期刊
EUROPEAN POLYMER JOURNAL
卷 49, 期 12, 页码 3796-3805出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2013.08.026
关键词
Fe3O4; Electrospun magnetic nanofiber; Hyperthermia
资金
- Chonbuk National University Grant
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012-0001611, 2012-013341]
- Ministry of Education, Science and Technology through the Leaders in Industry-University Cooperation (LinC) Project [2012-C-0043-010111]
A facile method of fabricating novel heat-generating membranes composed of electrospun polyurethane (PU) nanofibers decorated with superparamagnetic iron oxide nanoparticles (NPs) is reported. Electrospinning was used to produce polymeric nanofibrous matrix, whereas polyol immersion technique allowed in situ assembly of well-dispersed Fe3O4 NPs on the nanofibrous membranes without any surfactant, and without sensitizing and stabilizing reagent. The assembly phenomena can be explained by the hydrogen-bonding interactions between the amide groups in the PU matrix and the hydroxyl groups capped on the surface of the Fe3O4 NPs. The prepared nanocomposite fibers showed acceptable magnetization value of 33.12 emu/g, after measuring the magnetic hysteresis loops using SQUID. Moreover, the inductive heating property of electrospun magnetic nanofibrous membranes under an alternating current (AC) magnetic field was investigated. We observed a progressive increase in the heating rate with the increase in the amount of magnetic Fe3O4 NPs in/on the membranes. The present electrospun magnetic nanofibrous membrane may be a potential candidate as a novel heat-generating substrate for localized hyperthermia cancer therapy. (C) 2013 Elsevier Ltd. All rights reserved.
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