Article
Biochemistry & Molecular Biology
Ana L. Moreno-Salinas, Brian J. Holleran, Estefania Y. Ojeda-Muniz, Kerlys G. Correoso-Brana, Sheila Ribalta-Mena, Jose-Carlos Ovando-Zambrano, Richard Leduc, Antony A. Boucard
Summary: Research has uncovered genetic variants in the Lphn3 gene that are associated with ADHD. These variants affect the function of the Lphn3 receptor, particularly its coupling with G protein signaling. These findings provide new insights into the pathogenesis of ADHD.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Barbara D. Fontana, Florian Reichmann, Ceinwen A. Tilley, Perrine Lavlou, Alena Shkumatava, Nancy Alnassar, Courtney Hillman, Karl aegir Karlsson, William H. J. Norton, Matthew O. Parker
Summary: Externalizing disorders (ED) are a public health concern and have a high heritability. The ADGRL3 gene is strongly associated with EDs and affects various ED-related behaviors. This study found that adgrl3.1(-/-) zebrafish exhibited impulsive, risk-taking, attention deficits, and hyperactive behaviors, which could be rescued by atomoxetine. Transcriptomic analysis revealed potential functional pathways and targets for the treatment of ED.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Monica S. Carbajal, Asiah J. C. Bounmy, Olivia B. Harrison, Hunter G. Nolen, Samantha L. Regan, Michael T. Williams, Charles V. Vorhees, Helen J. K. Sable
Summary: Impulsive choice was examined in rats with Lphn3 deletion and spontaneously hypertensive rats (SHRs) using a delay-discounting task. Only SHRs showed a decrease in choosing the larger reward. There was no effect of Lphn3 deletion on impulsive choice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Weam Fageera, Sarojini M. Sengupta, Marie-Eve Fortier, Natalie Grizenko, Svetlana Babienco, Aurelie Labbe, Ridha Joober
Summary: The study found a significant association of the TPH2 rs17110747 variant in female ADHD probands, with potential involvement in behavioral and cognitive dimensions of ADHD. Furthermore, female probands with the G/G genotype showed greater response to placebo.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Ting Wu, Xiaoli Liu, Fang Cheng, Shuai Wang, Chang Li, Dongsheng Zhou, Wenwu Zhang
Summary: This study investigated brain activity changes in children with ADHD using functional near-infrared spectroscopy (fNIRS) during a go/no-go task, compared to typically developing children. The results showed lower changes in average oxygenated hemoglobin signaling in the dorsolateral prefrontal cortices of the ADHD group, indicating brain dysfunction. The go/no-go task paired with fNIRS is a useful tool for assessing prefrontal brain dysfunction in children with ADHD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pediatrics
Christine Strand Bachmann, Kari Risnes, Johan Hakon Bjorngaard, Jorun Schei, Kristine Pape
Summary: The study examines the impact of relative age on mental health, specifically in preterm infants. The results show that being relatively young within a school class is associated with an increased likelihood of psychostimulant prescription, and this effect persists into young adulthood for preterm individuals.
Article
Microbiology
Yoon Jae Cho, Bokyoung Shin, Sung-Ha Lee, Sangmin Park, Yoon-Keun Kim, Jae-Jin Kim, Eunjoo Kim
Summary: This study analyzed urine microbiome profiles to explore the potential of the urine microbiome as a biomarker for pediatric ADHD. The ADHD group showed decreased alpha diversity and significant beta diversity differences compared to the control group. The genus Afipia exhibited significant correlations with ADHD symptoms, suggesting its potential as a biomarker for ADHD.
Article
Multidisciplinary Sciences
Ana Moreno-Alcazar, Josep A. Ramos-Quiroga, Marta Ribases, Cristina Sanchez-Mora, Gloria Palomar, Rosa Bosch, Josep Salavert, Lydia Fortea, Gemma C. Monte-Rubio, Erick J. Canales-Rodriguez, Michael P. Milham, F. Xavier Castellanos, Miquel Casas, Edith Pomarol-Clotet, Joaquim Radua
Summary: The study found that both risk and protective ADGRL3 haplotypes are associated with significant hypo-activation in the brain during working memory tasks. However, there were no brain effects of the interactions between adult ADHD and ADGRL3 haplotypes.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Multidisciplinary
Najme Ariyan, Sana Nourimoghadam
Summary: This study compared the levels of mindfulness in children with ADHD and typically developing children, as well as their mothers. The findings showed that children with ADHD and their mothers had significantly lower levels of mindfulness compared to typically developing children and their mothers. This suggests that childhood mental disorders like ADHD can reduce mindfulness in children and their mothers.
