Article
Clinical Neurology
Ahmet O. Ceceli, Yuefeng Huang, Greg Kronberg, Pias Malaker, Pazia Miller, Sarah G. King, Pierre-Olivier Gaudreault, Natalie McClain, Lily Gabay, Devarshi Vasa, Jeffrey H. Newcorn, Defne Ekin, Nelly Alia-Klein, Rita Z. Goldstein
Summary: Opiate and stimulant addictions have significant impacts on society, resulting in numerous deaths each year. This study found that individuals with heroin use disorder have lower grey matter volume in the corticostriatal and ventromedial prefrontal cortex, while those with cocaine addiction have lower grey matter volume in the inferior frontal gyrus. These results suggest substance-specific volumetric changes in human psychostimulant or opiate addiction, highlighting the importance of biomarker development and targeted treatments.
Article
Biochemistry & Molecular Biology
Min Liu, Shouhong Mu, Weikai Han, Xu Tan, E. Liu, Zhaofang Hang, Shaowei Zhu, Qingwei Yue, Jinhao Sun
Summary: The study demonstrated that methamphetamine (MA) increases c-Fos expression and synaptic plasticity in the orbitofrontal cortex (OFC) and dorsal striatum (DS). MA activates projection neurons from the OFC to the DS and affects conditioned place preference (CPP) scores. The study also showed that DA release in the OFC is increased in the MA group, and D1R neurons in the OFC-DS pathway play a role in MA addiction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Psychiatry
Stuti Chhabra, Leonardo Nardi, Petra Leukel, Clemens J. Sommer, Michael J. Schmeisser
Summary: Autism spectrum disorder (ASD) is characterized by impaired social interaction and repetitive behavior, and is believed to be caused by a combination of environmental and genetic factors. The dopaminergic system and its impact on motor and reward-motivated behaviors play a role in ASD, and alterations in dopaminergic metabolism and neurotransmission have been observed in ASD mouse models. This study examines the distribution of dopamine receptors in different brain regions in three well-established ASD mouse models and provides insights into the potential mechanisms underlying ASD traits. The findings may also contribute to the development of targeted treatments for ASD.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Allen P. F. Chen, Lu Chen, Thomas A. Kim, Qiaojie Xiong
Summary: Dopamine plays a crucial role in controlling CNS function and its dysregulation can lead to various cognitive symptoms associated with neuropsychiatric diseases. Different brain areas have varying functions and roles for dopamine, suggesting potential differential dysregulation in different disease states.
Article
Neurosciences
Thomas Contesse, Loic Broussot, Hugo Fofo, Peter Vanhoutte, Sebastian P. Fernandez, Jacques Barik
Summary: Stress is recognized as a major risk factor for the onset of psychiatric disorders, with social stress being the most common type encountered in daily life. Molecular changes in the reward system were found to be significantly increased following social defeat stress in mice, potentially contributing to the long-lasting impact of stress on the brain.
Review
Biochemistry & Molecular Biology
Jaromir Myslivecek
Summary: There are tight interactions between dopamine and acetylcholine signaling in the striatum, affecting neurotransmitter release and movement regulation. Both neurotransmitters and their receptors show diurnal variations, with research indicating that reward function is also influenced by the circadian system.
Article
Biochemistry & Molecular Biology
Chuan-Ching Lai, Rathinasamy Baskaran, Chih-Yu Tsao, Li-Heng Tuan, Pei-Fen Siow, Mahalakshmi Palani, Lukas Jyuhn-Hsiarn Lee, Chih-Min Liu, Hai-Gwo Hwu, Li-Jen Lee
Summary: Schizophrenia usually manifests during adolescence to young adulthood, providing an opportunity for early intervention. This study investigated the preventive effect of chronic N-acetylcysteine (NAC) treatment on the outbreak of psychosis in Disc1 Het mice and found that NAC can normalize biochemical and morphological features in the striatum. The findings not only support the use of NAC as a dietary supplement for schizophrenia prodromes, but also contribute to our understanding of potential therapeutic targets for treating mental disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Raphael Goutaudier, Fanny Joly, David Mallet, Magali Bartolomucci, Denis Guicherd, Carole Carcenac, Frederique Vossier, Thibault Dufourd, Sabrina Boulet, Colin Deransart, Benoit Chovelon, Sebastien Carnicella
Summary: This study provides evidence for the involvement of reduced dopamine levels in the dorsolateral striatum in compulsive alcohol use. The researchers showed that selective hypodopaminergia in this pathway leads to compulsive-like alcohol self-administration and alcohol withdrawal-like motivational impairments. Treatment with the monoamine stabilizer OSU6162 transiently decreased compulsive-like alcohol self-administration in vulnerable rats.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Carla L. Busceti, Roxana P. Ginerete, Luisa Di Menna, Giovanna D'Errico, Francesca Cisani, Paola Di Pietro, Tiziana Imbriglio, Valeria Bruno, Giuseppe Battaglia, Francesco Fornai, James A. Monn, Anna Pittaluga, Ferdinando Nicoletti
Summary: Genetic knockout of mGlu2 and mGlu3 receptors affects mice's preference and motor responses to methamphetamine, indicating different roles of these two receptors in methamphetamine addiction. mGlu3(-/-) mice show increased sensitization and elevated levels of phospho-ERK1/2 and free radicals in relevant brain areas, while mGlu2(-/-) mice exhibit reduced motor response to the first methamphetamine injection.
