Article
Immunology
Yiyun Weng, Yufan Gao, Mingyue Zhao, Tian Zeng, Jiaqi Huang, Haobo Xie, Jiexi Huang, Yiqun Chen, Xiaoya Hu, Jiahan Xu, Jinrong Zhu, Suichai Lin, Tingting Ke, Xiang Li, Xu Zhang
Summary: This study aimed to investigate the prognostic value of white blood cell count to mean platelet volume ratio (WMR) in patients with acute ischemic stroke (AIS). The results showed that WMR was significantly correlated with stroke severity and was an independent risk factor for poor prognosis at 3 months. The study also found a significant association between WMR and poor outcome in patients with high baseline stroke severity. A nomogram that included age, sex, NIHSS on admission, and high WMR was developed to predict 1-year survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Xue Jia, Wen Wang, Bo Wu, Xin Sun
Summary: The study shows that IVT in patients with stroke onset for >4.5 h can improve functional outcomes at 90 days, but may increase the risk of symptomatic intracerebral hemorrhage. Care for these patients should carefully balance the potential benefits and harms of IVT.
CHINESE MEDICAL JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Houwei Du, Hanhan Lei, Gareth Ambler, Shuangfang Fang, Raoli He, Qilin Yuan, David J. Werring, Nan Liu
Summary: This meta-analysis comparing direct mechanical thrombectomy (dMT) to bridging therapy (BT) in acute ischemic stroke patients found no significant differences in 90-day functional outcome or mortality, but a lower rate of symptomatic intracranial hemorrhage in the dMT group.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Immunology
Dehao Yang, Honghao Huang, Yiyun Weng, Junli Ren, Chenguang Yang, Jianing Wang, Beibei Gao, Tian Zeng, Jingyu Hu, Wenjing Pan, Fangyue Sun, Xinbo Zhou, Guangyong Chen
Summary: The study found that dynamic decrease in eosinophil after intravenous thrombolysis in AIS patients with r-tPA treatment can predict a 3-month poor outcome and death, and it also improves the predictive ability of conventional model. However, this result should be interpreted cautiously in non-cardioembolic AIS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Marietta Pohl, David Hesszenberger, Krisztian Kapus, Janos Meszaros, Andrea Feher, Imre Varadi, Gabriella Pusch, Eva Fejes, Antal Tibold, Gergely Feher
Summary: The study reviewed different aspects of ischemic stroke mimics, identified various types and characteristics, and highlighted differences between stroke mimics and ischemic stroke patients in some aspects, emphasizing the need for evaluation of patients.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Review
Clinical Neurology
Jing Chen, Teng-Fei Wan, Tian-Ce Xu, Guo-Can Chang, Hui-Sheng Chen, Liang Liu
Summary: This study compared endovascular thrombectomy alone with intravenous thrombolysis plus endovascular thrombectomy in patients with acute large vessel occlusion stroke, showing that the two approaches had similar neurological outcomes, suggesting that endovascular thrombectomy alone is non-inferior to the combined treatment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Chunmiao Duan, Yunyun Xiong, Hong-Qiu Gu, Shang Wang, Kai-Xuan Yang, Manjun Hao, Xingquan Zhao, Xia Meng, Yongjun Wang
Summary: This study aimed to investigate the short-, medium-, and long-term outcomes of intravenous thrombolysis in minor stroke patients. The results suggest that intravenous thrombolysis may be safe and effective in improving functional outcomes in minor stroke patients within a 4.5-h window. However, further randomized controlled trials are needed for validation. The functional recovery rate in the overall study population ranged from 12.8% to 18.85%.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Nat Satumanatpan, Warinyupa Tonpho, Nutchanon Thiraratananukulchai, Pheerawat Chaichanamongkol, Pittawat Lekcharoen, Kitti Thiankhaw
Summary: This study found that older age, diabetes, atrial fibrillation, higher admission NIHSS, and lower ASPECTS on the initial NCCT brain were related to unfavorable functional outcomes following IVT.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Clinical Neurology
Xinke Peng, Xiaomei Wu, Lingling Lv, Qile Xiao, Yajing Zhan, Chunyu Wang, Hainan Zhang
Summary: Tuberculous meningitis can lead to ischemic stroke as a common complication, and intravenous thrombolysis may be an effective treatment option for infectious stroke caused by TBM.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Navreet Kaur, Smit Patel, Michael Omoniyi Ayanbadejo, Haydn Hoffman, Emmanuel Akano, Nnabuchi Anikpezie, Ehimen Aneni, Oluwatomi Lamikanra, Claribel Wee, Karen Albright, Priyank Khandelwal, Julius Gene Latorre, Seemant Chaturvedi, Fadar Oliver Otite
Summary: This study evaluates the utilization trends of intravenous thrombolysis and mechanical thrombectomy in pediatric acute ischemic stroke in the United States. The findings show an increase in IV-tPA and MT utilization over the past decade, mainly in older children aged 10-17 years, while the utilization in children's hospitals did not change significantly over time.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Clinical Neurology
Klearchos Psychogios, Georgios Tsivgoulis
Summary: Despite theoretical concerns about increased bleeding risk, there is no evidence showing higher risk of symptomatic intracerebral hemorrhage (sICH) in patients with stroke mimics who receive intravenous thrombolysis (IVT) using recombinant tissue-plasminogen activator (rt-PA). Recent randomized evidence allows for the expansion of the time window for IVT in acute ischemic stroke (AIS) patients using advanced neuroimaging, including wake-up stroke patients and those presenting within 4.5-9 hours from symptom onset fulfilling certain neuroimaging criteria.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Peripheral Vascular Disease
Linzhe Du, Yuqiao Zhang, Xiaohui Li, Chengfang Liu, Zhongyuan Li, Junshan Zhou, Yukai Liu
Summary: BP excursion on admission is associated with poor outcome in patients with acute ischemic stroke, especially those with severe stroke.
JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Miaomiao Yang, Wei Zhong, Wenhui Zou, Jingzi Peng, Xiangqi Tang
Summary: This study aimed to establish a nomogram to predict the probability of hemorrhagic transformation (HT) after intravenous thrombolysis in patients with ischemic stroke. Early infarct signs, NIHSS scores, uric acid, and albumin-to-globulin ratio were identified as independent predictors for HT, and a nomogram was constructed. The nomogram showed good discriminative performance, calibration performance, and clinical validity in both the training and validation cohorts.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Rongrong Zhang, Hui Wei, Yu Ren, Yanping Wu, Yetao Luo, Lei Zhang, Yingchao Huo, Jinzhou Feng, Philippe P. P. Monnier, Xinyue Qin
Summary: Patients treated with urokinase had similar outcomes but a higher risk of extracranial bleeding compared to patients treated with alteplase. The risk of extracranial bleeding was higher in the patients treated with high-dose urokinase than in the patients treated with low-dose urokinase. Patients who received low-dose urokinase had similar outcomes and complications compared to patients treated with alteplase.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Charith Cooray, Michal Karlinski, Adam Kobayashi, Peter Ringleb, Janika Korv, Mary J. Macleod, Anand Dixit, Elsa Azevedo, Christopher Bladin, Niaz Ahmed
Summary: In acute ischemic stroke patients treated with intravenous thrombolysis, those with prestroke disability did not have a significantly increased risk of symptomatic intracerebral hemorrhage or parenchymal hemorrhage. However, they were associated with a higher risk of early mortality compared to patients without prestroke disability.
INTERNATIONAL JOURNAL OF STROKE
(2021)
