Review
Pharmacology & Pharmacy
Asma AlDawsari, Trevor J. Bushell, Nouf Abutheraa, Shuzo Sakata, Sarah Al Hussain, Amanj Kurdi
Summary: This study aimed to examine the association between sedative-hypnotic medications and risk of dementia using a meta-analysis approach. The results showed that all investigated sedative-hypnotics did not have an increased risk of dementia except for benzodiazepines (BZDs). However, the observed association with BZDs did not persist after potential reverse causation and confounding by indication were excluded.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Psychiatry
Yusuke Okada, Manabu Akazawa
Summary: The 2018 revision of Japanese medical service fees aimed at reducing irrational psychotropic polypharmacy by reducing fees for patients prescribed more than the standard number of drugs. A study using a large administrative claims database found that only the proportion of patients prescribed the sum of anxiolytics and hypnotics exceeding the standard significantly decreased after the revision, while other drug groups did not show significant changes. The revision resulted in a promotion of reduction in the number of prescribed drugs, which was an important factor in decreasing the proportion of patients prescribed more than the standard number of drugs.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Oncology
Anna Wikman, Emma Hoven, Anette Alvariza, Malin Lovgren, Ulrika Kreicbergs, Charlotte Skoglund, Emma Fransson, Gustaf Ljungman, Rickard Ljung, Lisa Ljungman
Summary: Parents of adolescent cancer survivors have an increased risk of using anxiolytics and sedatives in the first 6 months after the cancer diagnosis, while only mothers have an increased risk of using antidepressants from 6 months to 2 years after the diagnosis. Risk factors include being divorced/widowed, born in a non-Nordic country, older age, and having had previous mental health problems.
Review
Pharmacology & Pharmacy
Delia Bishara
Summary: The paper reviews the growing evidence of the risks associated with anticholinergic agents, including peripheral side effects and central effects such as cognitive impairment. It also highlights the consistent link between anticholinergics and an increased risk of dementia and mortality in older people.
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Sara Baldelli, Stefania Cheli, Cristina Montrasio, Dario Cattaneo, Emilio Clementi
Summary: This study analyzed data from the past 5 years to evaluate the application of AGNP guidelines in the clinical management of psychiatric patients. The results showed a significant interpatient variability in drug concentrations and a potential benefit of therapeutic drug monitoring and pharmacogenetic testing in optimizing treatment for individual patients with psychiatric disorders.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Zhengyun Shang, Yong Chen, Lejian Zhang, Xiaoxiao Zhu, Xinping Wang, Chuan Shi
Summary: This paper reports an efficient additive, TMG, for modifying the crystal growth of ZSM-5 zeolites to obtain a hierarchical and lamellar structure. The resulting crystals with a plate-like morphology and single-crystalline nature display higher catalytic activity and stability compared to conventional spherical crystals.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Neurosciences
Takao Kato, Nozomu Kotorii, Motohiro Ozone, Kenta Murotani, Hayato Ohshima, Hiroyuki Mori, Kenjirou Wasano, Hiroshi Hiejima, Mitsunari Habukawa, Naohisa Uchimura
Summary: This study aimed to examine the factors related to the elimination of prescriptions of three or more hypnotic drugs within 1 year in a Japanese clinic. The frequency of prescribing three or more hypnotic drugs was higher in psychiatry compared to other departments. Flunitrazepam and brotizolam were the most commonly prescribed drugs, while eszopiclone, zopiclone, and suvorexant had the highest discontinuation rates. Age, trazodone addition, and number of years of psychiatric experience were identified as success factors for drug reduction.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Review
Gastroenterology & Hepatology
Mihaela Fadgyas Stanculete, Dan Lucian Dumitrascu, Douglas A. Drossman
Summary: Irritable bowel syndrome (IBS) is a chronic disorder characterized by gut-brain dysregulation, leading to high disability levels and poor health-related quality of life in patients. Drug therapy, particularly central neuromodulators, focuses on reducing symptoms, improving quality of life, and targeting associated mental health symptoms related to IBS. Neuromodulators have shown promise in treating IBS by targeting central and peripheral mechanisms and are currently being researched for further advancements.
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2021)
Review
Psychiatry
Su Yin Seow, Kah Foo Victor Kwok, Kai Hong Tay, Weng Seng Ashwin Chee, Iris Rawtaer, Yao Cheng, Qi Xuan Tan, Shian Ming Tan
Summary: This systematic review assessed the quality and reporting of clinical practice guidelines on the treatment of insomnia disorder. The results indicated that there are variations in the recommended pharmacological treatment options among the guidelines, and most of them do not provide specific recommendations for subsequent clinical considerations.
