Article
Clinical Neurology
Frederic Briend, Laurent Barantin, Helen Clery, Jean-Philippe Cottier, Frederique Bonnet-Brilhault, Emmanuelle Houy-Durand, Marie Gomot
Summary: In this study, the glutamate levels in the bilateral anterior cingulate cortex were analyzed in high-functioning autistic adults using proton magnetic resonance spectroscopy. No significant differences in glutamate levels were found between the autistic group and the control group. The study emphasizes the importance of analyzing the GABAergic pathway for better understanding the neuropathology of autism.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Alice B. Van Derveer, Jordan M. Ross, Jordan P. Hamm
Summary: Context modulates how information is processed in the mammalian brain. This study investigates the manifestation of neural deviance detection in the cortex, specifically in the parietal associative area and primary visual cortex, when exposed to unisensory and multisensory deviants. The results suggest that deviance detection signals in the cortex can be conceptualized as prediction errors, exhibiting a hierarchical distribution across cortical networks.
Article
Biochemistry & Molecular Biology
Anna Todeva-Radneva, Sevdalina Kandilarova, Rositsa Paunova, Drozdstoy Stoyanov, Tina Zdravkova, Ronald Sladky
Summary: This study aimed to explore possible differences in whole-brain functional connectivity in patients with major depressive disorder (MDD), bipolar disorder (BD), and healthy controls (HC). The results showed increased connectivity in certain brain regions in the BD group compared to the HC group, while the MDD group showed enhanced connectivity in different regions. These findings suggest that these connectivity patterns may serve as potential diagnostic biomarkers for MDD and BD.
Article
Neurosciences
Marcos Domic-Siede, Martin Irani, Joaquin Valdes, Marcela Perrone-Bertolotti, Tomas Ossandon
Summary: The study reveals the importance of cognitive planning in human goal-directed behavior, with different brain regions playing specific roles in the planning process. Activity in the prefrontal cortex is associated with increased time needed for plan elaboration, while activity in the frontopolar cortex is negatively correlated with execution time, indicating its role in efficiency and accuracy in plan execution. Theta activity in different brain regions reflects high cognitive demand and the successful generation of self-made plans.
Article
Psychiatry
Huan Wang, Rongxin Zhu, Shui Tian, Siqi Zhang, Zhongpeng Dai, Junneng Shao, Li Xue, Zhijian Yao, Qing Lu
Summary: By studying the dynamic functional connectivity in patients with bipolar disorder, the dysfunction of anterior cingulate cortex (ACC) was found to be relevant to suicide attempts. Specifically, suicide attempt patients showed significantly reduced dwell time in the suicide-related functional state, accompanied by a significantly increased functional connectivity strength between the right ACC and the regions within the subcortical network. These altered indicators were significantly correlated with suicide risk.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Samara J. Brown, Amelia M. Brown, Tertia D. Purves-Tyson, Xu-Feng Huang, Cynthia Shannon Weickert, Kelly A. Newell
Summary: This study found that the glutamatergic system may play a central role in the neurobiology and treatment of major depressive disorder (MDD) and psychosis. Gene expression measurement showed increased levels of GRIN2B mRNA and a trend increase in GRIN1 mRNA in MDD subjects, suggesting dysfunction of the glutamatergic system in MDD. Additionally, a significant decrease in the GRIN2A:GRIN2B mRNA ratio was observed in MDD subjects with psychosis.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ariel Furstenberg, Haim Sompolinsky, Leon Y. Deouell
Summary: Some decisions are important, but most are arbitrary and inconsequential. This study investigates the mechanisms involved in arbitrary picking decisions and suggests that they are subject to similar control mechanisms as reasoned decisions. The findings provide new directions in understanding decision-making and its deficits.
