Article
Medicine, General & Internal
Meaghan Clough, Jade Bartholomew, Owen B. White, Joanne Fielding
Summary: Working memory impairments are common in early multiple sclerosis, and the most frequent impairment phenotypes are visual-spatial and auditory. The test of visual-spatial working memory provides the best measure of impairment, while the symbol digit modalities test has limitations in screening cognitive impairment in early MS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ignacio Casanova, Maria I. Dominguez-Mozo, Laura De Torres, Yolanda Aladro-Benito, Angel Garcia-Martinez, Patricia Gomez, Sara Abellan, Esther De Antonio, Roberto Alvarez-Lafuente
Summary: This study investigates the association between a preselected list of miRNAs in the serum of relapsing-remitting multiple sclerosis (RRMS) patients with therapeutic response to Glatiramer Acetate (GA) and clinical evolution. The findings suggest that certain miRNAs may serve as potential biomarkers for disease progression and response to treatment in multiple sclerosis.
Review
Clinical Neurology
Virginia Meca-Lallana, Leticia Berenguer-Ruiz, Joan Carreres-Polo, Sara Eichau-Madueno, Jaime Ferrer-Lozano, Lucia Forero, Yolanda Higueras, Nieves Tellez Lara, Angela Vidal-Jordana, Francisco Carlos Perez-Miralles
Summary: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system triggered by unknown environmental factors in patients with genetic risk profiles. Prevention of neurological disability is essential, but mechanisms driving disease progression remain unknown. Lack of markers for early detection and varying definitions of disability progression complicate assessment in clinical practice.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
M. Alluqmani, W. Roda, M. Qqrmli, G. Blevins, F. Giuliani, C. Power
Summary: The RR-MS phenotypes in Canada and Saudi Arabia showed similar features despite differences in disease duration, annual relapse rate, EDSS change, and lesion locations. The Saudi cohort had a more severe disease course compared to the Canadian cohort, with a higher change in EDSS between assessments.
Article
Clinical Neurology
Jing Wu, Tomas Olsson, Jan Hillert, Lars Alfredsson, Anna Karin Hedstrom
Summary: This study aimed to investigate the influence of smoking habits, exposure to passive smoking and snuff use on disease progression, cognitive performance and quality of life in patients with multiple sclerosis (MS). The study found that smoking and passive smoking have negative effects on MS, and smoking cessation post diagnosis may be an important secondary preventive measure. Snuff use was associated with slower disease progression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Eloy Martinez-Heras, Elisabeth Solana, Francesc Vivo, Elisabet Lopez-Soley, Alberto Calvi, Salut Alba-Arbalat, Menno M. Schoonheim, Eva M. Strijbis, Hugo Vrenken, Frederik Barkhof, Maria A. Rocca, Massimo Filippi, Elisabetta Pagani, Sergiu Groppa, Vinzenz Fleischer, Robert A. Dineen, Barbara Bellenberg, Carsten Lukas, Deborah Pareto, Alex Rovira, Jaume Sastre-Garriga, Sara Collorone, Ferran Prados, Ahmed Toosy, Olga Ciccarelli, Albert Saiz, Yolanda Blanco, Sara Llufriu
Summary: This study analyzed brain diffusion-based connectivity in 823 MS patients and 221 healthy individuals using MRI and found that different clinical phenotypes of MS have distinct patterns of network changes and microstructural characteristics. Secondary progressive patients showed more widespread changes in connectivity compared to other groups.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Timo Uphaus, Falk Steffen, Muthuraman Muthuraman, Nina Ripfel, Vinzenz Fleischer, Sergiu Groppa, Tobias Ruck, Sven G. Meuth, Refik Pul, Christoph Kleinschnitz, Erik Ellwardt, Julia Loos, Sinah Engel, Frauke Zipp, Stefan Bittner
Summary: This study found that sNfL levels at baseline predict relapse-free disability progression in patients with multiple sclerosis, and further discriminates patients with secondary progressive MS (SPMS) at follow-up.
