Article
Surgery
Madeline D. Cetlin, Tamar Polonsky, Karen Ho, Dongxue Zhang, Lu Tian, Lihui Zhao, Philip Greenland, Diane Treat-Jacobson, Melina R. Kibbe, Michael H. Criqui, Jack M. Guralnik, Mary M. McDermott
Summary: This study identified barriers to participation in supervised exercise therapy covered by CMS for lower extremity PAD. The majority of participants had never been prescribed or recommended supervised exercise therapy by their physicians, and most were unwilling or unable to pay the required copay for CMS-covered sessions. Many individuals also cited travel to medical centers as a significant obstacle to participation. These findings highlight the significant barriers faced by PAD patients in accessing and participating in supervised exercise therapy.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Pabon, Susan Cheng, S. Elissa Altin, Sanjum S. Sethi, Michael D. Nelson, Kerrie L. Moreau, Naomi Hamburg, Connie N. Hess
Summary: Peripheral artery disease (PAD) has similar or higher prevalence in women compared to men, but there are sex differences in the mechanisms and clinical manifestations. Despite available treatments, there are still sex differences in treatment and outcomes.
CIRCULATION RESEARCH
(2022)
Article
Medicine, General & Internal
Po-Sheng Chen, Meng Lee, Sung-Chun Tang, Po-Hsun Huang, Hung- Yeh, Charles Jia-Yin Hou, I-Chang Hsieh, Jiunn-Tay Lee, Jiann-Shing Jeng, Yi-Heng Li
Summary: This article highlights the significance of the 2017 Taiwan Lipid Guidelines for High Risk Patients and discusses the impact of lipid management in ASCVD patients. It mentions the changing treatment concept of ASCVD based on recent clinical trials, leading to an update in lipid treatment strategy for ASCVD patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Derek Klarin, Philip S. Tsao, Scott M. Damrauer
Summary: Peripheral artery disease is a common and complex disease with both environmental and genetic determinants. Recent advances in genetic analysis have focused on identifying disease genes, rare variant and structural variant analysis, and the inclusion of individuals with diverse genetic ancestries in future studies.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Marc P. Bonaca, Naomi M. Hamburg, Mark A. Creager
Summary: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis with modifiable risk factors including smoking, dyslipidemia, and diabetes. Medical therapies can reduce the risk of major adverse cardiovascular events and major adverse limb events, and improve function. Diagnosis and treatment should consider the individual risk profile of the patient.
CIRCULATION RESEARCH
(2021)
Review
Environmental Sciences
Alexandru Achim, Agata Stanek, Calin Homorodean, Mihail Spinu, Horea Laurentiu Onea, Leontin Lazar, Madalin Marc, Zoltan Ruzsa, Dan Mircea Olinic
Summary: Peripheral artery disease (PAD) and diabetes have a harmful interplay, with certain symptoms increasing the risk of contracting the other disease. This review explores the phenotype of patients with both diabetes and PAD, and whether individualized treatment is necessary for this high-risk population. Additionally, guideline recommendations for treating PAD are analyzed to identify the differences and evidence gaps in this population suffering from the two interconnected disorders.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Cardiac & Cardiovascular Systems
Tanner I. Kim, Raul J. Guzman
Summary: Medial artery calcification (MAC) is a regulated process associated with age, diabetes, and chronic kidney disease. It often occurs with atherosclerotic occlusive disease in lower extremity arteries, leading to negative limb outcomes. In patients with peripheral artery disease (PAD), MAC independently correlates with major amputation and mortality rates, affecting outcomes after endovascular interventions. Understanding the role of medial calcification in PAD and developing strategies for patient outcomes improvement are areas for further investigation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Environmental Sciences
Rance Nault, Matthew C. Cave, Gabriele Ludewig, Hunter N. B. Moseley, Kelly G. Pennell, Tim Zacharewski
Summary: In the field of environmental health science, there is a need for cultural shifts and strategies to improve data management and develop reliable resources. Efforts have been made to enhance data collection and metadata, and new tools and resources have been introduced. The environmental health science community plays a key role in achieving the FAIR guiding principles and proposes a framework to promote these objectives.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Review
