期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 42, 页码 13488-13491出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b09286
关键词
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资金
- Hundred Talents Program of Chinese Academy of Sciences
- Shenzhen Sciences & Technology Innovation Council [KQCX20130628112914285, KQCX2015033117354154, JCYJ20150316143416083]
- National Natural Science Foundation of China [21402232, 21432003]
Coibamide A is a highly potent antiproliferalive cyclodepsipeptide originally isolated from a Panamanian marine cyanobacterium. Herein we report an efficient solid-phase strategy for assembly of highly N-methylated cyclodepsipeptides, which is invaluable in generating coibamide A derivatives for structure-activity relationship studies. As a consequence of our synthetic studies, two stereochemical assignments of coibamide A were revised and the total synthesis of this natural compound was achieved for the first time.
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