Article
Clinical Neurology
Houman Rashidian, Mehala Subramaniapillai, Caroline Park, Orly Lipsitz, Hannah Zuckerman, Kayla Teopiz, Bing Cao, Yena Lee, Hartej Gill, Roger Ho, Kangguang Lin, Nelson B. Rodrigues, Michelle Iacobucci, Joshua D. Rosenblat, Roger S. McIntyre, Rodrigo B. Mansur
Summary: The study revealed that insulin resistance affects the efficacy of the antidepressant vortioxetine in patients with Major Depressive Disorder. Higher baseline insulin resistance predicted decreased early improvements in depressive symptoms and worsening cognitive function and functional impairment at the end of treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
David S. Baldwin, Oscar Necking, Simon Nitschky Schmidt, Hongye Ren, Elin H. Reines
Summary: The multimodal antidepressant vortioxetine is effective in reducing somatic symptoms in patients with major depressive disorder (MDD), and also effective in reducing depressive symptoms in patients with common comorbid physical illnesses. The rate and pattern of adverse events were consistent with that expected for vortioxetine treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Yuanyuan An, Junyi Shi, Hu Chuan-Peng, Xinchun Wu
Summary: This study utilized network analysis to investigate the comorbidity of PTSD and depression among college students with childhood abuse history, identifying key symptoms and trigger roles. The findings provide important insights for clinical intervention.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Mario Ignacio Zelada, Veronica Garrido, Andres Liberona, Natalia Jones, Karen Zuniga, Hernan Silva, Rodrigo R. Nieto
Summary: This article reviews the studies on the relationship between brain-derived neurotrophic factor (BDNF) and treatment response in major depressive disorder (MDD). A systematic review was conducted to explore the association between BDNF and both pharmacological and non-pharmacological treatment. The evidence related to peripheral levels of BDNF and BDNF polymorphisms in the development and management of treatment-resistant depression was also reviewed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Laura M. Fiori, Massimiliano Orri, Zahia Aouabed, Jean Francois Theroux, Rixing Lin, Corina Nagy, Benicio N. Frey, Raymond W. Lam, Glenda M. MacQueen, Roumen Milev, Daniel J. Muller, Sagar Parikh, Susan Rotzinger, Rudolf Uher, Jane A. Foster, Sidney H. Kennedy, Gustavo Turecki
Summary: By longitudinally assessing gene expression, we offer insights into the biological processes involved in the intermediate stages of escitalopram response, highlighting several genes with potential utility as biomarkers of antidepressant response.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Stephen Murata, Nausheen Baig, Kyle Decker, Angelos Halaris
Summary: This study retrospectively analyzed the treatment of bipolar depression and found that the baseline systemic inflammatory response index (SIRI) is correlated with the severity of depression and treatment response.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Isaure Estrade, Anne-Cecile Petit, Vincent Sylvestre, Michel Danon, Sylvain Leroy, Rebecca Perrain, Fabien Vinckier, Lila Mekaoui, Raphael Gaillard, Emmanuelle Advenier-Iakovlev, Rossella Letizia Mancusi, Daphnee Poupon, Pierre De Maricourt, Philip Gorwood
Summary: This study found that the MADRS score after the first administration of esketamine has a good capacity to predict the most plausible trajectory of treatment response in patients with treatment-resistant depression. This finding can help clinicians make decisions during the treatment process.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Matthew Bourke, Rhiannon K. Patten, Lisa Klamert, Bojana Klepac, Sarah Dash, Michaela C. Pascoe
Summary: The study found that acute bouts of physical activity can significantly improve affective states in people with depression. This effect is consistent across different types of affective states, exercise conditions, and participant characteristics. Future research should explore the impact of physical activity on affective states in non-experimental settings and investigate whether the affective response to physical activity can predict long-term antidepressant effects.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Roger S. McIntyre, Nelson B. Rodrigues, Orly Lipsitz, Yena Lee, Danielle S. Cha, Hartej Gill, Leanna M. W. Lui, Mehala Subramaniapillai, Kevin Kratiuk, Roger Ho, Rodrigo B. Mansur, Joshua D. Rosenblat
Summary: This study validated the McIntyre and Rosenblat Rapid Response Scale (MARRRS) for assessing the efficacy of the rapid-acting antidepressant ketamine. Results demonstrated high internal consistency, significant convergent validity with other assessment tools, and sensitivity to change of MARRRS during acute treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Jean Baptiste Yaro, Alfred B. Tiono, Alphonse Ouedraogo, Ben Lambert, Z. Amidou Ouedraogo, Amidou Diarra, Adama Traore, Malik Lankouande, Issiaka Soulama, Antoine Sanou, Eve Worrall, Efundem Agboraw, N'Fale Sagnon, Hilary Ranson, Thomas S. Churcher, Steve W. Lindsay, Anne L. Wilson