Article
Clinical Neurology
Hyun Chan Hwang, Sun Mi Kim, Doug Hyun Han
Summary: The study found that schizophrenic patients have lower emotional perception abilities compared to bipolar disorder patients, indicating disrupted emotional perception abilities are linked to altered brain functional connectivity. Schizophrenic patients show reduced usage of the frontal lobe, while bipolar patients compensate for facial emotion recognition using the parietal lobe.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Behavioral Sciences
Caroline Tandetnik, Elisa Sohier, Laurent Capelle, Viviane du Boullay, Michael Obadia, Mariam Chammat, Nadya Pyatigorskaia, Lionel Naccache
Summary: The free choice paradigm is extensively studied in cognitive dissonance research, with recent studies showing that choice-induced preference changes only occur for remembered choices, requiring normal functioning of executive networks. The crucial role of executive functions mediated by the frontal lobe in cognitive dissonance resolution has been demonstrated.
Article
Psychiatry
Atle Brathen Pentz, Clara Maria Fides Timpe, Elizabeth Marie Normann, Nora Berz Slapo, Ingrid Melle, Trine Vik Lagerberg, Nils Eiel Steen, Lars T. Westlye, Erik G. Jonsson, Unn K. Haukvik, Torgeir Moberget, Ole A. Andreassen, Torbjrn Elvsashagen
Summary: Research indicates that MMN is attenuated in schizophrenia and correlates with the severity of psychotic symptoms and level of functioning, possibly indicating gender-dependent differences in glutamatergic function.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Clinical Neurology
Norma Verdolini, Marta Moreno-Ortega, Pilar Salgado-Pineda, Gemma Monte, Ana Martinez de Aragon, Monica Dompablo, Peter J. McKenna, Raymond Salvador, Tomas Palomo, Edith Pomarol-Clotet, Roberto Rodriguez-Jimenez
Summary: This study examined the brain activity of bipolar disorder patients during the Stroop task and found that there were no differences in activation between the patients and healthy subjects. However, the patients showed significant failure of de-activation in specific brain regions. These findings suggest that the regulatory component of cognitive control remains intact in bipolar disorder, but there may be dysfunction in the default mode network.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Veronica Pelliccia, Pietro Avanzini, Michele Rizzi, Fausto Caruana, Laura Tassi, Stefano Francione, Francesca Gozzo, Valeria Mariani, Piergiorgio d'Orio, Laura Castana, Roberto Mai, Michele Terzaghi, Lino Nobili, Ivana Sartori
Summary: Cingulate epilepsy is characterized by complex behaviors accompanied by emotional components. Different ictal variables have distinct distribution patterns among cingulate cortex subregions.
Article
Psychiatry
Juanita Todd, Zachary Howard, Ryszard Auksztulewicz, Dean Salisbury
Summary: This study used computational modeling and dynamic causal modeling to investigate differences in perception and processing of sound in patients with schizophrenia-spectrum disorders. The results suggest that these differences are associated with changes in intrinsic connectivity within the brain regions, and these changes become more pronounced as the illness progresses. The modeling results also revealed differences in neural activity and plasticity between the first-episode schizophrenia-spectrum group and the established illness group.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Steliana Yanakieva, Mathias L. Mathiasen, Eman Amin, Andrew J. D. Nelson, Shane M. O'Mara, John P. Aggleton
Summary: This study compared collateral projections from different rostral thalamic nuclei terminating in different cortical areas. The results showed that these projections predominantly arise from separate populations of neurons with discrete cortical termination zones.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Niels T. de Joode, Anders L. Thorsen, Eline L. Vester, Chris Vriend, Petra J. W. Pouwels, Kristen Hagen, Olga T. Ousdal, Bjarne Hansen, Gerd Kvale, Odile A. van den Heuvel
Summary: The study found no abnormalities in neurometabolites in the dACC of OCD patients before treatment or over time, and the changes induced by ERP treatment seem to depend more on comorbid mood disorders and disease stage rather than OCD itself.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Health Policy & Services
Caroline X. Gao, Lachlan P. McDonald, Matthew P. Hamilton, Koen Simons, Jana M. Menssink, Kate Filia, Debra Rickwood, Simon Rice, Ian Hickie, Patrick D. McGorry, Sue M. Cotton
Summary: The authors evaluated the changes in the use of government-subsidized primary mental health services by young people during the first year of the COVID-19 pandemic in Australia. They found that overall, there was an increase in the use of these services, but the increase was unevenly distributed among different age, sex, and socioeconomic status groups.
