期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 10, 页码 3462-3465出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja5130836
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资金
- National Institutes of Health [NIGMS R01GM063540]
We report a highly enantioselective intermolecular Heck reaction of alkenyl triflates and acyclic primary or racemic secondary alkenols. The mild reaction conditions permit installation of a wide range of alkenyl groups at positions beta, gamma, or delta to a carbonyl group in high enantioselectivity. The success of this reaction is attributed to the use of electron-withdrawing alkenyl triflates, which offer selective beta-hydride elimination followed by migration of the catalyst through the alkyl chain to give the alkenylated carbonyl products. The synthetic utility of the process is demonstrated by a two-step modification of a reaction product to yield a tricyclic core structure, present in various natural products.
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