期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 21, 期 12, 页码 880-884出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2011.02.001
关键词
Dementia; Genetic imaging; Working memory; Clusterin; Hippocampus; Prefrontal cortex
资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/G021538]
- Wales Institute of Cognitive Neuroscience (WICN)
- MRC [G0700102] Funding Source: UKRI
- Medical Research Council [G0700102, G0801418B] Funding Source: researchfish
Recent GWAS identified a risk variant for Alzheimer's disease (AD) at a locus (rs11136000) of the clusterin gene (CLU). Here we use functional magnetic resonance imaging (fMRI) during working memory to probe the effect of the risk variant on brain activation in healthy individuals. Participants with the CLU risk genotype had higher activity than participants with the protective allele in frontal and posterior cingulate cortex and the hippocampus, particularly during high memory demand. These results inform pathophysiological models of the preclinical progression of AD. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.
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