Article
Clinical Neurology
Jose E. Meca-Lallana, Bonaventura Casanova, Alfredo Rodriguez-Antiguedad, Sara Eichau, Guillermo Izquierdo, Carmen Duran, Jordi Rio, Miguel Angel Hernandez, Carmen Calles, Jose M. Prieto-Gonzalez, Jose Ramon Ara, Dionisio F. Uria, Lucienne Costa-Frossard, Antonio Garcia-Merino, Celia Oreja-Guevara
Summary: This study aimed to establish consensus among a panel of 15 MS experts on the monitoring and identification of early disease progression in MS, and found agreement on several variables and assessment tools that could guide neurologists in identifying and treating SPMS at its earliest stages.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Milagros Hidalgo de la Cruz, Paola Valsasina, Claudio Gobbi, Antonio Gallo, Chiara Zecca, Alvino Bisecco, Gioacchino Tedeschi, Massimo Filippi, Maria A. Rocca
Summary: The study found that baseline atrophy in the frontal, parietal, and sensorimotor cortex was present in MS compared to healthy controls. RRMS was the main driver of this pattern, while PMS showed additional cortical atrophy in the parietal, insular, and sensorimotor areas. One-year progression revealed further thinning in the frontal and temporal cortex in RRMS patients, and widespread reduction in CTh in PMS patients, which was significantly different compared to RRMS. Baseline fronto-parietal atrophy in MS correlated with more severe disability and higher lesion volume, while inferior parietal CTh decrease and 1-year temporal cortical thinning were associated with increased disability.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Review
Clinical Neurology
Daniela Castillo Villagran, E. Ann Yeh
Summary: Multiple sclerosis is a chronic inflammatory disease affecting the central nervous system, with a more active and severe course in children and adolescents. Early recognition, diagnosis, and treatment are crucial in order to change the developmental trajectories. Lifestyle interventions and more effective therapies are currently being investigated.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Clinical Neurology
Emilio Portaccio, Angelo Bellinvia, Mattia Fonderico, Luisa Pasto, Lorenzo Razzolini, Rocco Totaro, Daniele Spitaleri, Alessandra Lugaresi, Eleonora Cocco, Marco Onofrj, Franco Di Palma, Francesco Patti, Davide Maimone, Paola Valentino, Paolo Confalonieri, Alessandra Protti, Patrizia Sola, Giacomo Lus, Giorgia Teresa Maniscalco, Vincenzo Brescia Morra, Giuseppe Salemi, Franco Granella, Ilaria Pesci, Roberto Bergamaschi, Umberto Aguglia, Marika Vianello, Marta Simone, Vito Lepore, Pietro Iaffaldano, Massimo Filippi, Maria Trojano, Maria Pia Amato
Summary: In early multiple sclerosis, progression independent of relapse activity is an important contributor to disability accumulation. The study suggests that inflammation and neurodegeneration may represent a single disease continuum, even in the earliest stages of the disease.
Review
Clinical Neurology
Stefan Bittner, Frauke Zipp
Summary: This article discusses current views and concepts for targeting progressive multiple sclerosis (MS). Recent clinical studies have found a closer relationship between relapse-remitting and progressive MS, leading to the introduction of new concepts such as "progression independent of relapse activity". Research on molecular and imaging biomarkers for progressive MS holds promise for identifying high-risk patients at an earlier stage. Novel treatment approaches focus on neuroaxonal protection, myelin regeneration, and modulation of CNS inflammation. Despite some unsuccessful trials, important lessons can still be learned from novel trial designs.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jeff Rodgers, Tim Friede, Frederick W. Vonberg, Cris S. Constantinescu, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, Helen Ford, Lennora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin McDonnell, Brendan McLean, Owen R. Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Heather C. Wilson, David Ford, Rod M. Middleton, Richard Nicholas
Summary: The negative impact of smoking in multiple sclerosis is well documented, but there is limited evidence on the benefits of smoking cessation for disease progression. This study found that current smokers had higher disability scores compared to those who had never smoked, and there was no improvement in scores with increasing time since quitting. However, when smokers quit, the rate of motor disability deterioration slowed down to match that of non-smokers. This suggests that smoking cessation is beneficial for people with multiple sclerosis.
Article
Medicine, General & Internal
Katarzyna Kapica-Topczewska, Francois Collin, Joanna Tarasiuk, Agata Czarnowska, Monika Chorazy, Anna Mironczuk, Jan Kochanowicz, Alina Kulakowska
Summary: The study aimed to verify the association between clinical relapses and brain activity with disability progression in relapsing/remitting multiple sclerosis patients receiving disease-modifying treatments in Poland. The results showed that disability progression was independent of relapses and brain MRI activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Alexander V. Blagov, Vasily N. Sukhorukov, Alexander N. Orekhov, Margarita A. Sazonova, Alexandra A. Melnichenko
Summary: This article reviews the role of mitochondrial dysfunction in the pathogenesis of multiple sclerosis and proposes new therapeutic strategies to restore mitochondrial function in this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)