Article
Pharmacology & Pharmacy
Kenneth Chappell, Abd El Kader Ait Tayeb, Romain Colle, Jerome Bouligand, Khalil El-Asmar, Florence Gressier, Severine Trabado, Denis Joseph David, Bruno Feve, Laurent Becquemont, Emmanuelle Corruble, Celine Verstuyft
Summary: This study found that genetic variants of ARRB1 may influence the response to antidepressant drug treatment in depressed patients. The analysis of rare variants showed significant associations with changes in HDRS scores and remission. The results suggest that beta-arrestin 1 and genetic variants of ARRB1 may serve as useful clinical biomarkers for clinical improvement following antidepressant drug treatment in depressed individuals.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Multidisciplinary
Yves de Roten, Slimane Djillali, Fabienne Crettaz von Roten, Jean-Nicolas Despland, Gilles Ambresin
Summary: This study investigated the predictive value of defensive functioning and defense mechanisms in determining the effectiveness of brief psychodynamic psychotherapy for recurrent and chronic depression in an inpatient setting. The results showed that changes in defensive functioning along with mature and immature defense mechanisms during therapy were predictive of treatment response, with the addition of psychotic defenses enhancing the prediction of treatment outcomes. The findings support the role of defensive functioning as a predictor of treatment outcomes and a mechanism of change in psychotherapy.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Duan Liu, Yongxian Zhuang, Lingxin Zhang, Huanyao Gao, Drew Neavin, Tania Carrillo-Roa, Yani Wang, Jia Yu, Sisi Qin, Daniel C. Kim, Erica Liu, Thanh Thanh Le Nguyen, Joanna M. Biernacka, Rima Kaddurah-Daouk, Boadie W. Dunlop, W. Edward Craighead, Helen S. Mayberg, Elisabeth B. Binder, Mark A. Frye, Liewei Wang, Richard M. Weinshilboum
Summary: ERICH3 gene may play a significant role in vesicular function in serotonergic and other neuronal cell types, which could help explain its association with plasma serotonin concentrations and SSRI clinical response.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Clinical
K. El Asmar, N. B. Annan, R. Khoury, R. Colle, S. Martin, T. E. Ghoul, S. Trabado, P. Chanson, B. Feve, C. Verstuyft, L. Becquemont, E. Corruble
Summary: The study aimed to assess the impact of response to antidepressant treatment on developing metabolic syndrome (MetS). The results showed that patients who responded to treatment after 3 months had a higher risk of developing MetS.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Dana Schultchen, Carolin Schneider, Goetz Berberich, Michael Zaudig, Thorsten M. Erle, Olga Pollatos
Summary: Depressed patients exhibit deficits in interoception and attention, with no clear mediating relationship between the two variables identified in this study. Further research is needed to explore the effectiveness of different approaches to improving interoceptive accuracy in depressed patients as a potential aspect of therapy.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Fabrice Duval, Marie-Claude Mokrani, Alexis Erb, Felix Gonzalez Lopera, Vlad Danila, Mihaela Tomsa
Summary: The effects of antidepressants on dopamine receptor sensitivity in the mesolimbic-hypothalamic system may lead to clinical improvement by reducing the activity of the HPA axis and desensitizing postsynaptic DA receptors.
Article
Psychology, Multidisciplinary
Anna Vilalta-Lacarra, Joan Vilalta-Franch, Domenec Serrano-Sarbosa, Ruth Marti-Lluch, Jaume Marrugat, Josep Garre-Olmo
Summary: This study aimed to assess the association between different types of depressive symptoms and mortality due to cancer and other causes. The results showed that cognitive/emotional depressive symptoms (C-EDS) were associated with an increased risk of cancer mortality in both men and women, while somatic depressive symptoms (SDS) were significantly associated with non-cancer mortality in men. The use of selective serotonin reuptake inhibitors (SSRIs) was also associated with both cancer and non-cancer mortality, but only in the male population.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Holly Christina Smith, Irene Petersen, Patricia Schartau
Summary: This study found that recently having a child was not associated with an increase in antidepressant treatment among men. However, fathers who had previously received antidepressant treatment were more likely to receive antidepressant treatment after childbirth. Further research is needed to understand if antidepressant treatment or experiencing depression can hinder fatherhood and if fatherhood can be a barrier to receiving antidepressant treatment.
