期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 37, 页码 11946-11949出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b08551
关键词
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资金
- National High Technology Projects 973 [2015CB856200]
- NNSFC [21222209, 91313303, 21472010]
We report herein the first total synthesis of (-)-incarviatone A (1) in 14 steps starting from commercially available inexpensive phenylacetic acid (9). Our early stage synthesis relies on the scalable and sequential C-H functionalitation to rapidly assemble the indanyl dialdehyde framework. Further biomimetic cascade strategy allows us to obtain the natural product in a onepot operation. We also conduct detailed mechanistic studies and disclose all the possible intermediates and isomers formed during the biomimetic cascade process.
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