Summary: Burkina Faso has a high burden of malaria despite the implementation of malaria control measures. A study conducted in the country found that malaria infections were highest in children aged 5 to 15 years, despite the use of insecticide-treated nets. The study also showed that administering seasonal malaria chemoprevention to children aged 10 and 15 could significantly reduce malaria cases.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Luke Myhre, Joseph Featherall, Dillon O'Neill, David Rothberg, Justin Haller, Thomas Higgins, Lucas Marchand
Summary: There is an association between early postoperative anxiety symptoms and late recovery of self-reported physical function in patients with orthopaedic trauma. Psychosocial factors play an important role in the outcomes of orthopaedic trauma, in addition to injury severity or surgical treatment. Further research is needed to explore this association and the impact of psychosocial interventions on functional scores.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Yves de Roten, Slimane Djillali, Fabienne Crettaz von Roten, Jean-Nicolas Despland, Gilles Ambresin
Summary: This study investigated the predictive value of defensive functioning and defense mechanisms in determining the effectiveness of brief psychodynamic psychotherapy for recurrent and chronic depression in an inpatient setting. The results showed that changes in defensive functioning along with mature and immature defense mechanisms during therapy were predictive of treatment response, with the addition of psychotic defenses enhancing the prediction of treatment outcomes. The findings support the role of defensive functioning as a predictor of treatment outcomes and a mechanism of change in psychotherapy.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Melody J. Y. Kang, Gustavo H. Vazquez
Summary: This study evaluated the efficacy of acute intravenous ketamine treatment for treatment-resistant depression (TRD) and explored the peripheral blood-based biomarkers associated with treatment response. The results showed that ketamine significantly improved depressive symptoms and was well tolerated. In addition, baseline BDNF levels were found to be predictive of treatment response to ketamine.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Engineering, Environmental
Lu Wang, Tianlun Zhang, Tiangui Cai, Qian Xiang, Xiaohui Liu, Dong Zhu
Summary: Heavy metals and disinfectants can affect the spread of antibiotic resistance genes in soil microbes. The stability and availability of these substances, as well as the pH of the soil, play a role in the resistance profiles in soil. This study found that the simultaneous addition of arsenic and triclocarban increased the abundance of antibiotic resistance genes at pH > 6 due to co-selective pressures. Arsenic and triclocarban also influenced the spread of mobile genetic elements affecting the soil resistome. Additionally, pH altered the patterns of microbial inhabitants and impacted the prevalence of certain antibiotic resistance genes.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Cardiac & Cardiovascular Systems
Rishi K. Patel, Marianna Fontana, Frederick L. Ruberg
Summary: Cardiac amyloidosis (CA) is a disease characterized by the deposition of misfolded protein deposits in the myocardial interstitium, with varying degrees of severity and clinical manifestations. Contemporary therapies and imaging modalities play a crucial role in diagnosing and treating CA, leading to improved outcomes and understanding of the disease.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Psychology, Clinical
Chiara Fabbri, Julian Mutz, Cathryn M. Lewis, Alessandro Serretti
Summary: This study was the first to comprehensively evaluate the predictors of wellbeing in relation to the history of MDD. The identified variables are important to identify individuals at risk and promote wellbeing.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Marcelo B. Generoso, Ivan Taiar, Quirino Cordeiro, Pedro Shiozawa, Siegfried Kasper
Summary: Early treatment of psychotic illness is important for better outcomes, and cariprazine, a promising antipsychotic drug, may be beneficial in treating psychosis regardless of the diagnosis of schizophrenia or bipolar disorder.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Editorial Material
Neurosciences
Dekel Taliaz, Alessandro Serretti
Summary: The validity of clinical trials in psychiatry has been under discussion in the past two decades. The commonly used method of randomized controlled trials (RCTs) faces challenges when applied in the psychiatric field due to strict participant criteria and inconsistency in endpoint parameters. This has led to problematic clinical practice in psychiatry.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Psychiatry
