期刊
EUROPEAN POLYMER JOURNAL
卷 49, 期 8, 页码 2082-2091出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2013.04.032
关键词
Starch nanoparticles; Poly (L-glutamic acid); Click reaction; Drug delivery
资金
- National Natural Science Foundation of China [50903012, 51273037]
- Jilin Science and Technology Bureau [20120729]
- Jilin Human Resources and Social Security Bureau [201125020]
In this article, a novel oral protein drug delivery made of starch nanoparticles (SNPs) as backbone and poly (L-glutamic acid) (PGA) as graft chains was successfully synthesized by click reaction. The grafting efficiency and structure of the resultant copolymer SNP-g-PGA were verified by H-1 NMR and FT-IR spectra. The copolymer could assemble into amphiphilic aggregates. Hydrodynamic radii (R-h) of the aggregate decreased obviously as increasing pH value due to its excellent pH-dependent property. To take advantage of this pH-responsive property, in vitro insulin release experiment was carried out. The loaded-insulin released from the copolymers more slowly in artificial gastric juice (pH = 1.2) than that in artificial intestinal liquid (pH = 6.8) due to the excellent stability in acidic condition. These results suggested that the natural starch based material with pH sensitivity could be a promising delivery for insulin controlled release. (C) 2013 Elsevier Ltd. All rights reserved.
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