Article
Biochemistry & Molecular Biology
Kenneth Chappell, Romain Colle, Jerome Bouligand, Severine Trabado, Bruno Feve, Laurent Becquemont, Emmanuelle Corruble, Celine Verstuyft
Summary: Genetic variants in the MAOA and MAOB genes are associated with clinical improvement and plasma 5HIAA/5HT ratio in patients treated with antidepressant drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Dogukan Koc, Ecem Ince, Tugba San, Pinar Akan, Ahu Paketci, Ece Bober, Nese Direk Tecirli, Neslihan Inal, Aynur Pekcanlar Akay
Summary: This study aimed to explore the association between thyroid autoimmunity and treatment-emergent mania (ATEM) in pediatric mood disorders. The findings showed that the seroprevalence and titer of anti-thyroid peroxidase antibodies (TPO-abs) were significantly higher in patients with ATEM compared to controls. Logistic regression analysis revealed a significant association between TPO-abs seroprevalence and ATEM even after adjusting for various factors. These findings suggest that TPO-abs could potentially serve as a biomarker for assessing the risk of ATEM in children and adolescents.
PSYCHIATRY RESEARCH
(2022)
Article
Geriatrics & Gerontology
Xiao-Ming Zhang, Jing Jiao, Na Guo, Hai-Xin Bo, Tao Xu, Xin-Juan Wu
Summary: Polypharmacy is common among older Chinese hospitalized patients and is an independent risk factor for falls. Clinicians should conduct comprehensive evaluations of medications and implement deprescribing strategies to reduce unnecessary medications and decrease the rate of falls.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Nicolas Hoertel, Marina Sanchez-Rico, Johannes Kornhuber, Erich Gulbins, Angela M. Reiersen, Eric J. Lenze, Bradley A. Fritz, Farid Jalali, Edward J. Mills, Celine Cougoule, Alexander Carpinteiro, Christiane Muehle, Katrin Anne Becker, David R. Boulware, Carlos Blanco, Jesus M. Alvarado, Nathalie Strub-Wourgaft, Cedric Lemogne, Frederic Limosin
Summary: To reduce mortality and morbidity related to COVID-19, there is an urgent need for widely available oral COVID-19 treatments. Certain antidepressants may be beneficial against COVID-19 and reduce mortality rates among hospitalized patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Rick W. Wright, Laura J. Huston, Amanda K. Haas, Jacquelyn S. Pennings, Christina R. Allen, Daniel E. Cooper, Thomas M. DeBerardino, Warren R. Dunn, Brett (Brick) A. Lantz, Kurt P. Spindler, Michael J. Stuart, John P. Albright, Annunziato (Ned) Amendola, Jack T. Andrish, Christopher C. Annunziata, Robert A. Arciero, Bernard R. Bach, Champ L. Baker, Arthur R. Bartolozzi, Keith M. Baumgarten, Jeffery R. Bechler, Jeffrey H. Berg, Geoffrey A. Bernas, Stephen F. Brockmeier, Robert H. Brophy, Charles A. Bush-Joseph, J. Brad Butler, John D. Campbell, James L. Carey, James E. Carpenter, Brian J. Cole, Jonathan M. Cooper, Charles L. Cox, R. Alexander Creighton, Diane L. Dahm, Tal S. David, David C. Flanigan, Robert W. Frederick, Theodore J. Ganley, Elizabeth A. Garofoli, Charles J. Gatt, Steven R. Gecha, James Robert Giffin, Sharon L. Hame, Jo A. Hannafin, Christopher D. Harner, Norman Lindsay Harris, Keith S. Hechtman, Elliott B. Hershman, Rudolf G. Hoellrich, David C. Johnson, Timothy S. Johnson, Morgan H. Jones, Christopher C. Kaeding, Ganesh V. Kamath, Thomas E. Klootwyk, Bruce A. Levy, C. Benjamin Ma, G. Peter Maiers, Robert G. Marx, Matthew J. Matava, Gregory M. Mathien, David R. McAllister, Eric C. McCarty, Robert G. McCormack, Bruce S. Miller, Carl W. Nissen, Daniel F. O'Neill, Brett D. Owens, Richard D. Parker, Mark L. Purnell, Arun J. Ramappa, Michael A. Rauh, Arthur C. Rettig, Jon K. Sekiya, Kevin G. Shea, Orrin H. Sherman, James R. Slauterbeck, Matthew V. Smith, Jeffrey T. Spang, Steven J. Svoboda, Timothy N. Taft, Joachim J. Tenuta, Edwin M. Tingstad, Armando F. Vidal, Darius G. Viskontas, Richard A. White, James S. Williams, Michelle L. Wolcott, Brian R. Wolf, James J. York
Summary: Based on a cohort study involving 1234 patients undergoing ACL revision surgery, it was found that autografts had lower rerupture rates and higher activity levels compared to allografts at the 6-year follow-up. Bone-patellar tendon-bone and soft tissue autografts performed better than bone-patellar tendon-bone allografts, highlighting the importance of graft choice in revision ACL reconstruction outcomes.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Psychiatry
J. Engelmann, L. Zillich, J. Frank, S. Wagner, M. Cetin, D. P. Herzog, M. B. Mueller, A. Tadic, J. C. Foo, L. Sirignano, D. F. Braus, N. Dahmen, S. Sordon, M. Riemenschneider, C. Spaniol, G. Gasparoni, M. Rietschel, S. H. Witt, K. Lieb, F. Streit
Summary: This study explores the relationship between DNA methylation and antidepressant response, and the results suggest its potential in personalized medicine for predicting patients' response before treatment.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Gina R. A. Ferrari, Marie-Anne Vanderhasselt, Mike Rinck, Ineke Demeyer, Rudi De Raedt, Sylvia Beisel, Johannes Lindenmeyer, Eni S. Becker
Summary: While Cognitive Control Training (CCT) has been suggested as a potential adjunctive intervention for depression, this study found no short-term beneficial effects when added to usual treatment for depressed inpatients. Further research on individual differences and conditions predicting training response is crucial for understanding the effectiveness of CCT.
