Review
Surgery
Hozan Mufty, Jef Van den Eynde, Hans P. Steenackers, Willem-Jan Metsemakers, Bart Meuris, Inge Fourneau
Summary: This study reviews preclinical studies on the role of commercially available silver-coated grafts in preventing vascular graft infection (VGI). In vitro studies showed positive antimicrobial effects, while in vivo studies had conflicting and mixed results. More data are needed to guide the appropriate use of silver grafts given the lack of convincing preclinical evidence and their poor performance in clinical studies.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Infectious Diseases
Jiri Molacek, Vladislav Treska, Karel Houdek, Vaclav Opatrny, Bohuslav Certik, Jan Baxa
Summary: The study evaluated the use of a silver-impregnated vascular graft in various situations, showing it to be a suitable alternative for infectious or potentially infectious conditions. The 30-day mortality rate was 19.7%, with a silver graft infection rate of 4.2%.
Article
Multidisciplinary Sciences
Maria Anna Smolle, Marko Bergovec, Susanne Scheipl, Walter Goessler, Florian Amerstorfer, Mathias Glehr, Andreas Leithner, Joerg Friesenbichler
Summary: This study analyzed the serum silver concentrations in patients with silver-coated megaprostheses over a prolonged period of time. The results showed that the silver ion levels exhibited an unspecific undulating course during the follow-up period, and the development of periprosthetic joint infection was significantly associated with increased silver ion levels. No systemic complications related to high silver levels were observed.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Harleen K. Sandhu, Alexander P. Nissen, Harith Mushtaq, Charles C. Miller, Hazim J. Safi, Anthony L. Estrera, Kristofer M. Charlton-Ouw
Summary: This study reviewed 22 years of experience in managing thoracic aortic graft infection, and found that factors such as vascularized tissue coverage, antibiotics, and timing of treatment have significant impacts on long-term survival outcomes for patients. Patients with endograft infection and aortobronchial fistula had poor prognoses.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
William Alonso, Baris Ozdemir, Lucien Chassin-Trubert, Vicent Ziza, Pierre Alric, Ludovic Canaud
Summary: This study reported the surgical strategy and early outcomes of abdominal aortic reconstruction using in situ xenopericardial grafts for both native and graft-related aortic infection. The technical success rate was 100%, with good short-term results observed. Longer follow-up is needed to determine the durability of the reconstruction and the need for reinterventions.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuntae Kim, Kazuhiro Ishikawa, Fujimi Kawai, Nobuyoshi Mori
Summary: A case of aortic graft infection with splenomegaly and splenic infarction is reported. The patient, who had undergone total arch replacement for Stanford type A acute aortic dissection, presented with fever, night sweat, and weight loss. Imaging tests revealed splenic infarction, fluid collection, and thrombus around the stent graft, as well as abnormal F-18-fluorodeoxyglucose uptake in the graft and spleen. The patient was diagnosed with graft infection and underwent graft replacement and antibiotic treatment.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Surgery
Caroline Caradu, Benjamin Jolivet, Mathilde Puges, Charles Cazanave, Eric Ducasse, Xavier Berard
Summary: This study evaluates the survival and freedom from reinfection after in situ reconstruction using an antimicrobial graft for infectious native aortic aneurysms or vascular graft infection. The results show encouraging early mortality and mid-term reinfection rates.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Armin Tabiei, Sebastian Cifuentes, Amy E. Glasgow, Jill J. Colglazier, Manju Kalra, Bernardo C. Mendes, Todd E. Rasmussen, Fahad Shuja, Randall R. Demartino
Summary: This study compared the safety and effectiveness of cryopreserved arterial allografts (CAA) and rifampin-soaked Dacron (RSD) for in situ reconstruction in patients with aortic and iliac graft infections. The results showed similar postoperative survival rates and 30-day/in-hospital mortality rates between CAA and RSD, but CAA use led to a higher frequency of reintervention.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Qiqi Liu, Ying Zhang, Jingkai Huang, Zhourui Xu, Xiang Li, Jingyu Yang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Jinbo Lin, Chengbin Yang, Jia Liu, Suxia Lin
Summary: A core-shell structured nanoplatform was developed to co-load ciprofloxacin and tumor necrosis factor-alpha small interfering RNA for treating bacterial-infected wounds. The released silver ions and ciprofloxacin inhibited the growth of bacterial pathogens. Macrophage cells internalized the loaded siTNF-alpha, silencing the expression of inflammatory cytokines and promoting wound healing. In vivo, the infected wounds almost completely disappeared after treatment with the nanoplatform, and no suppuration symptoms were observed. The nanoplatform showed negligible side effects, highlighting its potential for clinical wound infections.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Hao Yin, Mao Zhou, Xia Chen, Teng-Fei Wan, Ling Jin, Shan-Shan Rao, Yi-Juan Tan, Ran Duan, Yu Zhang, Zhen-Xing Wang, Yi-Yi Wang, Ze-Hui He, Ming-Jie Luo, Xiong-Ke Hu, Yang Wang, Wei-Yi Situ, Si-Yuan Tang, Wen-En Liu, Chun-Yuan Chen, Hui Xie
Summary: This study demonstrates the potential of fructose-coated Angstrom-scale silver particles (F-AgAPs) as a promising intravenous agent for treating severe bacterial infections, by efficiently killing various bacteria, competing with host cells to bind with bacterial toxins, and reducing bacterial burden, reversing dysregulated inflammation, and enhancing survival rates in mouse models of sepsis.