PSYCHIATRIC SERVICES
(2023)
Article
Psychiatry
William Capon, Ian B. Hickie, Sarah McKenna, Mathew Varidel, Matthew Richards, Haley M. LaMonica, Daniel Rock, Elizabeth M. Scott, Frank Iorfino
Summary: This study utilized digital technology to assess the clinical needs of young people presenting for care at headspace centers across Australia. The findings showed significant variations in demographics, types of needs, and severity of needs across different services and geographical locations. The heterogeneity of youth mental health populations suggests the importance of appropriate early intervention and prevention service provisions.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Psychiatry
Sarah Bendall, Oliver Eastwood, Tim Spelman, Patrick McGorry, Ian Hickie, Alison R. Yung, Paul Amminger, Stephen J. Wood, Christos Pantelis, Rosemary Purcell, Lisa Phillips
Summary: This study found that childhood trauma is common in youth mental health services and is associated with a mixture of affective, anxiety, and psychotic symptoms. Exposure to multiple types of trauma is common. Childhood trauma is significantly associated with each symptom domain, and more severe trauma is more strongly associated with symptom clustering.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Psychiatry
Harvey Whiteford, Nasser Bagheri, Sandra Diminic, Joanne Enticott, Caroline X. Gao, Matthew Hamilton, Ian B. Hickie, Long Khanh-Dao Le, Yong Yi Lee, Katrina M. Long, Patrick McGorry, Graham Meadows, Cathrine Mihalopoulos, Jo-An Occhipinti, Daniel Rock, Sebastian Rosenberg, Luis Salvador-Carulla, Adam Skinner
Summary: Australia's Fifth National Mental Health Plan requires governments to report on the progress of mental health service delivery changes and plan for future service provision. Modelling uncertain demands on the system can help decision-makers understand future changes in mental health service demand and choose appropriate responses. Modelling can also enhance scrutiny, accountability, and transparency of these processes.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Biology
Timothy R. Wong, Ian B. Hickie, Joanne S. Carpenter, Elizabeth M. Scott, Adam J. Guastella, Parisa Vidafar, Jan Scott, Daniel F. Hermens, Jacob J. Crouse
Summary: There is limited evidence that chronotype can predict future hypo/manic and depressive symptoms in young people with emerging mental disorders.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Mafruha Alam, Ian B. Hickie, Adam Poulsen, Mahalakshmi Ekambareshwar, Victoria Loblay, Jacob Crouse, Gabrielle Hindmarsh, Yun J. C. Song, Adam Yoon, Grace Cha, Chloe Wilson, Madelaine Sweeney-Nash, Jakelin Troy, Haley M. LaMonica
Summary: By utilizing digital technologies and iterative codesign, the Thrive by Five International Program has developed a culturally relevant app to support early child development in low-income and middle-income countries in Asia and Africa, addressing the lack of support from parents and caregivers.
Article
Medicine, General & Internal
Chloe Wilson, Joanne Sarah Carpenter, Alissa Nichles, Natalia Zmicerevska, Yun Ju Christine Song, Catherine McHugh, Blake Hamilton, Samuel Hockey, Jacob Crouse, Dagmar Koethe, Elizabeth M. Scott, Ian B. Hickie
Summary: This study aims to investigate the efficacy of metformin pharmacotherapy as an adjunct to a healthy lifestyle behavioral intervention in improving cardiometabolic outcomes, and depressive, anxiety, and psychotic symptoms in youth with clinically diagnosed major mood syndromes. At least 266 young people aged 16-25 presenting for mental healthcare will be invited to participate, and they will undergo a 12-week sleep-wake, activity, and metabolically focused behavioral intervention program. The results of this study will be disseminated through various outlets to reach the scientific and broader community.