CURRENT PSYCHOLOGY
(2023)
Article
Clinical Neurology
Alasdair Vance, Jo Winther
Summary: The study revealed that MDD is associated with more severe SWM impairment compared to DD, and there is no additive effect of MDD and DD on SWM deficits. Furthermore, these findings are consistent across different age groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Lorenzo Soldati, Francesco Bianchi-Demicheli, Pauline Schockaert, John Kohl, Mylene Bolmont, Roland Hasler, Nader Perroud
Summary: The literature review examines the association between ADHD, hypersexuality, and paraphilias, finding that individuals with ADHD may report these behaviors but the frequency of hypersexuality and paraphilias in the ADHD population is not definitively established. Conversely, studies suggest a high prevalence of ADHD in individuals with hypersexuality and paraphilias. The review is limited by methodological differences, varying measurement instruments, and small sample sizes in existing studies.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ahmet Ozaslan, Esra Guney, Mehmet Ali Ergun, Ilyas Okur, Dilek Yapar
Summary: This study found associations between LPHN3 gene polymorphisms (rs6551665 and rs1947274) and ADHD, indicating that the GG genotype and CC genotype may increase the risk of ADHD, especially in male participants. Additionally, high severity of ADHD and the GG genotype of the LPHN3 rs6551665 polymorphism were associated with poor response to treatment.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Ozgun Kaya Kara, Hasan Atacan Tonak, Koray Kara, Hazal Sonbahar Ulu, Barkin Kose, Sedef Sahin, Mahmut Zabit Kara
Summary: This study compared the participation, support, and barriers for children with ADHD at home pre-COVID-19 and during the COVID-19 outbreak. Results showed a significant increase in participation frequency in activities like computer games, socializing, and household chores during the COVID-19 period. Mothers reported higher involvement levels and easier participation due to reduced cognitive and social demands, as well as more readily available resources in the home environment during the COVID-19 period.
Article
Psychiatry
Rickard Ahlberg, E. Du Rietz, E. Ahnemark, L. M. Andersson, T. Werner-Kiechle, P. Lichtenstein, H. Larsson, M. Garcia-Argibay
Summary: Studies have shown that individuals with ADHD are more likely to experience functional impairments in social and occupational settings, but there is limited evidence on real-life instability. It is also unclear if these impairments differ across sex and throughout adulthood.
Review
Neurosciences
Martine Hoogman, Daan van Rooij, Marieke Klein, Premika Boedhoe, Iva Ilioska, Ting Li, Yash Patel, Merel C. Postema, Yanli Zhang-James, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Tobias Banaschewski, Claiton H. D. Bau, Marlene Behrmann, Mark A. Bellgrove, Daniel Brandeis, Silvia Brem, Geraldo F. Busatto, Sara Calderoni, Rosa Calvo, Francisco X. Castellanos, David Coghill, Annette Conzelmann, Eileen Daly, Christine Deruelle, Ilan Dinstein, Sarah Durston, Christine Ecker, Stefan Ehrlich, Jeffery N. Epstein, Damien A. Fair, Jacqueline Fitzgerald, Christine M. Freitag, Thomas Frodl, Louise Gallagher, Eugenio H. Grevet, Jan Haavik, Pieter J. Hoekstra, Joost Janssen, Georgii Karkashadze, Joseph A. King, Kerstin Konrad, Jonna Kuntsi, Luisa Lazaro, Jason P. Lerch, Klaus-Peter Lesch, Mario R. Louza, Beatriz Luna, Paulo Mattos, Jane McGrath, Filippo Muratori, Clodagh Murphy, Joel T. Nigg, Eileen Oberwelland-Weiss, Ruth L. O'Gorman Tuura, Kirsten O'Hearn, Jaap Oosterlaan, Mara Parellada, Paul Pauli, Kerstin J. Plessen, J. Antoni Ramos-Quiroga, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G. P. Rosa, Katya Rubia, Philip Shaw, Tim J. Silk, Leanne Tamm, Oscar Vilarroya, Susanne Walitza, Neda Jahanshad, Stephen Faraone, Clyde Francks, Odile A. van den Heuvel, Tomas Paus, Paul M. Thompson, Jan K. Buitelaar, Barbara Franke
Summary: Neuroimaging has been extensively used to study brain structure and function in individuals with ADHD and ASD. However, there have been limitations in the current literature, such as small sample sizes and heterogeneous methods. To address these limitations, the ENIGMA-ADHD and ENIGMA-ASD working groups were established to collaborate on large-scale neuroimaging projects. The findings so far have shown overlap and unique differences in cortical structures between ASD and ADHD. Ongoing work is exploring other research questions.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Cristopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia De la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis Van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Sophia Frangou
Summary: Age has a significant impact on brain volume, with different regions showing varying trajectories. Basal ganglia volume decreases with age, while lateral ventricles continue to enlarge. These findings provide important insights into the functional significance of age-related morphometric patterns in the brain.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Sophia Frangou, Amirhossein Modabbernia, Steven C. R. Williams, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Christopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Danai Dima
Summary: The study used data from the ENIGMA Consortium to explore the relationship between age and cortical thickness, finding that most regions peak in cortical thickness during childhood, with a negative association between age and cortical thickness where the slope is steeper before the age of 30 and more gradual afterwards.
