to accurately assess perfusion defects in CLI. In this study, we propose new methodologies for evaluating perfusion defects using dynamic contrast-enhanced MRI and find that the inclusion of heterogeneity features significantly improves sensitivity and accuracy.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Noam Demri, Simon Dumas, Manh-Louis Nguyen, Giacomo Gropplero, Ali Abou-Hassan, Stephanie Descroix, Claire Wilhelm
Summary: A new method is proposed to align muscle, stromal, and stem cells using magnetic fields in a thermoresponsive collagen hydrogel, creating anisotropic tissue structures. Spheroids are generated efficiently using microfabricated micromagnets and used as building blocks for creating 3D structures of various scales.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Vladimir Mulens-Arias, Alba Nicolas-Boluda, Florent Carn, Florence Gazeau
Summary: Nanomedicines based on inorganic nanoparticles have shown promise in the field of medicine due to their versatile properties. However, concerns exist regarding the immunological effects of nanoparticles. This study investigated the effects of AuPEI nanocomposites on the tumor microenvironment and found differential effects in vitro and in vivo, suggesting the importance of testing nanomaterials in relevant immunocompetent mouse tumor models.
Article
Materials Science, Biomaterials
Georgios Kasparis, Anouchka Plan Sangnier, Lilin Wang, Christoforos Efstathiou, Alec P. P. LaGrow, Andreas Sergides, Claire Wilhelm, Nguyen Thi Kim Thanh
Summary: This study explored the effects of zinc doping on the magnetic properties and structural characteristics of iron oxide nanoparticles. The results showed that zinc doping improved the magnetic properties and reduced the lattice strain of the nanoparticles. The zinc ferrite nanoparticles had long-term magnetic and colloidal stability and showed similar biocompatibility to iron oxide nanoparticles. Compared to magnetothermal therapy, semiconductor photo-hyperthermia using zinc ferrite nanoparticles achieved higher efficiency and faster temperature increase.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Multidisciplinary Sciences
Alexandre Fromain, Jose Efrain Perez, Aurore van de Walle, Yoann Lalatonne, Claire Wilhelm
Summary: This study demonstrates that photothermia at the nanoscale can trigger the degradation of magnetic nanoparticles, leading to the release of Fe(II) and enabling photothermo-ferroptotic therapy. The temperature acts as an accelerator for nanoparticle degradation and can be remotely triggered by laser-mediated photothermal conversion. The efficacy of this treatment method has been confirmed in in vitro experiments.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Thulaciga Yoganathan, Mailyn Perez-Liva, Daniel Balvay, Morgane Le Gall, Alice Lallemand, Anais Certain, Gwennhael Autret, Yasmine Mokrani, Francois Guillonneau, Johanna Bruce, Vincent Nguyen, Umit Gencer, Alain Schmitt, Franck Lager, Thomas Guilbert, Patrick Bruneval, Jose Vilar, Nawal Maissa, Elie Mousseaux, Thomas Viel, Gilles Renault, Nadjia Kachenoura, Bertrand Tavitian
Summary: This study demonstrates that stress-induced cardiomyopathy can lead to continuous deterioration of heart function and structure due to abnormalities in cardiac metabolism, contradicting the supposed reversibility of Takotsubo. This highlights the dysregulation of glucose metabolic pathways as a main cause of long-term cardiac disease.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jose E. Perez, Audric Jan, Catherine Villard, Claire Wilhelm
Summary: Engineered 3D magnetic brain-like tissue spheroids reveal that glial and neuronal cells have different distributions within the spheroids, with neuronal cells located in the periphery and glial cells forming the core. The surface tension and elasticity of the tissue can be determined from the deformation caused by a magnetic field gradient. This mechanical contribution may influence tissue development and homeostasis in the field of neuroengineering.
Article
Materials Science, Multidisciplinary
Erwann Guenin, Alexandre Fromain, Aida Serrano, Giacomo Gropplero, Yoann Lalatonne, Ana Espinosa, Claire Wilhelm
Summary: Platinum nanoparticles are emerging as promising candidates for enhancing radiotherapy sensitivity, with their multi-core structure showing efficient near-infrared photothermal treatment on glioblastoma tumoroids and demonstrating good biostability.
COMMUNICATIONS MATERIALS
(2023)
Article
Materials Science, Biomaterials
Cristina de la Encarnacion, Felix Jungwirth, David Vila-Liarte, Carlos Renero-Lecuna, Safiyye Kavak, Inaki Orue, Claire Wilhelm, Sara Bals, Malou Henriksen-Lacey, Dorleta Jimenez de Aberasturi, Luis M. Liz-Marzan
Summary: Hyperthermia has been shown to be an effective and selective cancer therapy strategy by heating malignant cells above 42 degrees C to trigger cell death. Magnetic and photothermal hyperthermia can benefit from the use of nanomaterials. This hybrid colloidal nanostructure, consisting of plasmonic gold nanorods covered by a silica shell and subsequently grown with iron oxide nanoparticles, is responsive to both external magnetic fields and near-infrared irradiation, enabling targeted magnetic separation and photothermal heating.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Alexandre Fromain, Aurore Van de Walle, Guilhem Cure, Christine Pechoux, Aida Serrano, Yoann Lalatonne, Ana Espinosa, Claire Wilhelm
Summary: Iron is commonly found in the human body, with proteins involved in its various functions. The presence of magnetic iron, especially in the brain, is not well explored. Recent studies have shown that human stem cells have the ability to synthesize magnetic nanoparticles using iron released from synthetic magnetic nanoparticles. This study demonstrated the biosynthesis of magnetic nanoparticles in mouse and human mesenchymal stem cells using ferric quinate, and found that it correlated with significant doses of intracellular iron.
Review
Chemistry, Multidisciplinary
Aurore Van de Walle, Albert Figuerola, Ana Espinosa, Ali Abou-Hassan, Marta Estrader, Claire Wilhelm
Summary: Due to their unique physicochemical features, nanoparticles, especially magnetic nanoparticles with iron-based composition, have become effective multifunctional tools for biomedical applications. In oncology, these nanoparticles have been widely used in magnetic resonance imaging, magnetic hyperthermia, photothermal therapy, and ferroptosis induction.
MATERIALS HORIZONS
(2023)
Review
Chemistry, Multidisciplinary
Aurore Van de Walle, Albert Figuerola, Ana Espinosa, Ali Abou-Hassan, Marta Estrader, Claire Wilhelm
Summary: With their unique physicochemical features, nanoparticles, especially magnetic nanoparticles with iron-based composition, have been recognized as effective multifunctional tools for biomedical applications. This review focuses on the recent applications of iron-based nanomaterials in oncology, specifically photothermal therapy (PTT) and ferroptosis. These emerging physical and chemical methods for cancer therapy, facilitated by magnetic nanoparticles, offer versatile opportunities, combining multiple functionalities.
MATERIALS HORIZONS
(2023)