Article
Engineering, Biomedical
Sunfang Chen, Dan Cai, Qi Dong, Gaoxiang Ma, Chennan Xu, Xiaogang Bao, Wei Yuan, Bing Wu, Bin Fang
Summary: This study developed a multifunctional tendon graft with high mechanical strength, antibacterial and antiadhesion activity. By attaching silver nanoparticles to a decellularized extracellular matrix, the graft exhibited long-lasting antibacterial and antiadhesion properties. The results showed that the graft was biocompatible, mechanically resilient, and effective in treating tendon defects in animals.
BIOMATERIALS RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian Kreibich, Matthias Siepe, Tim Berger, Clarence Pingpoh, Paul Puiu, Julia Morlock, Tim Walter, Stoyan Kondov, Friedhelm Beyersdorf, Bartosz Rylski, Martin Czerny
Summary: The mid-term outcomes of bovine pericardial tube graft repair for infectious aortic disease were evaluated in 45 patients, showing that it is effective in treating infectious aortic disease in any aortic segment but with a higher early mortality rate.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Sakkarin Lethongkam, Supakit Paosen, Siwaporn Bilhman, Krittima Dumjun, Suttiwan Wunnoo, Suntree Choojit, Ratchaneewan Siri, Chalongrat Daengngam, Supayang P. Voravuthikunchai, Tanan Bejrananda
Summary: A Foley urinary catheter coated with synthesized silver nanoparticles was developed to inhibit microbial adhesion and biofilm formation, reducing the risk of catheter-associated urinary tract infections.
Article
Cardiac & Cardiovascular Systems
Ilse J. E. Kouijzer, Celine T. Baranelli, Ianthe Maat, Frederik M. A. van den Heuvel, Erik H. J. G. Aarntzen, Tim Smith, Quirijn de Mast, Guillaume S. C. Geuzebroek
Summary: The study aimed to evaluate the outcome of patients with thoracic aortic vascular graft infection (VGI) who were treated without graft removal. It found that long-term targeted antibiotic therapy without graft removal may be an effective treatment option.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Sharjeel A. Chaudhry, Ethan S. Rosenfeld, Brandon N. Glousman, Andrew D. Sparks, Salim Lala, Robyn Macsata, Richard Amdur, Anton N. Sidawy, Bao-Ngoc Nguyen
Summary: Dependent functional status is significantly associated with adverse outcomes after excision of infected abdominal aortic grafts, while old age alone does not have a negative impact on the results. Therefore, this procedure can be considered in elderly patients with good functional status.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Jaap G. Neels, Reda Hassen-Khodja, Giulia Chinetti
Review
Surgery
Juliette Raffort, Cedric Adam, Marion Carrier, Ali Ballaith, Raphael Coscas, Elixene Jean-Baptiste, Reda Hassen-Khodja, Nabil Chakfe, Fabien Lareyre
JOURNAL OF VASCULAR SURGERY
(2020)
Article
Surgery
Ali Ballaith, Juliette Raffort, Khalid Rajhi, Benjamin Salucki, Celine Drai, Elixene Jean-Baptiste, Reda Hassen-Khodja, Fabien Lareyre
Summary: This paper reports a case of mycotic aortic and ruptured left iliac aneurysm caused by E. Coli, which is described as a rare causative agent. The literature overview discusses the clinical characteristics, disease management, and post-operative outcomes of mycotic aortic aneurysms specifically due to E. Coli.
ACTA CHIRURGICA BELGICA
(2022)
Article
Peripheral Vascular Disease
Marc Clement, Fabien Lareyre, Alexia Loste, Aurelie Sannier, Fanny Burel-Vandenbos, Nicolas Massiot, Joseph Carboni, Elixene Jean-Baptiste, Giuseppina Caligiuri, Antonino Nicoletti, Juliette Raffort
Summary: The study identified histological features of SAAs, showing characteristics such as atherosclerotic lesions, calcifications, and intraluminal thrombus. SAAs were characterized by intense vascular remodeling, loss of VSMCs, elastin degradation, fibrosis, enhanced apoptosis, and increased matrix metalloproteinase 9 expression. Immune cell infiltration was observed, but lymphoid neogenesis in SAAs appeared to be incomplete.