Article
Cell Biology
Alicia Rivera, Diana Suarez-Boomgaard, Cristina Miguelez, Alejandra Valderrama-Carvajal, Jerome Baufreton, Kirill Shumilov, Anne Taupignon, Belen Gago, M. Angeles Real
Summary: Long-term exposure to morphine induces structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, the morphine-induced neuroadaptations in the dorsal striatum, which is crucial for drug-related habit learning, have not been well studied. This study finds that prolonged treatment with morphine leads to retraction of dendritic arbor and loss of dendritic spines in the dorsal striatal projection neurons. Additionally, the dopamine D-4 receptor (D4R) is found to modulate striatal morphine-induced plasticity, as the combined treatment of morphine with a D4R agonist restores dendritic arbor and spine density while altering the electrical properties of the neurons.
Article
Biochemistry & Molecular Biology
Uma Maheswari Deshetty, Anand Tamatam, Mahantesh Mallikarjun Patil
Summary: Motion sickness (MS) can be related to increased levels of dopamine and DRD2 in the striatum and brainstem. Menthol may serve as an herbal alternative medicine for MS by potentially reducing dopamine and DRD2 levels.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Review
Nutrition & Dietetics
Gemma Mestre-Bach, Marc N. Potenza
Summary: This review article discusses the relevance of the reward system in behavioral addictions such as gambling disorder, internet gaming disorder, and food addiction/binge eating disorder. Specifically, it explores the role of the ventral striatum as a possible biomarker for these conditions and discusses studies analyzing brain changes following interventions for these disorders.
Article
Health Care Sciences & Services
Chieh-Liang Huang, Ping-Ho Chen, Hsien-Yuan Lane, Ing-Kang Ho, Chia-Min Chung
Summary: This study aimed to identify heroin addicts with specific genetic variants in their dopaminergic reward systems and found multiple genes associated with heroin use and craving scores. The results showed a dose-response relationship between the number of genetic risk alleles and heroin craving scores, suggesting potential implications for predicting relapse risk and developing targeted therapies for heroin addiction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Kathryn Lanza, Christopher Bishop
Summary: Parkinson's Disease (PD) and long-term L-DOPA treatment induce plasticity that contributes to L-DOPA-induced dyskinesia (LID), with the dopamine D3 receptor (D3R) emerging as a promising target in LID management due to its upregulation in LID. D3R undergoes dynamic changes in both PD and LID, and recent genetic and pharmacologic tools have helped clarify its role in LID.
Article
Psychiatry
Serenella Tolomeo, Alex Baldacchino, Nora D. Volkow, J. Douglas Steele
Summary: Opioid use disorder has a significant impact globally, with limited recovery observed during protracted abstinence. Neuroimaging findings from this study support the allostasis theory by demonstrating improved negative valence brain function and similar positive valence function during protracted abstinence among patients.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
C. Henrico Stam, Frederik M. van der Veen, Ingmar H. A. Franken
Summary: The study revealed that smoking, heavy drinking, and delay discounting were associated with faster estimation of time, while smoking and delay discounting were linked to differences in autocorrelation. Fun seeking was associated with smoking and alcohol use, but not with time estimation or delay discounting.
