☆ 4.8 Article

Atom-Economical Transformation of Diaryliodonium Salts: Tandem C-H and N-H Arylation of Indoles

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

卷 137, 期 4, 页码 1416-1419

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ja5124754

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Chemistry, Multidisciplinary

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EPSRC
EPSRC [EP/K013599/1] Funding Source: UKRI
Engineering and Physical Sciences Research Council [EP/K013599/1] Funding Source: researchfish

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Reagent

摘要

Arylation using diaryliodonium salts generates one equivalent of an iodoarene as a side-product, a significant waste of atom economy. Here, we show that diaryliodoniums can undergo Cu-catalyzed tandem C-H/N-H arylation, producing novel indoles that incorporate both aryl groups from the reagent.

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