期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 19, 期 4, 页码 250-255出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2008.12.001
关键词
Vagus nerve stimulation (VNS); Stimulation parameters; Serotonin; Electrophysiology; Depression
资金
- Canadian Institute in Health Research [UOP-71713]
- Cyberonics Inc. Houston, Texas
Vagus nerve stimulation (VNS) is a recently approved adjunctive intervention for treatment-resistant depression. This therapy enhances the firing rate of rat norepinephrine neurons after 1 h and that of serotonin (5-HT) neurons only after 14 days. Various stimulation parameters were thus tested on their capacity to enhance 5-HT neuronal firing because of the delayed action of VNS on the 5-HT system and its important rote in the antidepressant response. Rats were implanted with a stimulator and treated for 14 days, each group of rats having only one stimulation parameter modified from the standard ones (0.25 mA, 20 Hz, 500 mu s, 30 s ON/5 min OFF). Electrophysiological recordings showed that the usual parameters utilized in depressed patients, with the exception of current intensity, produced an optimal activation of 5-HT neurons. Excessive enhancement of the charge delivered to the nerve can lead to a loss of VNS effect on 5-HT neuronal firing. (c) 2008 Elsevier B.V. and ECNP. All rights reserved.
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