Miquel Roca, Annalisa Bonelli, Agnese Cattaneo, Alessandro Comandini, Giorgio Di Dato, Franca Heiman, Valeria Pegoraro, Siegfried Kasper, Hans-Peter Volz, Diego Palao
Summary: This study explores the impact of pharmacological approaches in treating MDD patients and identifies factors associated with longer sick leave duration. Combination/switch/add-on treatments are associated with a higher risk of longer sick leave periods, while timely and careful selection of antidepressant treatment approach may help reduce sick leave.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Review
Psychiatry
Hans-Peter Volz, Johanna Stirnweiss, Siegfried Kasper, Hans-Juergen Moeller, Erich Seifritz
Summary: This paper reviews the research on subthreshold depression (SD) based on a scoping review. The results show that the operationalisation criteria used are highly heterogeneous, leading to inconsistent epidemiological data. The impact of SD on quality of life and related parameters is similar to that of major depression, and therapeutic approaches can be helpful in both preventing and treating SD.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Vincenzo Oliva, Giuseppe Fanelli, Manuel Zamparini, Cristina Zarbo, Matteo Rocchetti, Letizia Casiraghi, Fabrizio Starace, Alessandra Martinelli, Alessandro Serretti, Giovanni de Girolamo, DiAPASon Consortium
Summary: Antipsychotic polypharmacy (APP) is commonly used in patients with schizophrenia spectrum disorders (SSDs) despite recommendations against it. This study found high rates of APP and lower levels of physical activity in both residential and outpatient patients. However, patients on APP showed trends of reduced sedentariness and higher levels of light physical activity compared to those on monopharmacy.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Fabio Panariello, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Alessandro Serretti, Chiara Fabbri
Summary: This study aimed to identify factors associated with side effects of psychotropic drugs in a real-world setting enriched with treatment-resistant depression (TRD) patients. Results showed that the severity of depressive symptoms was associated with total, psychic, and neurological side effects, while autonomic side effects were higher in patients with somatic comorbidities and lower in patients receiving trazodone. Multivariate analyses revealed that depressive symptom severity was associated with psychic and total side effects, generalized anxiety disorder (GAD) with neurological side effects, and somatic comorbidities remained associated with autonomic side effects. Trazodone was associated with lower side effects and with augmentation treatments. Augmentation therapies showed opposite effects depending on response status, i.e. increased or decreased the risk of side effects in responders and non-responders/resistant patients, respectively.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Laura Mandelli, Yuri Milaneschi, Sarah Hiles, Alessandro Serretti, Brenda W. Penninx
Summary: An unhealthy lifestyle plays a crucial role in the development and progression of chronic disorders, and it may also affect biological systems involved in stress response. Using data from the Netherlands Study of Depression and Anxiety, researchers calculated a global index of unhealthy lifestyle based on five self-reported habits. They found that the index was associated with hyperactivity of the hypothalamus-pituitary-adrenal axis and increased inflammation, indicating that unhealthy habits increase biological stress. The use of drugs also impacted the autonomic nervous system activity.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Vincenzo Oliva, Giuseppe Fanelli, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Chiara Fabbri, Alessandro Serretti
Summary: This study found that different clinical subtypes of major depressive disorder (MDD), particularly melancholic features and typical neurovegetative symptoms, may be associated with distinct underlying genetics. These findings contribute to a better understanding of the genetic heterogeneity of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Genetics & Heredity
Raffaella Zanardi, Matteo Carminati, Francesco Attanasio, Chiara Fabbri, Alessandro Serretti
Summary: Nonpharmacological treatments for depression show effectiveness and tolerability in certain patients with diverse response. Genetic variables associated with treatment efficacy need to be examined to assist treatment selection. Most studies using candidate gene approach yielded poorly replicated findings due to small sample sizes, while a few methylome-wide and genome-wide association studies (GWASs) provided interesting results with the use of polygenic risk scores in small samples of electroconvulsive therapy (ECT) and cognitive-behavioral therapy. Further GWAS with larger sample sizes, such as the gen-ECT-ic consortium, can enhance our understanding of the genetic factors underlying treatment response in nonpharmacological therapies for depression.
