Article
Radiology, Nuclear Medicine & Medical Imaging
J. S. Louis, F. Odille, D. Mandry, C. De Chillou, O. Huttin, J. Felblinger, C. Venner, M. Beaumont
Summary: The study aimed to assess the feasibility of early estimation of ECV through a quantitative pixel-wise DCE analysis workflow. Results showed strong correlation between ECV values obtained from a 2-minute DCE acquisition using RC-REG algorithm and ECV values from the T1-based method, indicating the potential for accurate ECV estimation in a shorter timeframe. The proposed workflow demonstrated systematic improvements in image and map quality assessment, making it a promising approach for ECV mapping.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
Yong Jin, Hui Peng, Jie Peng
Summary: This study utilized DCE-MRI technology and its perfusion parameters to diagnose and differentially diagnose brain tumors, showing that DCE-MRI can accurately distinguish between HGG and LGG, with t-Ktrans value demonstrating higher specificity and sensitivity.
WORLD NEUROSURGERY
(2021)
Article
Oncology
Jon-Vidar Gaustad, Einar K. Rofstad
Summary: K (trans) maps are strongly correlated with hypoxic fraction and can predict disease-free and overall survival in cervical carcinoma patients, while v (e) maps do not provide relevant information on hypoxia status or patient outcome.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Aleksandrs Krigers, Matthias Demetz, Astrid E. Grams, Claudius Thome, Christian F. Freyschlag
Summary: In the context of gadolinium contrast enhancement, the presence of anaplasia is associated with a higher likelihood of detecting CE, which in turn is linked to unfavorable prognostic features.
ACTA NEUROCHIRURGICA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stig P. Cramer, Henrik B. W. Larsson, Maria H. Knudsen, Helle J. Simonsen, Mark B. Vestergaard, Ulrich Lindberg
Summary: This study investigates the reproducibility of DCE-MRI in healthy controls and evaluates the impact of arterial input function selection and manual region of interests delineation versus automated global segmentation. The results show excellent reproducibility of pharmacokinetic variables derived from DCE-MRI in healthy controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Akane Ohashi, Masako Kataoka, Mami Iima, Maya Honda, Rie Ota, Yuta Urushibata, Marcel Dominik Nickel, Masakazu Toi, Sophia Zackrisson, Yuji Nakamoto
Summary: This study evaluates the agreement in morphological information obtained from malignant breast mass lesions between ultrafast dynamic contrast-enhanced (DCE) MRI and conventional DCE-MRI. The results show high agreement between the two methods, suggesting that ultrafast DCE-MRI may replace conventional DCE-MRI to evaluate the morphological information of malignant breast mass lesions.
Article
Medicine, General & Internal
Mohammed A. Azab, Sherief Ghozy, Sherif F. Hassanein, Ahmed Y. Azzam
Summary: This study investigated the relationship between qualitative markers of glioblastoma assessed through dynamic contrast-enhanced MRI and vascularity, identifying VEGF expression as a potential non-invasive marker for tumor grade estimation and recurrence risk prediction. Further large-scale studies are needed to validate these findings.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhipeng Xia, Hao Gu, Ying Yuan, Shiyu Xiang, Zimin Zhang, Xiaofeng Tao
Summary: DCE-MRI shows promise in predicting the efficacy of foam sclerotherapy for venous malformations, with whole lesion volume of interest-based model performing better than region of interest-based model. This can potentially guide surgical approach in the future.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Michelle Roytman, Sean Kim, Shannon Glynn, Charlene Thomas, Eaton Lin, Whitney Feltus, Rajiv S. Magge, Benjamin Liechty, Theodore H. Schwartz, Rohan Ramakrishna, Nicolas A. Karakatsanis, Susan C. Pannullo, Joseph R. Osborne, Jonathan P. S. Knisely, Jana Ivanidze
Summary: This study investigated the correlation between tumor vascularity and SSTR2 expression in meningiomas using Gallium-68-DOTATATE PET/MRI. The results showed a strong correlation between tumor vascularity and SSTR2 expression in WHO-2 and WHO-3 meningiomas, but not in WHO-1 meningiomas.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Hirsch Matani, Ankur K. K. Patel, Zachary D. D. Horne, Sushil Beriwal