Article
Psychiatry
William Capon, Ian B. Hickie, Masoud Fetanat, Mathew Varidel, Haley M. LaMonica, Ante Prodan, Sarah Piper, Tracey A. Davenport, Sarah Mughal, Jai L. Shah, Elizabeth M. Scott, Frank Iorfino
Summary: This study aimed to understand the clinical needs of young people aged 12-25 presenting to primary youth mental health services through multidimensional assessments. Three different illness stages were identified, highlighting the importance of multidimensional assessments for determining appropriate service pathways and care options.
COMPREHENSIVE PSYCHIATRY
(2023)
Article
Psychiatry
Jan Scott, Jacob J. Crouse, Sarah Medland, Enda Byrne, Frank Iorfino, Brittany Mitchell, Nathan A. Gillespie, Nicholas Martin, Naomi Wray, Ian B. Hickie
Summary: The study found that combining polygenic risk scores (PRS) with other risk factors may improve outcome prediction in youth. Adding PRS improved prediction of mood and/or psychotic disorder cases, as shown in receiver operating curve and logistic regression analyses.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychiatry
M. J. C. Formica, M. Fuller-Tyszkiewicz, I. Hickie, L. Olive, S. J. Wood, R. Purcell, A. R. Yung, L. J. Phillips, B. Nelson, C. Pantelis, P. D. Mcgorry, J. A. Hartmann
Summary: This study aimed to investigate the relationship between self-reported sleep disturbance and the development of attenuated psychotic symptoms (APS), while adjusting for anxiety and depressive symptoms. The results showed that self-reported sleep disturbance had both direct and indirect predictive relationships with APS domains, with anxiety and depressive symptoms mediating some of these relationships.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Medicine, General & Internal
Ian B. Hickie, Frank Iorfino, Cathrin Rohleder, Yun Ju Christine Song, Alissa Nichles, Natalia Zmicerevska, William Capon, Adam J. Guastella, F. Markus Leweke, Jan Scott, Patrick Mcgorry, Cathrine Mihalopoulos, Eoin Killackey, Min K. Chong, Sarah Mckenna, Melissa Aji, Carla Gorban, Jacob J. Crouse, Dagmar Koethe, Robert Battisti, Blake Hamilton, Alice Lo, Maree L. Hackett, Daniel F. Hermens, Elizabeth Mind Plasticity Consortia, headspace Camperdown Consortia, Elizabeth M. Scott
Summary: The objective of this study is to test whether a highly personalised and measurement-based care approach delivers better functional improvements than standard care and digital support.
Article
Psychology, Clinical
Erin Kelty, Kate Chitty, David B. Preen
Summary: This study investigated the impact of alprazolam use in pregnancy on maternal and neonatal health. Data from state administrative prescribing records and perinatal data were used to identify women prescribed alprazolam during pregnancy, as well as comparison groups of women. The results showed that while alprazolam use during pregnancy did not increase the risk of severe adverse neonatal outcomes, it was associated with a higher likelihood of neonates being born with low birth weight for gestational age.
JOURNAL OF PSYCHOACTIVE DRUGS
(2023)
Article
Medicine, General & Internal
Kate M. Chitty, Sandro Sperandei, Gregory L. Carter, Zein Ali, Jacques E. Raubenheimer, Andrea L. Schaffer, Andrew Page, Nicholas A. Buckley
Summary: Studying healthcare engagement patterns of individuals who died by suicide can provide alternative directions for suicide prevention. Most suicide decedents had at least one healthcare contact in the year before death, but contact frequency was overall very low. Therefore, suicide preventive interventions should be delivered in the community, workplace, schools, or online platforms.
Meeting Abstract
Psychiatry
M. Hopwood, E. Scott, B. Schoeninger, P. Rocha, G. Stratton, A. Puig, J. King, G. Joks, I. Hickie
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
M. Hopwood, E. Scott, B. Schoeninger, P. Rocha, G. Stratton, A. Puig, J. King, G. Joks, I. Hickie
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)