COGNITIVE THERAPY AND RESEARCH
(2021)
Review
Clinical Neurology
Yasmin Busch, Andreas Menke
JOURNAL OF NEURAL TRANSMISSION
(2019)
Review
Pharmacology & Pharmacy
Andreas Menke, Torsten Klengel, Elisabeth B. Binder
CURRENT PHARMACEUTICAL DESIGN
(2012)
Article
Behavioral Sciences
A. Menke, T. Klengel, J. Rubel, T. Brueckl, H. Pfister, S. Lucae, M. Uhr, F. Holsboer, E. B. Binder
GENES BRAIN AND BEHAVIOR
(2013)
Article
Neurosciences
Orna Issler, Sharon Haramati, Evan D. Paul, Hiroshi Maeno, Inbal Navon, Rayya Zwang, Shosh Gil, Helen S. Mayberg, Boadie W. Dunlop, Andreas Menke, Rajeshwar Awatramani, Elisabeth B. Binder, Evan S. Deneris, Christopher A. Lowry, Alon Chen
Article
Multidisciplinary Sciences
Johannes M. Hennings, Martin A. Kohli, Darina Czamara, Maria Giese, Anne Eckert, Christiane Wolf, Angela Heck, Katharina Domschke, Volker Arolt, Bernhard T. Baune, Sonja Horstmann, Tanja Brueckl, Torsten Klengel, Andreas Menke, Bertram Mueller-Myhsok, Marcus Ising, Manfred Uhr, Susanne Lucae
Article
Endocrinology & Metabolism
Andreas Menke, Philipp Saemann, Stefan Kloiber, Darina Czamara, Susanne Lucae, Johannes Hennings, Angela Heck, Martin A. Kohli, Michael Czisch, Bertram Mueller-Myhsok, Florian Holsboer, Elisabeth B. Binder
PSYCHONEUROENDOCRINOLOGY
(2012)
Article
Endocrinology & Metabolism
Andreas Menke, Janine Arloth, Markus Gerber, Monika Rex-Haffner, Manfred Uhr, Florian Holsboer, Elisabeth B. Binder, Edith Holsboer-Trachsler, Johannes Beck
PSYCHONEUROENDOCRINOLOGY
(2014)
Article
Psychiatry
K. Ganea, A. Menke, M. V. Schmidt, S. Lucae, G. Rammes, C. Liebl, D. Harbich, V. Sterlemann, C. Storch, M. Uhr, F. Holsboer, E. B. Binder, I. Sillaber, M. B. Mueller
TRANSLATIONAL PSYCHIATRY
(2012)
Article
Immunology
Andreas Menke, Felix Nitschke, Anna Hellmuth, Jacqueline Helmel, Catherina Wurst, Saskia Stonawski, Manuel Blickle, Carolin Weiss, Heike Weber, Leif Hommers, Katharina Domschke, Juergen Deckert
Summary: This study investigates the effects of childhood trauma and severe events later in life on the stress-response systems of the body in depressed patients. Severe recent life events were found to impair the stress-response systems and treatment response in patients with major depressive disorder. Additional treatment options, such as psychotherapy or immune-modulating approaches, may be needed for patients with a history of severe life events.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Andreas Menke, Elisabeth B. Binder
DIALOGUES IN CLINICAL NEUROSCIENCE
(2014)
Meeting Abstract
Neurosciences
Andreas Menke, Johanna Best, Florian Holsboer, Elisabeth Binder, Manfred Uhr
BIOLOGICAL PSYCHIATRY
(2014)
Article
Psychiatry
Andreas Menke
INTERNATIONAL REVIEW OF PSYCHIATRY
(2013)
Meeting Abstract
Neurosciences
Andreas Menke, Stefan Kloiber, Johanna Best, Monika Rex-Haffner, Manfred Uhr, Florian Holsboer, Elisabeth B. Binder
BIOLOGICAL PSYCHIATRY
(2013)
Meeting Abstract
Clinical Neurology
A. Menke, T. Klengel, M. Rex-Haffner, M. Uhr, F. Holsboer, E. Binder
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2012)
Review
Pharmacology & Pharmacy
Andreas Menke
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2018)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)