PSYCHIATRIC GENETICS
(2023)
Article
Psychiatry
Daniele Rucco, Guendalina Gentile, Stefano Tambuzzi, Beatrice Fanton, Raffaella Calati, Riccardo Zoja
Summary: This retrospective study investigated the characteristics of hospital inpatient suicides in Milan, Italy over a twenty-eight-year period from 1993 to 2020. The study compared the features of suicides in patients with psychiatric diagnoses and those without. Data were collected from historical archives, annual registers, and autopsy reports. The results showed that the majority of inpatient suicides were men of Italian nationality, admitted to non-psychiatric wards, with a single illness, treated with psychotropic medications, who used violent suicide methods and died of organic injuries outside the buildings. Comparing psychiatric and non-psychiatric inpatients, suicide cases with a non-psychiatric diagnosis were predominantly men, hospitalized in non-psychiatric wards, assuming non-psychotropic drugs, and died in outside hospital spaces.
SUICIDE AND LIFE-THREATENING BEHAVIOR
(2023)
Review
Neurosciences
Alessandro Serretti
Summary: Anhedonia is a core symptom of depression and other psychiatric disorders, referring to a lack of pleasure or reward. It is not only a psychological distress but also encompasses a range of reward processing deficits. Anhedonia is a relevant risk factor for suicidal behaviors and may operate independently of the severity of depressive episodes. It has also been associated with inflammation, which can have a reciprocal detrimental effect on depression. The neurophysiological bases of anhedonia mainly involve changes in striatal and prefrontal areas, with dopamine playing a key role as the neurotransmitter involved. Anhedonia is believed to have a significant genetic component and polygenic risk scores may be a tool for predicting an individual's risk for developing anhedonia. Traditional antidepressants have shown limited benefit in treating anhedonia, also considering their potential to worsen anhedonia in some individuals. Other treatments such as agomelatine, vortioxetine, ketamine, and transcranial magnetic stimulation may be more effective. Psychotherapy, particularly cognitive-behavioral therapy and behavioral activation, is widely supported as beneficial for anhedonia. In conclusion, evidence suggests that anhedonia is partially independent from depression and requires careful evaluation and targeted treatment.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychiatry
Alexander Kautzky, Lucie Bartova, Gernot Fugger, Markus Dold, Daniel Souery, Stuart Montgomery, Joseph Zohar, Julien Mendlewicz, Chiara Fabbri, Alessandro Serretti, Dan Rujescu, Siegfried Kasper
Summary: This study investigates the differences in presentation and treatment outcomes of treatment-resistant depression (TRD) among different age groups. It finds that age has an impact on depressive symptoms and treatment outcomes. In TRD patients, symptom load and hospitalization time increase with age, while treatment responders do not show this trend. Older patients are more likely to have symptoms such as inner tension, reduced appetite, concentration difficulties, and lassitude.
EUROPEAN PSYCHIATRY
(2023)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)