Article
Surgery
Fabien Lareyre, Emmanuel Augene, Damien Massalou, Julien Chikande, Lucas Guidi, Elixene Jean-Baptiste, Reda Hassen-Khodja, Juliette Raffort
Summary: This study found that vascular calcifications in the superior mesenteric artery are associated with increased mortality in patients with acute mesenteric ischemia. Further research is needed to understand the mechanisms underlying this association.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Surgery
Guillaume Mahe, Gudrun Boge, Alessandra Bura-Riviere, Nabil Chakfe, Joel Constants, Yann Goueffic, Philippe Lacroix, Claire Le Hello, Gilles Pernod, Antonia Perez-Martin, Jean Picquet, Muriel Sprynger
Summary: Several recent international guidelines on Lower Extremity Arterial Disease (LEAD) published by various medical societies have differences and gaps in addressing certain issues. This consensus driven by French Societies of Vascular Medicine and Surgery aims to analyze the disparities and propose solutions in various fields related to LEAD.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Neurosciences
Nirvana Sadaghianloo, Julie Contenti, Serge Declemy, Damien Ambrosetti, Masa Zdralevic, Mounia Tannour-Louet, Lucilla Fabbri, Gilles Pages, Frederic Bost, Reda Hassen-Khodja, Jacques Pouyssegur, Elixene Jean-Baptiste, Alan Dardik, Nathalie M. Mazure
Summary: Patients with end-stage renal failure need AVFs for dialysis, but these AVFs often fail due to excessive venous thickness. This study found that venous cells adapt their metabolism depending on oxygen concentration, and targeting the hypoxic response pathway with drugs can help decrease excessive venous thickness. In a mouse model, inhibiting HIFs decreased neointimal hyperplasia, suggesting that drugs targeting HIFs could prevent AVF failure.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Surgery
Marine Gaudry, Pierre-Antoine Barral, Arnaud Blanchard, Sylvie Palazzolo, Sonia Bolomey, Virgile Omnes, Mariangela De Masi, Magali Carcopino-Tusoli, Olivier Meyrignac, Herve Rousseau, Alexis Jacquier, Reda Hassen-Khodja, Alessandra Bura-Riviere, Jean-Michel Bartoli, Stephanie Gentile, Philippe Piquet, Laurence Bal
Summary: The study revealed a high prevalence of TAAs in patients with AAAs, with one fifth of these TAAs requiring surgery. Atrial fibrillation and mild aortic valvulopathy were identified as independent risk factors for TAAs, while age and atrial fibrillation were independently associated with ectasia.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Surgery
Aurelien Hostalrich, Thomas Mesnard, Raphael Soler, Paul Girardet, Adrien Kaladji, Elixene Jean Baptiste, Serguei Malikov, Thierry Reix, Jean-Baptiste Ricco, Xavier Chaufour
Summary: The study evaluated the effectiveness of fenestrated/branched EVAR (F/BEVAR) in treating failed EVAR with type Ia endoleak, showing a technical success rate of 94%. However, some patients still required secondary endovascular and open surgical procedures, with a low rate of post-operative complications.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Urology & Nephrology
Julie Contenti, Matthieu Durand, Sandor Vido, Serge Declemy, Juliette Raffort, Joseph Carboni, Sophie Bonnet, Christophe Koelsch, Reda Hassen-Khodja, Philippe Gual, Nathalie M. Mazure, Nirvana Sadaghianloo
Summary: The study found that the level of pOPN in hemodialysis patients was associated with the presence of AVF stenosis requiring intervention, suggesting its potential as a diagnostic biomarker for evaluation in a vascular access surveillance program.
JOURNAL OF NEPHROLOGY
(2022)
Article
Peripheral Vascular Disease
Emmanuel Augene, Fabien Lareyre, Julien Chikande, Lucas Guidi, Gregoire Mutambayi, Cong Duy Le, Elixene Jean-Baptiste, Niki Katsiki, Dimitri P. Mikhailidis, Juliette Raffort
Summary: This study evaluated the incidence of contrast-induced acute kidney injury (CI-AKI) in patients with acute mesenteric ischemia and identified plasma bilirubin levels as a predictive factor for CI-AKI in these patients. The use of contrast media during revascularization was not associated with an increased risk of CI-AKI.
Article
Biochemistry & Molecular Biology
Giulia Chinetti, Joseph Carboni, Joseph Murdaca, Claudine Moratal, Brigitte Sibille, Juliette Raffort, Fabien Lareyre, Elixene Jean Baptiste, Reda Hassen-Khodja, Jaap G. Neels
Summary: Patients with type 2 diabetes are less likely to develop abdominal aortic aneurysm (AAA), possibly due to diabetes-induced changes in the metabolism of macrophages. This study found that macrophages treated with serum from diabetic AAA patients showed increased metabolism and a shift towards an anti-inflammatory state, suggesting a potential mechanism for the reduced risk of AAA development in diabetic patients.