Medicine, General & Internal
Alex H. Krist, Karina W. Davidson, Carol M. Mangione, Michael J. Barry, Michael Cabana, Aaron B. Caughey, Katrina Donahue, Chyke A. Doubeni, John W. Epling, Martha Kubik, Gbenga Ogedegbe, Lori Pbert, Michael Silverstein, Melissa A. Simon, Chien-Wen Tseng, John B. Wong
Summary: This recommendation advises against screening for asymptomatic carotid artery stenosis in the general adult population due to the harms outweighing the benefits.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Surgery
Mark A. Eid, Kunal Mehta, Zachary Wanken, Jesse A. Columbo, David H. Stone, Philip Goodney, Michael Mayo Smith
Summary: This study analyzed the global burden of peripheral artery disease (PAD) using data from the Global Burden of Diseases, Injuries and Risk Factors Study. The results showed a significant increase in the global prevalence and mortality associated with PAD, in contrast with other forms of ischemic cardiovascular disease. Public health efforts and vascular surgical resources are needed to address this increasing health threat.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Biology
Lilla Horvath, Noemi Nemeth, Gergely Feher, Zsuzsanna Kives, Dora Endrei, Imre Boncz
Summary: The past decades have seen a significant increase in atherosclerotic cardiovascular diseases (CVDs), particularly in low-income and middle-income countries (LMICs). Peripheral artery disease (PAD), which is strongly age-related, is estimated to become more prevalent in the future. PAD shares risk factors with coronary and cerebrovascular diseases and is associated with significant morbidity and mortality. Despite advances in treatment, the prevalence of PAD continues to rise, and data from LMICs are scarce.
Review
Hematology
Sanjay Divakaran, Anna K. Krawisz, Eric A. Secemsky, Shashi Kant
Summary: Women and racial and ethnic minority patients have an increased risk of developing lower extremity peripheral artery disease and experiencing adverse outcomes. The underlying causes of these increased risks are not fully understood. Opportunities for improving care include increased screening rates, higher clinical suspicion, and proactive management of risk factors.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aaron W. Aday, Kunihiro Matsushita
Summary: PAD is increasingly recognized as a major cause of cardiovascular morbidity and mortality worldwide. The focus on PAD in recent years has led to new epidemiological insights and highlighted the importance of polyvascular disease in cardiovascular research and clinical practice. PAD may present similar or even greater risk compared to coronary artery disease or stroke.
CIRCULATION RESEARCH
(2021)
Review
Medicine, Research & Experimental
Jingxuan Han, Lailiu Luo, Olivia Marcelina, Vivi Kasim, Shourong Wu
Summary: Peripheral artery disease (PAD) poses a significant challenge to society and its prevalence is expected to increase in the coming years. Patients in severe stages of PAD are at high risk of amputation and death, leading to decreased quality of life and socio-economic burden. Therapeutic angiogenesis has emerged as a potential strategy for treating PAD, but further efforts are needed to address certain issues.
Review
Cardiac & Cardiovascular Systems
Isma N. Javed, Beau M. Hawkins
Summary: Aorto-iliac disease is a common manifestation of atherosclerosis, with treatment options including medication, risk factor modification, exercise, and revascularization for severe cases. Various endovascular therapies are now available for complex lesions.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Naveed Akbar, Calum Forteath, Muhammad S. Hussain, Kathleen Reyskens, Jill J. F. Belch, Chim C. Lang, Ify Mordi, U. Bhalraam, J. Simon C. Arthur, Faisel Khan
Summary: In this study, it was found that mitogen and stress kinase 1/2 (MSK1/2) play a significant role in the development of endothelial dysfunction in myocardial infarction patients and mouse models. Genetic deficiency of MSK1/2 increased plasma levels of pro-inflammatory cytokines and promoted endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Jill J. F. Belch, Marianne Brodmann, Iris Baumgartner, Christoph J. Binder, Manuela Casula, Christian Heiss, Thomas Kahan, Paolo Parini, Pavel Poredos, Alberico L. Catapano, Lale Tokgozoglu
Summary: Patients with peripheral arterial disease (PAD) are at high risk of cardiovascular events, but effective management of dyslipidaemia and thrombotic factors can reduce this risk and improve walking performance. Adding ezetimibe or PCSK9 inhibitors can further decrease cardiovascular event risk, while dual antiplatelet therapy can prevent cardiovascular events.