Summary: Functional MRI has potential in the diagnosis and management of cervical cancer. Current techniques such as DWI and DCE imaging are helpful in assessing tumor perfusion and hypoxia. However, further validation through large prospective studies is needed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Roberta Fusco, Vincenza Granata, Mauro Mattace Raso, Paolo Vallone, Alessandro Pasquale De Rosa, Claudio Siani, Maurizio Di Bonito, Antonella Petrillo, Mario Sansone
Summary: The study aimed to differentiate benign and malignant breast lesions by combining BOLD-MRI, DCE-MRI, and DW-MRI, but found that the combined use of these imaging techniques did not provide a significant improvement compared to using DCE-MRI alone. An interesting result was the negative correlation between R-2* and D.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cristina Grippo, Pooja Jagmohan, Thomas H. Helbich, Panagiotis Kapetas, Paola Clauser, Pascal A. T. Baltzer
Summary: The study found that using peak enhancement as the initial timepoint significantly improves the diagnostic performance of the Kaiser score, particularly in increasing sensitivity.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Francois Lallemand, Natacha Leroi, Silvia Blacher, Mohamed Ali Bahri, Evelyne Balteau, Philippe Coucke, Agnes Noel, Alain Plenevaux, Philippe Martinive
Summary: Significant changes in perfusion-related parameters were observed on day 6 in a neoadjuvant radiotherapy model using SCID mice, which correlated with an increase in perfused vessels and metastasis spreading after surgery. This observation suggests the potential for personalized treatment by adjusting the timing of surgery based on MRI functional data, especially tumor perfusion.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
He-Ping Deng, Xue-Ming Li, Liu Yang, Yi Wang, Shao-Yu Wang, Peng Zhou, Yu-Jie Lu, Jin Ren, Min Wang
Summary: The study demonstrated that the star-VIBE sequence can offer higher image quality compared to the conventional 3D-VIBE sequence in the dynamic contrast-enhanced magnetic resonance imaging of esophageal carcinoma under free breathing conditions. Subjective and objective evaluations confirmed the superiority of the star-VIBE sequence in providing better image quality for this specific imaging modality.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Han, Yang Yang, Zhe-sheng Shi, An-ding Zhang, Lin-feng Yan, Yu-chuan Hu, Lan-lan Feng, Jiao Ma, Wen Wang, Guang-bin Cui
Summary: The study successfully differentiated brain inflammation from grade II glioma using radiomics features, showing better diagnostic efficacy compared to experienced radiologists.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Cheriyan, Alexandra Roberts, Caleb Roberts, Martin J. Graves, Ilse Patterson, Rhys A. Slough, Rosemary Schroyer, Disala Fernando, Subramanya Kumar, Sarah Lee, Geoffrey J. M. Parker, Lea Sarov-Blat, Carmel McEniery, Jessica Middlemiss, Dennis Sprecher, Robert L. Janiczek
Summary: This study aimed to evaluate lung fluid volume in HF patients using DCE-MRI, finding significantly higher v(e) in HF patients compared to healthy volunteers. The results showed good tolerability of the scanning protocol and repeatability of v(e) in HF patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Endocrinology & Metabolism
Ben R. Dickie, Tao Jin, Ping Wang, Rainer Hinz, William Harris, Herve Boutin, Geoff J. M. Parker, Laura M. Parkes, Julian C. Matthews
Summary: Chemical-exchange spin-lock (CESL) MRI is a useful technique for mapping glucose uptake and utilization in the brain. The study proposes two quantitative kinetic models to describe glucose-induced changes and applies them to tumor-bearing and healthy rats.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Oncology
Isabella Fornacon-Wood, Hitesh Mistry, Corinne Johnson-Hart, Corinne Faivre-Finn, James P. B. O'Connor, Gareth J. Price