HUMAN BRAIN MAPPING
(2022)
Article
Behavioral Sciences
Atae Akhrif, Arunima Roy, Katharina Peters, Klaus-Peter Lesch, Marcel Romanos, Angelika Schmitt-Boehrer, Susanne Neufang
Summary: The study aimed to validate the ADHD experimental model by considering allelic variation of TPH2 function. Results showed that the relation between TPH2 G-703T and aggression was mediated by structure and function of specific brain regions. Reverse phenotyping proved to be a promising method to validate experimental models and human findings for refined analysis of disease mechanisms.
BRAIN AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Britt Mossink, Jon-Ruben Van Rhijn, Shan Wang, Katrin Linda, Maria R. Vitale, Johanna E. M. Zoller, Eline J. H. van Hugte, Jitske Bak, Anouk H. A. Verboven, Martijn Selten, Moritz Negwer, Brooke L. Latour, Ilse van der Werf, Jason M. Keller, Teun M. Klein Gunnewiek, Chantal Schoenmaker, Astrid Oudakker, Alessia Anania, Sophie Jansen, Klaus-Peter Lesch, Monica Frega, Hans van Bokhoven, Dirk Schubert, Nael Nadif Kasri
Summary: This study revealed the regulatory role of CDH13 in inhibitory synapse function by establishing a human neuronal model. By culturing iGABAs in vitro, we found that CDH13 deficiency increases inhibition, thereby reducing the excitatory/inhibitory balance. Through these findings, we identified a potential mechanism by which CDH13 may contribute to the pathophysiology of brain disorders.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Moritz Julian Maier, Julian Elias Schiel, David Rosenbaum, Martin Hautzinger, Andreas Jochen Fallgatter, Ann-Christine Ehlis
Summary: Successful emotion regulation is closely associated with the cognitive control network, with individuals high in cognitive control showing implicit capabilities for emotion regulation, while those low in cognitive control require external instructions for explicit emotion regulation to achieve similar levels of emotional expression.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Alina Haipt, David Rosenbaum, Kristina Fuhr, Martin Giese, Anil Batra, Ann-Christine Ehlis
Summary: In this study, the neuronal mechanisms of functional reorganization after hypnotherapy (HT) for depressed patients were investigated. The results showed that HT had differential effects on the patients' emotional processing, depending on their rumination style. The study suggests that HT affects emotional processing and this effect is moderated by rumination.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tatyana Strekalova, Dmitrii Pavlov, Alexander Trofimov, Daniel C. Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch, Raymond Cespuglio
Summary: The role of hippocampal cyclooxygenase-2 (COX-2) in stress-induced anhedonia has been investigated. Inhibition of COX-2 in the hippocampus has antidepressant effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Tatyana Strekalova, Yanzhi Liu, Daniel Kiselev, Sharafuddin Khairuddin, Jennifer Lok Yu Chiu, Justin Lam, Ying-Shing Chan, Dmitrii Pavlov, Andrey Proshin, Klaus-Peter Lesch, Daniel C. Anthony, Lee Wei Lim
Summary: The Chronic Mild Stress (CMS) paradigm is a widely used model for finding antidepressant drugs for Major Depressive Disorder (MDD). While literature analysis supports the validity of this model, further improvements could be achieved by stratifying animals, using refined experimental protocols, and systematically evaluating non-specific effects.
PSYCHOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Noelia Fernandez-Castillo, Judit Cabana-Dominguez, Djenifer B. Kappel, Barbara Torrico, Heike Weber, Klaus-Peter Lesch, Oscar Lao, Andreas Reif, Bru Cormand
Summary: By studying genes related to Mendelian disorders presenting with ADHD symptoms, we identified new candidate risk genes for ADHD that are mainly associated with neurodevelopment and brain function. We also found rare variants associated with the severity of inattention symptoms and identified common variants associated with ADHD and its comorbidities.
Article
Genetics & Heredity
Andrew D. Grotzinger, Travis T. Mallard, Wonuola A. Akingbuwa, Hill F. Ip, Mark J. Adams, Cathryn M. Lewis, Andrew M. McIntosh, Jakob Grove, Soren Dalsgaard, Klaus-Peter Lesch, Nora Strom, Sandra M. Meier, Manuel Mattheisen, Anders D. Borglum, Ole Mors, Gerome Breen, Phil H. Lee, Kenneth S. Kendler, Jordan W. Smoller, Elliot M. Tucker-Drob, Michel G. Nivard
Summary: A joint analysis of 11 major psychiatric disorders identified four broad factors underlying the genetic correlations among the disorders, along with multiple loci acting on these factors. These findings suggest the presence of genetic overlap among different psychiatric disorders, but also highlight the heterogeneity within each factor. However, a single dimension of genetic risk does not appear to be useful in explaining the biobehavioral correlates or individual variants of psychiatric disorders.
Article
Cell Biology
Evgeniy Svirin, Ekaterina Veniaminova, Joao Pedro Costa-Nunes, Anna Gorlova, Aleksei Umriukhin, Allan Kalueff, Andrey Proshin, Daniel C. Anthony, Andrey Nedorubov, Anna Chung Kwan Tse, Susanne Walitza, Lee Wei Lim, Klaus-Peter Lesch, Tatyana Strekalova
Summary: The interaction between brain serotonin deficiency and environmental adversity leads to excessive aggression in females. Complete inactivation of the gene encoding tryptophan hydroxylase-2 results in the absence of neuronal serotonin synthesis and aggression in male and female mice. Moderate reduction in brain serotonin levels and exposure to stress also lead to increased aggression in male mice. Furthermore, changes in gene expression and myelination-related processes may underlie the molecular mechanisms of aggressive behavior.
Article
Genetics & Heredity
Liliana Elizabeth Rodriguez-Salgado, Claudia Tamar Silva-Aldana, Esteban Medina-Mendez, Jose Bareno-Silva, Mauricio Arcos-Burgos, Daniel Felipe Silgado-Guzman, Carlos M. Restrepo
Summary: This study aimed to determine the prevalence of secondary findings (SF) in a Colombian population for 59 genes associated with 27 genetic diseases. The results showed that 8.13% of patients had pathogenic variants in 11 genes. No association was found between socio-demographic variables and the need to report SF. This study provides the first approach to the spectrum of actionable pathogenic variants in the Colombian population.
Article
Multidisciplinary Sciences
Oscar M. Vidal, Jorge I. Velez, Mauricio Arcos-Burgos
Summary: Attention deficit/hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder. This study examined the impact of non-synonymous SNPs in the ADGRL3 gene on ADHD development. The findings suggest that these mutations disrupt the normal structure of ADGRL3 and may affect its metabolic regulation, potentially linking ADHD to the pathogenesis of diabetes mellitus.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Yina D. Carrillo, Paula Rueda-Gaitan, Orlando Gualdron, Carlos Estrada-Serrato, Taryn A. Castro-Cuesta, Olga Londono, Luna Rodriguez-Salazar, Mario Isaza-Ruget, Mauricio Arcos-Burgos, Juan Javier Lopez Rivera
Summary: Copy number variants (CNVs) are a major cause of neurodevelopmental delay and congenital malformations, and chromosomal microarray analysis (CMA) is the gold standard for molecular characterization of CNVs. We applied CMA in the clinical diagnostic process of patients as requested by their medical provider. Among 3380 patients, we identified 830 CNVs with potential clinical significance, and 10.6% of them were most likely the final cause of the patients' clinical phenotype. The rate of pathogenic or likely pathogenic findings among patients with CNVs was 60.75% for neurodevelopmental phenotypes and 59% for epileptic phenotypes.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)