期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 18, 期 9, 页码 673-681出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2008.05.002
关键词
generalized anxiety disorder; duloxetine; relapse prevention; treatment; antidepressant; serotonin and norepinephrine reuptake inhibitor
The objective was to examine duloxetine 60-120 mg/day treatment for relapse prevention in adults with generalized anxiety disorder (GAD). Adult patients (N = 887; mean age = 43.3 years; 61.0% female) with DSM-IV-TR-defined GAD diagnosis were treated with duloxetine for 26 weeks. Patients who completed open-label phase and were treatment responders (>= 50% reduction in Hamilton Anxiety Rating Scale total score to <= 11 and much/very much improved ratings for the last 2 visits of open-label phase) were randomly assigned to receive duloxetine or placebo for a 26-week double-blind continuation phase. Relapse was defined as >= 2-point increase in illness severity ratings or by discontinuation due to tack of efficacy. During the double-blind phase, placebo-treated patients (N = 201) relapsed more frequently (41.8%) than duloxetine-treated patients (13.7%, N = 204, P <= 0.001) and worsened on each outcome measure (P <= 0.001, all comparisons). Duloxetine 60-120 mg/day treatment was efficacious and reduced risk of relapse in patients with GAD. (C) 2008 Elsevier B.V. and ECNP. All rights reserved.
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