期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 18, 期 5, 页码 390-393出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2008.01.005
关键词
heroin; methadone; craving; stress; cortisol
Craving and stress frequently drive compulsive heroin use. Although methadone attenuates craving, drug-conditioned stimuli can trigger craving and possibly stress arousal in heroin-dependent patients receiving methadone maintenance. This study investigated drug cue-related craving, affectivity, and cortisol reactivity in 16 methadone-maintained patients before and after daily methadone. Unexpectedly, drug cues significantly increased craving after (t[15]=-4.27, p=0.001), but not before methadone intake. Patients displayed blunted cortisol response after post-methadone drug cues (t[15]=3.05, p=0.008) suggesting dissociated craving and cortisol reactivity after methadone intake of possible clinical relevance. (C) 2008 Elsevier B.V. and ECNP. All rights reserved.
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