JOURNAL OF PSYCHIATRIC PRACTICE
(2022)
Article
Public, Environmental & Occupational Health
Xuguang (Grant) Tao, Robert A. Lavin, Larry Yuspeh, Nicholas F. Tsourmas, Nimisha Kalia, Nina Leung, Leila Williams, Dan L. Hunt, Judith Green-McKenzie, Edward J. Bernacki
Summary: The study aims to investigate the relationship between workers' compensation claim costs and return to work with drugs prescribed for early symptom management. The results show that the use of certain drugs in the first 3 or 6 months after injury is significantly associated with higher claim costs and may affect the ability to return to work within three years after the injury.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Adam J. Pawson, Christopher Southan, Joanna L. Sharman, Brice Campo, David R. Cavanagh, Stephen P. H. Alexander, Anthony P. Davenport, Michael Spedding, Jamie A. Davies
NUCLEIC ACIDS RESEARCH
(2020)
Review
Immunology
Simon D. Harding, Elena Faccenda, Christopher Southan, Adam J. Pawson, Pasquale Maffia, Stephen P. H. Alexander, Anthony P. Davenport, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding, Jamie A. Davies
Article
Psychiatry
Anushree Tripathi, Michael Spedding, Esther Schenker, Michael Didriksen, Arnaud Cressant, Therese M. Jay
TRANSLATIONAL PSYCHIATRY
(2020)
Review
Pharmacology & Pharmacy
Steve P. H. Alexander, Jane F. Armstrong, Anthony P. Davenport, Jamie A. Davies, Elena Faccenda, Simon D. Harding, Francesca Levi-Schaffer, Janet J. Maguire, Adam J. Pawson, Christopher Southan, Michael Spedding
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Editorial Material
Immunology
Simon Milling, Michael Spedding, Pasquale Maffia
Article
Pharmacology & Pharmacy
Alexandra Bouscary, Cyril Quessada, Frederique Rene, Michael Spedding, Alexandre Henriques, Shyuan Ngo, Jean-Philippe Loeffler
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mikael Hoffmann, Robert Vander Stichele, David W. Bates, Johanna Bjorklund, Steve Alexander, Marine L. Andersson, Ane Auraaen, Marion Bennie, Marja-Liisa Dahl, Birgit Eiermann, Werner Hackl, Tora Hammar, Paul Hjemdahl, Sabine Koch, Ilkka Kunnamo, Herve Le Louet, Papapetrou Panagiotis, Lembit Raego, Michael Spedding, Hanna M. Seidling, Dina Demner-Fushman, Lars L. Gustafsson
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Michael Spedding, Sumantra Chattarji, Charlotte Spedding, Therese M. Jay
Summary: This review focuses on key brain circuits and their role in health and disease, as well as the impact of upbringing, stress, genetics, and pharmacotherapy on psychiatric diseases.
Review
Cell Biology
Alexandra Bouscary, Cyril Quessada, Frederique Rene, Michael Spedding, Bradley J. Turner, Alexandre Henriques, Shyuan T. Ngo, Jean-Philippe Loeffler
Summary: Sphingolipids play crucial roles in the development and maintenance of the nervous system, with dysregulated metabolism being linked to specific neurodegenerative diseases. Current research primarily focuses on ALS, seeking potential treatments that target sphingolipid metabolism in neurodegenerative diseases.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Simon D. Harding, Jane F. Armstrong, Elena Faccenda, Christopher Southan, Stephen P. H. Alexander, Anthony P. Davenport, Adam J. Pawson, Michael Spedding, Jamie A. Davies
Summary: The IUPHAR/BPS Guide to PHARMACOLOGY has expanded its content in the past two years, focusing on infection, malaria, and antibiotic resistance. It has included a new family of Coronavirus proteins and collaborated with Medicines for Malaria Venture and AntibioticDB to enhance coverage of malaria pharmacology and antibacterials.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Michael Spedding, Claude Sebban, Therese M. Jay, Cyril Rocher, Brigitte Tesolin-Decros, Paul Chazot, Esther Schenker, Gabor Szenasi, Gyorgy Levay, Katalin Megyeri, Jozsef Barkoczy, Laszlo G. Harsing, Ian Thomson, Mark O. Cunningham, Miles A. Whittington, Lori-An Etherington, Jeremy J. Lambert, Ferenc A. Antoni, Istvan Gacsalyi
Summary: Dysfunction in the H-PFC circuit is a critical factor in schizophrenia, and a new drug called EGIS 11150 has been found to induce theta rhythm, enhance H-PFC coherence, and restore long-term potentiation in this circuit. This suggests that phenotypical screening on H-PFC connectivity can uncover novel antipsychotics.
Review
Pharmacology & Pharmacy
Christopher N. Connolly, Stephen P. H. Alexander, Jamie A. Davies, Michael Spedding
Summary: The article proposes the application of standard pharmacological principles to assess the dosing of the environment and suggests the concept of an "environmental therapeutic window" for risk assessment of pesticides. To achieve this, a freely accessible database containing quantitative data on pesticide action is needed.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Meeting Abstract
Toxicology
M. Spedding
TOXICOLOGY LETTERS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
M. Fazzari, A. Henriques, G. Lunghi, L. Mauri, M. G. Ciampa, G. Tedeschi, N. Mitro, S. Sonnino, M. Spedding, E. Chiricozzi
Meeting Abstract
Pharmacology & Pharmacy
Michael Spedding
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2019)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)