Summary: The study compared two cohorts of NSCLC patients treated with IGRT before and after a protocol change, finding a reduced impact of set-up errors on the heart after the threshold reduction. The Bayesian approach used in the analysis demonstrated increased survival for patients with residual set-up errors towards the heart, supporting its consideration in future evaluations of clinical practice changes.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nandita M. DeSouza, Aad van Der Lugt, Christophe M. Deroose, Angel Alberich-Bayarri, Luc Bidaut, Laure Fournier, Lena Costaridou, Daniela E. Oprea-Lager, Elmar Kotter, Marion Smits, Marius E. Mayerhoefer, Ronald Boellaard, Anna Caroli, Lioe-Fee De Geus-Oei, Wolfgang G. Kunz, Edwin H. Oei, Frederic Lecouvet, Manuela Franca, Christian Loewe, Egesta Lopci, Caroline Caramella, Anders Persson, Xavier Golay, Marc Dewey, James P. B. O'Connor, Pim DeGraaf, Sergios Gatidis, Gudrun Zahlmann
Summary: This study proposes standardized criteria for background lesion/tissue segmentation on digital medical images, which is crucial for biomarker extraction and developing artificial intelligence algorithms. The criteria were established through a modified Delphi process involving expert participants and cover various factors such as system performance certification, thresholds for image quality, and operator training and certification.
INSIGHTS INTO IMAGING
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
S. J. Mills, R. A. Dineen
CLINICAL RADIOLOGY
(2023)
Article
Oncology
Abdurrahman I. Islim, Jing X. Lee, Mohammad A. Mustafa, Christopher P. Millward, Conor S. Gillespie, George E. Richardson, Basel A. Taweel, Emmanuel Chavredakis, Samantha J. Mills, Andrew R. Brodbelt, Michael D. Jenkinson
Summary: The clinical outcomes of sporadic multiple meningioma may not be worse than solitary meningioma. Management should be tailored towards symptomatic or high-risk asymptomatic meningioma.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Sumirat M. M. Keshwara, Conor S. S. Gillespie, Mohammad A. A. Mustafa, Alan M. M. George, George E. E. Richardson, Abigail L. L. Clynch, Justin Z. Z. Wang, David D. A. Lawson, Catherine E. E. Gilkes, J. Osman Farah, Jawad Yousaf, Emmanuel Chavredakis, Samantha J. J. Mills, Andrew R. R. Brodbelt, Gelareh Zadeh, Christopher P. P. Millward, Abdurrahman I. I. Islim, Michael D. D. Jenkinson
Summary: This study evaluated the longer-term health-related quality of life (HRQoL) in meningioma patients following diagnosis and treatment. Clinically relevant impairments in several HRQoL domains were identified. Education level, employment status, and absence of postoperative complications were associated with better HRQoL scores.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Oncology
Erich P. Huang, James P. B. O'Connor, Lisa M. McShane, Maryellen L. Giger, Philippe Lambin, Paul E. Kinahan, Eliot L. Siegel, Lalitha K. Shankar
Summary: Integration of computer-extracted tumour characteristics into medical imaging computer-aided diagnosis (CAD) algorithms has been a long-standing practice. However, the translation of radiomics, an extension of CAD involving quantitative characterization of healthy or pathological structures and processes captured by medical imaging, into clinically useful tools has been limited. This may be due to factors such as varying imaging and radiomic feature extraction protocols, potential pitfalls in radiomic data analysis, and a lack of evidence demonstrating the clinical benefit of radiomic-based tools. The authors provide 16 criteria to guide the clinical translation of radiomics, with the aim of accelerating the use of this technology to improve patient outcomes.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Conor S. Gillespie, George E. Richardson, Mohammad A. Mustafa, Basel A. Taweel, Ali Bakhsh, Siddhant Kumar, Sumirat M. Keshwara, Abdurrahman I. Islim, Shaveta Mehta, Christopher P. Millward, Andrew R. Brodbelt, Samantha J. Mills, Michael D. Jenkinson
Summary: This study aimed to determine the volumetric growth rates, growth trajectory, and factors associated with progression of residual meningioma after surgery. The study revealed that the absolute growth rate of residual meningioma was 0.11 cm³ per year, and the relative growth rate was 4.3% per year. Most meningiomas met the criteria for progression according to the RANO criteria. Skull base location and Ki-67 index were associated with residual meningioma progression.