Article
Peripheral Vascular Disease
Christian Heiss, Dan-Mircea Olinic, Jill J. F. Belch, Marianne Brodmann, Lucia Mazzolai, Agata Stanek, Juraj Madaric, Andrew Krentz, Oliver Schlager, Michael Lichtenberg, Ulrich Frank
Summary: With an increasing global burden of patients with chronic peripheral artery disease (PAD), the safe and effective provision of lower limb revascularisation is becoming a growing medical need. Endovascular procedures have become crucial in modern vascular medicine as the first line approach for revascularisation, given its technical feasibility and patient choice. Open vascular surgery is often not feasible due to the increasing age and comorbidities of PAD patients. We outline key messages endorsed by the European Society of Vascular Medicine for managing patients requiring endovascular arterial procedures, emphasizing the important role of interventional vascular physicians.
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2022)
Review
Oncology
Evangelos Dimakakos, Georgia Gomatou, Mariella Catalano, Dan-Mircea Olinic, Alex C. Spyropoulos, Anna Falanga, Anthony Maraveyas, Aaron Liew, Sam Schulman, Jill Belch, Grigorios Gerotziafas, Peter Marschang, Benilde Cosmi, Jonas Spaak, Konstantinos Syrigos
Summary: Cancer and COVID-19 both increase the risk of thrombosis. Thromboprophylaxis is recommended for hospitalized patients with cancer and high-risk outpatients with cancer receiving treatment. The use of LMWH is currently indicated for hospitalized patients with COVID-19. However, it is unclear if there is an additive risk of thrombosis when a cancer patient is infected with COVID-19.
ANTICANCER RESEARCH
(2022)
Article
Peripheral Vascular Disease
Jean-Claude Wautrecht, Dan-Mircea Olinic, Mariella Catalano, Colin Baines, Jill Belch, Ales Blinc, Ivo Buschmann, Denisa Celovska, Mary-Paula Colgan, Evangelos Dimakakos, Christian Heiss, Endre Kolossvary, Matija Kozak, Bram Kroon, Lucia Mazzolai, George Marakomichelakis, Zsolt Pecsvarady, Maria A. Pias Canedo, Isabelle Quere, Karel Roztocil, Gerit H. Schernthaner, Aleksander Sieron, Jonas Spaak, Muriel Sprynger, Agata Stanek, Daniel Staub, Dragan Vasic, Adriana Visona, andrea Willfort-Ehringer
INTERNATIONAL ANGIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Catherine A. Fitton, Jill J. F. Belch
CARDIOVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Stefano Lanzi, Jill Belch, Marianne Brodmann, Juraj Madaric, Alessandra Bura-Riviere, Adriana Visona, Lucia Mazzolai
Summary: This article describes the perception, accessibility, and structure of SET in patients with PAD through a survey conducted in Europe. The data shows significant variations in the availability and characteristics of SET across European countries.
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
Paola Bigolin, Beniamino Zalunardo, Lucia Mazzolai, Jill Belch, Adriana Visona
Summary: This study aims to facilitate decision making for health professionals in their daily practice by using integrated care pathways, aiming to minimize the impact of cardiovascular disease and improve the quality of prevention measures.