ADDICTIVE BEHAVIORS
(2022)
Article
Neurosciences
Carmen S. Sergiou, Emiliano Santarnecchi, Sara M. Romanella, Matthias J. Wieser, Ingmar H. A. Franken, Eric G. C. Rassin, Josanne D. M. van Dongen
Summary: This study investigated the effects of high-definition transcranial direct current stimulation (HD-tDCS) on reducing aggressive behavior and modulating electrophysiological responses in forensic substance dependent offenders. The results showed a decrease in aggressive responses and self-reported reactive aggression after active tDCS, along with a general increase in late positive potential amplitude. These findings suggest the potential of using tDCS as an intervention to reduce aggression in forensic mental health care.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychology, Educational
Donna A. de Maat, Isabel K. Schuurmans, Joran Jongerling, Stephen A. Metcalf, Nicole Lucassen, Ingmar H. A. Franken, Peter Prinzie, Pauline W. Jansen
Summary: This study found that child temperament and executive functions can moderate the longitudinal association between early life stress and behavior problems. Lower surgency can buffer the increase in externalizing problems, while better shifting capacities can reduce the increase in internalizing problems. The importance of examining multiple protective factors simultaneously was also emphasized by the findings.
Article
Psychology, Clinical
Nouran AlMoghrabi, Ingmar H. A. Franken, Birgit Mayer, Jorg Huijding
Summary: The experimental study on cognitive bias modification has shown that combined training targeting both attention and interpretation biases did not have a greater effect on reducing aggression compared to training interpretation bias alone. Training interpretation bias may lead to changes in attention bias, and elements of the control condition unexpectedly affected attention and interpretation biases. Single-session CBM procedures did not produce robust effects on self-report or behavioral measures of aggression in unselected samples.
Article
Public, Environmental & Occupational Health
Annelot Wismans, Peter van der Zwan, Karl Wennberg, Ingmar Franken, Jinia Mukerjee, Rui Baptista, Jorge Barrientos Marin, Andrew Burke, Marcus Dejardin, Frank Janssen, Srebrenka Letina, Jose Maria Millan, Enrico Santarelli, Olivier Torres, Roy Thurik
Summary: The study found a strong positive association between policy stringency and face mask use. Self-related risk perception was positively associated with mask use, but there was no relationship between mask use and experience with COVID-19 or attitudes towards government. However, government trust and perceived clarity of communication were found to moderate the link between policy stringency and mask use, with positive government perceptions relating to higher use in countries with regulations and lower use in countries without regulations.
Article
Psychology, Biological
Marcelo Malbec, Joshua N. Hindmarsh, Joran Jongerling, Ingmar H. Franken, Matthias J. Wieser
Summary: Errors are seen as internal threats that can cause harm in unpredictable ways. The study found that total intolerance of uncertainty (IU) explains 5% of the variance in correct-response negativity (CRN), but does not appear to be associated with error-related negativity (ERN). Contrary to previous research, the subfactors of IU do not predict ERN or post-error slowing.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2022)
Article
Criminology & Penology
Josanne D. M. van Dongen, Anuska Gobardhan, Pauline Korpel, Ingmar H. A. Franken
Summary: This study aimed to investigate the role of recognizing faux pas in the relationship between psychopathy and aggression. The results showed a positive relationship between psychopathic personality traits and self-reported proactive and reactive aggression. Only the boldness trait was negatively associated with faux pas recognition. Faux pas did not mediate the relationship between psychopathy and aggression.
JOURNAL OF FORENSIC PSYCHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Substance Abuse
Antonio Verdejo-Garcia, Tara Rezapour, Emily Giddens, Arash Khojasteh Zonoozi, Parnian Rafei, Jamie Berry, Alfonso Caracuel, Marc L. Copersino, Matt Field, Eric L. Garland, Valentina Lorenzetti, Leandro Malloy-Diniz, Victoria Manning, Ely M. Marceau, David L. Pennington, Justin C. Strickland, Reinout Wiers, Rahia Fairhead, Alexandra Anderson, Morris Bell, Wouter J. Boendermaker, Samantha Brooks, Raimondo Bruno, Salvatore Campanella, Janna Cousijn, W. Miles Cox, Andrew C. Dean, Karen D. Ersche, Ingmar Franken, Brett Froeliger, Pedro Gamito, Thomas E. Gladwin, Priscila D. Goncalves, Katrijn Houben, Joanna Jacobus, Andrew Jones, Anne M. Kaag, Johannes Lindenmeyer, Elly McGrath, Talia Nardo, Jorge Oliveira, Charlotte R. Pennington, Kelsey Perrykkad, Hugh Piercy, Claudia Rupp, Mieke H. J. Schulte, Lindsay M. Squeglia, Petra Staiger, Dan J. Stein, Jeff Stein, Maria Stein, William W. Stoops, Mary Sweeney, Katie Witkiewitz, Steven P. Woods, Richard Yi, Min Zhao, Hamed Ekhtiari
Summary: This study used a Delphi approach to reach consensus on recommendations for developing and applying cognitive training and remediation interventions for substance use disorders. Through two rounds of surveys, experts reached consensus on the targets, approaches, active ingredients, and modes of delivery for these interventions. The study indicates that intervention measures based on validated techniques and flexible delivery methods can effectively improve cognitive deficits in the treatment of substance use disorders.
