期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 83, 期 7, 页码 1098-1105出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2014.03.027
关键词
Three-dimensional ultrasound; Contrast enhanced ultrasound; Dynamic contrast-enhanced magnetic resonance imaging; Breast tumor; Angiogenesis; Biological factors
资金
- National Natural Science Foundation of China [81172078]
- Huangpu District Health System in Shanghai Municipal
Objective: To explore the clinical value of three-dimensional contrast enhanced ultrasound (3D-CEUS) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) score systems in evaluating breast tumor angiogenesis by comparing their diagnostic efficacy and correlation with biological factors. Methods: 3D-CEUS was performed in 183 patients with breast tumors by Esaote Mylab90 with SonoVue (Bacco, Italy), DCE-MRI was performed on a dedicated breast magnetic resonance imaging (DBMRI) system (Aurora Dedicated Breast MRI Systems, USA) with a dedicated breast coil. 3D-CEUS and DCE-MRI score systems were created based on tumor perfusion and vascular characteristics. Microvessel density (MVD), vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP-2, MMP-9) expression were measured by immunohistochemistry. Results: Pathological results showed 35 benign and 148 malignant breast tumors. MVD (P= 0.000, r = 0.76), VEGF (P= 0.000, r = 0.55), MMP-2 (A = 0.000, r = 0.39) and MMP-9 (A = 0.000, r = 0.41) expression were all significantly different between benignity and malignancy. Regarding 3D-CEUS 4 points as cutoff value, the sensitivity, specificity and accuracy were 85.1%, 94.3% and 86.9%, respectively, and correlated well with MVD (A = 0.000, r = 0.50), VEGF (A = 0.000, r = 0.50), MMP-2 (A = 0.000, r = 0.50) and MMP-9 (A = 0.000, r = 0.66). Taking DCE-MRI 5 points as cutoff value, the sensitivity, specificity and accuracy were 86.5%, 94.3% and 88.0%, respectively and also correlated well with MVD (P=0.000, r= 0.52), VEGF (P=0.000, r = 0.44), MMP-2 (P = 0.000, r = 0.42) and MMP-9 (P = 0.000, r = 0.35). Conclusions: 3D-CEUS score system displays inspiring diagnostic performance and good agreement with DCE-MRI scoring. Moreover, both score systems correlate well with MVD, VEGF, MMP-2 and MMP-9 expression, and thus have great potentials in tumor angiogenesis evaluation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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