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Matthew A. Lambert, J. Graeme Houston, Roberta Littleford, Catherine A. Fitton, Allan Struthers, Frank Sullivan, Stephen Gandy, Jill J. F. Belch
Summary: Risk factor-based models have limitations in accurately predicting individual-level cardiovascular disease (CVD) development. This study aims to identify low-risk individuals who may develop CVD for tailored advice and informed treatment decisions. The TASCFORCE study recruited participants aged >= 40 years without known CVD and is investigating the predictive ability of BNP and WBCE-MRI in a low/intermediate-risk population.
Review
Medicine, General & Internal
Konstantinos G. Kyriakoulis, Evangelos Dimakakos, Ioannis G. Kyriakoulis, Mariella Catalano, Alex C. Spyropoulos, Sam Schulman, James Douketis, Anna Falanga, Anthony Maraveyas, Dan-Mircea Olinic, Jill Belch, Grigorios Gerotziafas, Konstantinos Syrigos, Anastasios Kollias
Summary: COVID-19 is strongly associated with increased risk for venous thromboembolism events. Pharmacologic thromboprophylaxis has shown significant benefits in reducing VTE events and mortality, especially in hospitalized patients. However, it is not routinely recommended for outpatient setting. Randomized controlled trials provide further support for optimal thromboprophylaxis strategies, but the evidence is mainly derived from observational studies with limitations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Marco De Carlo, Oliver Schlager, Lucia Mazzolai, Marianne Brodmann, Christine Espinola-Klein, Daniel Staub, Victor Aboyans, Henrik Sillesen, Sebastian Debus, Maarit Venermo, Jill Belch, Mauro Ferrari, Raffaele De Caterina
Summary: This study investigated the use of antithrombotic therapy by European physicians after lower extremity revascularization surgeries. The results showed variations in the choice of therapy among different countries and specialties, with a minority of physicians having dedicated protocols for treatment.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Peripheral Vascular Disease
Bernd Krabbe, Christine Espinola-Klein, Nasser Malyar, Marianne Brodmann, Lucia Mazzolai, Jill J. F. Belch, Oliver J. Mueller, Christian Heiss
Summary: Tobacco consumption is a major risk factor for cardiovascular disease. Despite efforts to reduce smoking, the use of e-cigarettes is increasing, while tobacco smoking is decreasing. E-cigarettes are advertised as less harmful than regular cigarettes and helpful for quitting smoking, but they still pose risks and can cause vascular damage. Long-term health risks of e-cigarettes and their use by non-smokers as a first contact with nicotine are a concern. The controversy surrounding the use of e-cigarettes for smoking cessation is also discussed.
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2023)
Article
Environmental Sciences
Catherine A. Fitton, Bianca Cox, Munro Stewart, James Chalmers, Jill J. F. Belch
Summary: This study investigates the effects of air pollution on respiratory hospital admissions in Dundee, Scotland. It finds a significant association between nitrogen oxides and respiratory admissions in children, emphasizing the need to improve and enforce pollution limits in cities.
AEROSOL AND AIR QUALITY RESEARCH
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
K. Ali, J. R. Weir-Mccall, F. Khan, J. Belch, J. G. Houston, I. R. Mordi, C. C. Lang, J. T. J. Huang, A. M. Choy
EUROPEAN HEART JOURNAL
(2022)
Article
Cell Biology
Faisel Khan, Isabel Goncalves, Angela C. Shore, Andrea Natali, Carlo Palombo, Helen M. Colhoun, Gerd Ostling, Francesco Casanova, Cecilia Kennbaeck, Kunihiko Aizawa, Margaretha Persson, Kim M. Gooding, David Strain, Helen Looker, Fiona Dove, Jill Belch, Silvia Pinnola, Elena Venturi, Michaela Kozakova, Jan Nilsson
Summary: This study used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with changes in carotid disease severity in high-risk subjects. The results show that changes primarily occur in fibrotic plaques and are associated with increased levels of platelet-derived growth factor (PDGF).
CELL REPORTS MEDICINE
(2022)