Article
Psychology, Clinical
Michiel Boog, Anna E. Goudriaan, Ben J. M. v. d. Wetering, Ingmar H. A. Franken, Arnoud Arntz
Summary: This study examines the effectiveness of schema therapy (ST) for borderline personality disorder (BPD) with comorbid alcohol dependence (AD). The study includes 20 patients in a case series design with baseline measurement. Results show a significant decrease in BPD and AD symptoms, with the most noticeable change occurring during the experiential techniques phase. After three months of therapy termination, 68% of patients achieved remission from BPD, and drinking days decreased significantly. This study demonstrates that meaningful change can be achieved in BPD and AD patients using ST, although treatment may be challenging.
CLINICAL PSYCHOLOGY & PSYCHOTHERAPY
(2023)
Article
Substance Abuse
Rene Freichel, Janine Pfirrmann, Janna Cousjin, Peter de Jong, Ingmar Franken, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah H. Hohmann, Juliane N. Froehner, Michael Smolka, Nilakshi Vaidya, Robert Whelan, Gunter Schumann, Henrik M. Walter, Ilya W. Veer, Reinout Wiers
Summary: This study aims to examine the dynamic associations between distal and proximal risk factors (personality traits, life stressors, and drinking motives) and their relationship with alcohol use in adolescence and early adulthood. The findings suggest that heavy and frequent alcohol use, along with social drinking motives, are key targets for preventing alcohol-related problems during late adolescence. However, there was no evidence found for personality traits and life stressors predisposing towards distinct drinking motives over time.
Correction
Substance Abuse
Andrew J. Waters, Tim M. Schoenmakers, Michelle Snelleman, Edwin H. Szeto, Ingmar H. A. Franken, Vincent M. Hendriks, Dike van de Mheen
DRUG AND ALCOHOL DEPENDENCE
(2023)
Editorial Material
Substance Abuse
Ingmar H. A. Franken
Article
Psychology, Clinical
Carmen S. Sergiou, Elisa Tatti, Sara M. Romanella, Emiliano Santarnecchi, Alix D. Weidema, Eric G. C. Rassin, Ingmar H. A. Franken, Josanne D. M. van Dongen
Summary: Violence is a prominent issue in society, leading to increased research on the neural aspects of aggression. This study aimed to investigate the impact of HD-tDCS on neural oscillations in violent offenders. The results showed no effect on power in different frequency bands, but increased synchronicity in the frontal regions, indicating enhanced connectivity. This study contributes to our understanding of aggression and violence, emphasizing the importance of alpha and beta frequency bands. Future studies should explore this further. Evaluation: 7/10.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Criminology & Penology
Josanne D. M. van Dongen, Manon de Groot, Eric Rassin, Rick H. Hoyle, Ingmar H. A. Franken
Summary: This study examined the associations between sensation seeking and psychopathic traits, impulsivity, and aggression using the Dutch version of the Brief Sensation Seeking Scale. The results showed that the BSSS has good psychometric properties and supports associations with psychopathic traits, impulsivity, and total scores of aggression. However, specific associations with different types of aggression were not found. The Dutch BSSS is considered a valuable tool for assessing sensation seeking in both the general population and forensic patients.
PSYCHIATRY PSYCHOLOGY AND LAW
(2022)
Article
Psychology, Multidisciplinary
C. Henrico Stam, Frederik M. van der Veen, Ingmar H. A. Franken
Summary: This study examined the associations between subjective time estimation ability, impulsivity, and substance use. The results showed that both delay discounting and degree of alcohol use were related to time estimation abilities. Alcohol use was positively associated with time estimation error.
CURRENT PSYCHOLOGY
(2022)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)