Review
Oncology
Mueez Waqar, Petra J. Van Houdt, Eline Hessen, Ka-Loh Li, Xiaoping Zhu, Alan Jackson, Mudassar Iqbal, James O'Connor, Ibrahim Djoukhadar, Uulke A. van der Heide, David J. Coope, Gerben R. Borst
Summary: In this review, different methodologies to derive imaging habitats in glioblastoma, strategies to overcome its technical challenges, contrasting experiences to other cancers, and potential clinical applications are explored.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Oncology
Nandita M. M. deSouza, Ananya Choudhury, Mel Greaves, James P. B. O'Connor, Peter J. J. Hoskin
FRONTIERS IN ONCOLOGY
(2022)
Review
Clinical Neurology
Abigail L. Clynch, Conor S. Gillespie, George E. Richardson, Mohammad A. Mustafa, Abdurrahman I. Islim, Sumirat M. Keshwara, Ali Bakhsh, Siddhant Kumar, Rasheed Zakaria, Christopher P. Millward, Samantha J. Mills, Andrew R. Brodbelt, Michael D. Jenkinson
Summary: This study evaluated the use of Tranexamic Acid (TXA) in meningioma surgery and its effects on intraoperative and postoperative outcomes. The meta-analysis of four studies showed that TXA significantly reduced intraoperative blood loss but did not affect transfusion requirement or postoperative complications.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Oncology
Abdurrahman I. Islim, Christopher P. Millward, Samantha J. Mills, Daniel M. Fountain, Rasheed Zakaria, Omar N. Pathmanaban, Ryan K. Mathew, Thomas Santarius, Michael D. Jenkinson
Summary: The increased availability and use of brain imaging have led to more incidental diagnoses of meningioma. Most incidental meningiomas are small and do not require treatment, but in some cases, surgical or radiation treatment may be necessary due to growth or symptoms. There is a need for regular follow-up but the duration is not specified. Treatment options must be carefully considered due to potential risks and lack of sufficient evidence.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Oncology
J. Pearson, A. Khan, T. Bhogal, H. Wong, A. Law, S. Mills, N. Santamaria, J. Bishop, J. Cliff, D. Errington, A. Hall, C. Hart, Z. Malik, R. Sripadam, H. Innes, H. Flint, G. Langton, E. Ahmed, R. Jackson, C. Palmieri
Summary: This real-world study demonstrates the efficacy of T-DXd in patients with active brain metastasis and extracranial disease progression in advanced breast cancer. Patients with active brain metastasis treated with T-DXd had comparable outcomes to those with extracranial disease alone, with longer progression-free survival and overall survival. However, the high incidence of pneumonitis warrants further consideration.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah H. Needleman, Mina Kim, Jamie R. Mcclelland, Josephine H. Naish, Marta Tibiletti, James P. B. O'Connor, Geoff J. M. Parker
Summary: This study aims to address the challenges of dynamic lung oxygen-enhanced MRI (OE-MRI) at 3 T, including confounding signals and poor signal-to-noise ratio. The study utilizes independent component analysis (ICA) to automatically extract the oxygen-induced signal change and improve the accuracy and sensitivity of lung OE-MRI. The results demonstrate that the developed pipeline shows sensitivity to the signal enhancements of lung tissue and oxygenated blood.
MAGNETIC RESONANCE IN MEDICINE
(2023)